Pleiotropic effects of thyroid hormones: Learning from hypothyroidism

Journal of Thyroid Research

Volumn 2011, Issue , 2011, Pages

  Franco, Martha ^a   Chavez, Edmundo ^a   Pérez Méndez, Oscar ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR; ARYLDIALKYLPHOSPHATASE 1; CALCIUM ION; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; NITRIC OXIDE; THYROID HORMONE; THYROID HORMONE RECEPTOR BETA; THYROXINE;

AORTA ATHEROSCLEROSIS; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL TONE; CARDIOVASCULAR MORTALITY; CHOLESTEROL BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GLOMERULUS FILTRATION RATE; HEART INFARCTION; HEART INJURY; HEART PERFUSION; HORMONE ACTION; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; ISCHEMIC HEART DISEASE; KIDNEY BLOOD FLOW; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LIPOPROTEIN METABOLISM; METABOLIC REGULATION; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; PATHOPHYSIOLOGY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REPERFUSION INJURY; VASOCONSTRICTION;

EID: 84868290186     PISSN: 20908067     EISSN: 20420072     Source Type: Journal    
DOI: 10.4061/2011/321030     Document Type: Article

References (119)

1. I. E. Scheffler, Mitochondria, Whiley and Sons, New Jersey, NJ, USA, 2nd edition, 2008.
2. G. Paradies and F. M. Ruggiero, "The influence of hypothyroidism on the transport of phosphate and on the lipid composition in rat-liver mitochondria", Biochimica and Biophysica Acta, vol. 1070, no. 1, pp. 180-186, 1991.
3. G. Paradies, F. M. Ruggiero, G. Petrosillo, and E. Quagliariello, "Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats", Biochimica et Biophysica Acta, vol. 1225, no. 2, pp. 165-170, 1994. (Pubitemid 24033277)
4. S. G. Robles, M. Franco, C. Zazueta et al., "Thyroid hormone may induce changes in the concentration of the mitochondrial calcium uniporter", Comparative Biochemistry and Physiology B, vol. 135, no. 1, pp. 177-182, 2003. (Pubitemid 36627740)
5. P. Schonfeld, M. R. Wieckowski, and L. Wojtczak, "Thyroid hormone-induced expression of the ADP/ATP carrier and its effect on fatty acid-induced uncoupling of oxidative phosphorylation", FEBS Letters, vol. 416, no. 1, pp. 19-22, 1997. (Pubitemid 27470792)
6. R. Mangiullo, A. Gnoni, F. Damiano et al., "3, 5-diiodo-L-thyronine upregulates rat-liver mitochondrial FoF1-ATP synthase by GA-binding protein/nuclear respiratory factor-2", Biochimica et Biophysica Acta, vol. 1797, no. 2, pp. 233-240, 2010.
7. J. Kvetny, L. Wilms, P. L. Pedersen, and J. Larsen, "Subclinical hypothyroidism affects mitochondrial function", Hormone and Metabolic Research, vol. 42, no. 5, pp. 324-327, 2010.
8. G. M. Hatch, "Cardiolipin: biosynthesis, remodeling and trafficking in the heart and mammalian cells", International Journal of Molecular Medicine, vol. 1, no. 1, pp. 33-41, 1998.
9. D. L. Pehowich, "Hypothyroid state and membrane fatty acid composition influence cardiac mitochondrial pyruvate oxidation", Biochimica et Biophysica Acta, vol. 1235, no. 2, pp. 231-238, 1995.
10. G. Paradies, F. M. Ruggiero, G. Petrosillo, and E. Quagliariello, "Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats", Federation of European Biochemical Societies Letters, vol. 397, no. 2-3, pp. 260-262, 1996. (Pubitemid 26414029)
11. G. Paradies, F. M. Ruggiero, G. Petrosillo, and E. Quagliariello, "Alterations in carnitine-acylcarnitine translocase activity and in phospholipid composition in heart mitochondria from hypothyroid rats", Biochimica et Biophysica Acta, vol. 1362, no. 2-3, pp. 193-200, 1997. (Pubitemid 28164172)
12. K. Beyer and M. Klingenberg, "ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by P nuclear magnetic resonance", Biochemistry, vol. 24, no. 15, pp. 3821-3826, 1985.
