Rapid and sensitive measurement of PET radioligands in plasma by fast liquid chromatography/radiometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 895-896, Issue , 2012, Pages 116-122

  Nakao, Ryuji ^a   Schou, Magnus ^a,b   Halldin, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Fast liquid chromatography (fast LC); Metabolite analysis; Positron emission tomography (PET); Radioactive metabolite; Short lived radioligand

Indexed keywords

FAST-LC; LIMITS OF DETECTION; METABOLITE ANALYSIS; OPTIMUM CONDITIONS; PLASMA SAMPLES; RADIOLIGANDS; RADIOMETRIC DETECTION; RUNTIMES; SENSITIVE MEASUREMENT;

ACETONITRILE; BIOMOLECULES; LIQUID CHROMATOGRAPHY; METABOLITES; PLASMAS; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY;

DETECTORS;

ACETONITRILE; AZ 10419369; AZD 2184; CARBON 11; CARIPRAZINE; FLUORINE 18; RADIOLIGAND; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; EXPERIMENTAL MONKEY; HUMAN; METABOLITE; NONHUMAN; PLASMA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DETECTION; RADIOMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, LIQUID; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; LIMIT OF DETECTION; MACACA FASCICULARIS; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOMETRY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS;

EID: 84860155961     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.03.028     Document Type: Article

References (22)

1. Halldin C., Gulyás B., Farde L. Curr. Pharm. Des. 2001, 7:1907.
2. Laruelle M., Slifstein M., Huang Y. Methods 2002, 27:287.
3. Lammertsma A.A. Eur. Neuropsychopharmacol. 2002, 12:513.
4. Ma Y., Kiesewetter D.O., Lang L., Gu D., Chen X. Curr. Drug Metab. 2010, 11:483.
5. Halldin C., Swahn C.G., Farde L., Sedvall G. PET for Drug Development and Evaluation 1995, 55. Kluwer Academic Publishers. D. Comar (Ed.).
6. Takei M., Kida T., Suzuki K. Appl. Radiat. Isot. 2001, 55:229.
7. Nakao R., Okada M., Inoue O., Fukumura T., Suzuki K. J. Chromatogr. A 2008, 1203:193.
8. Greuter H.N., Ophemert P.L.B., Luurtsema G., Franssen E.J., Boellaard R., Lammertsma A.A. J. Nucl. Med. Technol. 2004, 32:28.
9. Chitneni S.K., Serdons K., Evens N., Fonge H., Celen S., Deroose C.M., Debyser Z., Mortelmans L., Verbruggen A.M., Bormans G.M. J. Chromatogr. A 2008, 1189:323.
10. MacNair J.E., Lewis K.C., Jorgenson J.W. Anal. Chem. 1997, 69:983.
11. Dejaegher B., Heyden Y.V. J. Chromatogr. A 2007, 1158:138.
12. Nováková L., Vlcková H. Anal. Chim. Acta 2009, 656:8.
13. Guillarme D., Ruta J., Rudaz S., Veuthey J.L. Anal. Bioanal. Chem. 2010, 397:1069.
14. Pierson M.E., Andersson J., Nyberg S., McCarthy D.J., Finnema S.J., Varnäs K., Takano A., Karlsson P., Gulyás B., Medd A.M., Lee C.M., Powell M.E., Heys J.R., Potts W., Seneca N., Mrzljak L., Farde L., Halldin C. Neuroimage 2008, 41:1075.
15. Nyberg S., Jönhagen M.E., Cselényi Z., Halldin C., Julin P., Olsson H., Freund-Levi Y., Andersson J., Varnäs K., Svensson S., Farde L. Eur. J. Nucl. Med. Mol. Imaging 2009, 36:1859.
16. Andersson J.D., Varnäs K., Cselényi Z., Gulyás B., Wensbo D., Finnema S.J., Swahn B.M., Svensson S., Nyberg S., Farde L., Halldin C. Synapse 2010, 64:733.
17. Yasuno F., Brown A.K., Zoghbi S.S., Krushinski J.H., Chernet E., Tauscher J., Schaus J.M., Phebus L.A., Chesterfield A.K., Felder C.C., Gladding R.L., Hong J., Halldin C., Pike V.W., Innis R.B. Neuropsychopharmacology 2008, 33:259.
18. Elsinga P.H., Franssen E.J., Hendrikse N.H., Fluks L., Weemaes A.M., van der Graaf W.T., de Vries E.G., Visser G.M., Vaalburg W. J. Nucl. Med. 1996, 37:1571.
19. Varrone A., Stepanov V., Nakao R., Tóth M., Gulyás B., Emond P., Deloye J.B., Vercouillie J., Stabin M.G., Jonsson C., Guilloteau D., Halldin C. J. Nucl. Med. 2011, 52:1313.
20. Varnäs K., Nyberg S., Halldin C., Varrone A., Takano A., Karlsson P., Andersson J., McCarthy D., Smith M., Pierson M.E., Söderström J., Farde L. J. Cereb. Blood Flow Metab. 2011, 31:113.
21. Shetty H.U., Zoghbi S.S., Liow J.S., Ichise M., Hong J., Musachio J.L., Halldin C., Seidel J., Innis R.B., Pike V.W. Eur. J. Nucl. Med. Mol. Imaging 2007, 34:667.
22. Varrone A., Tóth M., Steiger C., Takano A., Guilloteau D., Ichise M., Gulyás B., Halldin C. J. Nucl. Med. 2011, 52:132.