Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice

Pharmaceutical Research

Volumn 26, Issue 9, 2009, Pages 2133-2140

  Kaur, Manjinder ^a   Velmurugan, Balaiya ^a   Rajamanickam, Subapriya ^a   Agarwal, Rajesh ^a,b   Agarwal, Chapla ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Apoptosis; Cell proliferation; Chemoprevention; Gallic acid; Prostate cancer

Indexed keywords

ANDROGEN; CD31 ANTIGEN; DRINKING WATER; GALLIC ACID; GRAPE SEED EXTRACT; LIPOCORTIN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DENSITY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CARCINOMA; TUMOR CELL; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GALLIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, NUDE; PROSTATIC NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 68149099008     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9926-y     Document Type: Article

References (30)

1. DL Bemis JL Capodice JE Costello GC Vorys AE Katz R Buttyan 2006 The use of herbal and over-the-counter dietary supplements for the prevention of prostate cancer Curr Urol Rep 7 166 174 (Pubitemid 44624000)
2. D Bagchi M Bagchi SJ Stohs DK Das SD Ray CA Kuszynski SS Joshi HG Pruess 2000 Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention Toxicology 148 187 197
3. X Ye RL Krohn W Liu SS Joshi CA Kuszynski TR McGinn M Bagchi HG Preuss SJ Stohs D Bagchi 1999 The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells Mol Cell Biochem 196 99 108
4. M Kaur RP Singh M Gu R Agarwal C Agarwal 2006 Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells Clin Cancer Res 12 6194 6202
5. I Durak R Cetin E Devrim IB Erguder 2005 Effects of black grape extract on activities of DNA turn-over enzymes in cancerous and non cancerous human colon tissues Life Sci 76 2995 3000
6. R Veluri RP Singh Z Liu JA Thompson R Agarwal C Agarwal 2006 Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells Carcinogenesis 27 1445 1453
7. R Niemetz GG Gross 2005 Enzymology of gallotannin and ellagitannin biosynthesis Phytochemistry 66 2001 2011
8. YF Chu J Sun X Wu RH Liu 2002 Antioxidant and antiproliferative activities of common vegetables J Agric Food Chem 50 6910 6916 (Pubitemid 35253192)
9. K Wolfe X Wu RH Liu 2003 Antioxidant activity of apple peels J Agric Food Chem 51 609 614
10. MS Kang JS Oh IC Kang SJ Hong CH Choi 2008 Inhibitory effect of methyl gallate and gallic acid on oral bacteria J Microbiol 46 744 750
11. JM Kratz CR Andrighetti-Frohner PC Leal RJ Nunes RA Yunes E Trybala T Bergstorm CR Barardi CM Simoes 2008 Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate Biol Pharm Bull 31 903 907
12. SH Kim CD Jun K Suk BJ Choi H Lim S Park SH Lee HY Shin DK Kim TY Shin 2006 Gallic acid inhibits histamine release and pro-inflammatory cytokine productionin mast cells Toxicol Sci 91 123 131
13. YJ Kim 2007 Antimelanogenic and antioxidant properties of gallic acid Biol Pharm Bull 30 1052 1055
14. CL Hsu GC Yen 2007 Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats Br J Nutr 3 1 9
15. PS Makena KT Chung 2007 Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity Food Chem Toxicol 45 1899 1909
16. M Inoue N Sakaguchi K Isuzugawa H Tani Y Ogihara 2000 Role of reactive oxygen species in gallic acid-induced apoptosis Biol Pharm Bull 23 1153 1157
17. A Faried D Kurnia LS Faried N Usman T Miyazaki H Kato H Kuwano 2007 Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines Int J Oncol 30 605 613
18. C Agarwal A Tyagi R Agarwal 2006 Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells Mol Cancer Ther 5 3294 3302
19. K Raina S Rajamanickam G Deep M Singh R Agarwal C Agarwal 2008 Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice Mol Cancer Ther 7 1258 1267
20. MA Rubin 2008 Targeted therapy of cancer: new roles for pathologists-prostate cancer Mod Pathol 21 S44 S55
21. H Huang DJ Tindall 2002 The role of the androgen receptor in prostate cancer Crit Rev Eukaryot Gene Expr 12 193 207
22. M Gu S Dhanalakshmi S Mohan RP Singh R Agarwal 2005 Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin Carcinogenesis 26 1404 1413
23. M Pavia C Pileggi CG Nobile IF Angelillo 2006 Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies Am J Clin Nutr 83 1126 1134
24. SC Larsson L Bergkvist A Wolk 2006 Fruit and vegetable consumption and incidence of gastric cancer: a prospective study Cancer Epidemiol Biomarkers Prev 15 1998 2001 (Pubitemid 44664281)
25. H Nishino Y Satomi H Tokuda M Masuda 2007 Cancer control by phytochemicals Curr Pharm Des 13 3394 3399
26. C Agarwal RP Singh R Agarwal 2002 Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release Carcinogenesis 23 1869 1876
27. RP Singh AK Tyagi S Dhanalakshmi R Agarwal C Agarwal 2004 Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3 Int J Cancer 108 733 740
28. K Raina RP Singh R Agarwal C Agarwal 2007 Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice Cancer Res 67 5976 5982
29. M Kaur R Agarwal C Agarwal 2006 Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation Mol Cancer Ther 5 1265 1274
30. Z Liu J Schwimer D Liu J Lewis FL Greenway DA York EA Woltering 2006 Gallic acid is partially responsible for the antiangiogenic activities of Rubus leaf extract Phytother Res 20 806 813