13. A. P. Halestrap and C. Brenner, "The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death", Current Medicinal Chemistry, vol. 10, no. 16, pp. 1507-1525, 2003. (Pubitemid 36896553)
14. N. Brustovetsky and M. Klingenberg, "Mitochondrial ADP/ATP carrier can be reversible converted into a large channel by Ca2+", Biochemistry, vol. 35, no. 26, pp. 8483-8488, 1996. (Pubitemid 26240181)
15. 2+ content by the ADP/ATP carrier in brown adipose tissue mitochondria. Influence of membrane lipid composition", Journal of Bioenergetics and Biomembranes, vol. 28, no. 1, pp. 69-76, 1996.
16. G. K. Asimakis and L. A. Sordahl, "Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria", Archives of Biochemistry and Biophysics, vol. 179, no. 1, pp. 200-210, 1977. (Pubitemid 8047929)
17. E. Chávez, C. Zazueta, N. García, E. Martínez- Abundis, N. Pavon, and L. Hernández-Esquivel, "Titration of cardiolipin by either 10-N-nonyl acridine orange or acridine orange sensitizes the adenine nucleotide carrier to permeability transition", Journal of Bioenergetics and Biomembranes, vol. 40, no. 2, pp. 77-84, 2008.
18. E. Chávez, M. Franco, H. Reyes-Vivas, C. Zazueta, J. Ramirez, and R. Carrillo, "Hypothyroidism renders liver mitochondria resistant to the opening of membrane permeability transition pore", Biochimica et Biophysica Acta, vol. 1407, no. 3, pp. 243-248, 1998. (Pubitemid 29067442)
19. C. Zazueta, M. Franco, F. Correa et al., "Hypothyroidism provides resistance to kidney mitochondria against the injury induced by renal ischemia-reperfusion", Life Sciences, vol. 80, no. 14, pp. 1252-1258, 2007. (Pubitemid 46335802)
20. C. Pantos, V. Malliopoulou, I. Mourouzis et al., "Propylthiouracil- induce hypothyroidism is associated with increased tolerance of the isolated rat heart to ischaemiareperfusion", Journal of Endocrinology, vol. 178, no. 3, pp. 427-435, 2003. (Pubitemid 37220169)
21. M. Masztalerz, Z. Wlodarczyk, J. Czuczejko, M. Slupski, and J. Kedziora, "Superoxide anion as a marker of ischemia-reperfusion injury of the transplanted kidney", Transplantation Proceedings, vol. 38, no. 1, pp. 46-48, 2006.
22. N. García, C. Zazueta, M. El-Hafidi et al., "Cyclosporin A inhibits UV-radiation-induced membrane damage but is unable to inhibit carboxyatractyloside-induced permeability transition", Radiation research, vol. 172, no. 5, pp. 575-583, 2009.
23. E. Doran and A. P. Halestrap, "Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites", Biochemical Journal, vol. 348, no. 2, pp. 343-350, 2000. (Pubitemid 30345207)
24. N. Pavon, A. Aranda, N. García, L. Hernández-Esquivel, and E. Chaívez, "In hyperthyroid rats octylguanidine protects the heart from reperfusion damage", Endocrine, vol. 35, no. 6, pp. 158-165, 2009.
25. E. Chávez, R. Moreno-Sánchez, C. Zazueta, H. Reyes-Vivas, and D. Arteaga, "Intramitochondrial K+ as activator of carboxyatractyloside-induced Ca2+ release", Biochimica et Biophysica Acta, vol. 1070, no. 2, pp. 461-466, 1991.
