The potential of South African plants against Mycobacterium infections

Journal of Ethnopharmacology

Volumn 119, Issue 3, 2008, Pages 482-500

  McGaw, L J ^a   Lall, N ^a   Meyer, J J M ^a   Eloff, J N ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Antimycobacterial; Mycobacterium; South Africa; Tuberculosis

Indexed keywords

AMARYLLIDACEAE ALKALOID; ANTIMYCOBACTERIAL AGENT; PLANT EXTRACT;

ACANTHACEAE; AGAVACEAE; AIZOACEAE; ALLIACEAE; ANACARDIACEAE; ANGIOSPERM; ANTIBACTERIAL ACTIVITY; APIALES; ARACEAE; ARTICLE; ASCLEPIADACEAE; ASTERACEAE; BALATANITACEAE; BORAGINACEAE; CACTACEAE; CANELLACEAE; CAPPARACEAE; CELASTRACEAE; COMBRETACEAE; CUCUMBER; DIOSCOREACEAE; DRUG EFFICACY; DRUG ISOLATION; DRUG SCREENING; EBENACEAE; ETHNOBOTANY; EUPHORBIA; FLACOURTIACEAE; GERANIACEAE; GOOSEFOOT; GUNNERACEAE; GUTTIFERAE; HYACINTHACEAE; IRIDACEAE; LEGUME; LOGANIACEAE; MEDICINAL PLANT; MELIACEAE; MORACEAE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; MYRSINACEAE; NYMPHAEACEAE; OLEACEAE; PASSION FRUIT; PHYTOLACCACEAE; POACEAE; POLYGALACEAE; PORTULACACEAE; RANUNCULACEAE; RHAMNACEAE; RHODOMELACEAE; ROSACEAE; RUTACEAE; SAPINDACEAE; SOUTH AFRICA; STERCULIACEAE; THYMELAEACEAE; VERBENACEAE; WILLOW; ZINGIBERACEAE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; ETHNOBOTANY; HUMANS; MEDICINE, AFRICAN TRADITIONAL; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; PLANTS, MEDICINAL; SOUTH AFRICA; TUBERCULOSIS;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 53449097935     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.08.022     Document Type: Article

References (130)

1. Allen O.N., and Allen E.K. The Leguminosae (1981), University of Wisconsin Press, Wisconsin
2. Anderson D.M.W., and McDougall F.J. The composition of the proteinaceous gums exuded by Acacia gerrardii and Acacia goetzii subsp. goetzii. Food Hydrocolloids 1 (1987) 327-331
3. Ayele W.Y., Neill S.D., Zinsstag J., Weiss M.G., and Pavlik I. Bovine tuberculosis: an old disease but a new threat to Africa. The International Journal of Tuberculosis and Lung Disease 8 (2004) 924-937
4. Ayoub H.S.M. Molluscidal properties of Acacia nilotica. Planta Medica 46 (1982) 181-183
5. Bamuamba K., Gammon D.W., Meyers P., Dijoux-Franca M.-G., and Scott G. Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa). Journal of Ethnopharmacology 117 (2008) 385-390
6. Bapela N.B., Lall N., Fourie P.B., Franzblau S.G., and Van Rensburg C.E.J. Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis. Phytomedicine 13 (2006) 630-635
7. ®. Phytomedicine 14 (2007) 2-4
8. Bohlmann F., and Zdero C. Neue Sesquiterpenlactone aus Osmitopsis asteriscoides (L.) Cass. Chemische Berichte 107 (1974) 1409-1415
9. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants (1995), Intercept, Hampshire
10. Bryant A.T. Zulu Medicine and Medicine-men (1966), C. Struik, Cape Town
11. Candy H.A., McGarry E.J., and Pegel K.H. Constituents of Syzygium cordatum. Phytochemistry 7 (1968) 889-890
12. Cantrell C.L., Franzblau S.G., and Fischer N.H. Antimycobacterial plant terpenoids. Planta Medica 67 (2001) 685-694
13. CDC, 2006. Revised definition of extensively drug-resistant tuberculosis. Morbidity and Mortality Weekly Report, Centers for Disease Control and Prevention 55, 301-305.
