Evaluation of a mitochondrial voltage sensor, (18F-fluoropentyl) triphenylphosphonium cation, in a rat myocardial infarction model

Journal of Nuclear Medicine

Volumn 53, Issue 11, 2012, Pages 1779-1785

  Kim, Dong Yeon ^a,b   Kim, Hyeon Sik ^a   Le, Uyenchi Nguyen ^a   Jiang, Sheng Nan ^a   Kim, Hee Jung ^b   Lee, Kyo Chul ^c   Woo, Sang Keun ^c   Chung, Jihwa ^a   Kim, Hyung Seok ^a   Bom, Hee Seung ^a   Yu, Kook Hyun ^b   Min, Jung Joon ^a  

^a Chonnam National University   (South Korea)

^b Dongguk University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

18F labeled phosphonium salt; Mitochondrial membrane potential; Myocardial imaging agent; Myocardial infarction; Positron emission tomography (PET)

Indexed keywords

FLUOROPENTYLTRIPHENYLPHOSPHONIUM F 18; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; TETRAPHENYLPHOSPHONIUM H 3; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG RETENTION; DRUG SYNTHESIS; DRUG UPTAKE; EMBRYO; EMBRYO CELL; HEART CELL CULTURE; HEART INFARCTION; HEART INFARCTION SIZE; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY; RAT; SKIN FIBROBLAST; SUBSTITUTION REACTION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MYOCARDIAL INFARCTION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHINES; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84868316344     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.102657     Document Type: Article

References (38)

1. Camici PG, Rimoldi OE. The clinical value of myocardial blood flow measurement. J Nucl Med. 2009;50:1076-1087.
2. 18F-fluorobenzyl triphenyl phosphonium in dog myocardium. J Nucl Med. 2006;47:1359-1366.
3. Knuuti J, Bengel FM. Positron emission tomography and molecular imaging. Heart. 2008;94:360-367.
4. 13N-ammonia myocardial perfusion imaging with a PET/CT scanner: impact on clinical decision making and cost-effectiveness. Eur J Nucl Med Mol Imaging. 2008;35: 889-895.
5. Sampson UK, Dorbala S, Limaye A, Kwong R, Di Carli MF. Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease. J Am Coll Cardiol. 2007;49:1052-1058.
6. 18F-labeled myocardial perfusion tracer. J Nucl Med. 2008;49:630-636.
7. Yu M, Guaraldi MT, Mistry M, et al. BMS-747158-02: a novel PET myocardial perfusion imaging agent. J Nucl Cardiol. 2007;14:789-798.
8. 18F]-labeled (6-fluorohexyl) triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography. Bioconjug Chem. 2012;23:431-437.
9. 18F]-labeled (2-(2-fluoroethoxy) ethyl)triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography. Bioorg Med Chem Lett. 2012; 22:319-322.
10. 18F-fluorobenzyl triphenylphosphonium cation. Eur J Nucl Med Mol Imaging. 2007;34:2057-2065.
11. 18F] fluorophenyl)triphenylphosphonium as a mitochondrial voltage sensor for PET. Nucl Med Mol Imaging. 2007;41:561-565.
12. 18F]fluorophenyl) triphenylphosphonium as a potential imaging agent for mitochondrial dysfunction. J Labelled Compd Radiopharm. 2005;48:131-137.
13. Min JJ, Biswal S, Deroose C, Gambhir SS. Tetraphenylphosphonium as a novel molecular probe for imaging tumors. J Nucl Med. 2004;45:636-643.
14. 99mTc-tetrofosmin. J Nucl Med. 2007;48:1021-1030.
15. Murphy MP. Selective targeting of bioactive compounds to mitochondria. Trends Biotechnol. 1997;15:326-330.
16. 11C- triphenylmethylphosphonium for the evaluation of membrane potential in the heart by positron-emission tomography. Eur J Nucl Med. 1986;11:478-483.
17. 18F-fluorobenzyl triphenyl phosphonium after transient coronary occlusion. J Nucl Med. 2011;52:965-969.
18. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun. 2003;304:433-435.
19. Ross MF, Kelso GF, Blaikie FH, et al. Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Mosc). 2005;70:222-230.
20. Cesselli D, Jakoniuk I, Barlucchi L, et al. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res. 2001;89:279-286.
21. 18F] Fluoroclofilium as a potential cardiac imaging agent for PET studies. J Labelled Compd Radiopharm. 2003;46: 1151-1160.
22. 18F]fluorobenzyl triarylphosphonium ions. J Labelled Compd Radiopharm. 2004; 47:469-476.
23. 64Cu-labeled phosphonium cations as PET radiotracers for tumor imaging. Bioconjug Chem. 2011;22:1459-1472.
24. 64Cu-labeled triphenylphosphonium cations. J Med Chem. 2008;51:2971-2984.
25. 18F] fluoroalkylated ciprofloxacin as a potential bacterial infection imaging agent for PET study. Bioconjug Chem. 2010;21:2282-2288.
26. Steen H, Maring JG, Meijer DK. Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in rat liver. Biochem Pharmacol. 1993;45:809-818.
27. Cheng Z, Winant RC, Gambhir SS. A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Nucl Med. 2005;46: 878-886.
28. Samsamshariat SA, Samsamshariat ZA, Movahed MR. A novel method for safe and accurate left anterior descending coronary artery ligation for research in rats. Cardiovasc Revasc Med. 2005;6:121-123.
29. Guide for the Care and Use of Laboratory Animals. Bethesda, MD: National Institutes of Health; 1985. NIH publication 85-23.
30. 13N-ammonia and 3-dimensional PET. J Nucl Med. 2007;48: 1783-1789.
31. Koepfli P, Hany TF, Wyss CA, et al. CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. J Nucl Med. 2004;45: 537-542.
32. Acton PD, Thomas D, Zhou R. Quantitative imaging of myocardial infarct in rats with high resolution pinhole SPECT. Int J Cardiovasc Imaging. 2006;22: 429-434.
33. Gibbons RJ, Valeti US, Araoz PA, Jaffe AS. The quantification of infarct size. J Am Coll Cardiol. 2004;44:1533-1542.
34. Grinius LL, Jasaitis AA, Kadziauskas YP, et al. Conversion of biomembraneproduced energy into electric form. I. Submitochondrial particles. Biochim Biophys Acta. 1970;216:1-12.
35. Nakajima K, Taki J, Shuke N, Bunko H, Takata S, Hisada K. Myocardial perfusion imaging and dynamic analysis with technetium-99m tetrofosmin. J Nucl Med. 1993;34:1478-1484.
36. Okada RD, Glover D, Gaffney T, Williams S. Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation. 1988;77:491-498.
37. Nuyts J, Dupont P, Van den Maegdenbergh V, Vleugels S, Suetens P, Mortelmans L. A study of the liver-heart artifact in emission tomography. J Nucl Med. 1995;36: 133-139.
38. Kailasnath P, Sinusas AJ. Comparison of Tl-201 with Tc-99m-labeled myocardial perfusion agents: technical, physiologic, and clinical issues. J Nucl Cardiol. 2001;8:482-498.