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Volumn 13, Issue , 2012, Pages

Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells

Author keywords

Expectorant; MUC5AC; Mucolytic; Mucus rheology; Respiratory infections

Indexed keywords

ACETYLCYSTEINE; AMBROXOL; ANTIOXIDANT; GUAIFENESIN; INTERLEUKIN 13; MUCIN 5AC; EXPECTORANT AGENT; MUC5AC PROTEIN, HUMAN;

EID: 84868262745     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-13-98     Document Type: Article
Times cited : (49)

References (25)
  • 1
    • 38449109697 scopus 로고    scopus 로고
    • Mucoactive agents for airway mucus hypersecretory diseases
    • Rogers DF. Mucoactive agents for airway mucus hypersecretory diseases. Respir Care 2007, 52:1176-1193.
    • (2007) Respir Care , vol.52 , pp. 1176-1193
    • Rogers, D.F.1
  • 2
    • 60249095813 scopus 로고    scopus 로고
    • Mucins, Mucus, and Sputum
    • 10.1378/chest.08-0412, 19201713
    • Voynow JA, Rubin BK. Mucins, Mucus, and Sputum. Chest 2009, 135:505-512. 10.1378/chest.08-0412, 19201713.
    • (2009) Chest , vol.135 , pp. 505-512
    • Voynow, J.A.1    Rubin, B.K.2
  • 3
    • 0032530370 scopus 로고    scopus 로고
    • Coordinated clearance of periciliary liquid and mucus from airway surfaces
    • 10.1172/JCI2687, 509095, 9739046
    • Matsui H, Randell SH, Peretti SW, Davis CW, Boucher RC. Coordinated clearance of periciliary liquid and mucus from airway surfaces. J Clin Invest 1998, 102:1125-1131. 10.1172/JCI2687, 509095, 9739046.
    • (1998) J Clin Invest , vol.102 , pp. 1125-1131
    • Matsui, H.1    Randell, S.H.2    Peretti, S.W.3    Davis, C.W.4    Boucher, R.C.5
  • 4
    • 78649735324 scopus 로고    scopus 로고
    • Airway mucus function and dysfunction
    • 10.1056/NEJMra0910061, 21121836
    • Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010, 363:2233-2247. 10.1056/NEJMra0910061, 21121836.
    • (2010) N Engl J Med , vol.363 , pp. 2233-2247
    • Fahy, J.V.1    Dickey, B.F.2
  • 5
    • 0029841922 scopus 로고    scopus 로고
    • Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells
    • 1217624, 8761488
    • Hovenberg HW, Davies JR, Carlstedt I. Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. Biochem J 1996, 318:319-324. 1217624, 8761488.
    • (1996) Biochem J , vol.318 , pp. 319-324
    • Hovenberg, H.W.1    Davies, J.R.2    Carlstedt, I.3
  • 6
    • 0032531083 scopus 로고    scopus 로고
    • MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage
    • 1219739, 9729478
    • Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 1998, 334(Pt 3):685-693. 1219739, 9729478.
    • (1998) Biochem J , vol.334 , Issue.PART 3 , pp. 685-693
    • Wickstrom, C.1    Davies, J.R.2    Eriksen, G.V.3    Veerman, E.C.4    Carlstedt, I.5
  • 7
    • 0034129127 scopus 로고    scopus 로고
    • Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways
    • Zuhdi AM, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 2000, 22:253-260.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 253-260
    • Zuhdi, A.M.1    Piazza, F.M.2    Selby, D.M.3    Letwin, N.4    Huang, L.5    Rose, M.C.6
  • 8
    • 81455138221 scopus 로고    scopus 로고
    • Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells
    • 10.3109/01902148.2011.623116, 22044398
    • Seagrave J, Albrecht H, Park YS, Rubin B, Solomon G, Kim KC. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res 2011, 37:606-614. 10.3109/01902148.2011.623116, 22044398.
    • (2011) Exp Lung Res , vol.37 , pp. 606-614
    • Seagrave, J.1    Albrecht, H.2    Park, Y.S.3    Rubin, B.4    Solomon, G.5    Kim, K.C.6
  • 10
    • 0043011579 scopus 로고    scopus 로고
    • IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    • Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003, 285:L730-L739.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285
    • Atherton, H.C.1    Jones, G.2    Danahay, H.3
  • 11
    • 51049121538 scopus 로고    scopus 로고
    • Ambroxol in the 21st century: pharmacological and clinical update
    • 10.1517/17425255.4.8.1119, 18680446
    • Malerba M, Ragnoli B. Ambroxol in the 21st century: pharmacological and clinical update. Expert Opin Drug Metab Toxicol 2008, 4:1119-1129. 10.1517/17425255.4.8.1119, 18680446.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 1119-1129
    • Malerba, M.1    Ragnoli, B.2
  • 14
    • 84856362211 scopus 로고    scopus 로고
    • Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function
    • 10.1007/978-1-61779-513-8_15, 22259141
    • Hill DB, Button B. Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function. Methods Mol Biol 2012, 842:245-258. 10.1007/978-1-61779-513-8_15, 22259141.
