N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential

Biochemical Pharmacology

Volumn 84, Issue 11, 2012, Pages 1522-1533

  Giustarini, Daniela ^a   Milzani, Aldo ^b   Dalle Donne, Isabella ^b   Tsikas, Dimitrios ^c   Rossi, Ranieri ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cysteine; Glutathione; Metabolism; N Acetylcysteine; Paracetamol

Indexed keywords

ACETYLCYSTEINE; ACETYLCYSTEINE DERIVATIVE; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; GLUTATHIONE; HYDROGEN SULFIDE; LACTATE DEHYDROGENASE; METHEMOGLOBIN; N ACETYLCYSTEINE ETHYL ESTER; PARACETAMOL; THIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG INTOXICATION; DRUG METABOLISM; ERYTHROCYTE; HUMAN; HUMAN CELL; LIPOPHILICITY; LIVER CELL; LIVER PERFUSION; LONG TERM CARE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OXIDATIVE STRESS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; PERMEABILITY; RATS;

EID: 84868475995     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.09.010     Document Type: Article

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