14. Chung G.A.C., Aktar Z., Jackson S., and Duncan K. High-throughput screen for detecting antimycobacterial agents. Antimicrobial Agents and Chemotherapy 39 (1995) 2235-2238
15. Clarkson C., Madikane E.V., Hansen S.H., Smith P.J., and Jaroszewski J.W. HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris. Planta Medica 73 (2007) 578-584
16. Copp B.R. Antimycobacterial natural products. Natural Product Reports 20 (2003) 535-557
17. Corbett E.L., Marston B., Churchyard G.J., and De Cock K.M. Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment. Lancet 367 (2006) 926-937
18. Cosivi O., Grange J.M., Daborn C.J., Raviglione M.C., Fujikura T., Cousins D., Robinson R.A., Huchzermeyer H.F., de Kantor I., and Meslin F.X. Zoonotic tuberculosis due to Mycobacterium bovis in developing countries. Emerging Infectious Diseases 4 (1998) 59-70
19. Cragg G.M., Newman D.J., and Snader K.M. Natural products in drug discovery and development. Journal of Natural Products 60 (1997) 52-60
20. Crombie L., Crombie W.M.L., and Whiting D.A. Alkaloids of Khat (Catha edulis). In: Brossi A. (Ed). The Alkaloids, Chemistry and Pharmacology vol. 39 (1990), Academic Press, San Diego 139-164
21. Daely C.J., and Griggith D.E. Pulmonary disease caused by rapidly growing mycobacteria. Clinical Chest Medicine 23 (2002) 623-632
22. De Castro A., and Van Wyk B.-E. Diagnostic characters and geographical distribution of Alepidea species used in traditional medicine. South African Journal of Botany 60 (1994) 345-350
23. Dekker T.G., Fourie T.D., Matthee E., and Snyckers F.O. An oxindole from the roots of Capparis tomentosa. Phytochemistry 26 (1987) 1845-1846
24. Dictionary of Natural Products on CD-ROM, release 4:2, 1996. Chapman & Hall, London.
25. Di Paolo E.R., Hamburger M., Stoekli-Evans H., Rogers C., and Hostettmann K. New chromonocoumarin derivatives from Polygala fruticosa Berg. Helvetica Chimica Acta 72 (1989) 1455-1462
26. Donald P.R., Sirgel F.A., Venter A., Parkin D.P., Seifart H.I., van de Wal B.W., Maritz J.S., and Fourie P.B. Early bactericidal activity of antituberculosis agents. Expert Review of Anti-Infective Therapy 1 (2003) 141-155
27. Drobniewski F., Strutt M., Smith G., Magee J., and Flanagan P. Audit of scope and culture techniques applied to samples for the diagnosis of Mycobacterium bovis by hospital laboratories in England and Wales. Epidemiology and Infection 130 (2003) 235-237
28. Eldeen I.M.S., and Van Staden J. Antimycobacterial activity of some trees used in South African traditional medicine. South African Journal of Botany 73 (2007) 248-251
29. Eldeen I.M.S., and Van Staden J. Cyclooxygenase inhibition and antimycobacterial effects of extracts from Sudanese medicinal plants. South African Journal of Botany 74 (2008) 225-229
30. Eldeen I.M.S., and Van Staden J. Anti-inflammatory activity and mycobacterial activity of leaf extracts of Coleonema album. South African Journal of Botany 74 (2008) 345-347
31. Eldeen I.M.S., Van Heerden F.R., and Van Staden J. Isolation and biological activities of termilignan B and arjunic acid from Terminalia sericea roots. Planta Medica 74 (2008) 411-413
32. Eloff J.N. A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria. Planta Medica 64 (1998) 711-713
33. Esterhuizen L.L., Meyer R., and Dubery I.A. Antimicrobial compounds from Coleonema album (Rutaceae). Zeitschrift für Naturforschung-Section C Journal of Biosciences 61 (2006) 489-498
34. Fennell C.W., Lindsey K.L., McGaw L.J., Sparg S.G., Stafford G.I., Elgorashi E.E., Grace O.M., and Van Staden J. Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. Journal of Ethnopharmacology 94 (2004) 205-217
35. Forbes V.S. Carl Peter Thunberg Travels at the Cape of Good Hope (1986), Van Riebeeck Society, Cape Town pp. 1772-1775
