Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification

Biochemical and Biophysical Research Communications

Volumn 418, Issue 4, 2012, Pages 634-640

  Oh, Jung Hoon ^a   Park, Seung Yoon ^b   de Crombrugghe, Benoit ^c   Kim, Jung Eun ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Dongguk University College of Medicine   (South Korea)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Chondrocytes; Col2a1 Cre; Endochondral ossification; Osterix

Indexed keywords

TRANSCRIPTION FACTOR OSTERIX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MARROW; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENCHONDRAL OSSIFICATION; FEMALE; GENE DELETION; GROWTH PLATE; HISTOPATHOLOGY; HYPERTROPHY; KNOCKOUT GENE; LONG BONE; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKELETON MALFORMATION; TRABECULAR BONE;

ANIMALS; BONE AND BONES; CHONDROCYTES; CHONDROGENESIS; GENE DELETION; HUMERUS; MICE; MICE, KNOCKOUT; OSTEOCLASTS; OSTEOGENESIS; TRANSCRIPTION FACTORS;

EID: 84862784199     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.064     Document Type: Article

References (22)

1. Olsen B.R., Reginato A.M., Wang W. Bone development. Annu. Rev. Cell Dev. 2000, 16:191-220.
2. Mackie E.J., Ahmed Y.A., Tatarczuch L., Chen K.S., Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int. J. Biochem. Cell Biol. 2008, 40:46-62.
3. Wallis G.A. Bone growth: coordinating chondrocyte differentiation. Curr. Biol. 1996, 6:1577-1580.
4. Karsenty G., Kronenberg H.M., Settembre C. Genetic control of bone formation. Annu. Rev. Cell Dev. Biol. 2009, 25:629-648.
5. Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
6. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., de Crombrugghe B. The novel zinc finger containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108:17-29.
7. Nakashima K., de Crombrugghe B. Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet. 2003, 19:458-466.
8. Baek W.Y., Lee M.A., Jung J.W., Kim S.Y., Akiyama H., de Crombrugghe B., Kim J.E. Positive regulation of adult bone formation by osteoblast-specific transcription factor Osterix. J. Bone Miner. Res. 2009, 24:1055-1065.
9. Baek W.Y., de Crombrugghe B., Kim J.E. Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone 2010, 46:920-928.
10. Zhou X., Zhang Z., Feng J.Q., Dusevich V.M., Sinha K., Zhang H., Darnay B.G., de Crombrugghe B. Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc. Natl. Acad. Sci. USA 2010, 107:12919-12924.
11. Omoteyama K., Takagi M. The effects of Sp7/Osterix gene silencing in the chondroprogenitor cell line, ATDC5. Biochem. Biophys. Res. Commun. 2010, 403:242-246.
12. Ovchinnikov D.A., Deng J.M., Ogunrinu G., Behringer R.R. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 2000, 26:145-146.
13. Akiyama H., Kim J.E., Nakashima K., Balmes G., Iwai N., Deng J.M., Zhang Z., Martin J.F., Behringer R.R., Nakamura T., de Crombrugghe B. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc. Natl. Acad. Sci. USA 2005, 102:14665-14670.
14. Park S.Y., Choi J.H., Ryu H.S., Pak Y.K., Park K.S., Lee H.K., Lee W. C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. J. Biol. Chem. 2009, 284:27780-27789.
15. St-Jacques B., Hammerschmidt M., McMahon A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999, 13:2072-2086.
16. Karsenty G. Transcriptional control of skeletogenesis. Annu. Rev. Genomics Hum. Genet. 2008, 9:183-196.
17. Colnot C.I., Helms J.A. A molecular analysis of matrix remodeling and angiogenesis during long bone development. Mech. Dev. 2001, 100:245-250.
18. Provot S., Schipani E. Molecular mechanisms of endochondral bone development. Biochem. Biophys. Res. Commun. 2005, 328:658-665.
19. Lefebvre V., Smits P. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res. C. Embryo Today 2005, 75:200-212.
20. Yoshida C.A., Yamamoto H., Fujita T., Furuichi T., Ito K., Inoue K., Yamana K., Zanma A., Takada K., Ito Y., Komori T. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004, 18:952-963.
21. Wang W., Lian N., Li L., Moss H.E., Wang W., Perrien D.S., Elefteriou F., Yang X. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development 2009, 136:4143-4153.
22. Amano K., Ichida F., Sugita A., Hata K., Wada M., Takigawa Y., Nakanishi M., Kogo M., Nishimura R., Yoneda T. MSX2 stimulates chondrocyte maturation by controlling Ihh expression. J. Biol. Chem. 2008, 283:29513-29521.