Placebo theory and its implications for research and clinical practice: A review of the recent literature

Pain Practice

Volumn 7, Issue 1, 2007, Pages 4-20

  Koshi, Edvin B ^a,b   Short, Christine Ann ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b Pain Management Unit   (Canada)

Author keywords

Conditioning; Context; Expectation; Meaning; Placebo; Research

Indexed keywords

MORPHINE; PLACEBO; PROGLUMIDE;

ANALGESIA; CLINICAL PRACTICE; CLINICAL RESEARCH; CLINICAL TRIAL; DEPRESSION; HUMAN; MOTOR DYSFUNCTION; PAIN; PSYCHOLOGICAL ASPECT; REVIEW; SOCIAL ASPECT; THEORY;

ANALGESICS; ATTITUDE TO HEALTH; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PLACEBO EFFECT; PLACEBOS; RANDOMIZED CONTROLLED TRIALS;

EID: 33846968808     PISSN: 15307085     EISSN: 15332500     Source Type: Journal    
DOI: 10.1111/j.1533-2500.2007.00104.x     Document Type: Review

References (124)

1. De La Fuente-Fernandez R, Stoessl AJ. The biochemical bases for reward. Implications for the placebo effect. Eval Health Prof. 2002; 25: 387-398.
2. Benedetti F, Pollo A, Lopiano L, Lanotte M, Vighetti S, Rainero I. Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci. 2003; 23: 4315-4323.
3. Shapiro AK. A contribution to the history of the placebo effect. Behav Sci. 1960; 5: 109-135.
4. Biller N. The placebo effect: Mocking or mirroring medicine? Perspect Biol Med. 1999; 42: 398-401.
5. Shapiro AK, Morris LA. The placebo effect in medical and psychological therapies. In: Garfield SL, Bergin AE, eds. Handbook of Psychotherapy and Behavior Change. New York: John Wiley & Sons; 1978: 369-410.
6. White L, Tursky B, Schwartz GE. Placebo in perspective. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 3-8.
7. Wall PD. Pain and the placebo response. Ciba Found Symp. 1993; 174: 187-216.
8. Rawlinson M. Truth-telling and paternalism in the clinic: Philosophical reflection on the use of placebo in medical practice. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 403-418.
9. Benedetti F, Colloca L. Placebo-induced analgesia: Methodology, neurobiology, clinical use, and ethics. Rev Analgesia. 2004; 7: 129-143.
10. Colloca L, Benedetti F. Placebos and painkillers: Is mind as real as matter? Nat Rev Neurosci. 2005; 6: 545-552.
11. Benedetti F, Amanzio M. The neurobiology of placebo analgesia: From endogenous opioids to cholecystokinin. Prog Neurobiol. 1997; 52: 109-125.
12. Hoffman GA, Harrington A, Fields HL. Pain and the placebo: What we have learned. Perspect Biol Med. 2005; 48: 248-265.
13. Brody H. Placebos and the Philosophy of Medicine. Chicago, IL: Chicago University Press; 1977.
14. Kissel P, Barrucand D. Placebos En Medecine. Paris: Masson; 1974.
15. Talbot M. The placebo prescription. NY Times Mag. 2000, Jan 9.
16. Hrobjartsson A, Gotzche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. 2001; 334: 1594-1602.
17. Buckalew LW, Coffield KE. An investigation of drug expectancy as a function of capsule color and size and preparation form. J Clin Psychopharmacol. 1982; 2: 245-248.
18. Sox HC Jr, Margulies I, Sox CH. Psychologically mediated effects of diagnostic tests. Ann Intern Med. 1981; 95: 680-685.
19. Thomas KB. General practice consultations: Is there any point in being positive? Br Med J (Clin Res Ed). 1987; 294: 1200-1202.
20. Bass MJ, Buck C, Turner L, Dickie G, Pratt G, Robinson HC. The physician's actions and the outcome of illness in family practice. J Fam Pract. 1986; 23: 43-47.
21. Gracely RH, Dubner R, Deeter WR, Wolskee PJ. Clinicians'expectations influence placebo analgesia. Lancet. 1985; 1: 43.