36. Gautam R., Saklani A., and Jachak S.M. Indian medicinal plants as a source of antimycobacterial agents. Journal of Ethnopharmacology 110 (2007) 200-234
37. Gelfand M., Mavi S., Drummond R.R., and Ndemera B. The Traditional Medical Practitioner in Zimbabwe (1985), Mambo Press, Gweru, Zimbabwe
38. Germishuizen G., and Meyer N.L. Plants of Southern Africa, An Annotated Check List. Strelitzia 14 (2003), National Botanical Institute, Pretoria
39. Gerstner J. A preliminary checklist of Zulu names of plants with short notes. Bantu Studies 12 (1938) 215-236, 321-342
40. Gerstner J. A preliminary checklist of Zulu names of plants with short notes. Bantu Studies 13 (1939) 49-64, 131-149, 307-326
41. Gerstner J. A preliminary checklist of Zulu names of plants with short notes. Bantu Studies 13 (1941) 49-64
42. Gibbons S. Plants as a source of bacterial resistance modulators and anti-infective agents. Phytochemistry Reviews 4 (2005) 63-78
43. Gibson M.R. Glycyrrhiza in old and new perspectives. Journal of Natural Products (Lloydia) 41 (1978) 348-354
44. Gillespie S.H., Morrissey I., and Everett D. A comparison of the bactericidal activity of quinolone antibiotics in a Mycobacterium fortuitum model. Journal of Medical Microbiology 50 (2001) 565-570
45. Grange J.M., and Yates M.D. Infections caused by opportunist mycobacteria: a review. Journal of the Royal Society of Medicine 79 (1986) 226-229
46. Grange J.M., Yates M.D., and Boughton E. A review. The avian tubercle bacillus and its relatives. Journal of Applied Bacteriology 68 (1990) 411-431
47. Graven E.H., Deans S.G., Svododa K.P., Mavi S., and Gundidza M.G. Antimicrobial and antioxidative properties of the volatile (essential) oil of Artemisia afra Jacq. Flavour Fragrance Journal 7 (1992) 121-123
48. Grieve M. A Modern Herbal (1967), Hafner, London
49. Gutierrez-Lugo M.-T., and Bewley C.A. Natural products, small molecules, and genetics in tuberculosis drug development. Journal of Medicinal Chemistry 51 (2008) 2606-2612
50. Holzapfel C.W., Van Wyk B.-E., De Castro A., Marais W., and Herbst M. A chemotaxonomic survey of kaurene derivatives in the genus Alepidea (Apiaceae). Biochemical Systematics and Ecology 23 (1995) 799-803
51. Hulme M.M. Wild Flowers of Natal (1954), Shuter & Shooter, Pietermaritzburg
52. Hussein A.A., Meyer J.J.M., Jimeno M.L., and Rodríguez B. Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea. Journal of Natural Products 70 (2007) 293-295
53. Hutchings A., and Johnson C.T. Glimpses of a Xhosa herbal. Veld and Flora 72 (1986) 59-62
54. Hutchings A., Scott A.H., Lewis G., and Cunningham A.B. Zulu Medicinal Plants: An Inventory (1996), University of Natal Press, Pietermaritzburg
55. Hutchings A., and Van Staden J. Plants used for stress-related ailments in traditional Zulu, Xhosa and Sotho medicine. Part I. Plants used for headaches. Journal of Ethnopharmacology 43 (1994) 89-124
56. Iwu M.M. African Ethnomedicine (1986), USP Press, Enugu, Nigeria
57. Iwu M.M. Handbook of African Medicinal Plants (1993), CRC Press, Florida
58. Jacot Guillarmod A. Flora of Lesotho (1971), Cramer, Lehr
59. Jakupovic J., Kuhnke J., Schuster A., Metwally M.A., and Bohlmann F. Phloroglucinol derivatives and other constituents from South African Helichrysum species. Phytochemistry 25 (1986) 1133-1142
60. Janin Y.L. Antituberculosis drugs: ten years of research. Bioorganic and Medicinal Chemistry 15 (2007) 2479-2513
61. Jones K.D.J., Hesketh T., and Yudkin J. Extensively drug-resistant tuberculosis in sub-Saharan Africa: an emerging public-health concern. Transactions of the Royal Society of Tropical Medicine and Hygiene 102 (2008) 219-224
62. Kamara B.I., Brandt E.V., Ferreira D., and Joubert E. Polyphenols from Honeybush tea (Cyclopia intermedia). Journal of Agricultural and Food Chemistry 51 (2003) 3874-3879
