Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography: Main results from the randomized acetylcysteine for contrast-induced nephropathy trial (ACT)

Circulation

Volumn 124, Issue 11, 2011, Pages 1250-1259

  Berwanger, Otavio ^a  

^a Hospital Do Coração de São Paulo HCor   (Brazil)

Author keywords

acetylcysteine; Acute kidney injury; angioplasty; contrast media; coronary angiogram

Indexed keywords

ACETYLCYSTEINE; CONTRAST MEDIUM; PLACEBO;

ACUTE KIDNEY FAILURE; AGED; ANGIOGRAPHY; ARTERIOGRAPHY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIALYSIS; FEMALE; HEART FAILURE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ACETYLCYSTEINE; ACUTE KIDNEY INJURY; AGED; CONTRAST MEDIA; CORONARY ANGIOGRAPHY; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 80052770288     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.038943     Document Type: Article

References (43)

1. Parfrey PS, Griffiths SM, Barrett BJ, Paul MD, Genge M, Withers J, Farid N, McManamon PJ. Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both: a prospective controlled study. N Engl J Med. 1989;320:143-149. (Pubitemid 19033091)
2. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. Am J Med. 1997;103:368-375. (Pubitemid 27506242)
3. Dangas G, Iakovou I, Nikolsky E, Aymong ED, Mintz GS, Kipshidze NN, Lansky AJ, Moussa I, Stone GW, Moses JW, Leon MB, Mehran R. Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables. Am J Cardiol. 2005;95:13-19. (Pubitemid 40051105)
4. McCullough PA, Stacul F, Becker CR, Adam A, Lameire N, Tumlin JA, Davidson CJ. Contrast-Induced Nephropathy (CIN) Consensus Working Panel: executive summary. Rev Cardiovasc Med. 2006;7: 177-197. (Pubitemid 46139115)
5. Rihal CS, Textor SC, Grill DE, Berger PB, Ting HH, Best PJ, Singh M, Bell MR, Barsness GW, Mathew V, Garratt KN, Holmes DR Jr. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation. 2002;105:2259-2264. (Pubitemid 34535335)
6. Drager LF, Andrade L, Barros de Toledo JF, Laurindo FR, Machado Cesar LA, Seguro AC. Renal effects of N-acetylcysteine in patients at risk for contrast nephropathy: decrease in oxidant stress-mediated renal tubular injury. Nephrol Dial Transplant. 2004;19:1803-1807. (Pubitemid 38961391)
7. Lopez BL, Snyder JW, Birenbaum DS, Ma XI. N-Acetylcysteine enhances endothelium-dependent vasorelaxation in the isolated rat mesenteric artery. Ann Emerg Med. 1998;32:405-410. (Pubitemid 28495767)
8. Heyman SN, Rosen S, Khamaisi M, Idee JM, Rosenberger C. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol. 2010;45:188-195.
9. Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med. 2000;343:180-184. (Pubitemid 30489215)
10. Kelly AM, Dwamena B, Cronin P, Bernstein SJ, Carlos RC. Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann Intern Med. 2008;148:284-294. (Pubitemid 351665489)
11. Nallamothu BK, Shojania KG, Saint S, Hofer TP, Humes HD, Moscucci M, Bates ER. Is acetylcysteine effective in preventing contrast-related nephropathy? A meta-analysis. Am J Med. 2004;117:938-947. (Pubitemid 40075562)
12. Bagshaw SM, McAlister FA, Manns BJ, Ghali WA. Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence. Arch Intern Med. 2006;166:161-166. (Pubitemid 43144938)
13. Pannu N, Wiebe N, Tonelli M. Prophylaxis strategies for contrast-induced nephropathy. JAMA. 2006;295:2765-2779.
14. Zagler A, Azadpour M, Mercado C, Hennekens CH. N-Acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials. Am Heart J. 2006;151:140-145. (Pubitemid 41815344)
15. Gonzales DA, Norsworthy KJ, Kern SJ, Banks S, Sieving PC, Star RA, Natanson C, Danner RL. A meta-analysis of N-acetylcysteine in contrastinduced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med. 2007;5:32.
16. Trivedi H, Daram S, Szabo A, Bartorelli AL, Marenzi G. High-dose N-acetylcysteine for the prevention of contrast-induced nephropathy. Am J Med. 2009;122:874-815.