    • (2012) Methods Mol Biol , vol.842 , pp. 245-258
    • Hill, D.B.1    Button, B.2
  • 15
    • 84872415399 scopus 로고    scopus 로고
    • Uncertainty quantification and reduction in the dynamic moduli of biological fluids
    • in press
    • Vasquez P, Xu K, Mu F, Forest MG, Hill DB. Uncertainty quantification and reduction in the dynamic moduli of biological fluids. Biorheology 2012, in press.
    • (2012) Biorheology
    • Vasquez, P.1    Xu, K.2    Mu, F.3    Forest, M.G.4    Hill, D.B.5
  • 16
    • 0036634199 scopus 로고    scopus 로고
    • The pharmacologic approach to airway clearance: mucoactive agents
    • Rubin BK. The pharmacologic approach to airway clearance: mucoactive agents. Respir Care 2002, 47:818-822.
    • (2002) Respir Care , vol.47 , pp. 818-822
    • Rubin, B.K.1
  • 17
    • 4043052923 scopus 로고    scopus 로고
    • Ambroxol reduces LPS toxicity mediated by induction of alkaline phosphatases in rat lung
    • 10.1016/j.clinbiochem.2004.02.004, 15302612
    • Koyama I, Matsunaga T, Harada T, Kikuno A, Hokari S, Komoda T. Ambroxol reduces LPS toxicity mediated by induction of alkaline phosphatases in rat lung. Clin Biochem 2004, 37:688-693. 10.1016/j.clinbiochem.2004.02.004, 15302612.
    • (2004) Clin Biochem , vol.37 , pp. 688-693
    • Koyama, I.1    Matsunaga, T.2    Harada, T.3    Kikuno, A.4    Hokari, S.5    Komoda, T.6
  • 18
    • 33645127038 scopus 로고    scopus 로고
    • Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia
    • 10.1016/j.bbrc.2006.03.009, 16546120
    • Hasegawa I, Niisato N, Iwasaki Y, Marunaka Y. Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia. Biochem Biophys Res Commun 2006, 343:475-482. 10.1016/j.bbrc.2006.03.009, 16546120.
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 475-482
    • Hasegawa, I.1    Niisato, N.2    Iwasaki, Y.3    Marunaka, Y.4
  • 19
    • 67349254121 scopus 로고    scopus 로고
    • Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model
    • 10.1016/j.pupt.2008.12.020, 19166957
    • Kagan L, Lavy E, Hoffman A. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther 2009, 22:260-265. 10.1016/j.pupt.2008.12.020, 19166957.
    • (2009) Pulm Pharmacol Ther , vol.22 , pp. 260-265
    • Kagan, L.1    Lavy, E.2    Hoffman, A.3
  • 20
    • 0015757462 scopus 로고
    • A preliminary study of the effect of guaiphenesin on mucociliary clearance from the human lung
    • 10.1136/thx.28.6.742, 470109, 4595814
    • Thomson ML, Pavia D, McNicol MW. A preliminary study of the effect of guaiphenesin on mucociliary clearance from the human lung. Thorax 1973, 28:742-747. 10.1136/thx.28.6.742, 470109, 4595814.
    • (1973) Thorax , vol.28 , pp. 742-747
    • Thomson, M.L.1    Pavia, D.2    McNicol, M.W.3
  • 21
    • 0008235610 scopus 로고
    • Objective sputum changes associated with glyceryl guiacolate in chronic bronchial diseases
    • Chodosh S, Medici TC, Enslein K. Objective sputum changes associated with glyceryl guiacolate in chronic bronchial diseases. Bull Physiopathol Respir 1973, 9:452-456.
    • (1973) Bull Physiopathol Respir , vol.9 , pp. 452-456
    • Chodosh, S.1    Medici, T.C.2    Enslein, K.3
  • 22
    • 85048094964 scopus 로고    scopus 로고
    • Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians
    • 10.1378/chest.114.2_Supplement.133S, 9725800
    • Irwin RS, Boulet LP, Cloutier MM, Fuller R, Gold PM, Hoffstein V, Ing AJ, McCool FD, O'Byrne P, Poe RH, et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest 1998, 114:133S-181S. 10.1378/chest.114.2_Supplement.133S, 9725800.
    • (1998) Chest , vol.114
    • Irwin, R.S.1    Boulet, L.P.2    Cloutier, M.M.3    Fuller, R.4    Gold, P.M.5    Hoffstein, V.6    Ing, A.J.7    McCool, F.D.8    O'Byrne, P.9    Poe, R.H.10
  • 23
    • 0345732494 scopus 로고    scopus 로고
    • Effect of guaifenesin on cough reflex sensitivity
    • 10.1378/chest.124.6.2178, 14665498
    • Dicpinigaitis PV, Gayle YE. Effect of guaifenesin on cough reflex sensitivity. Chest 2003, 124:2178-2181. 10.1378/chest.124.6.2178, 14665498.
    • (2003) Chest , vol.124 , pp. 2178-2181
    • Dicpinigaitis, P.V.1    Gayle, Y.E.2
  • 24
    • 0028912457 scopus 로고
    • Effects of guaifenesin on nasal mucociliary clearance and ciliary beat frequency in healthy volunteers
    • 10.1378/chest.107.3.747, 7874947
    • Sisson JH, Yonkers AJ, Waldman RH. Effects of guaifenesin on nasal mucociliary clearance and ciliary beat frequency in healthy volunteers. Chest 1995, 107:747-751. 10.1378/chest.107.3.747, 7874947.
    • (1995) Chest , vol.107 , pp. 747-751
    • Sisson, J.H.1    Yonkers, A.J.2    Waldman, R.H.3


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