Gallotannin regulates apoptosis and COX-2 expression via Akt and p38kinase pathway in human lung cancer cell line, A549

Animal Cells and Systems

Volumn 16, Issue 5, 2012, Pages 366-375

  Yu, Seon Mi ^a   Gweon, Eun Jeong ^a   Chung, Ki Wha ^a   Kim, Kwang Hoon ^a   Cho, Hong Sik ^b   Kim, Song Ja ^a  

^a Kongju National University   (South Korea)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

A549; Akt; apoptosis; cyclooxygenase 2 (COX 2); gallotannin (GT); p38kinase

Indexed keywords

EID: 84868216751     PISSN: 19768354     EISSN: 21512485     Source Type: Journal    
DOI: 10.1080/19768354.2012.696553     Document Type: Article

References (46)

1. Al-Ayyoubi, S and Gali-Muhtasib, H. 2007. Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. Mol Carcinog., 46: 176-186.
2. Benoit, V, de Moraes, E, Dar, NA, Taranchon, E, Bours, V, Hautefeuille, A, Taniere, P, Chariot, A, Scoazec, JYde Moura Gallo, CV. 2006. Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. Oncogene, 25: 5708-5718.
3. Boo HJ, Hyun JH, Kim SC, Kang JI, Kim MK, Kim SY, Cho H, Yoo ES, Kang HK. 2011. Fucoidan from undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells. Phytother Res. Mar 31 [Epub ahead of print].
4. Brabender, J, Park, J, Metzger, R, Schneider, PM, Lord, RV, Holscher, AH, Danenberg, KD and Danenberg, PV. 2002. Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. Ann Surg., 235: 440-443.
5. Breuer, RH, Postmus, PE and Smit, EF. 2005. Molecular pathology of non-small-cell lung cancer. Respiration, 72: 313-330.
6. Brown, JR and DuBois, RN. 2004. Cyclooxygenase as a target in lung cancer. Clin Cancer Res., 10: 4266s-4269s.
7. Cao, W, Xie, YH, Li, XQ, Zhang, XK, Chen, YT, Kang, R, Chen, X, Miao, S and Wang, SW. 2011. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol., 106: 1207-1220.
8. Castelao, JE, Bart, RD III, DiPerna, CA, Sievers, EM and Bremner, RM. 2003. Lung cancer and cyclooxygenase-2. Ann Thorac Surg., 76: 1327-1335.
9. Chen, CH, Lin, WC, Kuo, CN and Lu, FJ. 2011. Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells. Food Chem Toxicol., 49: 494-501.
10. de Moraes, E, Dar, NA, de Moura Gallo, CV and Hainaut, P. 2007. Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: balancing life and death during inflammatory stress and carcinogenesis. Int J Cancer, 121: 929-937.
11. Dickinson, SE, Olson, ER, Zhang, J, Cooper, SJ, Melton, T, Criswell, PJ, Casanova, A, Dong, Z, Hu, CSaboda, K. 2011. p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis. Mol Carcinog., 50: 469-478.
12. Duarte, ML, de Moraes, E, Pontes, E, Schluckebier, L, de Moraes, JL, Hainaut, P and Ferreira, CG. 2009. Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. Cancer Lett., 279: 57-64.
13. Fiuza, SM, Gomes, C, Teixeira, LJ, Girao da Cruz, MT, Cordeiro, MN, Milhazes, N, Borges, F and Marques, MP. 2004. Phenolic acid derivatives with potential anticancer properties-a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids. Bioorg Med Chem., 12: 3581-3589.
14. Grundhofer, P, Niemetz, R, Schilling, G and Gross, GG. 2001. Biosynthesis and subcellular distribution of hydrolyzable tannins. Phytochemistry, 57: 915-927.
15. Hosomi, Y, Yokose, T, Hirose, Y, Nakajima, R, Nagai, K, Nishiwaki, Y and Ochiai, A. 2000. Increased cyclooxygenase 2 COX-2. Expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. Lung Cancer, 30: 73-81.
16. Hsu, CL, Lo, WH and Yen, GC. 2007. Gallic acid induces apoptosis in 3T3-L1 pre-adipocytes via a fas- and mitochondrial-mediated pathway. J Agric Food Chem., 55: 7359-7365.
17. Huh, YH, Kim, SH, Kim, SJ and Chun, JS. 2003. Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. J Biol Chem., 278: 9691-9697.
18. Inoue, M, Sakaguchi, N, Isuzugawa, K, Tani, H and Ogihara, Y. 2000. Role of reactive oxygen species in gallic acid-induced apoptosis. Biol Pharm Bull., 23: 1153-1157.
19. Jang, BC. 2009. Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, src, and glutathione depletion. Toxicol In Vitro, 23: 120-126.