22. Greenfield S, Kaplan S, Ware JE Jr. Expanding patient involvement in care. Effects on patient outcomes. Ann Intern Med. 1985; 102: 520-528.
23. Stewart MA. Effective physician-patient communication and health outcomes: A review. CMAJ. 1995; 152: 1423-1433.
24. Baliant M. The doctor, his patient, and the illness. Lancet. 1955; 1: 683-688.
25. Di Blasi Z, Harkness E, Ernst E, Georgiu A, Kleijnen J. Influence of context effect on health outcomes. A systemic review. Lancet. 2001; 375: 757-762.
26. Kaptchuk TJ. The placebo effect in alternative medicine: Can the performance of a healing ritual have clinical significance? Ann Intern Med. 2002; 136: 817-825.
27. Tallman K, Bohart AC. The client as a common factor: Clients as self-healers. In: Hubble MA, Duncan BL, Miller SD, eds. The Heart and Soul of Change. American Psychological Association: Washington, DC; 1999: 91-131.
28. Benedetti F. How the doctor's words affect the patient's brain. Eval Health Prof. 2002; 25: 369-386.
29. Evans FG. Expectancy, therapeutic instructions, and the placebo response. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 215-228.
30. Levine JD, Gordon NC. Influence of the method of drug administration on analgesic response. Nature. 1984; 312: 755-756.
31. Amanzio M, Pollo A, Maggi G, Benedetti F. Response variability to analgesics: A role for non-specific activation of endogenous opioids. Pain. 2001; 90: 205-215.
32. Benedetti F, Arduino C, Amanzio M. Somatotopic activation of opioid systems by target-directed expectations of analgesia. J Neurosci. 1999; 19: 3639-3648.
33. Jospe M. The Placebo Effect in Healing. Lexington, MA: Lexington Books; 1978: 170.
34. Sartorius N. Praised be placebo, may its glory shine. Croat Med J. 2006; 47: 189-190.
35. Benedetti F, Amanzio M, Maggi G. Potentiation of placebo analgesia by proglumide. Lancet. 1995; 346: 1231.
36. Benedetti F, Amanzio M, Baldi S, et al. The specific effects of prior opioid exposure on placebo analgesia and placebo respiratory depression. Pain. 1998; 75: 313-319.
37. Gracely RH, Dubner R, Wolskee PJ, Deeter WR. Placebo and naloxone can alter post-surgical pain by separate mechanisms. Nature. 1983; 306: 264-265.
38. Benedetti F. The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain. 1996; 64: 535-543.
39. Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in a chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001; 94: 149-158.
40. McRae C, Cherin E, Yamazaki TG, et al. Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Arch Gen Psychiatry. 2004; 61: 412-420.
41. Marchand S, Kupers RC, Bushnell MC, Duncan GH. Analgesic and placebo effects of thalamic stimulation. Pain. 2003; 105: 481-488.
42. Schwartz GE. Self-regulation of response patterning: Implications for psychophysiological research and therapy. Biofeedback Self Regul. 1976; 1: 7-30.
43. Barrett B, Muller D, Rakel D, Rabago D, Marchand L, Scheder JC. Placebo, meaning, and health. Perspect Biol Med. 2006; 49: 178-198.
44. Peck C, Coleman G. Implications of placebo theory for clinical research and practice in pain management. Theor Med. 1991; 12: 247-270.
45. Gleidman LH, Gnatt WH, Teitelbaum HA. Some implications of conditional reflex studies for placebo research. Am J Psychiatry. 1957; 113: 1103-1107.
46. Wickramasekera I. A conditioned response model of the placebo effect predictions from the model. Biofeedback Self Regul. 1980; 5: 5-18.
47. Pavlov IP. Conditioned Reflexes. London: Oxford Press; 1927.