26. P. Venditti, R. De Rosa, and S. Di Meo, "Effect of thyroid state on susceptibility to oxidants and swelling of mitochondria from rat tissues", Free Radical Biology and Medicine, vol. 35, no. 5, pp. 485-494, 2003. (Pubitemid 37289158)
27. E. Fernaíndez-Vizarra, J. A. Enriquez, A. Peírez-Martos, J. Montoya, and P. Fernaíndez-Silva, "Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones", Current Genetics, vol. 54, no. 1, pp. 13-22, 2008.
28. E. Yehuda-Shnaidman, B. Kalderon, N. Azazmeh, and J. Bar-Tana, "Gating of the mitochondrial permeability transition pore by thyroid hormone", FASEB Journal, vol. 24, no. 1, pp. 93-104, 2010.
29. E. Yehuda-Shnaidman, B. Kalderon, and J. Bar-Tana, "Modulation of mitochondrial transition pore components by thyroid hormone", Endocrinology, vol. 146, no. 5, pp. 2462-2472, 2005. (Pubitemid 40577535)
30. D. V. Cokkinos and C. Pantos, "Myocardial protection: a new holy grail of contemporary cardiology", Hellenic Journal of Cardiology, vol. 46, no. 4, pp. 249-257, 2005. (Pubitemid 41657692)
31. N. García, F. Correa, and E. Chavez, "On the role of the respiratory complex I on membrane permeability transition", Journal of Bioenergetics and Biomembranes, vol. 37, no. 1, pp. 17-23, 2005. (Pubitemid 40768561)
32. T. Munzel, T. Gori, R. M. Bruno, and S. Taddei, "Is oxidative stress a therapeutic target in cardiovascular disease?" European Heart Journal, vol. 31, no. 22, pp. 2741-2748, 2010.
33. L. zhang, J. R. Parrat, G. H. Beastall, N. J. Pyne, and B. L. Furman, "Streptozotocin diabetes protects against arrhthmias in isolated hearts: role of hypothyroidism", European Journal of Pharmacology, vol. 245, no. 2-3, pp. 269-276, 2002. (Pubitemid 34131711)
34. I. Bobadilla, M. Franco, D. Cruz, J. Zamora, S. G. Robles, and E. Chavez, "Hypothyroidism provides resistance to reperfusion injury following myocardium ischemia", International Journal of Biochemistry and Cell Biology, vol. 33, no. 5, pp. 399-506, 2001.
35. G. Capasso, N. G. De Santo, and R. Kinne, "Thyroid hormones and renal transport: cellular and biochemical aspects", Kidney International, vol. 32, no. 4, pp. 443-451, 1987. (Pubitemid 17154732)
36. I. van Hoek and S. Daminet, "Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review", General and Comparative Endocrinology, vol. 160, no. 3, pp. 205-215, 2009.
37. F. Vargas, J. M. Moreno, I. Rodriguez-Gomez et al., "Vascular and renal function in experimental thyroid disorders", European Journal of Endocrinology, vol. 154, no. 2, pp. 197-212, 2006.
38. M. Franco, N. A. Bobadilla, J. Suarez, E. Tapia, L. Sanchez, and J. Herrera-Acosta, "Participation of adenosine in the renal hemodynamic abnormalities of hypothyroidism", American Journal of Physiology, vol. 270, no. 2, pp. F254-F262, 1996.
39. D. M. Gillum, S. A. Falk, W. S. Hammond, and J. D. Conger, "Glomerular dynamics in the hypothyroid rat and the role of the renin-angiotensin system", American Journal of Physiology, vol. 253, no. 1, part 2, pp. F170-F179, 1987.
40. M. G. Collis, "The vasodilator role of adenosine", Pharmacology and Therapeutics, vol. 41, no. 1-2, pp. 143-162, 1989. (Pubitemid 19069659)
41. H. Osswald, "The role of adenosine in the regulation of glomerular filtration rate and renin secretion", Trends in Pharmacological Sciences, vol. 5, no. 1, 1984.
