Changes in 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D are associated with maturation of regulatory T lymphocytes in patients with chronic pancreatitis: A randomized controlled trial

Pancreas

Volumn 41, Issue 8, 2012, Pages 1213-1218

  Bang, Ulrich Christian ^a   Brandt, Lea ^b   Benfield, Thomas ^a   Jensen, Jens Erik Beck ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

bone density; chronic pancreatitis; FoxP3; ionized calcium; parathyroid hormone; randomized controlled trial; regulatory T lymphocytes; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; CALCIUM; COLECALCIFEROL;

ADULT; AGED; ARTICLE; BODY MASS; BONE DENSITY; BONE METABOLISM; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CHRONIC PANCREATITIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LIPID ABSORPTION; MALABSORPTION; MALE; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGULATORY T LYMPHOCYTE; TREATMENT DURATION; ULTRAVIOLET B RADIATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

AGED; DIETARY SUPPLEMENTS; FEMALE; HUMANS; LIPID METABOLISM; LYMPHOCYTE ACTIVATION; MALABSORPTION SYNDROMES; MALE; MIDDLE AGED; PANCREATITIS, CHRONIC; T-LYMPHOCYTES, REGULATORY; ULTRAVIOLET THERAPY; VITAMIN D;

EID: 84868281385     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31824da377     Document Type: Article

References (25)

1. Jupp J, Fine D, Johnson CD. The epidemiology and socioeconomic impact of chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24:219-231.
2. Emmrich J, Weber I, Nausch M, et al. Immunohistochemical characterization of the pancreatic cellular infiltrate in normal pancreas, chronic pancreatitis and pancreatic carcinoma. Digestion. 1998;59:192-198.
3. Jaskiewicz K, Nalecz A, Rzepko R, et al. Immunocytes and activated stellate cells in pancreatic fibrogenesis. Pancreas. 2003;26: 239-242.
4. Esposito I, Friess H, Kappeler A, et al. Mast cell distribution and activation in chronic pancreatitis. Hum Pathol. 2001;32: 1174-1183.
5. Haaber AB, Rosenfalck AM, Hansen B, et al. Bone mineral metabolism, bone mineral density, and body composition in patients with chronic pancreatitis and pancreatic exocrine insufficiency. Int J Pancreatol. 2000;27:21-27.
6. Tignor AS, Wu BU, Whitlock TL, et al. High prevalence of low-trauma fracture in chronic pancreatitis. Am J Gastroenterol. 2010;105:2680-2686.
7. Gansauge F, Gansauge S, Eh M, et al. Distributional and functional alterations of immunocompetent peripheral blood lymphocytes in patients with chronic pancreatitis. Ann Surg. 2001;233:365-370.
8. Grundsten M, Liu GZ, Permert J, et al. Increased central memory T cells in patients with chronic pancreatitis. Pancreatology. 2005;5:177-182.
9. Miyoshi H, Uchida K, Taniguchi T, et al. Circulating naive and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis. Pancreas. 2008;36:133-140.
10. Gorman S, Kuritzky LA, Judge MA, et al. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J Immunol. 2007;179:6273-6283.
11. Gregori S, Giarratana N, Smiroldo S, et al. A 1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes. 2002;51:1367-1374.
12. Ardalan MR, Maljaei H, Shoja MM, et al. Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients. Transplant Proc. 2007;39:951-953.
13. Prietl B, Pilz S, Wolf M, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J. 2010;12:136-139.
14. Bang UC, Matzen P, Benfield T, et al. Oral cholecalciferol versus ultraviolet radiation b: effect on vitamin D metabolites in patients with chronic pancreatitis and fat malabsorptionVa randomized clinical trial. Pancreatology. 2011;11:376-382.
15. Brandt L, Benfield T, Mens H, et al. Low level of regulatory T cells and maintenance of balance between regulatory T cells and Th17 cells in HIV-1-infected elite controllers. J Acquir Immune Defic Syndr. 2011;57:101-108.
16. Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell. 2008;133:775-787.
17. von HC, Mei W, Menk M, et al. Ethanol changes gene expression of transcription factors and cytokine production of CD4+ T-cell subsets in PBMCs stimulated with LPS. Alcohol Clin Exp Res. 2011;35:621-631.
18. Smolders J, Peelen E, Thewissen M, et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One. 2010;5:e15235.
19. Bendix-Struve M, Bartels LE, Agnholt J, et al. Vitamin D3 treatment of Crohn's disease patients increases stimulated T cell IL-6 production and proliferation. Aliment Pharmacol Ther. 2010;32:1364-1372.
20. Boonstra A, Barrat FJ, Crain C, et al. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol. 2001;167:4974-4980.
21. Porto G, Giordano RJ, Marti LC, et al. Identification of novel immunoregulatory molecules in human thymic regulatory CD4+CD25+ T cells by phage display. PLoS One. 2011;6:e21702.
22. Di RM, Malaguarnera M, Nicoletti F, et al. Vitamin D3: a helpful immuno-modulator. Immunology. 2011;134:123-139.
23. Peelen E, Knippenberg S, Muris AH, et al. Effects of vitamin D on the peripheral adaptive immune system: a review. Autoimmun Rev. 2011;10:733-743.
24. Larusch J, Whitcomb DC. Genetics of pancreatitis. Curr Opin Gastroenterol. 2011;27:467-474.
25. Zaiss MM, Sarter K, Hess A, et al. Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum. 2010;62:2328-2338.