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Volumn 37, Issue 10, 2011, Pages 606-614

Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells

Author keywords

In vitro; MUC5AC; Mucus; Rheology; Viscoelasticity

Indexed keywords

GUAIFENESIN; MUCIN; MUCIN 5AC;

EID: 81455138221     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2011.623116     Document Type: Article
Times cited : (22)

References (35)
  • 1
    • 81455147042 scopus 로고    scopus 로고
    • Does mucus hypersecretion matter in airway disease
    • Melton L: Does mucus hypersecretion matter in airway disease? Novartis Found Symp. 2002;10:2-4.
    • (2002) Novartis. Found Symp. , vol.10 , pp. 2-4
    • Melton, L.1
  • 2
    • 70449519959 scopus 로고    scopus 로고
    • Modulation of sensory nerve function and the cough reflex: Understanding disease pathogenesis
    • Nasra J, Belvisi MG:Modulation of sensory nerve function and the cough reflex: understanding disease pathogenesis. Pharmacol Ther. 2009;124:354-375.
    • (2009) Pharmacol. Ther. , vol.124 , pp. 354-375
    • Nasra, J.1    Belvisi, M.G.2
  • 3
    • 0008061791 scopus 로고    scopus 로고
    • Experimental and clinical methodologies in efficacy of expectorants using the example of guaifenesin
    • Loew D Rietbrock N eds Darmstadt Germany: Steinkopf Verlag;
    • Ayres PJW: Experimental and clinical methodologies in efficacy of expectorants using the example of guaifenesin. In: Loew D, Rietbrock N, eds. Phytopharmaka III. Darmstadt, Germany: Steinkopf Verlag; 1997:151-160.
    • (1997) Phytopharmaka III , pp. 151-160
    • Ayres, P.J.W.1
  • 4
    • 0015757462 scopus 로고
    • A preliminary study of the effect of guaiphenesin onmucociliary clearance from the human lung
    • Thomson ML, Pavia D, McNicol MW: A preliminary study of the effect of guaiphenesin onmucociliary clearance from the human lung. Thorax 1973;28:742-747.
    • (1973) Thorax , vol.28 , pp. 742-747
    • Thomson, M.L.1    Pavia, D.2    McNicol, M.W.3
  • 5
    • 38449109697 scopus 로고    scopus 로고
    • Mucoactive agents for airwaymucus hypersecretory diseases
    • RogersDF: Mucoactive agents for airwaymucus hypersecretory diseases. Respir Care. 2007;52:1176-1193.
    • (2007) Respir. Care , vol.52 , pp. 1176-1193
    • Rogers, D.F.1
  • 6
    • 0343657552 scopus 로고
    • Food drug administration: Cold cough allergy bronchodilator and antiasthmatic drug products for over-thecounter human use final rule
    • Food and Drug Administration: Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-thecounter human use, final rule. Fed Regist. 1989;54:8494.
    • (1989) Fed. Regist. , vol.54 , pp. 8494
  • 7
    • 0008235610 scopus 로고
    • Objective sputum changes associated with glyceryl guiacolate in chronic bronchial diseases
    • Chodosh S, Medici TC, Enslein K: Objective sputum changes associated with glyceryl guiacolate in chronic bronchial diseases. Bull Physiopathol Respir. 1973;9:452-456.
    • (1973) Bull. Physiopathol. Respir. , vol.9 , pp. 452-456
    • Chodosh, S.1    Medici, T.C.2    Enslein, K.3
  • 8
    • 85048094964 scopus 로고    scopus 로고
    • Managing cough as a defense mechanism and as a symptom a consensus panel report of the American college of chest physicians
    • Irwin RS, Boulet LP, Cloutier MM, Fuller R, Gold PM, Hoffstein V, et al.: Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114:133S-181S.
    • (1998) Chest , vol.114
    • Irwin, R.S.1    Boulet, L.P.2    Cloutier, M.M.3    Fuller, R.4    Gold, P.M.5    Hoffstein, V.6
  • 10
    • 67349254121 scopus 로고    scopus 로고
    • Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model
    • Kagan L, Lavy E, Hoffman A: Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther. 2009;22:260-265.
    • (2009) Pulm. Pharmacol. Ther. , vol.22 , pp. 260-265
    • Kagan, L.1    Lavy, E.2    Hoffman, A.3
  • 11
    • 0015187711 scopus 로고
    • Animal experiment on the absorption, distribution and elimination of C14- and H3-labelled guaiacolglyceryl- ether
    • Rossberg F, Luther D: Animal experiment on the absorption, distribution and elimination of C14- and H3-labelled guaiacolglyceryl- ether. Acta Biol Med Ger. 1971;26:331-339.
