Sex and gender in adverse drug events, addiction, and placebo

Handbook of Experimental Pharmacology

Volumn 214, Issue , 2012, Pages 107-126

  Franconi, Flavia ^a,b   Campesi, Ilaria ^a,b   Occhioni, Stefano ^a,b   Antonini, Paola ^c   Murphy, Michael F ^c  

^a UNIVERSITY OF SASSARI   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c Worldwide Clinical Trials   (United States)

Author keywords

Addiction; Adverse reactions; Aging; Pain; Placebo; Pregnancy; Sociocultural; Stress

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AMIODARONE; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; FLUOROURACIL; HYDRALAZINE; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; ORAL CONTRACEPTIVE AGENT; PROCAINAMIDE; QUINIDINE; SALICYLIC ACID DERIVATIVE; TACROLIMUS; THIAZIDE DIURETIC AGENT; VALPROIC ACID; DRUG;

ADDICTION; ADVERSE DRUG REACTION; AGING; AGRANULOCYTOSIS; ALCOHOLISM; ALOPECIA; ANALGESIA; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD TOXICITY; BRADYCARDIA; BRAIN HEMORRHAGE; CANNABIS ADDICTION; CARBOHYDRATE CRAVING; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CHILD CARE; CLINICAL TRIAL (TOPIC); COGNITION; CONDITIONING; CORTICOSTEROID INDUCED OSTEOPOROSIS; CULTURAL FACTOR; DEPRESSION; DISTRIBUTION VOLUME; DOCTOR PATIENT RELATION; DOMESTIC VIOLENCE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG ERUPTION; DRUG FEVER; DRUG SAFETY; DRUG TOLERABILITY; DRUG USE; EATING DISORDER; EXPECTANCY; FRACTURE; HEMATURIA; HEMOPTYSIS; HUMAN; HYPOKALEMIA; HYPONATREMIA; HYPOTHYROIDISM; LEUKOCYTE COUNT; LIVER DYSFUNCTION; LUPUS LIKE SYNDROME; MUCOSA INFLAMMATION; NAUSEA AND VOMITING; OSTEOPOROSIS; PHARMACODYNAMICS; PLACEBO EFFECT; PNEUMONIA; POLYPHARMACY; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; SAMPLE SIZE; SEX DIFFERENCE; SIDE EFFECT; SOCIAL ASPECT; SOCIOECONOMICS; STRESS; STUDY DESIGN; SUBSTANCE ABUSE; TOBACCO DEPENDENCE; VERBALIZATION; WEIGHT GAIN; FEMALE; MALE; REVIEW; SEXUAL DEVELOPMENT;

AGING; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; PLACEBO EFFECT; SEX CHARACTERISTICS; SUBSTANCE-RELATED DISORDERS;

EID: 84868306220     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-30726-3_6     Document Type: Article

References (141)

