Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

Cancer Research

Volumn 70, Issue 17, 2010, Pages 6957-6967

  House, Carrie D ^a   Vaske, Charles J ^b,e   Schwartz, Arnold M ^a   Obias, Vincent ^a   Frank, Bryan ^a   Luu, Truong ^a   Sarvazyan, Narine ^a   Irby, Rosalyn ^c   Strausberg, Robert L ^d   Hales, Tim G ^a,f   Stuart, Joshua M ^b   Lee, Norman H ^a,g  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b University of California Santa Cruz   (United States)

^c PENN STATE CANCER INSTITUTE   (United States)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^e PRINCETON UNIVERSITY   (United States)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g Ross Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; SODIUM CHANNEL NAV1.5; TETRODOTOXIN; WNT PROTEIN; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL;

ARTICLE; BIOTIC STRESS; CANCER CELL CULTURE; CANCER INVASION; CELL CYCLE REGULATION; CELL MIGRATION; COLON BIOPSY; COLON CANCER; CONTROLLED STUDY; ECTODERM; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; PRIORITY JOURNAL; STEROID METABOLISM; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CACO 2 CELL LINE; CELL MOTION; COLON TUMOR; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; HT 29 CELL LINE; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION;

CACO-2 CELLS; CELL MOVEMENT; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCLE PROTEINS; NEOPLASM INVASIVENESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM CHANNELS; TRANSCRIPTION, GENETIC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL;

EID: 77956287456     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1169     Document Type: Article

References (50)

