Role of specific dietary amino acids in clinical conditions

British Journal of Nutrition

Volumn 108, Issue SUPPL. 2, 2012, Pages

  Jonker, Renate ^a   Engelen, Mariëlle P K J ^a   Deutz, Nicolaas E P ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

dietary amino acids; leucine; muscle wasting; protein metabolism

Indexed keywords

AMINO ACID; ARGININE; CASEIN; CITRULLINE; LEUCINE; MUSCLE PROTEIN; PHENYLALANINE;

ACUTE DISEASE; AGING; AMINO ACID ANALYSIS; AMINO ACID COMPOSITION; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; DIET SUPPLEMENTATION; DIET THERAPY; HUMAN; INFLAMMATION; MUSCLE ATROPHY; MUSCLE MASS; NEOPLASM; NONHUMAN; PHYSICAL DISABILITY; PROTEIN DEGRADATION; PROTEIN DIET; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN QUALITY; PROTEIN SYNTHESIS; SKELETAL MUSCLE;

AMINO ACIDS; AMINO ACIDS, ESSENTIAL; CYSTIC FIBROSIS; DIETARY PROTEINS; HUMANS; LIVER; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULOSKELETAL DISEASES; NEOPLASMS; PROTEIN BIOSYNTHESIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84868119491     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512002358     Document Type: Article

References (81)