48. Lang WJ, Rand MJ. A placebo response as a conditional reflex to glyceryl trinitrate. Med J Aust. 1969; 1: 912-914.
49. Knowles JB. Conditioning and the placebo effect: The effect of decaffeinated coffee on simple reaction time in habitual coffee drinkers. Behav Res Ther. 1963; 19: 151-157.
50. Voudouris NJ, Peck CL, Coleman G. Conditioned placebo responses. J Pers Soc Psychol. 1985; 48: 47-53.
51. Voudouris NJ, Peck CL, Coleman G. Conditioned response models of placebo phenomena: Further support. Pain. 1989; 38: 109-116.
52. Voudouris NJ, Peck CL, Coleman G. The role of conditioning and verbal expectancy in the placebo response. Pain. 1990; 43: 121-128.
53. Wickramasekera I. The placebo effect and medical instruments in biofeedback. J Clin Engineering. 1977; 2: 227-230.
54. Wickramasekera I. A condition response model of the placebo effect: predictions from the model. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 255-287.
55. Phil RO, Altman J. An experimental analysis of the placebo effect. J Clin Pharmacol. 1971; 11: 91-95.
56. Goldstein AP. Participant expectancies in psychotherapy. Psychiatry. 1962; 25: 72-79.
57. Bootzin RR. The role of expectancy in behavior change. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 186-210.
58. Kirsch I. The placebo effect and the cognitive-behavioral revolution. Cognitive Ther Res. 1978; 2: 225-264.
59. Ross M, Olson JM. An expectancy-attribution model of the effects of placebos. Psychol Rev. 1981; 88: 408-437.
60. Wilson GT, Lawson DM. Expectancies, alcohol, and sexual arousal in male social drinkers. J Abnorm Psychol. 1976; 85: 587-594.
61. Lang AR, Goeckner DJ, Adesso VJ, Marlatt GA. Effects of alcohol on aggression in male social drinkers. J Abnorm Psychol. 1975; 84: 508-518.
62. Marlatt GA, Roshenow DJ. Cognitive processes in alcohol use: Expectancy and the balanced placebo design. In: Mello NK, ed. Advances in Substance Abuse: Behavioral and Biological Research. Greenwich, CT: JAI Press; 1980: 159-199.
63. Volkow ND, Wang GJ, Ma Y, et al. Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. Neuroscience. 2003; 23: 11461-11468.
64. Dinnerstein AJ, Lowenthal M, Blitz B. The interaction of drugs with placebos in the control of pain and anxiety. Perspect Biol Med. 1966; 10: 103-117.
65. Dinnerstein AJ, Halm J. Modification of placebo effects by means of drugs: Effects of aspirin and placebos on self-rated moods. J Abnorm Psychol. 1970; 75: 308-314.
66. Kirsch I. Response expectancy as a determinant of experience and behavior. Am Psychol. 1985; 40: 1189-1202.
67. Schachter S, Singer JE. Cognitive, social, and physiological determinants of emotional state. Psychol Rev. 1962; 69: 379-399.
68. Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975; 258: 577-580.
69. Fields H. State-dependent opioid control of pain. Nat Rev Neurosci. 2004; 5: 565-575.
70. Levine JD, Gordon NC, Fields HL. The mechanism of placebo analgesia. Lancet. 1978; 2: 654-657.
71. Lipman JJ, Miller BE, Mays KS, Miller MN, North WC, Byrne WL. Peak B endorphin concentration in cerebrospinal fluid: Reduced in chronic pain patients and increased during the placebo response. Psychopharmacology (Berl). 1990; 102: 112-116.
72. Amanzio M, Benedetti F. Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci. 1999; 19: 484-494.
73. Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and opioid analgesia-imaging a shared neuronal network. Science. 2002; 295: 1737-1740. Epub 2002 February 7.
74. Wager TD, Rilling JK, Smith EE, et al. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science. 2004; 303: 1162-1167.
