Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection

Journal of Chromatography A

Volumn 1266, Issue , 2012, Pages 76-83

  Nakao, Ryuji ^a   Schou, Magnus ^a,b   Halldin, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Direct plasma injection; Fast micellar liquid chromatography; Micellar cleanup; Positron emission tomography (PET); Radiometabolite analysis

Indexed keywords

COLUMN SWITCHING; DETECTION LIMITS; DIRECT PLASMA; FLOWTHROUGH; HIGH TEMPORAL RESOLUTION; METABOLITE ANALYSIS; MICELLAR CLEANUP; MOBILE PHASE; ON-LINE MEASUREMENT; PRE-TREATMENT; RADIOLIGANDS; RADIOMETABOLITE ANALYSIS; RADIOMETRIC ANALYSIS; RADIOMETRIC DETECTION; SMALL PARTICLE SIZE; SUB-MICELLAR CONDITIONS;

MAGNETOHYDRODYNAMICS; PARTICLE BEAMS; PLASMAS; POSITRON EMISSION TOMOGRAPHY; RADIOMETRY;

LIQUID CHROMATOGRAPHY;

AZ 10419369; AZ 10419369 C 11; AZD 214; AZD 2184 C 11; CARBON 11; DOXEPIN C 11; DRUG METABOLITE; FLUMAZENIL C 11; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VENLAFAXINE C 11;

ARTICLE; BETA RADIATION; BLOOD ANALYSIS; DRUG STRUCTURE; ELUTION; FAST MICELLAR LIQUID CHROMATOGRAPHY; HAPLORHINI; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; NONHUMAN; ONLINE SYSTEM; PARTICLE SIZE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DETECTION; RADIOMETRY; RELIABILITY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE;

ACETONITRILES; ANIMALS; CHROMATOGRAPHY, LIQUID; HAPLORHINI; HUMANS; INJECTIONS, INTRAVENOUS; MICELLES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY;

EID: 84868346422     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.10.022     Document Type: Article

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