1. Wolfe RR (2002) Regulation of muscle protein by amino acids. J Nutr 132, 3219S-3224S.
2. Wolfe RR & Miller SL (1999) Amino acid availability controls muscle protein metabolism. Diabetes Nutr and Metab 12, 322-328. (Pubitemid 30009013)
3. Stoll B & Burrin DG (2006) Measuring splanchnic amino acid metabolism in vivo using stable isotopic tracers. J Anim Sci 84, Suppl, E60-E72.
4. Tessari P, Inchiostro S, Barazzoni R, et al. (1994) Fasting and postprandial phenylalanine and leucine kinetics in liver cirrhosis. Am J Physiol - Endocrinol Metab 267, E140-E149. (Pubitemid 24225671)
5. Boirie Y, Gachon P & Beaufrere B (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 65, 489-495. (Pubitemid 27130757)
6. Matthews DE, Harkin R, Battezzati A, et al. (1999) Splanchnic bed utilization of enteral [alpha]-ketoisocaproate in humans. Metabolism 48, 1555-1563.
7. Volpi E, Mittendorfer B, Wolf SE, et al. (1999) Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 277, E513-E520. (Pubitemid 29458212)
8. Luiking YC, Deutz NE, Jakel M, et al. (2005) Casein and soy protein meals differentially affect whole-body and splanchnic protein metabolism in healthy humans. J Nutr 135, 1080-1087. (Pubitemid 40638310)
9. Engelen MP, Rutten EP, De Castro CL, et al. (2005) Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 82, 366-372.
10. Engelen MP, Rutten EP, De Castro CL, et al. (2007) Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 85, 431-439. (Pubitemid 46220945)
11. Gan WQ, Man SF, Senthilselvan A, et al. (2004) Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 59, 574-580. (Pubitemid 38901515)
12. Pinto-Plata VM, Mullerova H, Toso JF, et al. (2006) C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax 61, 23-28. (Pubitemid 43106973)
13. Hashimoto T, Yoneda M, Shimada T, et al. (2004) Intraportal nicotine infusion in rats decreases hepatic blood flow through endothelin-1 and both endothelin A and endothelin B receptors. Toxicol Appl Pharmacol 196, 1-10. (Pubitemid 38393688)
14. Volpi E, Sheffield-Moore M, Rasmussen BB, et al. (2001) Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 286, 1206-1212. (Pubitemid 33015550)
15. Paddon-Jones D, Sheffield-Moore M, Zhang XJ, et al. (2004) Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 286, E321-E328. (Pubitemid 38292680)
16. Cuthbertson D, Smith K, Babraj J, et al. (2005) Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 19, 422-424. (Pubitemid 40316537)
17. Symons TB, Schutzler SE, Cocke TL, et al. (2007) Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr 86, 451-456. (Pubitemid 47256931)
18. Smith GI, Atherton P, Villareal DT, et al. (2008) Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS One 3, e1875.
19. Koopman R, Walrand S, Beelen M, et al. (2009) Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J Nutr 139, 1707-1713.
20. Rennie MJ, Selby A, Atherton P, et al. (2010) Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy. Scand J Med Sci Sports 20, 5-9.
21. Paddon-Jones D, Sheffield-Moore M, Cree MG, et al. (2006) Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 91, 4836-4841. (Pubitemid 44917315)
22. Glover EI, Phillips SM, Oates BR, et al. (2008) Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 586, 6049-6061.
23. Ferrando AA, Paddon-Jones D, Hays NP, et al. (2010) EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. Clin Nutr 29, 18-23.
24. Kortebein P, Ferrando A, Lombeida J, et al. (2007) Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA 297, 1772-1774. (Pubitemid 46658661)
25. Toth MJ, Matthews DE, Tracy RP, et al. (2005) Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Physiol Endocrinol Metab 288, E883-E891. (Pubitemid 40547881)
26. Reeds PJ, Fjeld CR & Jahoor F (1994) Do the differences between the amino acid compositions of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states? J Nutr 124, 906-910. (Pubitemid 24200598)
27. Biolo G, Tipton KD, Klein S, et al. (1997) An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol 273, E122-E129.
28. Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. (2005) Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82, 1065-1073. (Pubitemid 43779766)
29. Dillon EL, Volpi E, Wolfe RR, et al. (2007) Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy. Clin Nutr 26, 736-743. (Pubitemid 350082494)
30. Symons TB, Sheffield-Moore M, Wolfe RR, et al. (2009) A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc 109, 1582-1586.
31. Wolfe RR, Miller SL & Miller KB (2008) Optimal protein intake in the elderly. Clin Nutr 27, 675-684.
32. Luiking YC, Engelen MP, Soeters PB, et al. (2010) Differential metabolic effects of casein and soy protein meals on skeletal muscle in healthy volunteers. Clin Nutr 30, 65-72.
33. Tang JE, Moore DR, Kujbida GW, et al. (2009) Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol 107, 987-992.
34. Boirie Y, Dangin M, Gachon P, et al. (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A 94, 14930-14935. (Pubitemid 28041477)
35. Reitelseder Sr, Agergaard J, Doessing S, et al. (2011) Whey and casein labeled with l-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion. Am J Physiol - Endocrinol Metab 300, E231-E242.
36. Volpi E, Ferrando AA, Yeckel CW, et al. (1998) Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 101, 2000-2007. (Pubitemid 28226120)
37. Volpi E, Kobayashi H, Sheffield-Moore M, et al. (2003) Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78, 250-258. (Pubitemid 39655228)
38. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, et al. (2006) Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 41, 215-219. (Pubitemid 43165694)
39. Kimball SR & Jefferson LS (2001) Regulation of protein synthesis by branched-chain amino acids. Curr Opin Clin Nutr Metab Care 4, 39-43. (Pubitemid 34754478)
40. Rennie MJ & Tipton KD (2000) Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr 20, 457-483.
41. Newsholme P, Brennan L, Rubi B, et al. (2005) New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond) 108, 185-194. (Pubitemid 40343565)
42. Floyd JC Jr, Fajans SS, Conn JW, et al. (1966) Stimulation of insulin secretion by amino acids. J Clin Invest 45, 1487-1502.
43. Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. (2006) A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 291, E381-E387. (Pubitemid 44035298)
