Modulation of P-glycoprotein atpase of helicoverpa armigera by cholesterol: Effects on atpase activity and interaction of insecticides

Archives of Insect Biochemistry and Physiology

Volumn 79, Issue 1, 2012, Pages 47-60

  Aurade, Ravindra M ^a   Jayalakshmi, Senigala K ^b   Udikeri, Shashikant S ^c   Sreeramulu, Kuruba ^a  

^a GULBARGA UNIVERSITY   (India)

^b UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

^c UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

Author keywords

Cholesterol; Helicoverpa armigera; Insecticides; P glycoprotein atpase; Tryptophan quenching

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHOLESTEROL; INSECTICIDE; MULTIDRUG RESISTANCE PROTEIN; PROTEOLIPID; PROTEOLIPOSOMES;

ANIMAL; ARTICLE; DRUG EFFECT; METABOLISM; MOTH;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CHOLESTEROL; INSECTICIDES; MOTHS; P-GLYCOPROTEINS; PROTEOLIPIDS;

HELICOVERPA ARMIGERA;

EID: 84868321501     PISSN: 07394462     EISSN: 15206327     Source Type: Journal    
DOI: 10.1002/arch.21004     Document Type: Article

References (29)

1. Aurade R, Jayalakshmi SK, SreeramuluK. 2006. Stimulatory effect of insecticides on partially purified P-glycoprotein ATPase from the resistant pest Helicoverpa armigera. Biochem Cell Biol 84:1045-1050.
2. Aurade RM, Jayalakshmi SK, Sreeramulu K. 2010. P-glycoprotein ATPase from the resistant pest, Helicoverpa armigera: purification, characterization and effect of various insecticides on its transport function. Biochim Biophys Acta (Biomembranes) 1798:1135-1143.
3. Beenakkers AMT, Vander Host DJ, Van Marrewijk WJA. 1985. Insect lipids and lipoproteins and their role in physiological processes. Progr Lipid Res 24:19-67.
4. Borgnia MJ, Eytan GD, Assaraf YG. 1996. Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem 271:3163-3171.
5. Bourguinat C, Ardelli BF, Pion SD, Kamgno J, Gardon J, Duke BO, Boussinesq M, Prichard RK. 2008. P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus. Mol Biochem Parasitol 158:101-111.
6. Dey S, RamachandraM, Pastan, Gottesman MM, Ambudkar SV. 1997. Evidence for two non-identical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci USA 94:10594-10599.
7. Dos SSM, Weber CC, Franke C, Muller WE, Eckert GP. 2007. Cholesterol: coupling between membrane microenvironment and ABC transporter activity. Biochem Biophys Res Commun 354:216-221.
8. Eckford PDW, Sharom FJ. 2008. Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport. Biochemistry 47:13686-13698.
9. Ferte J. 2000. Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane. Eur J Biochem 267:277-294.
10. Gaertner LS, Murray CL, Morris CE. 1998. Transepithelial transport of nicotine and vinblastine in isolated Malpighian tubules of the tobacco hornworm (Manduca sexta) suggests a Pglycoprotein-like mechanism. J Exp Biol 201:2637-2645.
11. Gatlik LE, Aanismaa P, Seelig A. 2006. Quantification and characterization of P-glycoproteinsubstrate interactions. Biochemistry 45:3020-3032.
12. Gayet L, Dayan G, Barakat S, Labialle S, Michaud M, Cogne S, Mazane A, Coleman AW, Rigal D, Baggetto LG. 2005. Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry 44:4499-4509.
13. Kimura Y, Noriyuki K, Hiroaki K, Michinori M, Kazumitsu U. 2007. Modulation of drug stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J 401:597-605.
14. Kranthi KR, Jadhav DR, Wanjari RR, Li SSA, Russell D. 2001. Carbamate and organophosphate resistance in cotton pests in India 1995 to 1999. Bull Entomol Res 91:37-46.
15. Kuhne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G, Brockmoller J. 2009. Influx and efflux transport as determinants of melphalan cytotoxicity: resistance to melphalan in MDR1 overexpressing tumor cell lines. Biochem Pharmacol 78:45-53.
16. Liu R, Siemiarczuk A, Sharom FJ. 2000. intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides. Biochemistry 39:14927-14938.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
18. Lu P, Liu R, Sharom FJ. 2001. Drug transport by reconstituted P-glycoprotein in proteoliposomes: effect of substrates and modulators, and dependence on bilayer phase state. Eur J Biochem 268:1687-1697.
19. Martin C, BerridgeG, Higgins CF, Mistry P, Charlton P, Callaghan R. 2000. Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol 58:624-632.
20. Porretta D, Gargani M, Bellini R, Medici A, Punelli F, Urbanelli S. 2008. Defencemechanisms against insecticides temephos and diflubenzuron in the mosquito Aedes caspius: the P-glycoprotein efflux pumps. Med Vet Entomol 22:48-54.
21. Romsicki Y, Sharom FJ. 1998. The ATPase and ATP binding functions of P-glycoprotein:modulation by interaction with defined phospholipids. Eur J Biochem 256:170-178.
22. Romsicki Y, Sharom FJ. 1999. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry 38:6887-6896.
23. Rothnie A, Theron D, Soceneantu L, Martin C, Traikia M, Berridge G, Higgins CF, Devaux PF, Callaghan R. 2001. The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence. Eur Biophys J 30:430-442.
24. Shapiro AB, Fox K, Lam P, Ling V. 1999. Stimulation of P-glycoprotein mediated drug transport by prazosin and progesterone: evidence for a third drug-binding site. Eur J Biochem 259:841-850.
25. Srinivas R, Udikeri SS, Jayalakshmi SK, Sreeramulu K. 2004. Identification of factors responsible for insecticide resistance in Helicoverpa armigera. Comp Biochem Physiol C Toxicol Pharmacol 137:261-269.
26. Van MG, Halter D, Sprong H, Somerharju P, Egmond MR. 2006. ABC lipid transporters: extruders, flippases, or flopless activators. FEBS Lett 580:1171-1177.
27. Wang EJ, Casciano CN, Clement RP,OhnsonWWJ. 2000. Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. Biochem Biophys Res Commun 276:909-916.
28. Wenzel JJ, Piehler A, Kaminski WE. 2007. ABC A-subclass proteins: gatekeepers of cellular phospho and sphingolipid transport. Front Biosci 12:3177-3193.
29. Zlatkis A, Zak B, Boyle AJ. 1953. A new method for the direct determination of serum cholesterol. J Lab Clin Med 41:486-492.