Genotoxicity of food preservative sodium sorbate in human lymphocytes in vitro

Cytotechnology

Volumn 64, Issue 5, 2012, Pages 553-562

  Mamur, Sevcan ^a   Yüzbaşıoğlu, Deniz ^a   ÜNal, Fatma ^a   Aksoy, Hüseyin ^b  

^a GAZI UNIVERSITY   (Turkey)

^b SAKARYA UNIVERSITY   (Turkey)

Author keywords

Food preservative; Genotoxic effects; Human lymphocytes; Sodium sorbate

Indexed keywords

EID: 84868462012     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-012-9434-5     Document Type: Article

References (52)

1. Altuǧ T (2003) Introduction to toxicology and food, food additives. CRC Press, New York, pp 81-100.
2. Arslan M (2004) Borik asitin insan periferal lenfositlerinde in vitro kromozom aberasyonu ve kardeş kromatid deǧ işimi üzerindeki etkileri. MSc Thesis, Ç ukurova Ü niversitesi, Fen Bilimleri Enstütüsü.
3. Banerjee TS, Giri AK (1986) Effects of sorbic acid and sorbic acid-nitrite in vivo on bone marrow chromosomes of mice. Toxicol Lett 31:101-106.
4. Biswas S, Talukder G, Sharma A (2000) Chromosome damage induced by selenium salts in human peripheral lymphocytes. Toxicol In Vitro 14:405-408.
5. Blaszczyk A (2006) DNA damage induced by ethoxyquin in human peripheral lymphocytes. Toxicol Lett 163:77-83.
6. Bonassi S, Ugolini D, Kirsch-Volders M, Stromberg U, Vermeulen R, Tucker JD (2005) Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ Mol Mutagen 45:258-270.
7. Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Cebulska-Wasilewska A, Fabianova E, Fucic A, Hagmar L, Joksic G, Martelli A, Migliore L, Mirkova E, Scarfi MR, Zijno A, Norppa H, Fenech M (2007) An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28:625-631.
8. Çelik M, Yilmaz S, Aksoy H, Ünal F, Yüzbaş ioǧlu D, Dönbak L (2009) Evaluation of the genotoxicity of fusarium mycotoxin moniliformin in human peripheral blood lymphocytes. Environ Mol Mutagen 50:431-434.
9. Duez P, Dehon G, Kumps A, Dubois J (2003) Statistics of the Comet assay: a key to discriminate between genotoxic effects. Mutagenesis 18:159-166.
10. Epel D (1963) The effects of carbon monoxide inhibition of ATP level and the date of mitosis in sea urchin egg. J Cell Biol 17:315-319.
11. Fenech M, Morley A (1985) Measurement of micronuclei in lymphocytes. Mutat Res 147:29-36.
12. Ferrand C, Marc F, Fritsch P, Cassand P, Blanquat de Saint G (2000) Mutagenicity and genotoxicity of sorbic acid ± - amine reaction products. Food Addit Contam 17:895-901.
13. Garaj-Vrhovac V, Zeljezic D (2000) Evaluation of DNA damage in workers occupationally exposed to pesticides using single-cell gel electrophoresis (SCGE) assay: pesticide genotoxicity revealed by comet assay. Mutat Res 469: 279-285.
14. Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, Reuterwall C (1998) Chromosomal aberrations in lymphocytes predict human cancer: a report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res 58:4117-4121.
15. Hagmar L, Stromberg U, Bonassi S, Hansteen IL, Knudsen LE, Lindholm C, Norppa H (2004) Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res 64: 2258-2263.
16. Hasegawa M, Nishi Y, Ohkawa Y, Inui N (1984) Effects of sorbic acid and its salts on chromosome aberrations, sister chromatid exchanges and gene mutations in cultured Chinese Hamster cells. Food Chem Toxicol 22:505-507.
17. Jain AK, Andsorbhoy RK (1988) Cytogenetical studies on the effects of some chlorinated pesticides. III. Concluding remarks. Cytologia 53:427-436.
18. Jung R, Cojocel C, Muller W, Bottger D, Luck E (1992) Evaluation of the genotoxic potential of sorbic acid and potassium sorbate. Food Chem Toxicol 30:1-7.
19. Kawachi T, Komatsu T, Kada T, Ishidate M, Sasaki M, Sugiyama T, Tazima Y (1980) Results of recent studies on the revelance of various short-term screening in Japan. Appl Methods Oncol 3:253.
20. Kaya FF, Topaktaş M (2007) Genotoxic effects of potassium bromate on human peripheral lymphocytes in vitro. Mutat Res 626:48-52.
21. Kirsch-Volders M, Elhajouji A, Cundari E, Van Hummelen P (1997) The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat Res 392:19-30.
22. Latt SA, Schreck RR (1980) Sister chromatid exchange analysis. Am J Hum Genet 32:297-313.
23. Liewen MB, Marth EH (1985) Growth and inhibition of microorganisms in the presence of sorbic acid: a rewiew. J Food Protect 48:364-375.
24. Madle S, Beek B, Nowak C (1993) Zum Verständis von Chromosomenmutationtest an Somazellen. In: Fahrig R (ed) Mutationsforschung und genetische Toxikologie. Wissenschaftliche Buchgesellschaft, Darmstadt, pp 224-242.