44. Koopman R, Verdijk L, Manders RJ, et al. (2006) Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr 84, 623-632. (Pubitemid 44713414)
45. Rieu I, Balage M, Sornet C, et al. (2006) Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575, 305-315. (Pubitemid 44182713)
46. Tipton KD, Elliott TA, Ferrando AA, et al. (2009) Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein. Appl Physiol Nutr Metab 34, 151-161.
47. van de Poll MC, Siroen MP, van Leeuwen PA, et al. (2007) Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr 85, 167-172. (Pubitemid 46067631)
48. Bruins MJ (2001) L-arginine treatment during acute and longterm endotoxemia in the pig - Effects on jejunal motility and interorgan protein, arginine and nitric oxide metabolism. PhD thesis, Maastricht University.
49. Bruins MJ, Soeters PB, Lamers WH, et al. (2002) L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. Am J Clin Nutr 75, 1031-1044. (Pubitemid 34547533)
50. Bruins MJ, Soeters PB, Lamers WH, et al. (2002) L-Arginine supplementation in hyperdynamic endotoxemic pigs: Effect on nitric oxide synthesis by the different organs. Crit Care Med 30, 508-517. (Pubitemid 34214609)
51. Bruins MJ, Luiking YC, Soeters PB, et al. (2004) Effects of long-term intravenous and intragastric L-arginine intervention on jejunal motility and visceral nitric oxide production in the hyperdynamic compensated endotoxaemic pig. Neurogastroenterol Motil 16, 819-828. (Pubitemid 40022789)
52. Yao K, Yin Y-L, Chu W, et al. (2008) Dietary Arginine Supplementation Increases mTOR Signaling Activity in Skeletal Muscle of Neonatal Pigs. J Nutr 138, 867-872. (Pubitemid 351571584)
53. Zhang XJ, Chinkes DL & Wolfe RR (2008) The anabolic effect of arginine on proteins in skin wound and muscle is independent of nitric oxide production. Clin Nutr 27, 649-656.
54. Cynober L, Moinard C & De Bandt JP (2009) The Sir ESPEN David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game? Clin Nutr 29, 545-551.
55. Tisdale MJ (2009) Mechanisms of Cancer Cachexia. Physiol Rev 89, 381-410.
56. Durham WJ, Dillon EL & Sheffield-Moore M (2009) Inflammatory burden and amino acid metabolism in cancer cachexia. Curr Opin Clin Nutr Metab Care 12, 72-77.
57. Melville S, McNurlan MA, Calder AG, et al. (1990) Increased protein turnover despite normal energy metabolism and responses to feeding in patients with lung cancer. Cancer Res 50, 1125-1131. (Pubitemid 20083998)
58. Vissers YL, Dejong CH, Luiking YC, et al. (2005) Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency? Am J Clin Nutr 81, 1142-1146. (Pubitemid 41724957)
59. Bossola M, Muscaritoli M, Costelli P, et al. (2001) Increased muscle ubiquitin mRNA levels in gastric cancer patients. Am J Physiol Regul Integr Comp Physiol 280, R1518-R1523.
60. Bossola M, Muscaritoli M, Costelli P, et al. (2003) Increased muscle proteasome activity correlates with disease severity in gastric cancer patients. Ann Surg 237, 384-389. (Pubitemid 38176454)
61. Deutz NE, Safar A, Schutzler S, et al. (2011) Muscle protein synthesis in cancer patients can be stimulated with an alternatively composed medical food. Clinical Nutr 30, 759-768.
62. Eley HL, Russell ST & Tisdale MJ (2007) Effect of branchedchain amino acids on muscle atrophy in cancer cachexia. Biochem J 407, 113-120. (Pubitemid 47535586)
63. Peters SJ, van Helvoort A, Kegler D, et al. (2011) Dosedependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice. Oncol Rep 26, 247-254.
64. Engelen MP, Deutz NE, Wouters EF, et al. (2000) Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 162, 1488-1492.
65. Engelen MP & Schols AM (2003) Altered amino acid metabolism in chronic obstructive pulmonary disease: new therapeutic perspective? Curr Opin Clin Nutr Metab Care 6, 73-78. (Pubitemid 40684620)
66. Hofford JM, Milakofsky L, Vogel WH, et al. (1990) The nutritional status in advanced emphysema associated with chronic bronchitis. A study of amino acid and catecholamine levels. Am Rev Respir Dis 141, 902-908. (Pubitemid 20157717)
67. Engelen MP, Wouters EF, Deutz NE, et al. (2000) Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 72, 1480-1487.
68. Holt TL, Ward LC, Francis PJ, et al. (1985) Whole body protein turnover in malnourished cystic fibrosis patients and its relationship to pulmonary disease. Am J Clin Nutr 41, 1061-1066. (Pubitemid 15013433)
69. Geukers VG, Oudshoorn JH, Taminiau JA, et al. (2005) Short-term protein intake and stimulation of protein synthesis in stunted children with cystic fibrosis. Am J Clin Nutr 81, 605-610.
70. Kien CL, Zipf WB, Horswill CA, et al. (1996) Effects of feeding on protein turnover in healthy children and in children with cystic fibrosis. Am J Clin Nutr 64, 608-614. (Pubitemid 26334241)
71. Kien CL, Horswill CA, Zipf WB, et al. (1995) Elevated Hepatic Glucose Production in Children with Cystic Fibrosis. Pediatr Res 37, 600-605.
72. Hardin DS, LeBlanc A, Lukenbaugh S, et al. (1998) Proteolysis associated with insulin resistance in cystic fibrosis. Pediatrics 101, 433-437. (Pubitemid 28136419)
73. Moran A, Milla C, Ducret R, et al. (2001) Protein metabolism in clinically stable adult cystic fibrosis patients with abnormal glucose tolerance. Diabetes 50, 1336-1343. (Pubitemid 32500166)
74. Lang CH, Frost RA & Vary TC (2007) Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab 293, E453-E459. (Pubitemid 47205087)
75. Lang CH, Frost RA, Bronson SK, et al. (2010) Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab 298, E1283-E1294.
76. van Waardenburg DA, de Betue CT, Luiking YC, et al. (2007) Plasma arginine and citrulline concentrations in critically ill children: strong relation with inflammation. Am J Clin Nutr 86, 1438-1444. (Pubitemid 350126249)
77. Argaman Z, Young VR, Noviski N, et al. (2003) Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 31, 591-597. (Pubitemid 36232960)
78. Luiking YC, Engelen MP & Deutz NE (2010) Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care 13, 97-104.
79. Bruins MJ, Deutz NE & Soeters PB (2003) Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis. Clin Sci (Lond) 104, 127-141. (Pubitemid 36238045)
80. Rhoads JM, Niu X, Odle J, et al. (2006) Role of mTOR signaling in intestinal cell migration. Am J Physiol Gastrointest Liver Physiol 291, G510-G517. (Pubitemid 44330172)
81. Corl BA, Odle J, Niu X, et al. (2008) Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr 138, 24-29.