Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism

Journal of Molecular Biology

Volumn 331, Issue 2, 2003, Pages 407-416

  González, Beatriz ^a   Pajares, María A ^b   Hermoso, Juan A ^a   Guillerm, Danielle ^c   Guillerm, Georges ^c   Sanz Aparicio, Julia ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

ATP and SAM binding site; Methionine; Methionine adenosyltransferase complexes; X ray structure

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO 4,5 EPOXYPENTANOIC ACID; ASPARAGINE; ENZYME INHIBITOR; LYSINE DERIVATIVE; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE INHIBITOR; S ADENOSYLMETHIONINE; SULFONIUM DERIVATIVE; UNCLASSIFIED DRUG; VALERIC ACID;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME BINDING; ENZYME SUBSTRATE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0042349621     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00728-9     Document Type: Article

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