42. W. S. Spielman and C. I. Thompson, "A proposed role for adenosine in the regulation of renal hemodynamics and renin release", American Journal of Physiology, vol. 242, no. 5, pp. F423-F435, 1982. (Pubitemid 12099166)
43. D. Mazurkiewicz and D. Saggerson, "Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism", Biochemical Journal, vol. 261, no. 2, pp. 667-672, 1989. (Pubitemid 19187399)
44. Z. Jamal and D. Saggerson, "Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences", Biochemical Journal, vol. 245, no. 3, pp. 881-886, 1987. (Pubitemid 17103979)
45. J. J. Ohisalo, S. Stoneham, and L. Keso, "Thyroid status and adenosine content of adipose tissue", Biochemical Journal, vol. 246, no. 2, pp. 555-557, 1987.
46. M. Franco, O. Galicia, A. Quintana, and F. Martinez, "Experimental hypothyroidism modifies specific binding of A1 and A2A analogues to adenosine receptors in the rat kidney", British Journal of Pharmacology, vol. 142, no. 3, pp. 461-468, 2004. (Pubitemid 38869859)
47. L. M. Harrison-Bernard and L. G. Navar, "Renal cortical and medullary microvascular blood flow autoregulation in rat", Kidney International, vol. 50, supplement 57, pp. S23-S29, 1996. (Pubitemid 26418467)
48. E. W. Holmes and V. A. DiScala, "Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid rat", Journal of Clinical Investigation, vol. 49, no. 6, pp. 1224-1236, 1970.
49. S. Dimitrios, D. S. Emmanouel, M. D. Lindheimer, and A. I. Katz, "Mechanism of impaired water excretion in the hypothyroid rat", Journal of Clinical Investigation, vol. 54, no. 4, pp. 926-934, 1974.
50. F. Michael, J. Kelley, H. Alpert, and C. A. Vaamonde, "Role of the distal delivery of filtrate in impaired renal dilution on the hypothyroid kidney", American Journal of Physiology, vol. 230, no. 3, pp. 699-705, 1976.
51. R. W. Schrier, "Body water homeostasis: clinical disorders of urinary dilution and concentration", Journal of the American Society of Nephrology, vol. 17, no. 7, pp. 1820-1832, 2006. (Pubitemid 44036166)
52. M. Miyamoto, Y. Yagil, T. Larson, C. Robertson, and R. L. N. Jamison, "Effects of intrarenal adenosine on renal function and medullary blood flow in the rat", American Journal of Physiology, vol. 255, no. 6, pp. F1230-F1234, 1988.
53. E. P. Silldorff, M. S. Kreisberg, and T. L. Pallone, "Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat", Journal of Clinical Investigation, vol. 98, no. 1, pp. 18-23, 1996. (Pubitemid 26243815)
54. H. J. Reineck and R. Parma, "Effect of medullary tonicity on urinary sodium excretion in the rat", Journal of Clinical Investigation, vol. 69, no. 4, pp. 971-978, 1982. (Pubitemid 12149174)
55. A. Vial and G. Burnstock, "A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide", British Journal of Pharmacology, vol. 109, no. 2, pp. 424-429, 1993. (Pubitemid 23161126)
56. P. L. Martin and A. A. Potts, "The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxiamidoadenosine and N6-cyclopentiladenosine", Journal of Pharmacology and Experimental Therapeutics, vol. 270, no. 3, pp. 893-899, 1994. (Pubitemid 24315201)
57. J. M. Li, R. A. Fenton, B. S. Cutler, and J. G. Dobson Jr., "Adenosine enhances nitric oxide production by vascular endothelial cells", American Journal of Physiology, vol. 269, no. 2, pp. C519-C523, 1995.
58. M.-H. Yen, C. C. Wu, and W.-F. Chiou, "Partially endothelium-dependent vasodilator effect of adenosine in rat aorta", Hypertension, vol. 11, no. 6, pp. 514-518, 1988.
59. R. J. Barrett and D. A. Droppleman, "Interactions of adenosine A1 receptor-mediated renal vasoconstriction with endogenous nitric oxide and Ang II", American Journal of Physiology, vol. 265, no. 5, pp. F651-F659, 1993.
