Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Zhou, Kang ^a   Zou, Ruiyang ^a   Stephanopoulos, Gregory ^a,c   Too, Heng Phon ^a,b  

^a SINGAPORE MIT ALLIANCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPRENOID; LYCOPENE; METHYLERYTHRITOL CYCLODIPHOSPHATE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; MASS SPECTROMETRY; METABOLIC ENGINEERING; NONHUMAN; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TRANSPORT KINETICS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CAROTENOIDS; CHEMISTRY, PHARMACEUTICAL; ERYTHRITOL; ESCHERICHIA COLI; FOSFOMYCIN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENETIC ENGINEERING; MASS SPECTROMETRY; METABOLIC ENGINEERING; MEVALONIC ACID; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PLASMIDS; TERPENES;

EID: 84868318317     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047513     Document Type: Article

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