Ultrafast LC method for purification and metabolite analysis of PET probes

Nuclear Medicine and Biology

Volumn 37, Issue 1, 2010, Pages 67-72

  Nakao, Ryuji ^a   Ito, Takehito ^a,b   Hayashi, Kazutaka ^a   Fukumura, Toshimitsu ^a   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Sumitomo Accelerator Service   (Japan)

Author keywords

Metabolite analysis; PET; Purification; Short lived radiopharmaceuticals; Ultrafast LC

Indexed keywords

2 [4' (METHYLAMINO)PHENYL] 6 HYDROXYBENZOTHIAZOLE C 11; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE C 11; ACETONITRILE; BUFFER; DIAGNOSTIC AGENT; EMAPUNIL; EMAPUNIL C 11; FLUMAZENIL C 11; N (3 IODOPROP 2 ENYL) 2BETA CARBOMETHOXY 3BETA (4 METHYLPHENYL)NORTROPANE C 11; N,N DIMETHYL 2 (2 AMINO 4 CYANOPHENYLTHIOL)BENZYLAMINE C 11; RADIOPHARMACEUTICAL AGENT; SODIUM DIHYDROGEN PHOSPHATE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CHEMICAL REACTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PURIFICATION; DRUG RETENTION; DRUG STRUCTURE; DRUG SYNTHESIS; EVAPORATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; PROCESS OPTIMIZATION; RADIOACTIVITY; RADIOMETRY; SEPARATION TECHNIQUE;

CARBON RADIOISOTOPES; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; HUMANS; POSITRON-EMISSION TOMOGRAPHY; PURINES; RADIOPHARMACEUTICALS; TIME FACTORS;

EID: 72449121802     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.08.002     Document Type: Article

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