60. M. Franco, E. Tapia, F. Martinez et al., "Adenosine regulates renal nitric oxide production in hypothyroid rats", Journal of the American Society of Nephrology, vol. 10, no. 8, pp. 1681-1688, 1999. (Pubitemid 29364666)
61. A. Quesada, J. Sainz, R. Wangensteen, I. Rodriguez-Gomez, F. Vargas, and A. Osuna, "Nitric oxide synthase activity in hyperthyroid and hypothyroid rats", European Journal of Endocrinology, vol. 147, no. 1, pp. 117-122, 2002. (Pubitemid 34814748)
62. J. M. Moreno, R. Wangensteen, J. Sainz et al., "Role of endothelium-derived relaxing factors in the renal response to vasoactive agents in hypothyroid rats", American Journal of Physiology, vol. 285, no. 1, pp. E182-E188, 2003. (Pubitemid 36736375)
63. F. Vargas, A. Fernandez-Rivas, J. GarciaEstan, and C. García del Rio, "Endothelium-dependent and endotheliumindependent vasodilation in hyperthyroid and hypothyroid rats", Pharmacology, vol. 51, no. 5, pp. 308-314, 1995.
64. D. J. Prentice and S. M. O. Hourani, "Activation of multiple sites by adenosine analogues in the rat isolated aorta", British Journal of Pharmacology, vol. 118, no. 6, pp. 1509-1517, 1996. (Pubitemid 26248806)
65. V. Ralevic and G. Burnstock, "Receptors for purines and pyrimidines", Pharmacological Reviews, vol. 50, no. 3, pp. 413-492, 1998. (Pubitemid 28477681)
66. K. J. Miller and B. J. Hoffman, "Adenosine A3 receptors regulate serotonin transport via nitric oxide and c GMP", Journal of Biological Chemistry, vol. 269, no. 44, pp. 27351-27356, 1994.
67. G. Banos, F. Martinez, J. I. Grimaldo, and M. Franco, "Adenosine participates in regulation of smooth muscle relaxation in aortas from rats with experimental hypothyroidism", Canadian Journal of Physiology and Pharmacology, vol. 80, no. 6, pp. 507-514, 2002. (Pubitemid 34743930)
68. J. M. Sabio, M. Rodriguez-Maresca, J. D. Luna, C. García del Rio, and F. Vargas, "Vascular reactivity to vasoconstrictors in aorta and renal vasculature of hyperthyroid and hypothyroid rats", Pharmacology, vol. 49, no. 4, pp. 257-264, 1994. (Pubitemid 24289801)
69. R. D. Gunasekera and H. Kuriyama, "The influence of thyroid states upon responses of the rat aorta to catecholamines", British Journal of Pharmacology, vol. 99, no. 3, pp. 541-547, 1990. (Pubitemid 20069160)
70. R. B. Meyer and W. Hope, "Evidence that A2 purinoceptors are involved in the endothelium-dependent relaxation of the rat thoraxic aorta", British Journal of Pharmacology, vol. 100, no. 3, pp. 576-580, 1990. (Pubitemid 20222295)
71. J. P. Headrick and R. M. Berne, "Endothelium-dependent and independent relaxations to adenosine in guinea pig aorta", American Journal of Physiology, vol. 259, no. 1, pp. H62-H67, 1990. (Pubitemid 20247716)
72. R. F. Furchgott, "Role of endothelium in responses of vascular smooth muscle", Circulation Research, vol. 53, no. 5, pp. 557-573, 1983. (Pubitemid 14248481)
73. J. Li, R. A. Fenton, H. B. Wheeler et al., "Adenosine A2a receptors increase arterial endothelial cell nitric oxide", Journal of Surgical Research, vol. 80, no. 2, pp. 357-364, 1998. (Pubitemid 29019694)
74. A. Vials and G. Burnstock, "A2 purinoceptor-mediated relaxation in the guinea pig coronary vasculature: role for nitric oxide", British Journal of Pharmacology, vol. 109, no. 2, pp. 424-429, 1993. (Pubitemid 23161126)
75. P. Vuorinen, I. Porsti, T. Metsa-Ketela, V. Manninen, H. Vapaatalo, and K. E. Laustiola, "Endothelium-dependent and-independent effects of exogenous ATP, adenosine, GTP, and guanosine on vascular tone and cyclic nucleotide accumulation of rat mesenteric artery", British Journal of Pharmacology, vol. 105, no. 2, pp. 279-284, 1992.
