A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Journal of Nuclear Medicine

Volumn 46, Issue 5, 2005, Pages 878-886

  Cheng, Zhen ^a   Winant, Richard C ^b   Gambhir, Sanjiv S ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Imaging; Matrix assisted laser desorption ionization; Mitochondria; Tetraphenylphosphonium

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; 4 FLUOROPHENYLTRIPHENYLPHOSPHONIUM; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CATION; METHYLTRIPHENYLPHOSPHONIUM; PHOSPHONIUM DERIVATIVE; TETRAPHENYLPHOSPHONIUM; TRITIUM; UNCLASSIFIED DRUG; VALINOMYCIN; DIAGNOSTIC AGENT; ORGANOPHOSPHORUS COMPOUND; TRITYL DERIVATIVE;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CALIBRATION; CELL CULTURE; CELL LYSATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG INHIBITION; DRUG PENETRATION; DRUG UPTAKE; HIGH THROUGHPUT SCREENING; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; ROOM TEMPERATURE; SCREENING; STANDARD; ANIMAL; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; GENETIC PROCEDURES; GLIOMA; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; MOLECULAR BIOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; GLIOMA; ISOTOPE LABELING; METABOLIC CLEARANCE RATE; MOLECULAR BIOLOGY; MOLECULAR PROBE TECHNIQUES; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRITYL COMPOUNDS;

EID: 20644457579     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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