63. Kamatou G.P.P., Van Vuuren S.F., Van Heerden F.R., Seaman T., and Viljoen A.M. Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea. South African Journal of Botany 73 (2007) 552-557
64. Katerere D.R., Gray A.I., Nash R.J., and Waigh R.D. Antimicrobial activity of pentacyclic triterpenes isolated from African Combretaceae. Phytochemistry 63 (2003) 81-88
65. Kayser O., and Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Medica 63 (1997) 508-510
66. Kayser O., Kolodziej H., and Kiderlen A.F. Immunomodulatory principles of Pelargonium sidoides. Phytotherapy Research 15 (2001) 122-126
67. Khan M.R., Ndaalio G., Nkunya M.H.H., Wevers H., and Sawhney A.N. Studies on African medicinal plants. Part 1. Preliminary screening of medicinal plants for antibacterial activity. Planta Medica Supplement 40 (1980) 91S-97S
68. Kolodziej H. Traditionally used Pelargonium species: chemistry and biological activity of umckaloabo extracts and their constituents. Current Topics in Phytochemistry 3 (2000) 77-93
69. Kuete V., Meli A.L., Komguem J., Louh G.N., Tangmouo J.G., Lontsi D., Meyer J.J.M., and Lall N. Antimycobacterial, antibacterial and antifungal activities of the methanolic extract and compounds from Garcinia polyantha. Pharmacologyonline 3 (2007) 87-95
70. Lall N., Das Sarma M., Hazra B., and Meyer J.J.M. Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro. Journal of Antimicrobial Agents and Chemotherapy 51 (2003) 435-438
71. Lall N., Hussein A.A., and Meyer J.J.M. Antiviral and antituberculous activity of Helichrysum melanacme constituents. Fitoterapia 77 (2006) 230-232
72. Lall N., and Meyer J.J.M. In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants. Journal of Ethnopharmacology 66 (1999) 347-354
73. Lall N., and Meyer J.J.M. Inhibition of drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis. Pharmaceutical Biology 43 (2001) 353-357
74. Lall N., Meyer J.J.M., Wang Y., Bapela N.B., Van Rensburg C.J.E., Fourie B., and Franzblau S.G. Characterization of intracellular activity of antitubercular constituents from the roots of Euclea natalensis. Pharmaceutical Biology 43 (2005) 353-357
75. Lewu F.B., Grierson D.S., and Afolayan A.J. The leaves of Pelargonium sidoides may substitute for its roots in the treatment of bacterial infections. Biological Conservation 128 (2008) 582-584
76. Mabogo, D.E.N., 1990. The ethnobotany of the Vhavenda. M.Sc. Thesis, University of Pretoria.
77. Madikane V.E., Bhakta S., Russell A.J., Campbell W.E., Claridge T.D.W., Elisha B.G., Davies S.G., Smith P., and Sim E. Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris. Bioorganic and Medicinal Chemistry 15 (2007) 3579-3586
78. Mahapatra A., Mativandlela S.P.N., Binneman B., Fourie P.B., Hamilton C.J., Meyer J.J.M., Van der Kooy F., Houghton P., and Lall N. Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase. Bioorganic and Medicinal Chemistry 15 (2007) 7638-7646
79. Mativandlela S.P.N., Lall N., and Meyer J.J.M. Antibacterial, antifungal and antitubercular activity of (the roots of) Pelargonium reniforme (CURT) and Pelargonium sidoides (DC) (Geraniaceae) root extracts. South African Journal of Botany 72 (2006) 232-237
80. Mativandlela S.P.N., Meyer J.J.M., Hussein A.A., Houghton P.J., Hamilton C.J., and Lall N. Activity against Mycobacterium smegmatis and M. tuberculosis by extracts of South African medicinal plants. Phytotherapy Research 22 (2008) 841-845
81. McGaw L.J., Lall N., Hlokwe T.M., Michel A.L., Meyer J.J.M., and Eloff J.N. Purified compounds and extracts from Euclea species with antimycobacterial activity against Mycobacterium bovis and fast-growing mycobacteria. Biological and Pharmaceutical Bulletin 31 (2008) 1429-1433
82. Meyer J.J.M., Lall N., and Mathekga A.D.M. In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by Helichrysum caespititium. South African Journal of Botany 68 (2002) 90-93