76. K. Yagi, I. Nishino, M. Eguchi, M. Kitagawa, Y. Miura, and T. Mizoguchi, "Involvement of ecto-ATPase as an ATP receptor in the stimulatory effect of extracellular ATP on NO release in bovine aorta endothelial cells", Biochemical and Biophysical Research Communications, vol. 203, no. 2, pp. 1237-1243, 1994. (Pubitemid 24304962)
77. J. Linden, "Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions", Trends in Pharmacological Sciences, vol. 15, no. 2, pp. 298-306, 1994.
78. C. E. Muller, "A1-adenosine receptor antagonist", Expert Opinion on Therapeutic Patents, vol. 7, no. 5, pp. 419-440, 1997.
79. H. Moritoki, T. Matsugi, H. Takase, H. Ueda, and A. Tanioka, "Evidence for the involvement of cyclic GMP in adenosineinduced, age-dependent vasodilatation", British Journal of Pharmacology, vol. 100, no. 3, pp. 569-575, 1990. (Pubitemid 20222294)
80. A. E. Hak, H. A. Pols, T. J. Visser, H. A. Drexhage, A. Hofman, and J. C. Witteman, "Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study", Annals of Internal Medicine, vol. 132, no. 4, pp. 270-278, 2000. (Pubitemid 30106257)
81. M. Aviram, M. Rosenblat, C. L. Bisgaier, R. S. Newton, S. L. Primo-Parmo, and B. N. La Du, "Paraoxonase inhibits highdensity lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase", Journal of Clinical Investigation, vol. 101, no. 8, pp. 1581-1590, 1998. (Pubitemid 28198486)
82. S. Deakin, I. Leviev, M. Gomaraschi, L. Calabresi, G. Franceschini, and R. W. James, "Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism", Journal of Biological Chemistry, vol. 277, no. 6, pp. 4301-4308, 2002. (Pubitemid 34968695)
83. A. Kontush, S. Chantepie, and M. J. Chapman, "Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress", Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 10, pp. 1881-1888, 2003. (Pubitemid 37254879)
84. C. Mineo, H. Deguchi, J. H. Griffin, and P. W. Shaul, "Endothelial and antithrombotic actions of HDL", Circulation Research, vol. 98, no. 11, pp. 1352-1364, 2006. (Pubitemid 43948059)
85. G. W. Cockerill, K. A. Rye, J. R. Gamble, M. A. Vadas, and P. J. Barter, "High-density lipoproteins inhibit cytokineinduced expression of endothelial cell adhesion molecules", Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 11, pp. 1987-1994, 1995.
86. L. Calabresi, G. Franceschini, C. R. Sirtori et al., "Inhibition of VCAM-1 expression in endothelial cells by reconstituted high density lipoproteins", Biochemical and Biophysical Research Communications, vol. 238, no. 1, pp. 61-65, 1997. (Pubitemid 27453274)
87. A. R. Cappola and P. W. Ladenson, "Hypothyroidism and atherosclerosis", Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 6, pp. 2438-2444, 2003. (Pubitemid 36724408)
88. M. P. Vanderpump, W. M. Tunbridge, J. M. French et al., "The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community", Thyroid, vol. 6, no. 3, pp. 155-160, 1996. (Pubitemid 26279405)
89. S. Razvi, J. U. Weaver, M. P. Vanderpump, and S. H. Pearce, "The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort", Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 4, pp. 1734-1740, 2010.