25. Mamur S, Yüzbaşioǧlu D, Ünal F, Yilmaz S (2010) Does the potassium sorbate induce genotoxic or mutagenic effects in lymphocytes? Toxicol In Vitro 24:790-794.
26. Manso JA, Pérez Prior MT, García Santos MP, Calle E, Casado J (2005) A kinetic approach to the alkylating potential of carcinogenic lactones. Chem Res Toxicol 18:1161-1166.
27. Mpountoukas P, Vantarakis A, Sivridis E, Lialiaris T (2008) Cytogenetic study in cultured human lymphocytes treated with three commonly used preservatives. Food Chem Toxicol 46:2390-2393.
28. Mukherjee A, Giri AK, Talukder G, Sharma A (1988) Sister chromatid exchanges and micronuclei formations induced by sorbic acid and sorbic acid-nitrite in vivo in mice. Toxicol Lett 42:47-53.
29. Münzner R, Guigas C, Renner HW (1990) Re-examination of potassium sorbate and sodium sorbate for possible genotoxic potential. Food Chem Toxicol 28:397-401.
30. Norppa H, Falck GC-M (2003) What do human micronuclei contain? Mutagenesis 18:221-233.
31. Ostling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Bioph Res Co 123:291-298.
32. Ostling O, Johanson KJ (1987) Bleomycin in contrast to gamma radiation induces extreme variation of DNA strand breakage from cell to cell. Int J Radiat Biol 52:683-691.
33. Palus J, Rydzynski K, Dziubaltowska E, Wyszynska K, Natarajan AT, Nilsson R (2003) Genotoxic effects of occupational exposure to lead and cadmium. Mutat Res 540: 19-28.
34. Pérez-Prior MT, Manso JA, García-Santos MP, Calle E, Casado J (2005) Alkylating potential of potassium sorbate. J Agric Food Chem 53:10244-10247.
35. Pérez-Prior MT, Manso JA, García-Santos MP, Calle E, Casado J (2008) Sorbic acid as an alkylating agent. J Solution Chem 37:459-466.
36. Potter NN (1984) Food Science, Food additives. AVI Publishing Co, New York, pp 685-697.
37. Sasaki YF, Kawaguchi S, Kamaya A, Ohshita M, Kabasawa K, Iwama K, Taniguchi K, Tsuda S (2002) The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutat Res 519:103-119.
38. Schiffmann D, Schlatter J (1992) Genotoxicity and cell transformation studies with sorbates in Syrian Hamster embryo fibroblasts. Food Chem Toxicol 30:669-672.
39. Schlatter J, Wurgler FE, Kranzlin R, Maier P, Holliger E, Graf U (1992) The potential genotoxicity of sorbates: effects on cell cycle in vitro in V79 cells and somatic mutations in Drosophila. Food Chem Toxicol 30:843-851.
40. Schneider EL, Lewis J (1981) Aging and sister chromatid exchange: VIII. Effect of the aging environment on sister chromatid exchange induction and cell cycle kinetics in Ehrlich ascites tumor cells. A brief note. Mech Ageing Dev 17:327-330.
41. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
42. Speit G, Houpter S (1985) On the mechanism of differential giemsa staining of bromodeoxyuridine substitute chromosomes. II. Differences between the demonstration of sister chromatid differentiation and replication patterns. Hum Genet 70:126-129.
43. Surrales J, Xamena N, Creus A, Catalan J, Norppa H, Marcos R (1995) Induction of micronuclei by five pyrethroid insecticides in whole blood and isolated human lymphocytes cultures. Mutat Res 341:169-184.
44. Thakur BR, Singh K, Arya SS (1994) Chemistry of sorbates: a basic perspective. Food Rev Int 10:71-91.
45. Walker R (1990) Toxicology of sorbic acid and sorbates. Food Addit Contam 7:671-676.
46. Warth AD (1985) Resistance of yeast species to benzoic and sorbic acids and to sulfur dioxide. J Food Protect 48:564-569.
47. Warwick GP (1963) The mechanism of action of alkylating agents. Cancer Res 23:1315-1333.
48. WHO (1974) Toxicological evaluation of some food additives including anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents. World Health Organisation Food Additive series no 5, pp 121-127.
49. Yilmaz S, Ünal F, Yüzbaşioǧlu D, Aksoy H (2008) Clastogenic effects of food additive citric acid in human peripheral lymphocytes. Cytotechnology 56:137-144.
50. Yilmaz S, Ünal F, Yüzbaşioǧlu D (2009) The in vitro genotoxicity of benzoic acid in human peripheral blood lymphocytes. Cytotechnology 60:55-61.
51. Yüzbaşioǧlu D, Çelik M, Yilmaz S, Ünal F, Aksoy H (2006) Clastogenicity of the fungicide afugan in cultured human lymphocytes. Mutat Res 604:53-59.
52. Zengin N, Yüzbaşioǧlu D, Ünal F, Yilmaz S, Aksoy H (2011) The evaluation of the genotoxicity of two food preservatives: sodium benzoate and potassium bezoate. Food Chem Toxicol 49:763-769.