Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation

Journal of Bone and Mineral Research

Volumn 22, Issue 8, 2007, Pages 1260-1270

  Soung, Do Y ^a   Dong, Yufeng ^a   Wang, YongJun ^a   Zuscik, Michael J ^a   Schwarz, Edward M ^a   O'Keefe, Regis J ^a   Drissi, Hicham ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Chondrocytes; Runx3 Cbfa3; Skeleton; Transfection

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 10; MESSENGER RNA; OSTEOCALCIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX3; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN; ISOPROTEIN; RUNX1 PROTEIN, MOUSE; RUNX3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR RUNX1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CHONDROGENESIS; EMBRYO; ENCHONDRAL OSSIFICATION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; MESENCHYME CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CELL CULTURE; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LIMB BUD; METABOLISM; TIME;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIMB BUD; MICE; PROTEIN ISOFORMS; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 34548081206     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070502     Document Type: Article

References (32)

1. Crosier PS, Kalev-Zylinska ML, Hall CJ, Flores MV, Horsfield JA, Crosier KE 2002 Pathways in blood and vessel development revealed through zebrafish genetics. Int J Dev Biol 46:493-502.
2. Lutterbach B, Hiebert SW 2000 Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 245:223-235.
3. Nam S, Jin YH, Li QL, Lee KY, Jeong GB, Ito Y, Lee J, Bae SC 2002 Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans. Mol Cell Biol 22:547-554.
4. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR 1996 AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330.
5. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA 1996 Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444-3449.
6. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
7. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771.
8. Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS 2001 Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci USA 98:8650-8655.
9. Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, Bernstein Y, Goldenberg D, Xiao C, Fliegauf M, Kremer E, Otto F, Brenner O, Lev-Tov A, Groner Y 2002 The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J 21:3454-3463.
10. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y 2002 Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109:113-124.
11. Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y 2004 Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci USA 101:16016-16021.
12. Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH 2005 Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol 203:133-143.
13. Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y 2001 Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev 109:413-417.
14. Strieker S, Fundele R, Vortkamp A, Mundlos S 2002 Role of Runx genes in chondrocyte differentiation. Dev Biol 245:95-108.
15. Coffman JA 2003 Runx transcription factors and the developmental balance between cell proliferation and differentiation. Cell Biol Int 27:315-324.
16. Ito Y 2004 Oncogenic potential of the RUNX gene family. 'Overview'. Oncogene 23:4198-4208.
17. Westendorf JJ, Hiebert SW 1999 Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia. J Cell Biochem Suppl 32-33:51-58.
18. Durst KL, Hiebert SW 2004 Role of RUNX family members in transcriptional repression and gene silencing. Oncogene 23:4220-4224.
19. Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H 2005 Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J Bone Miner Res 20:1624-1636.
20. Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H 2004 Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res 299:128-136.
21. Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ 2003 Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem 90:1287-1298.
22. Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T 2004 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18:952-963.
23. Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ 2004 Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone 34:809-817.
24. Rosen V, Nove J, Song JJ, Thies RS, Cox K, Wozney JM 1994 Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes. J Bone Miner Res 9:1759-1768.
25. Yarmus M, Woolf E, Bernstein Y, Fainaru O, Negreanu V, Levanon D, Groner Y 2006 Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc Natl Acad Sci USA 103:7384-7389.
26. Gori F, Divieti P, Demay MB 2001 Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J Biol Chem 276:46515-46522.
27. Gori F, Demay MB 2004 BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. Endocrinology 145:1050-1054.
28. Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Moroy T, Taniuchi I, Steimle V, Littman DR, Ehlers M 2005 Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175:1694-1705.
29. Spender LC, Whiteman HJ, Karstegl CE, Farrell PJ 2005 Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Oncogene 24:1873-1881.
30. Fukushima-Nakase Y, Naoe Y, Taniuchi I, Hosoi H, Sugimoto T, Okuda T 2005 Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood 105:4298-4307.
31. Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T, Komori T 2000 Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 275:8695-8702.
32. Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T 2004 Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166:85-95.