20. Janicke, RU, Sprengart, ML, Wati, MR and Porter, AG. 1998. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem., 273: 9357-9360.
21. Jemal, A, Siegel, R, Xu, J and Ward, E. 2010. Cancer statistics, 2010. CA Cancer J Clin., 60: 277-300.
22. Kaur, M, Velmurugan, B, Rajamanickam, S, Agarwal, R and Agarwal, C. 2009. Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharm Res., 26: 2133-2140.
23. Kim, SH, Jun, CD, Suk, K, Choi, BJ, Lim, H, Park, S, Lee, SH, Shin, HY, Kim, DK and Shin, TY. 2006. Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci., 91: 123-131.
24. Kirschenbaum, A, Liu, X, Yao, S and Levine, AC. 2001. The role of cyclooxygenase-2 in prostate cancer. Urology, 58: 127-131.
25. Kratz, JM, Andrighetti-Frohner, CR, Leal, PC, Nunes, RJ, Yunes, RA, Trybala, E, Bergstrom, T, Barardi, CR and Simoes, CM. 2008. Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate. Biol Pharm Bull., 31: 903-907.
26. Levine, AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331.
27. Lin, HY, Sun, M, Tang, HY, Simone, TM, Wu, YH, Grandis, JR, Cao, HJ, Davis, PJ and Davis, FB. 2008. Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. J Cell Biochem., 104: 2131-2142.
28. Manna, SK, Kuo, MT and Aggarwal, BB. 1999. Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1. Oncogene, 18: 4371-4382.
29. Maurya, DK, Nandakumar, N and Devasagayam, TP. 2011. Anticancer property of gallic acid in A549, a human lung adenocarcinoma cell line, and possible mechanisms. J Clin Biochem Nutr., 48: 85-90.
30. Meier, P and Vousden, KH. 2007. Lucifer's labyrinth-ten years of path finding in cell death. Mol Cell., 28: 746-754.
31. Niemetz, R and Gross, GG. 2005. Enzymology of gallotannin and ellagitannin biosynthesis. Phytochemistry, 66: 2001-2011.
32. Petty, RD, Nicolson, MC, Kerr, KM, Collie-Duguid, E and Murray, GI. 2004. Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application. Clin Cancer Res., 10: 3237-3248.
33. Riedl, K, Krysan, K, Pold, M, Dalwadi, H, Heuze-Vourc'h, N, Dohadwala, M, Liu, M, Cui, X, Figlin, RMao, JT. 2004. Multifaceted roles of cyclooxygenase-2 in lung cancer. Drug Resist Updat., 7: 169-184.
34. Sengupta, S and Harris, CC. 2005. p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Biol., 6: 44-55.
35. Soslow, RA, Dannenberg, AJ, Rush, D, Woerner, BM, Khan, KN, Masferrer, J and Koki, AT. 2000. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer, 89: 2637-2645.
36. Subbaramaiah, K, Marmo, TP, Dixon, DA and Dannenberg, AJ. 2003. Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR. J Biol Chem., 278: 37637-37647.
37. Thornberry, NA and Lazebnik, Y. 1998. Caspases: enemies within. Science, 281: 1312-1316.
38. Wang, L, Liu, XK and Shi, XQ. 2010. Involvement of akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis. Chin J Cancer, 29: 391-395.
39. Wang, SY, Yu, QJ, Bao, JK and Liu, B. 2011. Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways. Biochem Biophys Res Commun., 406: 497-500.
40. Williams, GT. 1991. Programmed cell death: apoptosis and oncogenesis. Cell, 65: 1097-1098.
41. Williams, JL, Nath, N, Chen, J, Hundley, TR, Gao, J, Kopelovich, L, Kashfi, K and Rigas, B. 2003. Growth inhibition of human colon cancer cells by nitric oxide NO-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: Implications for chemoprevention. Cancer Res., 63: 7613-7618.
42. Wyllie, AH, Kerr, JF and Currie, AR. 1980. Cell death: the significance of apoptosis. Int Rev Cytol., 68: 251-306.
43. Yoon, JB, Kim, SJ, Hwang, SG, Chang, S, Kang, SS and Chun, JS. 2003. Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity. J Biol Chem., 278: 15319-15325.
44. You, BR, Moon, HJ, Han, YH and Park, WH. 2010. Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis. Food Chem Toxicol., 48: 1334-1340.
45. Yu, SM and Kim, SJ. 2011. Gallotannin (GT) regulates apoptosis and inflammation via PI3-kinase/p38 MAP kinase in MDA-MB-231 human breast cancer cells. Cancer Prev Res., 16: 200-209.
46. Zahner, G, Wolf, G, Ayoub, M, Reinking, R, Panzer, U, Shankland, SJ and Stahl, RA. 2002. Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1. J Biol Chem., 277: 9763-9771.