75. Franklin KB. Analgesia and the neural substrate of reward. Neurosci Biobehav Rev. 1989; 13: 149-154.
76. Hanh RA. A sociocultural model of illness and healing. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 167-195.
77. Koenig HG, George LK, Cohen HJ, Hays JC, Larson DB, Blazer DG. The relationship between religious activities and cigarette smoking in older adults. J Gerontol A Biol Sci Med Sci. 1998; 53: M426-M434.
78. Koenig HG, Larson DB, Larson SS. Religion and coping with serious medical illness. Ann Pharmacother. 2001; 35: 352-359.
79. Oxman TE, Freeman DH Jr, Manheimer ED. Lack of social participation or religious strength and comfort as risk factors for death after cardiac surgery in the elderly. Psychosom Med. 1995; 57: 5-15.
80. de la Fuente-Fernandez R, Ruth TJ, Sossi V, Schulzer M, Calne DB, Stoessl AJ. Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease. Science. 2001; 293: 1164-1166.
81. de la Fuente-Fernandez R, Stoessl AJ. The placebo effect in Parkinson's disease. Trends Neurosci. 2002; 25: 302-306.
82. Schultz W. Predictive reward signal of dopamine neurons. J Neurophysiol. 1998; 80: 1-27.
83. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986; 9: 357-381.
84. Bjorklund A, Lindvall O. Dopamine-containing systems in the CSN. In: Bjorklund A, Hokfelt T, eds. Handbook of Chemical Neuroanatomy. Amsterdam: Elsevier Science; 1984: 55-122.
85. Robinson TE, Berridge KC. The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993; 18: 247-291.
86. Christie MJ, James LB, Beart PM. An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray. Brain Res Bull. 1986; 16: 127-129.
87. Mantyh PW. Forebrain projections to the periaqueductal gray in the monkey, with observations in the cat and rat. J Comp Neurol. 1982; 206: 146-158.
88. Ma QP, Han JS. Neurochemical studies on the mesolimbic circuitry of antinociception. Brain Res. 1991; 566: 95-102.
89. Yu LC, Han JS. Involvement of arcuate nucleus of hypothalamus in the descending pathway from nucleus accumbens to periaqueductal grey subserving an antinociceptive effect. Int J Neurosci. 1989; 48: 71-78.
90. Altier N, Stewart J. The role of dopamine in the nucleus accumbens in analgesia. Life Sci. 1999; 65: 2269-2287.
91. Spanagel R, Herz A, Shippenberg TS. The effects of opioid peptides on dopamine release in the nucleus accumbens: An in vivo microdialysis study. J Neurochem. 1990; 55: 1734-1740.
92. Garris PA, Kilpatrick M, Bunin MA, Michael D, Walker QD, Wightman RM. Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation. Nature. 1999; 398: 67-69.
93. Beecher HK. The powerful placebo. J Am Med Assoc. 1955; 159: 1602-1606.
94. Levine JD, Gordon NC, Bornstein JC, Fields HL. Role of pain in placebo analgesia. Proc Natl Acad Sci USA. 1979; 76: 3528-3531.
95. Walsh BT, Seidman SN, Sysko R, Gould M. Placebo response in studies of major depression: Variable, substantial, and growing. JAMA. 2002; 287: 1840-1847.
96. Liberman R. An experimental study of the placebo response under three different situations of pain. J Psychiatr Res. 1964; 33: 233-246.
97. Biller-Andorno N. The use of the placebo effect in clinical medicine-ethical blunder or ethical imperative? Sci Eng Ethics. 2004; 10: 43-50.
98. Mayberg HS, Silva JA, Brannan SK, et al. The functional neuroanatomy of the placebo effect. Am J Psychiatry. 2002; 159: 728-737.
99. Brody H. Placebo. In: Reich WT, ed. Encyclopedia of Bioethics. New York: Simon & Schuster Macmillan; 1995: 1951-1953.
100. Thomas KB. The placebo in general practice. Lancet. 1994; 344: 1066-1067.