83. Michel A.L., Bengis R.G., Keet D.F., Hofmeyr M., de Klerk L.M., Cross P.C., Jolles A.E., Cooper D., Whyte I.J., Buss P., and Godfroid J. Wildlife tuberculosis in South African conservation areas: implications and challenges. Veterinary Microbiology 112 (2006) 91-100
84. Mwangi J.W., Achola K.J., Lwande W., and Hassanali A. Volatile components of Heteromorpha trifoliata (Wendl.) Eckl. & Zeyh. Flavour Fragrance Journal 9 (1994) 241-243
85. Mwangi J.W., Addae-Mensah I., Munavu R.M., and Lwande W. Essential oils of Kenyan Lippia species. Part III. Flavour Fragrance Journal 6 (1991) 221-224
86. Neuwinger H. African Ethnobotany Poisons and Drugs Chemistry (1996), Chapman and Hall, Germany
87. Newman D.J., and Cragg G.M. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products 70 (2007) 461-477
88. Newton S.M., Lau C., Gurcha S.S., Besra G.S., and Wright C.W. The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. Journal of Ethnopharmacology 79 (2002) 57-67
89. Okunade A.L., Elvin-Lewis M.P.F., and Lewis W.H. Natural antimycobacterial metabolites: current status. Phytochemistry 65 (2004) 1017-1032
90. Pauli G.F., Case R.J., Inui T., Wang Y., Cho S., Fischer N.H., and Franzblau S.G. New perspectives on natural products in TB drug research. Life Sciences 78 (2005) 485-494
91. Pooley E. The Complete Field Guide to Trees of Natal, Zululand and Transkei (1993), Natal Flora Publications Trust, Durban
92. Pujol J. NaturAfrica-the Herbalist Handbook (1990), Jean Pujol Natural Healers' Foundation, Durban
93. Raviglione M.C., Snider D.E., and Kochi A. Global epidemiology of tuberculosis. Journal of the American Medical Association 273 (1995) 200-226
94. Roberts M. Indigenous Healing Plants (1990), Southern Book Publishers, Halfway House
95. Rogers C.B. Pentacyclic triterpenoid rhamnosides from Combretum imberbe leaves. Phytochemistry 27 (1988) 3217-3220
96. Rogers C.B., and Subramony G. The structure of imberbic acid, a 1α-hydroxy pentacyclic triterpenoid from Combretum imberbe. Phytochemistry 27 (1988) 531-533
97. Rustaiyan A., and Sadjada A.S. Kaurene derivatives from Alepidea amatynsia [= A. amatymbica]. Phytochemistry 26 (1987) 2106-2107
98. Sachev K., and Kulshreshtha D.K. Dodonic acid, a new diterpenoid from Dodonaea viscosa. Planta Medica 50 (1984) 448-449
99. Sachev K., and Kulshreshtha D.K. Flavonoids from Dodonaea viscosa. Phytochemistry 22 (1984) 1253-1256
100. Salie F., Eagles P.F.K., and Leng H.M.J. Preliminary antimicrobial screening of four South African Asteraceae species. Journal of Ethnopharmacology 52 (1996) 27-33
101. Saravanakumar D.E.M., Folb P.I., Campbell B.W., and Smith P. Antimycobacterial activity of the red alga Polysiphonia virgata. Pharmaceutical Biology 46 (2008) 254-260
102. Sawhney A.N., Khan M.R., Ndaalio G., Nkunya M.H.H., and Wevers H. Studies on the rationale of African traditional medicine. 2. Preliminary screening of medicinal plants for antigonoccocal activity. Pakistanian Journal of Scientific and Industrial Research 21 (1978) 189-192
103. Scott G.A., Springfield E.P., and Coldrey N. A pharmacognostical study of 26 South African plant species used as traditional medicines. Pharmaceutical Biology 42 (2004) 186-213
104. Seaman, T., 2005. The antimicrobial and antimycobacterial activity of plants used for the treatment of respiratory ailments in Southern Africa and the isolation of anacardic acid from Ozoroa paniculosa. M.Sc. Dissertation. University of the Witwatersrand, South Africa.
105. Seidel V., and Taylor P.W. In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria. International Journal of Antimicrobial Agents 23 (2004) 613-619
106. Singh J.A., Upshur R., and Padayatchi N. XDR-TB in South Africa: no time for denial or complacency. PLoS Medicine 4 (2007) 19-25
107. Smith, C.A., 1966. Common names of South African plants. Botanical Survey Memoir No. 35. Government Printer, Pretoria.
