Placebo: new insights into an old enigma

Drug Discovery Today

Volumn 12, Issue 9-10, 2007, Pages 413-418

  Ernst, Edzard ^a  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

CLINICAL PRACTICE; CLINICAL RESEARCH; MEDICAL RESEARCH; NOMENCLATURE; PATIENT CARE; PHYSIOLOGY; PSYCHOLOGY; REVIEW;

HUMANS; PLACEBO EFFECT; PLACEBOS; RANDOMIZED CONTROLLED TRIALS; TERMINOLOGY; TREATMENT OUTCOME;

EID: 34247328199     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.03.007     Document Type: Review

References (69)

1. Wall P.D. The placebo effect, an unpopular topic. Pain 51 (1992) 1-3
2. Davidson J. Self-healing and the placebo response. Br. Homoeopathic J. 85 (1996) 161-162
3. Wickramasekera I. Placebo and health - II: How to produce not only powerful but more importantly, reliable placebo healing and analgesia. Adv. Mind Body Med. 16 (2000) 211-232
4. Kaptchuk T.J. The placebo effect in alternative medicine: can the performance of a healing ritual clinical significance?. Ann. Intern. Med. 136 (2002) 817-825
5. Evans D. Placebo. The Belief Effect (2003), Harper Collins
6. Grant Thompson W. The Placebo Effect and Health. Combining Science and Compassionate Care (2005), Prometheus Books
7. Moore A., and McQuay H. Bandolier's Little Book of Making Sense of the Medical Evidence (2006), Oxford University Press
8. Haour F. Mechanisms of the placebo effect and of conditioning. Neuroimmunomodulation 12 (2005) 195-200
9. Stewart-Williams S., and Podd J. The placebo effect: dis-solving the expectancy versus conditioning debate. Psychol. Bull. 130 (2004) 324-340
10. Brody H. Placebos and the Philosophy of Medicine. Clinical, Conceptual and Ethical Issues (1980), University of Chicago Press
11. Shapiro A.K. A historical and heuristic definition of the placebo. Psychiatry 27 (1964) 52-58
12. Hröbjartsson A. What are the main methodological problems in the estimations of placebo effects?. J. Clin. Epidemiol. 55 (2002) 430-435
13. Ernst E., and Resch K.L. The concept of the perceived and true placebo effect. BMJ 311 (1995) 551-553
14. Wolf S. The pharmacology of placebos. Pharmacol. Rev. 11 (1959) 689-704
15. Grünbaum A. The placebo concept in medicine and psychiatry. Psychol. Med. 16 (1986) 19-38
16. Moerman D.E., and Jonas W.B. Deconstructing the placebo effect and finding the meaning response. Ann. Intern. Med. 136 (2002) 471-476
17. Gotzsche P.C. Is there logic in the placebo?. Lancet 344 (1994) 925-926
18. Mercado R., et al. Expectation and the placebo effect in Parkinson's disease patients with subthalamic nucleus deep brain stimulation. Mov. Disord. 21 (2006) 1457-1461
19. Stockhorst U., et al. Classical conditioning and conditionability of insulin and glucose effects in healthy humans. Physiol. Behav. 81 (2004) 375-388
20. Pacheco-Lopez G., et al. Expectations and associations that heal: immunomodulatory placebo effects and its neurobiology. Brain Behav. Immun. 20 (2006) 430-446
21. Miller F.G., and Rosenstein D.L. Variance and dissent: the nature and power of the placebo effect. J. Clin. Epidemiol. 59 (2006) 331-335
22. Geers A.L., et al. Goal activation, expectations, and the placebo effect. J. Pers. Soc. Psychol. 89 (2005) 143-159
23. Hrobjartsson A., and Gotzsche P. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. New Engl. J. Med. 344 (2001) 1594-1602
24. Hrobjartsson A., and Gotzsche P. Is the placebo powerless? Update of a systematic review with 52 new randomised trials comparing placebo with no treatment. J. Intern. Med. 256 (2004) 91-100
25. McCall W.V., et al. A comparison of placebo and no-treatment during a hypnotic clinical trial. Int. J. Clin. Pharmacol. Ther. 43 (2005) 355-359
26. Benedetti F., et al. Neurobiological mechanisms of the placebo effect. J. Neurosci. 25 (2005) 10390-10402
27. Sauro M.D. Endogenous opiates and the placebo effect: a meta-analytic review. J. Psychosom. Res. 58 (2005) 115-120
28. Benedetti F., et al. Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat. Neurosci. 7 (2004) 587-588
29. Vase L., et al. Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms. Pain 115 (2005) 338-347
30. Klosterhalfen S., and Enck P. Psychobiology of the placebo response. Auton. Neurosci. 125 (2006) 94-99
31. Price D.D., et al. Placebo analgesia is accompanied by large reductions in pain-related activity in irritable bowel syndrome patients. Pain 127 (2007) 63-72
32. de la Fuente-Fernández R., et al. Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science 293 (2001) 1164-1166
33. Petrovic P., et al. Placebo and opioid analgesia - imaging a shared neuronal network. Science 295 (2002) 1737-1740
34. Wager T.D., et al. Placebo-induced changes in fMRI in the anticipation and experience of pain. Science 303 (2004) 1162-1167
35. Lieberman M.D., et al. The neural correlates of placebo effects: a disruption account. Neuroimage 22 (2004) 447-455