1. Addis A, Moretti ME, Ahmed Syed F, Einarson TR, Koren G (2001) Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol 15:341-369
2. Ader R (1989) Conditioning effects in pharmacotherapy and the incompleteness of the doubleblind, crossover design. Integr Psychiatry 69:165-170
3. Ader R, Cohen N (1982) Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus. Science 215:1534-1536
4. Ader R, Mercurio MG, Walton J, James D, Davis M, Ojha V, Kimball AB, Fiorentino D (2010) Conditioned pharmacotherapeutic effects: a preliminary study. Psychosom Med 72:192-197
5. Alvestad S, Lydersen S, Brodtkorb E (2007) Rash from antiepileptic drugs: influence by gender, age, and learning disability. Epilepsia 48:1360-1365
6. Anthony M, Berg MJ (2002a) Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. J Womens Health Gend Based Med 11:601-615
7. Anthony M, Berg MJ (2002b) Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part II. J Womens Health Gend Based Med 11:617-629
8. Aslaksen PM, Flaten MA (2008) The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain. Psychosom Med 70:811-818
9. Aslaksen PM, Bystad M, Vambheim SM, Flaten MA (2011) Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosom Med 73:193-199
10. Averbuch M, Katzper M (2001) Gender and the placebo analgesic effect in acute pain. Clin Pharmacol Ther 70:287-291
11. Barsky AJ, Peekna HM, Borus JF (2001) Somatic symptom reporting in women and men. J Gen Intern Med 16:266-275
12. Barsky AJ, Saintfort R, Rogers MP, Borus JF (2002) Nonspecific medication side effects and the nocebo phenomenon. JAMA 287:622-627
13. Batcher EL, Tang XC, Singh BN, Singh SN, Reda DJ, Hershman JM (2007) Thyroid function abnormalities during amiodarone therapy for persistent atrial fibrillation. Am J Med 120:880-885
14. Batterman RC (1965) Methodology of analgesic evaluation: experience with orphenadrine citrate compound. Curr Ther Res Clin Exp 7:639-647
15. Becker JB, Hu M (2008) Sex differences in drug abuse. Front Neuroendocrinol 29:36-47
16. Beecher HK (1955) The powerful placebo. J Am Med Assoc 159:1602-1606
17. Benedetti F (2009) Placebo effects: understanding the mechanisms in health and disease. Oxford University Press, Oxford
18. Benedetti F, Lanotte M, Lopiano L, Colloca L (2007) When words are painful: unraveling the mechanisms of the nocebo effect. Neuroscience 147:260-271
19. Benowitz NL (2010) Nicotine addiction. N Engl J Med 362:2295-2303
20. Berkley KJ, Zalcman SS, Simon VR (2006) Sex and gender differences in pain and inflammation: a rapidly maturing field. Am J Physiol Regul Integr Comp Physiol 291:R241-R244
21. Borchers AT, Keen CL, Gershwin ME (2007) Drug-induced lupus. Ann N Y Acad Sci 1108:166-182
22. Broome MV, Hurley RA, Taber KH (2010) Substance use disorders: do males and females have differential vulnerability? J Neuropsychiatry Clin Neurosci 22:4
23. Caamano F, Pedone C, Zuccala G, Carbonin P (2005) Socio-demographic factors related to the prevalence of adverse drug reaction at hospital admission in an elderly population. Arch Gerontol Geriatr 40:45-52
24. Ceylan-Isik AF, McBride SM, Ren J (2010) Sex difference in alcoholism: who is at a greater risk for development of alcoholic complication? Life Sci 87:133-138
25. Chansky K, Benedetti J, Macdonald JS (2005) Differences in toxicity between men and women treated with 5-fluorouracil therapy for colorectal carcinoma. Cancer 103:1165-1171
26. Charron J, Rainville P, Marchand S (2006) Direct comparison of placebo effects on clinical and experimental pain. Clin J Pain 22:204-211
27. Cheng YC, Vyas A, Hymen E, Perlmuter LC (2011) Gender differences in orthostatic hypotension. Am J Med Sci 342:221-225
28. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO III, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354:795-808
29. Colloca L, Benedetti F (2005) Placebos and painkillers: is mind as real as matter? Nat Rev Neurosci 6:545-552
30. Curran GM, Stoltenberg SF, Hill EM, Mudd SA, Blow FC, Zucker RA (1999) Gender differences in the relationships among SES, family history of alcohol disorders and alcohol dependence. J Stud Alcohol 60:825-832
31. Donovan MD (2005) Sex and racial differences in pharmacological response: effect of route of administration and drug delivery system on pharmacokinetics. J Womens Health (Larchmt) 14:30-37