108. Springfield E.P., Amabeoku G., Weitz F., Mabusela W., and Johnson Q. An assessment of two Carpobrotus species extracts as potential antimicrobial agents. Phytomedicine 10 (2003) 434-439
109. Springfield E.P., and Weitz F. The scientific merit of Carpobrotus mellei L. based on antimicrobial activity and chemical profiling. African Journal of Biotechnology 5 (2006) 1289-1293
110. Tamm C. Die Homo-isoflavone, eine neue Klasse von Naturstoffen. Arzneimittel-Forschung 22 (1972) 1776-1784
111. Taylor P.W. Antimycobacterial activity of indigenous South African plants. South African Medical Journal 93 (2003) 904-907
112. Thami G.P., Kaur S., Chander J., and Attri A.K. Post surgical atypical mycobacterial infection due to Mycobacterium fortuitum. Journal of Infectious Diseases 45 (2002) 210-211
113. Thoen C., LoBue P., and de Kantor I. The importance of Mycobacterium bovis as a zoonosis. Veterinary Microbiology 112 (2006) 339-345
114. Thorel M.F., Krichevsky M., and Levy-Frebault V.V. Numerical taxonomy of mycobactin-dependent mycobacteria, amended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., Mycobacterium avium subsp. silvaticum subsp. nov. International Journal of Systematic Bacteriology 3 (1990) 254-260
115. Thring T.S.A., Springfield E.P., and Weitz F.M. Antimicrobial activities of four plant species from the Southern Overberg region of South Africa. African Journal of Biotechnology 6 (2007) 1779-1784
116. Van der Kooy F., Meyer J.J.M., and Lall N. Antimycobacterial activity and possible mode of action of newly isolated neodiospyrin and other naphthoquinones from Euclea natalensis. South African Journal of Botany 72 (2006) 349-352
117. Van der Vijver, L.M., 1975. Naphthoquinones of Plumbaginaceae and Ebenaceae. Doctoral Thesis, Vrije University of Amsterdam, Rodopi N.V., Amsterdam.
118. Van Puyvelde L., de Kimpe N., Costa J., and Munyjabo N. Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysin. Journal of Natural Products 52 (1989) 629-633
119. Van Puyvelde L., Dube S., Uwimana E., Uwera C., Dommisse R.A., Esmans E.L., Van Schoor O., and Vlietinck A.J. New α-pyrones from Iboza riparia. Phytochemistry 18 (1979) 1215-1218
120. Van Wyk B.-E., and Nicolson S.W. Xylose is a major nectar sugar in Protea and Faurea. South African Journal of Science 91 (1995) 151-153
121. Van Wyk B.-E., Van Oudtshoorn B., and Gericke N. Medicinal Plants of South Africa (1997), Briza Publications, Pretoria
122. Villegas M., Vargas D., Msonthi J.D., Marston A., and Hostettman K. Isolation of the antifungal compounds falcarindiol and sarisan from Heteromorpha trifoliata. Planta Medica 54 (1988) 36
123. Wagner H., and Bladt S. Cumarine aus Südafrikanischen Pelargonium-arten. Phytochemistry 14 (1975) 2061-2064
124. Watt J.M., and Breyer-Brandwijk M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 2nd ed. (1962), Livingstone, London
125. Wayne L.G., and Sramek H.A. Agents of newly recognized or infrequently encountered mycobacterial diseases. Clinical Microbiology Reviews 5 (1992) 1-25
126. Weigenand O., Hussein A.A., Lall N., and Meyer J.J.M. Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark. Journal of Natural Products 67 (2004) 1936-1938
127. World Health Organisation, 2008. Global Tuberculosis Control: Surveillance, Planning and Financing. WHO, Geneva. www.sahealthinfo.org/noveldrug/novelpamphlet.htm (accessed 30 April 2008).
128. Zager E.M., and McNerney R. Multidrug-resistant tuberculosis. BioMedCentral Infectious Diseases 8 (2008) 10 10.1186/1471-2334-8-10
129. Zelnik R., Rabenhorst E., Matida A.K., Gottlieb H.E., Lavie D., and Panizza S. Ibozol, a new diterpenoid from Iboza riparia. Phytochemistry 17 (1978) 1795-1797
130. Ziegler R., and Tamm C. Isolation and structure of eucosterol and 16β-hydroxyeucosterol, two novel spirocyclic nortriterpenes, and a new 24-nor-5α-chola-8,16-diene-23-oic acid from bulbs of several Eucomis species. Helvetica Chimica Acta 59 (1976) 1997-2011