Therapeutic potential for phenytoin: Targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

Breast Cancer Research and Treatment

Volumn 134, Issue 2, 2012, Pages 603-615

  Yang, Ming ^a   Kozminski, David J ^b   Wold, Lindsey A ^b   Modak, Rohan ^b   Calhoun, Jeffrey D ^b   Isom, Lori L ^b   Brackenbury, William J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Electrophysiology; Invasion; Metastasis; Migration; Phenytoin; Voltage gated Na+channel

Indexed keywords

PHENYTOIN; SODIUM CHANNEL NAV1.5;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST METASTASIS; CANCER INHIBITION; CANCER INVASION; CANCER RECURRENCE; CELL MIGRATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DISEASE ASSOCIATION; DRUG EFFECT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SODIUM CURRENT; UPREGULATION;

ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; MEMBRANE POTENTIALS; MOLECULAR TARGETED THERAPY; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NEOPLASM INVASIVENESS; PHENYTOIN; ROC CURVE; SODIUM CHANNEL BLOCKERS;

EID: 84868111320     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2102-9     Document Type: Article

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