32. Drici MD, Clement N (2001) Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 24:575-585
33. National Institute on Drug Abuse (1998) Nicotine addiction. In: 98-4342 Np (ed) Research report series. NIDA, Rockville, MD
34. El-Khatib F, Rauchenzauner M, Lechleitner M, Hoppichler F, Naser A, Waldmann M, Trinka E, Unterberger I, Bauer G, Luef GJ (2007) Valproate, weight gain and carbohydrate craving: a gender study. Seizure 16:226-232
35. Ernst E (2007) Placebo: new insights into an old enigma. Drug Discov Today 12:413-418
36. Essebag V, Reynolds MR, Hadjis T, Lemery R, Olshansky B, Buxton AE, Josephson ME, Zimetbaum P (2007) Sex differences in the relationship between amiodarone use and the need for permanent pacing in patients with atrial fibrillation. Arch Intern Med 167:1648-1653
37. Evans SM, Foltin RW (2010) Does the response to cocaine differ as a function of sex or hormonal status in human and non-human primates? Horm Behav 58:13-21
38. Exton MS, von Horsten S, Schult M, Voge J, Strubel T, Donath S, Steinmuller C, Seeliger H, Nagel E, Westermann J, Schedlowski M (1998) Behaviorally conditioned immunosuppression using cyclosporine A: central nervous system reduces IL-2 production via splenic innervation. J Neuroimmunol 88:182-191
39. Fattore L, Altea S, Fratta W (2008) Sex differences in drug addiction: a review of animal and human studies. Womens Health (Lond Engl) 4:51-65
40. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10:447-485
41. Flaten MA, Aslaksen PM, Finset A, Simonsen T, Johansen O (2006) Cognitive and emotional factors in placebo analgesia. J Psychosom Res 61:81-89
42. Fox HC, Sinha R (2009) Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women. Harv Rev Psychiatry 17:103-119
43. Franconi F, Brunelleschi S, Steardo L, Cuomo V (2007) Gender differences in drug responses. Pharmacol Res 55:81-95
44. Franconi F, Carru C, Malorni W, Vella S, Mercuro G (2011a) The effect of sex/gender on cardiovascular pharmacology. Curr Pharm Des 17:1095-1107
45. Franconi F, Carru C, Spoletini I, Malorni W, Vella S, Mercuro G, Deidda M, Rosano G (2011) A GENS-based approach to cardiovascular pharmacology: impact on metabolism, pharmacokinetics and pharmacodynamics. Ther Deliv 2:1437-1453
46. Frank E, Thase ME, Spanier CA, Reynolds CF III, Kupfer DJ (1999) Gender-specific response to depression treatment. J Gend Specif Med 2:40-44
47. Frot M, Feine JS, Bushnell MC (2004) Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin. Pain 108:230-236
48. Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF (2004) Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Pharmacol Toxicol 44:499-523
49. Giang DW, Goodman AD, Schiffer RB, Mattson DH, Petrie M, Cohen N, Ader R (1996) Conditioning of cyclophosphamide-induced leukopenia in humans. J Neuropsychiatry Clin Neurosci 8:194-201
50. Glaser R, Sheridan J, Malarkey WB, MacCallum RC, Kiecolt-Glaser JK (2000) Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom Med 62:804-807
51. Gochfeld M (2007) Framework for gender differences in human and animal toxicology. Environ Res 104:4-21
52. Goebel MU, Trebst AE, Steiner J, Xie YF, Exton MS, Frede S, Canbay AE, Michel MC, Heemann U, Schedlowski M (2002) Behavioral conditioning of immunosuppression is possible in humans. FASEB J 16:1869-1873
53. Goffaux P, Léonard G, Marchand S, Rainville P (2010) Placebo analgesia, in: pharmacology of pain. IASP Press, Seattle, WA
54. Gorczynski RM (1990) Conditioned enhancement of skin allografts in mice. Brain Behav Immun 4:85-92
55. Greenberg LM, Roth S (1966) Differential effects of abrupt versus gradual withdrawal of chlorpromazine in hospitalized chronic schizophrenic patients. Am J Psychiatry 123:221-226
56. Greenfield SF, Back SE, Lawson K, Brady KT (2010) Substance abuse in women. Psychiatr Clin North Am 33:339-355
57. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, Gold MS, Holdcroft A, Lautenbacher S, Mayer EA, Mogil JS, Murphy AZ, Traub RJ (2007) Studying sex and gender differences in pain and analgesia: a consensus report. Pain 132(Suppl 1): S26-S45
