Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies

International Journal of Pharmaceutics

Volumn 377, Issue 1-2, 2009, Pages 25-34

  Badens, Elisabeth ^b   Majerik, Viktor ^a   Horváth, Géza ^a   Szokonya, László ^a   Bosc, Nathalie ^c   Teillaud, Eric ^c   Charbit, Gérard ^b  

^a UNIVERSITY OF PANNONIA   (Hungary)

^b AIX MARSEILLE UNIVERSITÉ   (France)

^c Intl Pharmacological Support   (France)

Author keywords

Bioavailability; Oxeglitazar; Poorly water soluble drug; Solid dispersion; Spray freezing; Supercritical antisolvent

Indexed keywords

ALCOHOL; ANTIDIABETIC AGENT; CARBON DIOXIDE; CHLOROFORM; DICHLOROMETHANE; EXCIPIENT; LIQUID NITROGEN; MACROGOL; OXEGLITAZAR; POLOXAMER; POVIDONE; SOLVENT; TERT BUTYL ALCOHOL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG PURITY; DRUG RESEARCH; DRUG SOLUBILITY; DRUG STRUCTURE; FREEZE DRYING; GAS CHROMATOGRAPHY; MICROSCOPY; MORPHOLOGY; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STRUCTURE ANALYSIS; SUPERCRITICAL FLUID; ULTRAVIOLET SPECTROSCOPY; X RAY DIFFRACTION;

BENZOXEPINS; CHEMISTRY, PHARMACEUTICAL; FREEZE DRYING; FREEZING; PARTICLE SIZE; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 67649810756     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.04.047     Document Type: Article

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