    • (1971) Acta. Biol. Med. Ger. , vol.26 , pp. 331-339
    • Rossberg, F.1    Luther, D.2
  • 12
    • 0015443564 scopus 로고
    • 2-Methoxyphenoxy lactic acid the major urinary metabolite of glyceryl guaiacolate in man
    • Vandenheuvel WJ, Smith JL, Silber RH: -(2- Methoxyphenoxy)lactic acid, the major urinary metabolite of glyceryl guaiacolate in man. J Pharm Sci. 1972;61:1997-1998.
    • (1972) J. Pharm. Sci. , vol.61 , pp. 1997-1998
    • Vandenheuvel, W.J.1    Smith, J.L.2    Silber, R.H.3
  • 13
    • 0018910890 scopus 로고
    • UNTERSUCHUNGEN ZUM METABOLISMUS VON GUAIFENESIN MIT HILFE DER GASCHROMATOGRAPHIE-MASSENSPEKTROMETRIE
    • Kauert G, von ML, Drasch G: Investigations of guaifenesine metabolism with gas chromatography-mass spectrometry. Arch Toxicol. 1980;45:149-159. (Pubitemid 10066727)
    • (1980) Archives of Toxicology , vol.45 , Issue.2 , pp. 149-159
    • Kauert, G.1    Von Meyer, L.2    Drasch, G.3
  • 14
    • 0027365649 scopus 로고
    • Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine
    • DOI 10.1016/0731-7085(93)80072-9
    • Aluri JB, Stavchansky S: Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine. J Pharm Biomed Anal. 1993;11:803-808. (Pubitemid 23294670)
    • (1993) Journal of Pharmaceutical and Biomedical Analysis , vol.11 , Issue.9 , pp. 803-808
    • Aluri, J.B.1    Stavchansky, S.2
  • 16
    • 0026475585 scopus 로고
    • The role of guaifenesin in the treatment of sinonasal disease in patients infected with the human immunodeficiency virus HIV
    • Wawrose SF, Tami TA, Amoils CP: The role of guaifenesin in the treatment of sinonasal disease in patients infected with the human immunodeficiency virus (HIV). Laryngoscope. 1992;102:1225-1228.
    • (1992) Laryngoscope. , vol.102 , pp. 1225-1228
    • Wawrose, S.F.1    Tami, T.A.2    Amoils, C.P.3
  • 17
    • 11844301307 scopus 로고    scopus 로고
    • Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy
    • DOI 10.1097/01.mlg.0000150678.83602.d4
    • Rosen EJ, Calhoun KH: Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy. Laryngoscope. 2005;115:27-30. (Pubitemid 40096521)
    • (2005) Laryngoscope , vol.115 , Issue.1 , pp. 27-30
    • Rosen, E.J.1    Calhoun, K.H.2
  • 18
    • 0345732494 scopus 로고    scopus 로고
    • Effect of Guaifenesin on Cough Reflex Sensitivity
    • DOI 10.1378/chest.124.6.2178
    • Dicpinigaitis PV, Gayle YE: Effect of guaifenesin on cough reflex sensitivity. Chest. 2003;124:2178-2181. (Pubitemid 38010587)
    • (2003) Chest , vol.124 , Issue.6 , pp. 2178-2181
    • Dicpinigaitis, P.V.1    Gayle, Y.E.2
  • 19
    • 0028912457 scopus 로고
    • Effects of guaifenesin on nasalmucociliary clearance and ciliary beat frequency in healthy volunteers
    • Sisson JH, Yonkers AJ, Waldman RH: Effects of guaifenesin on nasalmucociliary clearance and ciliary beat frequency in healthy volunteers. Chest. 1995;107:747-751.
    • (1995) Chest , vol.107 , pp. 747-751
    • Sisson, J.H.1    Yonkers, A.J.2    Waldman, R.H.3
  • 20
    • 0032793770 scopus 로고    scopus 로고
    • An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterol
    • DOI 10.1378/chest.116.1.195
    • Rubin BK: An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterol. Chest. 1999;116:195-200. (Pubitemid 29340282)
    • (1999) Chest , vol.116 , Issue.1 , pp. 195-200
    • Rubin, B.K.1
  • 22
    • 11144279298 scopus 로고    scopus 로고
    • Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells
    • Lu W, Lillehoj EP, Kim KC: Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells. Am J Physiol Lung Cell Mol Physiol. 2005;288:52-58.
    • (2005) Am. J. Physiol. Lung. Cell Mol. Physiol. , vol.288 , pp. 52-58
    • Lu, W.1    Lillehoj, E.P.2    Kim, K.C.3
  • 23
    • 68149166400 scopus 로고    scopus 로고
    • IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells
    • Bautista MV, Chen Y, Ivanova VS, Rahimi MK, Watson AM, Rose MC: IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells. J Immunol. 2009;183:2159-2166.
    • (2009) J. Immunol. , vol.183 , pp. 2159-2166
    • Bautista, M.V.1    Chen, Y.2    Ivanova, V.S.3    Rahimi, M.K.4    Watson, A.M.5    Rose, M.C.6