58. Grella CE (2008) From generic to gender-responsive treatment: changes in social policies, treatment services, and outcomes of women in substance abuse treatment. J Psychoactive Drugs Suppl 5: 327-343
59. Gurwitz JH (2005) The age/gender interface in geriatric pharmacotherapy. J Womens Health (Larchmt) 14:68-72
60. Haltia LT, Rinne JO, Merisaari H, Maguire RP, Savontaus E, Helin S, Nagren K, Kaasinen V (2007) Effects of intravenous glucose on dopaminergic function in the human brain in vivo. Synapse 61:748-756
61. Haltia LT, Rinne JO, Helin S, Parkkola R, Nagren K, Kaasinen V (2008) Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function. Synapse 62:682-688
62. Han S, Fan Y, Mao L (2008) Gender difference in empathy for pain: an electrophysiological investigation. Brain Res 1196:85-93
63. Hauser W, Bartram-Wunn E, Bartram C, Reinecke H, Tolle T (2011) Systematic review: placebo response in drug trials of fibromyalgia syndrome and painful peripheral diabetic neuropathy-magnitude and patient-related predictors. Pain 152:1709-1717
64. Howland RH (2008) Understanding the placebo effect. Part 1: placebo use in clinical trials. J Psychosoc Nurs Ment Heal Serv 46(5):17-20
65. Hudson A, Stamp JA (2011) Ovarian hormones and propensity to drug relapse: a review. Neurosci Biobehav Rev 35:427-436
66. Jaeger GT, Larsen S, Moe L (2005) Stratification, blinding and placebo effect in a randomized, double blind placebo-controlled clinical trial of gold bead implantation in dogs with hip dysplasia. Acta Vet Scand 46:57-68
67. Jensen MP, Karoly P (1991) Motivation and expectancy factors in symptom perception: a laboratory study of the placebo effect. Psychosom Med 53:144-152
68. Jones RE, Moes N, Zwickey H, Cunningham CL, Gregory WL, Oken B (2008) Treatment of experimental autoimmune encephalomyelitis with alpha lipoic acid and associative conditioning. Brain Behav Immun 22:538-543
69. Kallai I, Barke A, Voss U (2004) The effects of experimenter characteristics on pain reports in women and men. Pain 112:142-147
70. Kandel DB, Wu P, Davies M (1994) Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health 84:1407-1413
71. Kaptchuk TJ (1998) Powerful placebo: the dark side of the randomised controlled trial. Lancet 351:1722-1725
72. Kaptchuk TJ, Stason WB, Davis RB, Legedza AR, Schnyer RN, Kerr CE, Stone DA, Nam BH, Kirsch I, Goldman RH (2006) Sham device v inert pill: randomised controlled trial of two placebo treatments. BMJ 332:391-397
73. Kashuba AD, Nafziger AN (1998) Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs. Clin Pharmacokinet 34:203-218
74. Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB, Sheridan J (1996) Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc Natl Acad Sci U S A 93:3043-3047
75. Kim JS, Nafziger AN (2000) Is it sex or is it gender? Clin Pharmacol Ther 68:1-3
76. Kirsch I (2004) Conditioning, expectancy, and the placebo effect: comment on Stewart-Williams and Podd (2004). Psychol Bull 130:341-343, discussion 344-345
77. Klosterhalfen S, Enck P (2008) Neurophysiology and psychobiology of the placebo response. Curr Opin Psychiatry 21:189-195
78. Klosterhalfen W, Klosterhalfen S (1983) Pavlovian conditioning of immunosuppression modifies adjuvant arthritis in rats. Behav Neurosci 97:663-666
79. Komukai K, Mochizuki S, Yoshimura M (2010) Gender and the renin-angiotensin-aldosterone system. Fundam Clin Pharmacol 24:687-698
80. Koshi EB, Short CA (2007) Placebo theory and its implications for research and clinical practice: a review of the recent literature. Pain Pract 7:4-20
81. Krahenbuhl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krahenbuhl S (2007) Drug-related problems in hospitals: a review of the recent literature. Drug Saf 30:379-407
82. Kurokawa J, Suzuki T, Furukawa T (2009) New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: acute effects of female hormones on cardiac ion channels and cardiac repolarization. J Pharmacol Sci 109:334-340
83. Lajtha A, Sershen H (2010) Heterogeneity of reward mechanisms. Neurochem Res 35:851-867
84. Levine FM, De Simone LL (1991) The effects of experimenter gender on pain report in male and female subjects. Pain 44:69-72
85. Levy G (1998) What are narrow therapeutic index drugs? Clin Pharmacol Ther 63:501-505
