Reducing cytotoxicity while improving anti-cancer drug loading capacity of polypropylenimine dendrimers by surface acetylation

Acta Biomaterialia

Volumn 8, Issue 12, 2012, Pages 4304-4313

  Wang, Fei ^a   Cai, Xiaopan ^b,c   Su, Yunzhang ^a   Hu, Jingjing ^d   Wu, Q ^e   Zhang, Hongfeng ^a   Xiao, Jianru ^b   Cheng, Yiyun ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c ANHUI MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^e HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Acetylation; Anticancer drug; Dendrimer; PPI; Sustained release

Indexed keywords

ACETYLATION; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DRUG PRODUCTS; LOADING; MEDICAL APPLICATIONS; NUCLEIC ACIDS; SODIUM; TARGETED DRUG DELIVERY;

A549 CELLS; ANTICANCER DRUG; BIOMEDICAL APPLICATIONS; DEGREE OF ACETYLATION; DELIVERY VEHICLE; DOXORUBICIN; DRUG LOADING CAPACITY; MCF-7 CELLS; POLYPROPYLENIMINE; SUSTAINED RELEASE;

DENDRIMERS;

ANTINEOPLASTIC AGENT; DENDRIMER; DEOXYCHOLATE SODIUM; DOXORUBICIN; METHOTREXATE; NANOPARTICLE; POLYPROPYLENIMINE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL STRAIN MCF 7; CELL VIABILITY; CYTOTOXICITY; DRUG RELEASE; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; SURFACE ACETYLATION; SYNTHESIS;

ACETYLATION; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXINS; DENDRIMERS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; NANOPARTICLES; POLYPROPYLENES;

EID: 84868202068     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.07.031     Document Type: Article

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