17. Benko A, Fraser-Hill M, Magner P, Capusten B, Barrett B, Myers A, Owen RJ. Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy. Can Assoc Radiol J. 2007;58:79-87. (Pubitemid 46607524)
18. Smith SC Jr, Feldman TE, Hirshfeld JW Jr, Jacobs AK, Kern MJ, King SB III, Morrison DA, O'Neill WW, Schaff HV, Whitlow PL, Williams DO, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention). J Am Coll Cardiol. 2006;47:1-121.
19. Wijns W, Kolh P, Danchin N, Di MC, Falk V, Folliguet T, Garg S, Huber K, James S, Knuuti J, Lopez-Sendon J, Marco J, Menicanti L, Ostojic M, Piepoli MF, Pirlet C, Pomar JL, Reifart N, Ribichini FL, Schalij MJ, Sergeant P, Serruys PW, Silber S, Sousa UM, Taggart D, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas PE, Widimsky P, Kolh P, Alfieri O, Dunning J, Elia S, Kappetein P, Lockowandt U, Sarris G, Vouhe P, Kearney P, von Segesser L, Agewall S, Aladashvili A, Alexopoulos D, Antunes MJ, Atalar E, Brutel dlR, Doganov A, Eha J, Fajadet J, Ferreira R, Garot J, Halcox J, Hasin Y, Janssens S, Kervinen K, Laufer G, Legrand V, Nashef SA, Neumann FJ, Niemela K, Nihoyannopoulos P, Noc M, Piek JJ, Pirk J, Rozenman Y, Sabate M, Starc R, Thielmann M, Wheatley DJ, Windecker S, Zembala M. Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2010;31:2501-2555.
20. Stacul F, Adam A, Becker CR, Davidson C, Lameire N, McCullough PA, Tumlin J. Strategies to reduce the risk of contrast-induced nephropathy. Am J Cardiol. 2006;98:59-77. (Pubitemid 44292094)
21. Caixeta A, Mehran R. Evidence-based management of patients undergoing PCI: contrast-induced acute kidney injury. Catheter Cardiovasc Interv. 2010;75:15-20.
22. Tepel M, Aspelin P, Lameire N. Contrast-induced nephropathy: a clinical and evidence-based approach. Circulation. 2006;113:1799-1806. (Pubitemid 43958473)
23. Costa E, Reis H, de Assis GM, Cardoso GL, Barbosa MM, de Aguiar Filho FA, Gama CA, Silva MG, Aguiar BM, Ferreira MG, Feitosa GS, Victor Filho E, Rocha EB, Paiva MS, Czochra ER, Oliveira LA, de Oliveira IR, Pinheiro F, Dourado GO, Luna Filho AL, Pacheco A, Nunes PM, de Sá Filho AP, Martins HC, Lopes MA, Barros MA, Mattos C, Neves MA, Medeiros CR, Mattos C, Duarte L, Mattos C, Cramer H, Santos B Jr, Tura BR, Rodrigues CV, Terreiro LA, Alves MA, Soares JS, da Cunha CC, da Silva AC, Barcelos AM, Teixeira MA, Pinto JS, Saad JA, Mandil A, Falcheto E, Arêas CA, Dall'Orto FT, Freitas IF, Botelho RV, Seabra MD, Rosa CA, Pereira AD, Reis SS, Pereira VJ, Cunha SM, Ramalho GM, dos Santos RR, Muniz AJ, Loures JB, Amorim T, Muniz AJ, Loures JB, Abraão AC, Padilha RM, Sousa JE, Sousa AG, Moreira AC, Sousa AG, Feres F, Centemero M, Costa R, Esteves V, Almeida BO, Janella BL, Almeida MC, Stella FP, Almeida JD, Kloth VR, Mangione JA, Mauro MF, Tallo F, Santos DJ, Castello H, Cantarelli MJ, Baradel S, Stella FP, das Candeias MO, Kloth VR, Maiello JR, Seixas EA, Teixerense PT, de Toledo JF, Gubolino LA, Prates GJ, Yokoyama H, de Almeida P, Pessoa CM, Machado NC, Garzon PG, Antonângelo AF, Galeazzi PB, Queirantes CS, Cavalini VH, Labrunie A, de Andrade PB, Tebet MA, Devito FS, Farias CE, Nicolela EL Jr, Passos HM, Rubio P, Gubolino LA, Teixerense PT, de Toledo JF, Nunes GL, Roehrig C, de Oliveira AT, Wainstein MV, Ribeiro JP, Teixeira C, Atallah TN, Gomes C, Morelli H, Costantini CR, Tarbine SG, Santos MF, Ortiz CC, de Souza AB, Pecoits-Filho R, Koppe G, Hoffman PD, Faria Neto JR, Wang R, Cury C, Stadler N, Nercolini DC, Zanuzzi C, Bueno RR, Guerios EE, Tarastchuk JC, Peixoto ML, Labrunie A, de Andrade PB, Tebet MA, Thiago LE, Giuliano LC, Aranha FG, Misiak M, Thiago LE, Giuliano LC, Antunes MH, da Concei̧ão RS, Abreu SM, Preve JC, Guimarães JS, de Araújo Filho D, Araújo EC, de Sousa LN, Fonseca AG, da Motta PA, Osterne EC, Da Motta VP, Zimmermann AC. Rationale, design, and baseline characteristics of the Acetylcystein for Contrast-Induced nephropaThy (ACT) Trial: a pragmatic randomized controlled trial to evaluate the efficacy of acetylcysteine for the prevention of contrastinduced nephropathy. Trials. 2009;10:38.