86. Liamis G, Milionis H, Elisaf M (2008) A review of drug-induced hyponatremia. Am J Kidney Dis 52:144-153
87. Lynch WJ, Sofuoglu M (2010) Role of progesterone in nicotine addiction: evidence from initiation to relapse. Exp Clin Psychopharmacol 18:451-461
88. Malanga CJ, Kosofsky BE (2003) Does drug abuse beget drug abuse? Behavioral analysis of addiction liability in animal models of prenatal drug exposure. Brain Res Dev Brain Res 147:47-57
89. Mancini S, Amorotti E, Vecchio S, Ponz de Leon M, Roncucci L (2010) Infliximab-related hepatitis: discussion of a case and review of the literature. Intern Emerg Med 5:193-200
90. Mazziotti G, Canalis E, Giustina A (2010) Drug-induced osteoporosis: mechanisms and clinical implications. Am J Med 123:877-884
91. Substance Abuse and Mental Health Services Administration (2005) http://www.girlscouts.org/research/facts-findings/tobacco-use-and-substance- abuse.asp
92. Miller FG, Colloca L, Kaptchuk TJ (2009) The placebo effect: illness and interpersonal healing. Perspect Biol Med 52:518-539
93. Moertel CG, Taylor WF, Roth A, Tyce FA (1976) Who responds to sugar pills? Mayo Clin Proc 51:96-100
94. Niesters M, Dahan A, Kest B, Zacny J, Stijnen T, Aarts L, Sarton E (2010) Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain 151:61-68
95. Office of Strategic Planning Health Care Financing Administration (1998) The profile of Medicare chart book. U.S. Department of Health and Human Services
96. Okuno J, Yanagi H, Tomura S (2001) Is cognitive impairment a risk factor for poor compliance among Japanese elderly in the community? Eur J Clin Pharmacol 57:589-594
97. Olness K, Ader R (1992) Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus. J Dev Behav Pediatr 13:124-125
98. Olofsen E, Romberg R, Bijl H, Mooren R, Engbers F, Kest B, Dahan A (2005) Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain. Anesthesiology 103:130-139
99. Onder G, Landi F, Della Vedova C, Atkinson H, Pedone C, Cesari M, Bernabei R, Gambassi G (2002) Moderate alcohol consumption and adverse drug reactions among older adults. Pharmacoepidemiol Drug Saf 11:385-392
100. Onder G, Penninx BW, Landi F, Atkinson H, Cesari M, Bernabei R, Pahor M (2003) Depression and adverse drug reactions among hospitalized older adults. Arch Intern Med 163:301-305
101. Paller CJ, Campbell CM, Edwards RR, Dobs AS (2009) Sex-based differences in pain perception and treatment. Pain Med 10:289-299
102. Patel H, Bell D, Molokhia M, Srishanmuganathan J, Patel M, Car J, Majeed A (2007) Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005. BMC Clin Pharmacol 7:9
103. Paulson PE, Minoshima S, Morrow TJ, Casey KL (1998) Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 76:223-229
104. Pinnow E, Sharma P, Parekh A, Gevorkian N, Uhl K (2009) Increasing participation of women in early phase clinical trials approved by the FDA. Womens Health Issues 19:89-93
105. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM (2004) Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 329:15-19
106. Price DD, Finniss DG, Benedetti F (2008) A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 59:565-590
107. Quinones-Jenab V, Jenab S (2010) Progesterone attenuates cocaine-induced responses. Horm Behav 58:22-32
108. Rademaker M (2001) Do women have more adverse drug reactions? Am J Clin Dermatol 2:349-351
109. Regitz-Zagrosek V (2006) Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 5:425-438
110. Rivero A, Curtis AB (2009) Sex differences in arrhythmias. Curr Opin Cardiol 25:8-15
111. Robinson ME, Riley JL III, Brown FF, Gremillion H (1998) Sex differences in response to cutaneous anesthesia: a double blind randomized study. Pain 77:143-149
112. Rodenburg EM, Stricker BH, Visser LE (2011) Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands. Br J Clin Pharmacol 71:95-104
113. Sanford SD, Kersh BC, Thorn BE, Rich MA, Ward LC (2002) Psychosocial mediators of sex differences in pain responsivity. J Pain 3:58-64
114. Sauro MD, Greenberg RP (2005) Endogenous opiates and the placebo effect: a meta-analytic review. J Psychosom Res 58:115-120
115. Saxon L, Hiltunen AJ, Hjemdahl P, Borg S (2001) Gender-related differences in response to placebo in benzodiazepine withdrawal: a single-blind pilot study. Psychopharmacology (Berl) 153:231-237