1. Kunzelmann K. Ion channels and cancer. J Membr Biol 2005;205: 159-73.
2. Schuller HM. Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev 2009;9:195-205.
3. Onkal R, Djamgoz MB. Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer. Eur J Pharmacol 2009;625:206-19.
4. Roger S, Potier M, Vandier C, Besson P, Le Guennec JY. Voltage-gated sodium channels: new targets in cancer therapy? Curr Pharm Des 2006;12:3681-95.
5. Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 1952;117:500-44.
6. Davis TH, Chen C, Isom LL. Sodium channel β1 subunits promote neurite outgrowth in cerebellar granule neurons. J Biol Chem 2004; 279:51424-32. (Pubitemid 40017890)
7. Cameron IL, Smith NK, Pool TB, Sparks RL. Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo. Cancer Res 1980;40:1493-500.
8. Laniado ME, Lalani EN, Fraser SP, et al. Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro. Am J Pathol 1997; 150:1213-21.
9. Fraser SP, Diss JK, Chioni AM, et al. Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 2005;11:5381-9.
10. Roger S, Rollin J, Barascu A, et al. Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. Int J Biochem Cell Biol 2007;39:774-86.
11. Gillet L, Roger S, Besson P, et al. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J Biol Chem 2009;284:8680-91.
12. Carrithers MD, Chatterjee G, Carrithers LM, et al. Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. J Biol Chem 2009;284:8114-26.
13. Malek RL, Irby RB, Guo QM, et al. Identification of Src transformation fingerprint in human colon cancer. Oncogene 2002;21:7256-65.
14. Teramoto H, Castellone MD, Malek RL, et al. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene 2005;24:489-501.
15. Onganer PU, Seckl MJ, Djamgoz MB. Neuronal characteristics of small-cell lung cancer. Br J Cancer 2005;93:1197-201.
16. Jull BA, Plummer HK III, Schuller HM. Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/ MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. J Cancer Res Clin Oncol 2001;127:707-17.
17. Roy R, Wewer UM, Zurakowski D, Pories SE, Moses MA. ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. J Biol Chem 2004;279:51323-30.
18. Tolon RM, Sanchez-Franco F, Lopez Fernandez J, Lorenzo MJ, Vazquez GF, Cacicedo L. Regulation of somatostatin gene expression by veratridine-induced depolarization in cultured fetal cerebrocortical cells. Brain Res 1996;35:103-10.
19. Juretic N, Urzua U, Munroe DJ, Jaimovich E, Riveros N. Differential gene expression in skeletal muscle cells after membrane depolarization. J Cell Physiol 2007;210:819-30. (Pubitemid 46185051)
20. Irby RB, Malek RL, Bloom G, et al. Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotype. Cancer Res 2005;65:1814-21.
21. Markowetz F, Kostka D, Troyanskaya OG, Spang R. Nested effects models for high-dimensional phenotyping screens. Bioinformatics 2007;23:i305-12.
22. Brey EM, Lalani Z, Johnston C, et al. Automated selection of DAB-labeled tissue for immunohistochemical quantification. J Histochem Cytochem 2003;51:575-84. (Pubitemid 36520613)
23. Vaske CJ, House C, Luu T, et al. A factor graph nested effects model to identify networks from genetic perturbations. PLoS Comput Biol 2009;5:e1000274.
24. Gavillet B, Rougier JS, Domenighetti AA, et al. Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin. Circ Res 2006;99:407-14.
25. Gellens ME, George AL, Jr., Chen LQ, et al. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci U S A 1992; 89:554-8.
26. + channel expression in Mat-LyLu rat prostate cancer cell line. J Physiol 2006;573:343-56.
27. Gaillard JL, Finlay BB. Effect of cell polarization and differentiation on entry of Listeria monocytogenes into the enterocyte-like Caco-2 cell line. Infect Immun 1996;64:1299-308.
28. Shen C, Gu M, Song C, et al. The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro. Biologicals 2008;36:263-8.
29. Barshack I, Levite M, Lang A, et al. Functional voltage-gated sodium channels are expressed in human intestinal epithelial cells. Digestion 2008;77:108-17.
30. Leibovitz A, Stinson JC, McCombs WB III, McCoy CE, Mazur KC, Mabry ND. Classification of human colorectal adenocarcinoma cell lines. Cancer Res 1976;36:4562-9.
31. Murphy G. The ADAMs: signalling scissors in the tumour microenvironment. Nat Rev 2008;8:929-41.
32. Meiners S, Hocher B, Weller A, et al. Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome. Hypertension 2004;44:471-7.
33. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. Activation of Gαi3 triggers cell migration via regulation of GIV. J Cell Biol 2008; 182:381-93.
34. Roberts RL, Fink GR. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev 1994;8: 2974-85.
35. Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science (New York, NY) 2006;314:268-74.
36. Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science (New York, NY) 2007; 318:1108-13.
37. Ashcroft FM. From molecule to malady. Nature 2006;440:440-7.
38. Sokolov S, Scheuer T, Catterall WA. Gating pore current in an inherited ion channelopathy. Nature 2007;446:76-8. (Pubitemid 46348048)
39. Lin J, Gan CM, Zhang X, et al. A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res 2007;17: 1304-18.
40. Nibbe RK, Markowitz S, Myeroff L, Ewing R, Chance MR. Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer. Mol Cell Proteomics 2009;8:827-45.
41. Andreu P, Colnot S, Godard C, et al. Identification of the IFITM family as a new molecular marker in human colorectal tumors. Cancer Res 2006;66:1949-55.
42. Hatano H, Kudo Y, Ogawa I, et al. IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression. Clin Cancer Res 2008;14:6097-105.
43. Yang Y, Lee JH, Kim KY, et al. The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells. Cancer Lett 2005;221:191-200.
44. Irby RB, McCarthy SM, Yeatman TJ. Osteopontin regulates multiple functions contributing to human colon cancer development and progression. Clin Exp Metastasis 2004;21:515-23.
45. Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, Feinstein E, Einat P, Ben-Ze'ev A. Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev 2002;16:2058-72.
46. Li CG, Gruidl M, Eschrich S, et al. Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. Int J Cancer 2008;123:273-82. (Pubitemid 351842010)
47. Sablina AA, Hahn WC. The role of PP2A A subunits in tumor suppression. Cell Adh Migr 2007;1:140-1.
48. Calin GA, di Iasio MG, Caprini E, et al. Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene 2000;19:1191-5.
49. Gressner OA, Gressner AM. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int 2008;28:1065-79.
50. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 2008;109: 180-7.