Block of human NaV 1.5 sodium channels by novel α-hydroxyphenylamide analogues of phenytoin

European Journal of Pharmaceutical Sciences

Volumn 21, Issue 5, 2004, Pages 635-644

  Lenkowski, Paul W ^a   Ko, Seong Hoon ^b   Anderson, James D ^a   Brown, Milton L ^a   Patel, Manoj K ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Hydroxyphenylamide; Phenytoin; Sodium channels

Indexed keywords

2 (2 CHLOROPHENYL) 2 HYDROXYNONANOIC ACID AMIDE; 2 (3 CHLOROPHENYL) 2 HYDROXYNONANOIC ACID AMIDE; 2 (4 CHLOROPHENYL) 2 HYDROXYNONANOIC ACID AMIDE; 2 (4 FLUOROPHENYL) 2 HYDROXYNONANOIC ACID AMIDE; 2 (4 METHYLPHENYL) 2 HYDROXYNONANOIC ACID AMIDE; 2 HYDROXY 2 PHENYLNONANOIC ACID AMIDE; AMIDE; PHENYL GROUP; PHENYTOIN; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; DRUG DERIVATIVE; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTRON; FEMALE; IC 50; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; HAMSTER; HUMAN; PHYSIOLOGY;

ANIMALS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MUSCLE PROTEINS; PHENYTOIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 1842555210     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.01.004     Document Type: Article

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