116. Schwartz JB (2007) The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther 82:87-96
117. Schweinhardt P, Seminowicz DA, Jaeger E, Duncan GH, Bushnell MC (2009) The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic response. J Neurosci 29:4882-4887
118. Scott DJ, Stohler CS, Egnatuk CM, Wang H, Koeppe RA, Zubieta JK (2007) Individual differences in reward responding explain placebo-induced expectations and effects. Neuron 55:325-336
119. Scott DJ, Stohler CS, Egnatuk CM, Wang H, Koeppe RA, Zubieta JK (2008) Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatry 65:220-231
120. Sikdar KC, Alaghehbandan R, MacDonald D, Barrett B, Collins KD, Donnan J, Gadag V (2010) Adverse drug events in adult patients leading to emergency department visits. Ann Pharmacother 44:641-649
121. Smith WB, Weisner C (2000) Women and alcohol problems: a critical analysis of the literature and unanswered questions. Alcohol Clin Exp Res 24:1320-1321
122. Soldin OP, Mattison DR (2009) Sex differences in pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 48:143-157
123. Soldin OP, Chung SH, Mattison DR (2011) Sex differences in drug disposition. J Biomed Biotechnol 2011:187103
124. Stewart-Williams S, Podd J (2004) The placebo effect: dissolving the expectancy versus conditioning debate. Psychol Bull 130:324-340
125. Stockhorst U, Mahl N, Krueger M, Huenig A, Schottenfeld-Naor Y, Huebinger A, Berresheim HW, Steingrueber HJ, Scherbaum WA (2004) Classical conditioning and conditionability of insulin and glucose effects in healthy humans. Physiol Behav 81:375-388
126. Suchman AL, Ader R (1992) Classic conditioning and placebo effects in crossover studies. Clin Pharmacol Ther 52:372-377
127. Sunshine A, Laska E, Meisner M, Morgan S (1964) Analgesic studies of indomethacin as analyzed by computer techniques. Clin Pharmacol Ther 5:699-707
128. American Academy of pediatrics (2000) Committee on Substance Abuse and the Committee on Children with Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. Pediatrics 106:358-361
129. Toner JM, Ramsay LE (1984) Thiazide-induced hypokalaemia; prevalence higher in women. Br J Clin Pharmacol 18:449-452
130. Tricot L, Lebbe C, Pillebout E, Martinez F, Legendre C, Thervet E (2005) Tacrolimus-induced alopecia in female kidney-pancreas transplant recipients. Transplantation 80:1546-1549
131. Unger A, Jung E, Winklbaur B, Fischer G (2010) Gender issues in the pharmacotherapy of opioid-addicted women: buprenorphine. J Addict Dis 29:217-230
132. van Leeuwen JH, Castro R, Busse M, Bemelmans BL (2006) The placebo effect in the pharmaco-logic treatment of patients with lower urinary tract symptoms. Eur Urol 50:440-452, discussion 453
133. Varvarigou AA, Asimakopoulou A, Beratis NG (2009) Impact of maternal smoking on birth size: effect of parity and sex dimorphism. Neonatology 95:61-67
134. Vedhara K, Cox NK, Wilcock GK, Perks P, Hunt M, Anderson S, Lightman SL, Shanks NM (1999) Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet 353:627-631
135. Wager TD, Atlas LY, Leotti LA, Rilling JK (2011) Predicting individual differences in placebo analgesia: contributions of brain activity during anticipation and pain experience. J Neurosci 31:439-452
136. White P, Lewith G, Hopwood V, Prescott P (2003) The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomised, single-blind, cross-over pilot trial. Pain 106:401-409
137. World Health Organization (2002) World health report-reducing risks, promoting healthy life. World Health Organization, Geneva
138. Yang Y, Carlin AS, Faustino PJ, Motta MI, Hamad ML, He R, Watanuki Y, Pinnow EE, Khan MA (2009) Participation of women in clinical trials for new drugs approved by the food and drug administration in 2000-2002. J Womens Health (Larchmt) 18:303-310
139. Zender R, Olshansky E (2009) Women's mental health: depression and anxiety. Nurs Clin North Am 44:355-364
140. Zopf Y, Rabe C, Neubert A, Gassmann KG, Rascher W, Hahn EG, Brune K, Dormann H (2008) Women encounter ADRs more often than do men. Eur J Clin Pharmacol 64:999-1004
141. Zubieta JK, Yau WY, Scott DJ, Stohler CS (2006) Belief or need? Accounting for individual variations in the neurochemistry of the placebo effect. Brain Behav Immun 20:15-26