36. Zubieta J.-K., et al. Placebo effects mediated endogenous opioid activity on μ-opioid receptors. J. Neurosci. 25 (2005) 7754-7762
37. Leuchter A.F., et al. Changes in brain function of depressed subjects during treatment with placebo. Am. J. Psychiatry 159 (2002) 122-129
38. Mayberg H.S., et al. The functional neuroanatomy of the placebo effect. Am. J. Psychiatry 159 (2002) 728-737
39. Kaasinen V., et al. Expectation of caffeine induces dopaminergic responses in humans. Eur. J. Neurosci. 19 (2004) 2352-2356
40. Zubieta J.-K., et al. Belief or need? Accounting for individual variations in the neurochemistry of the placebo effect. Brain Behav. Immun. 20 (2006) 15-26
41. Clegg D.O., et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New Engl. J. Med. 354 (2006) 795-808
42. Miller F.G. Unnecessary use of placebo controls. Arch. Intern. Med. 162 (2002) 1673-1677
43. Temple R., and Ellenberg S.S. Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: Ethical and scientific issues. Ann. Intern. Med. 133 (2000) 455-463
44. Boussageon R., et al. The difficulty of measurement of placebo effect. Therapie 61 (2006) 185-190
45. Feinstein A.R. Post-therapeutic response and therapeutic 'style': re-formulating the 'placebo effect'. J. Clin. Epidemiol. 55 (2002) 427-429
46. Eccles R. Mechanisms of the placebo effect of sweet cough syrups. Respir. Physiol. Neurobiol. 152 (2006) 340-348
47. Wampold B.E., et al. The placebo is powerful: estimating placebo effects in medicine and psychotherapy from randomized clinical trials. J. Clin. Psychol. 61 (2005) 835-854
48. Humphrey N. Great expectations: the evolutionary psychology of faith healing and the placebo effect. In: Humphrey N. (Ed). The Mind Made Flesh: Essays From the Frontiers of Psychology and Evolution (2002), Oxford University Press 255-285
49. Hougaard E. The relationship between the placebo effect and spontaneous improvement in research on antidepressants. Are placebos powerless?. Ugeskr. Laeger 167 (2005) 2865-2869
50. Baecker M., et al. Acupuncture, Quo Vadis?. Theime Almanac 2007 (2007), Thieme Verlag 29-36
51. Ernst E., and Abbot N.C. Placebos in clinical practice: results of a survey of nurses. Perfusion 10 (1997) 128-130
52. Nitzan U., and Lichtenberg P. Questionnaire survey on use of placebo. BMJ 329 (2004) 944-946
53. Ernst E. A systematic review of systematic reviews of homeopathy. Br. J. Clin. Pharmacol. 54 (2002) 577-582
54. Miller F.G., et al. Ethical issues concerning research in complementary and alternative medicine. J. Am. Med. Assoc. 291 (2004) 599-604
55. Brody H. The placebo response. Recent research and implications for family medicine. J. Fam. Pract. 49 (2000) 649-654
56. Enck P., et al. Determination of placebo effect in irritable bowel syndrome. Dtsch. Med. Wochenschr. 130 (2005) 1934-1937
57. de Craen A.J.M., et al. Placebo effect in the treatment of duodenal ulcer. Br. J. Clin. Pharmacol. 48 (1999) 853-860
58. Walach H., et al. The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials - a secondary analysis. BMC Med. Res. Methodol. 5 (2005) 26. http://www.biomedcentral.com 10.1186/1471-2288-5-26
59. Harkness E.F., and Ernst E. The enigmatic placebo effect - a systematic review to define its determinants. Perfusion 13 (2000) 164-170
60. Loder E., et al. Placebo effects in oral triptan trials: the scientific and ethical rationale for continued use of placebo controls. Cephalalgia 25 (2005) 124-131
61. Macedo A., et al. A meta-analysis of the placebo response in acute migraine and how this response may be influences by some of the characteristics of clinical trials. Eur. J. Clin. Pharmacol. 62 (2006) 161-172
62. Kaptchuk T.J., et al. Sham device ν inert pill: randomised controlled trial of two placebo treatments. BMJ 332 (2006) 391-397
63. Kaptchuk T.J., et al. Do medical devices have enhanced placebo effects?. J. Clin. Epidemiol. 53 (2000) 786-792
64. Charron J., et al. Direct comparison of placebo effects on clinical and experimental pain. Clin. J. Pain 22 (2006) 204-211
65. Talley N.J., et al. Predictors of the placebo response in functional dyspepsia. Aliment. Pharmacol. Ther. 23 (2006) 923-936
66. van Leeuwen J.H., et al. The placebo effect in the pharmacologic treatment of patients with lower urinary tract symptoms. Eur. Urol. 50 (2006) 440-452
67. Simpson S.H., et al. A meta-analysis of the associations between adherence to drug therapy and mortality. BMJ 333 (2006) 15
68. Geers A.L., et al. Reconsidering the role of personality in placebo effects: dispositional optimism, situational expectations, and the placebo response. J. Psychosom. Res. 58 (2005) 121-127
69. Walsh B.T., et al. Placebo response in studies of major depression. J. Am. Med. Assoc. 287 (2002) 1840-1847