Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages

Obesity Research and Clinical Practice

Volumn 6, Issue 4, 2012, Pages

  Kumamoto, Sonoko ^a   Kushiyama, Akifumi ^b   Nakatsu, Yusuke ^a   Sakoda, Hideyuki ^c   Fujishiro, Midori ^c   Iwashita, Misaki ^a   Ohno, Haruya ^a   Zhang, Jun ^a   Guo, Ying ^a   Aburatani, Hiroyuki ^c   Kamata, Hideaki ^a   Nishimura, Fusanori ^a   Asano, Tomoichiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b INSTITUTE FOR ADULT DISEASES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adipocytes; Insulin resistance; Macrophages; Type 2 diabetes

Indexed keywords

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; VALSARTAN;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOVASCULAR SYSTEM; CELL INFILTRATION; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; FIBROSIS; GENE EXPRESSION PROFILING; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 84868210176     PISSN: 1871403X     EISSN: 18780318     Source Type: Journal    
DOI: 10.1016/j.orcp.2012.05.005     Document Type: Article

References (33)

1. A. Lessard, N. Almeras, H. Turcotte, A. Tremblay, J.P. Despres, and L.P. Boulet Adiposity and pulmonary function: relationship with body fat distribution and systemic inflammation Clin Invest Med 34 2 2011 E64 E70
2. K. Popko, E. Gorska, A. Stelmaszczyk-Emmel, R. Plywaczewski, A. Stoklosa, and D. Gorecka Proinflammatory cytokines Il-6 and TNF-alpha and the development of inflammation in obese subjects Eur J Med Res 15 Suppl. 2 2010 120 122
3. M. Canoz, F. Erdenen, H. Uzun, C. Muderrisoglu, and S. Aydin The relationship of inflammatory cytokines with asthma and obesity Clin Invest Med 31 6 2008 E373 E379
4. M. Maachi, L. Pieroni, E. Bruckert, C. Jardel, S. Fellahi, and B. Hainque Systemic low-grade inflammation is related to both circulating and adipose tissue TNF-alpha, leptin and IL-6 levels in obese women Int J Obes Relat Metab Disord 28 8 2004 993 997
5. H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, and C.J. Chou Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 12 2003 1821 1830
6. H. Kanda, S. Tateya, Y. Tamori, K. Kotani, K. Hiasa, and R. Kitazawa MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance and hepatic steatosis in obesity J Clin Invest 116 6 2006 1494 1505
7. T. Suganami, J. Nishida, and Y. Ogawa A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha Arterioscler Thromb Vasc Biol 25 10 2005 2062 2068
8. M.T. Nguyen, S. Favelyukis, A.K. Nguyen, D. Reichart, P.A. Scott, and A. Jenn A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways J Biol Chem 282 48 2007 35279 35292
9. C. Yeop Han, A.Y. Kargi, M. Omer, C.K. Chan, M. Wabitsch, and K.D. O'Brien Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation Diabetes 59 2 2010 386 396
10. B. Gustafson, A. Hammarstedt, C.X. Andersson, and U. Smith Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis Arterioscler Thromb Vasc Biol 27 11 2007 2276 2283
11. G. Mathur, B. Noronha, E. Rodrigues, and G. Davis The role of angiotensin II type 1 receptor blockers in the prevention and management of diabetes mellitus Diabetes Obes Metab 9 5 2007 617 629
12. A. Prasad, and A.A. Quyyumi Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome Circulation 110 11 2004 1507 1512
13. D. Fitchett Results of the ONTARGET and TRANSCEND studies: an update and discussion Vasc Health Risk Manag 5 1 2009 21 29
14. S.C. Benson, H.A. Pershadsingh, C.I. Ho, A. Chittiboyina, P. Desai, and M. Pravenec Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Hypertension 43 5 2004 993 1002
15. T. Sawada, H. Yamada, B. Dahlof, and H. Matsubara Effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high cardiovascular risks: Kyoto Heart Study Eur Heart J 30 20 2009 2461 2469
16. A. Yamashita, Y. Soga, Y. Iwamoto, S. Yoshizawa, H. Iwata, and S. Kokeguchi Macrophage-adipocyte interaction: marked interleukin-6 production by lipopolysaccharide Obesity (Silver Spring) 15 11 2007 2549 2552
17. A. Yamashita, Y. Soga, Y. Iwamoto, T. Asano, Y. Li, and Y. Abiko DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin Int J Obes (Lond) 32 11 2008 1725 1729
18. H. Nakarai, A. Yamashita, S. Nagayasu, M. Iwashita, S. Kumamoto, and H. Ohyama Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications Innate Immun 18 1 2012 164 170
19. Y. Yamamoto, Y. Yoshimasa, M. Koh, J. Suga, H. Masuzaki, and Y. Ogawa Constitutively active mitogen-activated protein kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes Diabetes 49 3 2000 332 339
20. J.J. McMurray, R.R. Holman, S.M. Haffner, M.A. Bethel, B. Holzhauer, and T.A. Hua Effect of valsartan on the incidence of diabetes and cardiovascular events New Engl J Med 362 16 2010 1477 1490
21. M. Iwashita, H. Sakoda, A. Kushiyama, M. Fujishiro, H. Ohno, and Y. Nakatsu Valsartan, independently of the AT1 receptor or PPARγ, suppresses the inflammatory response of macrophages and thereby improves insulin resistance in co-cultured adipocytes Am J Physiol Endocrinol Metab 302 3 2012 E286 E296
22. S. Ghosh, and M. Karin Missing pieces in the NF-kappaB puzzle Cell 109 Suppl. 2002 S81 S96
23. R.G. Baker, M.S. Hayden, and S. Ghosh NF-kappaB, inflammation, and metabolic disease Cell Metab 13 1 2011 11 22
24. J.J. Diez, P. Sanchez, and P. Iglesias Prevalence of thyroid dysfunction in patients with type 2 diabetes Exp Clin Endocrinol Diabetes 119 4 2011 201 207
25. R. Kadiyala, R. Peter, and O.E. Okosieme Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies Int J Clin Pract 64 8 2010 1130 1139
26. T. Nagare, H. Sakaue, M. Matsumoto, Y. Cao, K. Inagaki, and M. Sakai Overexpression of KLF15 in adipocytes of mice results in down-regulation of SCD1 expression in adipocytes and consequent enhancement of glucose-induced insulin secretion J Biol Chem 286 43 2011 37458 37469
27. U.A. White, and J.M. Stephens Transcriptional factors that promote formation of white adipose tissue Mol Cell Endocrinol 318 1-2 2010 10 14
28. E. Shaulian, and M. Karin AP-1 as a regulator of cell life and death Nat Cell Biol 4 5 2002 E131 E136
29. R. Eferl, and E.F. Wagner AP-1: a double-edged sword in tumorigenesis Nat Rev Cancer 3 11 2003 859 868
30. K. Kessenbrock, V. Plaks, and Z. Werb Matrix metalloproteinases: regulators of the tumor microenvironment Cell 141 1 2010 52 67
31. A. O'Hara, F.L. Lim, D.J. Mazzatti, and P. Trayhurn Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium Pflugers Arch 458 6 2009 1103 1114
32. T. Suganami, and Y. Ogawa Adipose tissue macrophages: their role in adipose tissue remodeling J Leukoc Biol 88 1 2010 33 39
33. N. Alkhouri, A. Gornicka, M.P. Berk, S. Thapaliya, L.J. Dixon, and S. Kashyap Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis J Biol Chem 285 5 2010 3428 3438