Natural antisense makes sense for gene-specific a ctivation in brain

Molecular Therapy Nucleic Acids

Volumn 1, Issue 5, 2012, Pages e24-

  Varela, Miguel A ^a   Roberts, Thomas C ^a   Andaloussi, Samir El ^a   Wood, Matthew Ja ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84868354468     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2012.17     Document Type: Note

References (14)

1. Modarresi, F, Faghihi, MA, Lopez-Toledano, MA, Fatemi, RP, Magistri, M, Brothers, SP et al. (2012). Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol (epub ahead of print).
2. Katayama, S, Tomaru, Y, Kasukawa, T, Waki, K, Nakanishi, M, Nakamura, M et al.; RIKEN Genome Exploration Research Group; Genome Science Group (Genome Network Project Core Group); FANTOM Consortium. (2005). Antisense transcription in the mammalian transcriptome. Science 309: 1564-1566.
3. Janowski, BA, Younger, ST, Hardy, DB, Ram, R, Huffman, KE and Corey, DR (2007). Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol 3: 166-173.
4. Morris, KV, Chan, SW, Jacobsen, SE and Looney, DJ (2004). Small interfering RNAinduced transcriptional gene silencing in human cells. Science 305: 1289-1292. (Pubitemid 39129233)
5. Turunen, MP, Lehtola, T, Heinonen, SE, Assefa, GS, Korpisalo, P, Girnary, R et al. (2009). Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 105: 604-609.
6. Choi, DC, Maguschak, KA, Ye, K, Jang, SW, Myers, KM and Ressler, KJ (2010). Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci USA 107: 2675-2680.
7. Laske, C, Stellos, K, Hoffmann, N, Stransky, E, Straten, G, Eschweiler, GW et al. (2011). Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. Int J Neuropsychopharmacol 14: 399-404.
8. Wu, SY, Wang, TF, Yu, L, Jen, CJ, Chuang, JI, Wu, FS et al. (2011). Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immun 25: 135-146.
9. Veedu, RN and Wengel, J (2009). Locked nucleic acid as a novel class of therapeutic agents. RNA Biol 6: 321-323.
10. Alvarez-Erviti, L, Seow, Y, Yin, H, Betts, C, Lakhal, S and Wood, MJ (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29: 341-345.
11. Zhuang, X, Xiang, X, Grizzle, W, Sun, D, Zhang, S, Axtell, RC et al. (2011). Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 19: 1769-1779.
12. Wu, D and Pardridge, WM (1999). Neuroprotection with noninvasive neurotrophin delivery to the brain. Proc Natl Acad Sci USA 96: 254-259. (Pubitemid 29036086)
13. Zhang, Y and Pardridge, WM (2006). Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Res 1111: 227-229. (Pubitemid 44339581)
14. Conley, AB and King Jordan, I (2012). Epigenetic regulation of human cis-natural antisense transcripts. Nucleic Acids Res 40: 1438-1445.