90. N. Rodondi, A. B. Newman, E. Vittinghoff et al., "Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death", Archives of Internal Medicine, vol. 165, no. 21, pp. 2460-2466, 2005. (Pubitemid 41720006)
91. J. J. Staub, B. U. Althaus, H. Engler et al., "Spectrum of subclinical and overt hypothyroidism: effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues", American Journal of Medicine, vol. 92, no. 6, pp. 631-642, 1992.
92. B. Staels, A. Van Tol, L. Chan, H. Will, G. Verhoeven, and J. Auwerx, "Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats", Endocrinology, vol. 127, no. 3, pp. 1144-1152, 1990. (Pubitemid 20277594)
93. A. Chait, E. L. Bierman, and J. J. Albers, "Regulatory role of triiodothyronine in the degradation of low density lipoprotein by cultured human skin fibroblasts", Journal of Clinical Endocrinology and Metabolism, vol. 48, no. 5, pp. 887-889, 1979. (Pubitemid 9172134)
94. K. W. Walton, P. J. Scott, P. W. Dykes, and J. W. Davies, "The significance of alterations in serum lipids in thyroid dysfunction. II. Alterations of the metabolism and turnover of 131-I-low-density lipoproteins in hypothyroidism and thyrotoxicosis", Clinical Science, vol. 29, no. 2, pp. 217-238, 1965.
95. G. R. Thompson, A. K. Soutar, F. A. Spengel, A. Jadhav, S. J. Gavigan, and N. B. Myant, "Defects of receptormediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyrodism in vivo", Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 4, pp. 2591-2595, 1981. (Pubitemid 11067253)
96. O. Bakker, F. Hudig, S. Meijssen, and W. M. Wiersinga, "Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene", Biochemical and Biophysical Research Communications, vol. 249, no. 2, pp. 517-521, 1998. (Pubitemid 28431785)
97. O. Perez-Mendez, J. E. Carretón-Torres, M. Franco, and M. A. Juárez-Oropeza, "HDL physicochemical characteristics as determinants of their plasma concentrations: what we have learned from thiazolidinediones", in HDL and LDL Cholesterol: Physiology and Clinical Significance, F. Columbus, Ed., Nova Science, 2009.
98. B. U. Althaus, J. J. Staub, A. Ryff-De Leche, A. Oberhansli, and H. B. Stahelin, "LDL/HDL-changes in subclinical hypothyroidism: possible risk factors for coronary heart disease", Clinical Endocrinology, vol. 28, no. 2, pp. 157-163, 1988. (Pubitemid 18055752)
99. P. Caron, C. Calazel, H. J. Parra, M. Hoff, and J. P. Louvet, "Decreased HDL cholesterol in subclinical hypothyroidism: the effect of L-thyroxine therapy", Clinical Endocrinology, vol. 33, no. 4, pp. 519-523, 1990. (Pubitemid 20290691)
100. S. Valdemarsson, P. Hedner, and P. Nilsson-Ehle, " Dyslipoproteinaemia in hypothyroidism of pituitary origin: effects of L-thyroxine substitution on lipoprotein lipase, hepatic lipase, and on plasma lipoproteins", Acta Endocrinologica, vol. 103, no. 2, pp. 192-197, 1983. (Pubitemid 13093819)
101. E. Muls, M. Rosseneu, V. Blaton, E. Lesaffre, G. Lamberigts, and P. De Moor, "Serum lipids and apoliproteins A-I, A-II and B in primary hypothyroidism before and during treatment", European Journal of Clinical Investigation, vol. 14, no. 1, pp. 12-15, 1984. (Pubitemid 14190117)
102. A. G. Scottolini, N. V. Bhagavan, T. H. Oshiro, and S. Y. Abe, "Serum high-density lipoprotein cholesterol concentrations in hypo-and hyperthyroidism", Clinical Chemistry, vol. 26, no. 5, pp. 584-587, 1980.