  • 24
    • 77950897478 scopus 로고    scopus 로고
    • Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa
    • Chang JH, Song KJ, Kim HJ, Kim JH, Kim NH, Kim KS: Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa. AmJ Rhinol Allergy. 2010;24:e59-e62.
    • (2010) Am. J. Rhinol. Allergy. , vol.24
    • Chang, J.H.1    Song, K.J.2    Kim, H.J.3    Kim, J.H.4    Kim, N.H.5    Kim, K.S.6
  • 25
    • 0034755574 scopus 로고    scopus 로고
    • Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates
    • Chen Y, Zhao YH, Wu R: Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. Am J Respir Cell Mol Biol. 2001;25:409-417. (Pubitemid 33037672)
    • (2001) American Journal of Respiratory Cell and Molecular Biology , vol.25 , Issue.4 , pp. 409-417
    • Chen, Y.1    Yu Hua Zhao2    Wu, R.3
  • 27
    • 77954239363 scopus 로고    scopus 로고
    • Regulation of airway MUC5AC expression by IL- 1beta and IL-17A; The NF-kappaB paradigm
    • Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R: Regulation of airway MUC5AC expression by IL- 1{beta} and IL-17A; the NF-{kappa}B paradigm. J Immunol. 2009;118.:6236-6243.
    • (2009) J. Immunol. , vol.118 , pp. 6236-6243
    • Fujisawa, T.1    Velichko, S.2    Thai, P.3    Hung, L.Y.4    Huang, F.5    Wu, R.6
  • 28
    • 46749153544 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits interleukin-1betainducedMUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells
    • Kim HJ, Park SH, Park SY, Moon UY, Lee BD, Yoon SH, et al.: Epigallocatechin-3-gallate inhibits interleukin-1betainducedMUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells. J Nutr Biochem. 2008;19:536-544.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 536-544
    • Kim, H.J.1    Park, S.H.2    Park, S.Y.3    Moon, U.Y.4    Lee, B.D.5    Yoon, S.H.6
  • 29
    • 79953166053 scopus 로고    scopus 로고
    • CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial NCI-H292 cells
    • Kim S, Lewis C, Nadel JA: CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011;186:3392-3400.
    • (2011) J. Immunol. , vol.186 , pp. 3392-3400
    • Kim, S.1    Lewis, C.2    Nadel, J.A.3
  • 30
    • 77953525956 scopus 로고    scopus 로고
    • Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro
    • Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y: Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro. J Pharmacol Sci. 2010;113:76-83.
    • (2010) J. Pharmacol. Sci. , vol.113 , pp. 76-83
    • Nishimoto, Y.1    Hisatsune, A.2    Katsuki, H.3    Miyata, T.4    Yokomizo, K.5    Isohama, Y.6
  • 31
    • 34047144270 scopus 로고    scopus 로고
    • Taxonomy of mucoactive medications
    • Rubin BK van der Schans CP eds New York: Marcel Dekker;
    • Rubin BK: Taxonomy of mucoactive medications. In: Rubin BK, van der Schans CP, eds. Therapy for Mucus Clearance Disorders. New York: Marcel Dekker; 2004:129-146.
    • (2004) Therapy for Mucus Clearance Disorders , pp. 129-146
    • Rubin, B.K.1
  • 32
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • Rose MC, Voynow JA: Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006;86:245-278.
    • (2006) Physiol. Rev. , vol.86 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 33
    • 0029841922 scopus 로고    scopus 로고
    • Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells
    • Hovenberg HW, Davies JR, Carlstedt I: Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. Biochem J. 1996;318:319-324. (Pubitemid 26283662)
    • (1996) Biochemical Journal , vol.318 , Issue.1 , pp. 319-324
    • Hovenberg, H.W.1    Davies, J.R.2    Carlstedt, I.3
  • 34
    • 0032531083 scopus 로고    scopus 로고
    • MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-terminal cleavage
    • Wickstrom C,Davies JR, EriksenGV, Veerman EC, Carlstedt I: MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J. 1998;334(Pt 3):685-693. (Pubitemid 28457218)
    • (1998) Biochemical Journal , vol.334 , Issue.3 , pp. 685-693
    • Wickstrom, C.1    Davies, J.R.2    Eriksen, G.V.3    Veerman, E.C.I.4    Carlstedt, I.5


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