24. Bartholomew BA, Harjai KJ, Dukkipati S, Boura JA, Yerkey MW, Glazier S, Grines CL, O'Neill WW. Impact of nephropathy after percutaneous coronary intervention and a method for risk stratification. Am J Cardiol. 2004;93:1515-1519. (Pubitemid 38749208)
25. Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, Leon MB, Dangas G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44:1393-1399. (Pubitemid 39303939)
26. Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:31.
27. Buyse M, George SL, Evans S, Geller NL, Ranstam J, Scherrer B, Lesaffre E, Murray G, Edler L, Hutton J, Colton T, Lachenbruch P, Verma BL. The role of biostatistics in the prevention, detection and treatment of fraud in clinical trials. Stat Med. 1999;18:3435-3451. (Pubitemid 30041358)
28. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188. (Pubitemid 17189972)
29. Lefebvre C, Manheimer E, Glanville J; on behalf of Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JP, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: John Willey & Sons Ltd.; 2008.
30. Kotlyar E, Keogh AM, Thavapalachandran S, Allada CS, Sharp J, Dias L, Muller D. Prehydration alone is sufficient to prevent contrast-induced nephropathy after day-only angiography procedures: a randomised controlled trial. Heart Lung Circ. 2005;14:245-251. (Pubitemid 43055999)
31. Briguori C, Colombo A, Violante A, Balestrieri P, Manganelli F, Paolo EP, Golia B, Lepore S, Riviezzo G, Scarpato P, Focaccio A, Librera M, Bonizzoni E, Ricciardelli B. Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity. Eur Heart J. 2004; 25:206-211. (Pubitemid 38235156)
32. Juni P, Altman DG, Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ. 2001;323: 42-46. (Pubitemid 32682008)
33. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-412.
34. Marenzi G, Assanelli E, Marana I, Lauri G, Campodonico J, Grazi M, De MM, Galli S, Fabbiocchi F, Montorsi P, Veglia F, Bartorelli AL. N-Acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med. 2006;354:2773-2782. (Pubitemid 43974195)
35. Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fuernau G, Erbs S, Linke A, Diederich KW, Nowak M, Desch S, Gutberlet M, Schuler G. Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. J Am Coll Cardiol. 2010;55: 2201-2209.
36. Webb JG, Pate GE, Humphries KH, Buller CE, Shalansky S, Al SA, Sutander A, Williams T, Fox RS, Levin A. A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect. Am Heart J. 2004;148:422-429. (Pubitemid 39265114)
37. Herget-Rosenthal S, Marggraf G, Husing J, Goring F, Pietruck F, Janssen O, Philipp T, Kribben A. Early detection of acute renal failure by serum cystatin C. Kidney Int. 2004;66:1115-1122. (Pubitemid 39121017)
38. Hoffmann U, Fischereder M, Kruger B, Drobnik W, Kramer BK. The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol. 2004;15: 407-410. (Pubitemid 38140781)
39. D'Elia JA, Gleason RE, Alday M, Malarick C, Godley K, Warram J, Kaldany A, Weinrauch LA. Nephrotoxicity from angiographic contrast material: a prospective study. Am J Med. 1982;72:719-725. (Pubitemid 12112418)
40. Jakobsen JA, Berg KJ, Kjaersgaard P, Kolmannskog F, Nordal KP, Nossen JO, Rootwelt K. Angiography with nonionic X-ray contrast media in severe chronic renal failure: renal function and contrast retention. Nephron. 1996;73:549-556. (Pubitemid 26258187)
41. Gleeson TG, Bulugahapitiya S. Contrast-induced nephropathy. AJR Am J Roentgenol. 2004;183:1673-1689. (Pubitemid 44210538)
42. Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Nephrotoxic risks of renal angiography: contrast media-associated nephrotoxicity and atheroembolism: a critical review. Am J Kidney Dis. 1994;24:713-727. (Pubitemid 24318930)
43. Kay J, Chow WH, Chan TM, Lo SK, Kwok OH, Yip A, Fan K, Lee CH, Lam WF. Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA. 2003;289:553-558. (Pubitemid 37428626)