103. M. J. Diekman, N. Anghelescu, E. Endert, O. Bakker, and W. M. Wiersinga, "Changes in plasma low-density lipoprotein (LDL) - and high-density lipoprotein cholesterol in hypoand hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes", Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 5, pp. 1857-1862, 2000. (Pubitemid 32269289)
104. C. Meier, J. J. Staub, C. B. Roth et al., "TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study)", Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 10, pp. 4860-4866, 2001. (Pubitemid 33020533)
105. M. Franco, G. Castro, L. Romero et al., "Decreased activity of lecithin: cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: implications for reverse cholesterol transport", Molecular and Cellular Biochemistry, vol. 246, no. 1-2, pp. 51-56, 2003. (Pubitemid 36798722)
106. N. D. Ridgway and P. J. Dolphin, "Serum activity and hepatic secretion of lecithin: cholesterol acyltransferase in experimental hypothyroidism and hypercholesterolemia", Journal of Lipid Research, vol. 26, no. 11, pp. 1300-1313, 1985. (Pubitemid 16208308)
107. G. Brenta, G. Berg, P. Arias et al., "Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T (4) treatment", Thyroid, vol. 17, no. 5, pp. 453-460, 2007. (Pubitemid 46878848)
108. C. Huesca-Gomez, M. Franco, G. Luc et al., "Chronic hypothyroidism induces abnormal structure of high-density lipoproteins and impaired kinetics of apolipoprotein A-I in the rat", Metabolism, vol. 51, no. 4, pp. 443-450, 2002. (Pubitemid 34406559)
109. L. Johansson, M. Rudling, T. S. Scanlan et al., "Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice", Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 29, pp. 10297-10302, 2005. (Pubitemid 41024974)
110. N. R. Webb, L. Cai, K. S. Ziemba et al., "The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake", Journal of Lipid Research, vol. 43, no. 11, pp. 1890-1898, 2002. (Pubitemid 35315807)
111. M. Lacasana, I. Lopez-Flores, M. Rodríguez-Barranco et al., "Interaction between organophosphate pesticide exposure and PON1 activity on thyroid function", Toxicology and Applied Pharmacology, vol. 249, no. 1, pp. 16-24, 2010.
112. M. Aviram, E. Hardak, J. Vaya et al., "Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities", Circulation, vol. 101, no. 21, pp. 2510-2517, 2000. (Pubitemid 30366256)
113. E. Carreon-Torres, K. Rendon-Sauer, M. Monter Garrido et al., "Rosiglitazone modifies HDL structure and increases HDL-apo AI synthesis and catabolism", Clinica Chimica Acta, vol. 401, no. 1-2, pp. 37-41, 2009.
114. F. Azizi, F. Raiszadeh, M. Solati, A. Etemadi, M. Rahmani, and M. Arabi, "Serum paraoxonase 1 activity is decreased in thyroid dysfunction", Journal of Endocrinological Investigation, vol. 26, no. 8, pp. 703-709, 2003. (Pubitemid 37441497)
115. G. Baskol, H. Atmaca, F. Tanriverdi, M. Baskol, D. Kocer, and F. Bayram, "Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment", Experimental and Clinical Endocrinology & Diabetes, vol. 115, no. 8, pp. 522-526, 2007. (Pubitemid 350056765)
116. S. E. Nissen, E. M. Tuzcu, P. Schoenhagen et al., "Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease", The New England Journal of Medicine, vol. 352, no. 1, pp. 29-38, 2005. (Pubitemid 40075678)
117. I. Tancevski, P. Eller, J. R. Patsch, and A. Ritsch, "The resurgence of thyromimetics as lipid-modifying agents", Current Opinion in Investigational Drugs, vol. 10, no. 9, pp. 912-918, 2009.
118. F. Flamant, J. D. Baxter, D. Forrest et al., "International union of pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors", Pharmacological Reviews, vol. 58, no. 4, pp. 705-711, 2006. (Pubitemid 44833740)
119. B. Gloss, S. Trost, W. Bluhm et al., "Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta", Endocrinology, vol. 142, no. 2, pp. 544-550, 2001. (Pubitemid 32222402)