Peroxisome proliferator-activated receptor γ coactivator 1-α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle

Journal of Physiology

Volumn 590, Issue 21, 2012, Pages 5487-5502

  Godin, Richard ^a   Daussin, Frederic ^a   Matecki, Stefan ^b   Li, Tong ^c   Petrof, Basil J ^c   Burelle, Yan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTPELLIER   (France)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALPAIN; CASPASE 3; CASPASE 9; DYSTROPHIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CALCIUM TRANSPORT; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; DUCHENNE MUSCULAR DYSTROPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; GENE OVEREXPRESSION; GENE TRANSFER; HISTOPATHOLOGY; MALE; MITOCHONDRIAL BIOMASS; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; MUSCLE NECROSIS; NONHUMAN; NONVIRAL GENE THERAPY; PGC1ALPHA GENE; PHENOTYPE; PLASMID; PRIORITY JOURNAL;

ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; DYSTROPHIN; GENE TRANSFER TECHNIQUES; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; NECROSIS; TRANS-ACTIVATORS;

EID: 84868122492     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.240390     Document Type: Article

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