101. Moerman DE. The meaning response and the ethics of avoiding placebos. Eval Health Prof. 2002; 25: 399-409.
102. Moerman DE, Jonas WB. Deconstructing the placebo effect and finding the meaning response. Ann Intern Med. 2002; 136: 471-476.
103. Rosenzweig P, Brohier S, Zipfel A. The placebo effect in healthy volunteers: Influence of experimental conditions on physiological parameters during phase I studies. Br J Clin Pharmacol. 1995; 39: 657-664.
104. Wendler D, Miller FG. Deception in the pursuit of science. Arch Intern Med. 2004; 164: 597-600.
105. American Psychological Association. Ethical principles of psychologists and code of conduct. Am Psychol. 1992; 47: 1597-1611.
106. Sullivan M, Terman GW, Peck B, et al. APS position statement on the use of placebos in pain management. J Pain. 2005; 6: 215-217.
107. Price DD. New facts and improved ethical guidelines for placebo analgesia. J Pain. 2005; 6: 213-214.
108. Kirsch I, Weixel LJ. Double-blind versus deceptive administration of a placebo. Behav Neurosci. 1988; 102: 319-323.
109. Benedetti F, Maggi G, Lopiano L. Open versus hidden medical treatment: the patient's knowledge about a therapy affects the therapy outcome. Prev Treat. 2003; 6. Available at: http://journals.apa.org/prevention/ volume6/toc-jun-03.html.
110. Price DD. Assessing placebo effects without placebo groups: An untapped possibility? Pain. 2001; 90: 201-203.
111. Finniss DG, Benedetti F. Mechanisms of the placebo response and their impact on clinical trials and clinical practice. Pain. 2005; 114: 3-6. Epub 2005 January 21.
112. Kirsch I. Hidden administration as ethical alternatives to the balanced placebo design.HPrev Treat. 2003; 6: 00-00. Available at: http://journals.apa.org/prevention/volume6/toc-jun-03.html.
113. World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA. 1997; 277: 925-926.
114. Knight LJ, Barbaree HE, Boland F. Alcohol and the balanced-placebo design: The role of experimenter demands in expectancy. J Abnorm Psychol. 1986; 95: 335-340.
115. Sayette MA, Breslin FC, Wilson GT, Rosenblum GD. An evaluation of the balanced placebo design in alcohol administration research. Addict Behav. 1994; 19: 333-342.
116. Bausell RB, Lao L, Bergman S, Lee WL, Berman BM. Is acupuncture analgesia an expectancy effect? Preliminary evidence based on participants' perceived assignments in two placebo-controlled trials. Eval Health Prof. 2005; 28: 9-26.
117. Gryll SL, Katahn M. Situational factors contributing to the placebo effect. Psychopharmacology. 1978; 47: 253-261.
118. Bok S. The ethics of giving placebos. Sci Am. 1974; 231: 17-23.
119. Pollo A, Amanzio M, Arslanian A, Casadio C, Maggi G, Benedetti F. Response expectancies in placebo analgesia and their clinical relevance. Pain. 2001; 93: 77-84.
120. Honigfeld G. Non-specific factors in treatment. Diseases of the nervous system. 1964; 25: 145-156.
121. Ross S, Buchalew LW. Placebo: Assessment of drug and placebo effect. In: White L, Tursky B, Schwartz GE, eds. Placebo: Theory, Research and Mechanisms. New York: The Guilford Press; 1985: 67-82.
122. Frank JD. Persuasion and Healing. A Comparative Study of Psychotherapy. Baltimore, MD: John Hopkins; 1973.
123. Barsky AJ, Saintfort R, Rogers MP, Borus JF. Nonspecific medication side effects and the nocebo phenomenon. JAMA. 2002; 287: 622-627.
124. Moerman DE. Sorcerers, Magic, Meaning, and Healing: Or, Why It's Unethical to Avoid the "Placebo Effect". Abstracts. 11th World Congress on Pain. Seattle, WA: IASP Press; 2005: 136.