메뉴 건너뛰기




Volumn 28, Issue 6, 2012, Pages 1945-1952

hTERT-based therapy: A universal anticancer approach (Review)

Author keywords

Cancer; Human telomerase reverse transcriptase; Telomerase; Therapy

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; ARGINYLGLYCYLASPARTIC ACID; CANCER VACCINE; I 540; ISOLEUCYLLEUCYLALANYLLYSYLPHENYLALANYLLEUCYLHISTIDINYLTRYPTOPHYLLEUCINE; K 973; LYSYLLEUCYLPHENYLALANYLGLYCYLVALYLLEUCYLARGINYLLEUCYLLYSINE; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE; TETRACYCLINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 84868094033     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2036     Document Type: Conference Paper
Times cited : (43)

References (51)
  • 1
    • 34147095342 scopus 로고    scopus 로고
    • Protein composition of catalytically active human telomerase from immortal cells
    • DOI 10.1126/science.1138596
    • Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ and Reddel RR: Protein composition of catalytically active human telomerase from immortal cells. Science 315:1850-1853, 2007. (Pubitemid 46580145)
    • (2007) Science , vol.315 , Issue.5820 , pp. 1850-1853
    • Cohen, S.B.1    Graham, M.E.2    Lovrecz, G.O.3    Bache, N.4    Robinson, P.J.5    Reddel, R.R.6
  • 2
    • 0034774859 scopus 로고    scopus 로고
    • Cellular senescence, cancer and aging: The telomere connection
    • DOI 10.1016/S0531-5565(01)00160-7, PII S0531556501001607
    • Campisi J, Kim SH, Lim CS and Rubio M: Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36:1619-1637, 2001. (Pubitemid 32982869)
    • (2001) Experimental Gerontology , vol.36 , Issue.10 , pp. 1619-1637
    • Campisi, J.1    Kim, S.-H.2    Lim, C.-S.3    Rubio, M.4
  • 3
    • 79251611874 scopus 로고    scopus 로고
    • Telomerase: Structure, functions, and activity regulation
    • Zvereva MI, Shcherbakova DM and Dontsova OA: Telomerase: structure, functions, and activity regulation. Biochemistry 75:1563-1583, 2010.
    • (2010) Biochemistry , vol.75 , pp. 1563-1583
    • Zvereva, M.I.1    Shcherbakova, D.M.2    Dontsova, O.A.3
  • 4
    • 33644846842 scopus 로고    scopus 로고
    • Genetic instability in human tumors
    • Raptis S and Bapat B: Genetic instability in human tumors. EXS 303-320, 2006.
    • (2006) EXS , pp. 303-320
    • Raptis, S.1    Bapat, B.2
  • 5
    • 84863066136 scopus 로고    scopus 로고
    • Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis
    • Lü MH, Deng JQ, Cao YL, Fang DC, Zhang Y and Yang SM: Prognostic role of telomerase activity in gastric adenocarcinoma: a meta-analysis. Exp Ther Med 3:728-734, 2012.
    • (2012) Exp Ther Med , vol.3 , pp. 728-734
    • Lü, M.H.1    Deng, J.Q.2    Cao, Y.L.3    Fang, D.C.4    Zhang, Y.5    Yang, S.M.6
  • 6
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • DOI 10.1038/nrc2275, PII NRC2275
    • Harley CB: Telomerase and cancer therapeutics. Nat Rev Cancer 8:167-179, 2008. (Pubitemid 351305939)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 167-179
    • Harley, C.B.1
  • 7
    • 2442445080 scopus 로고    scopus 로고
    • Telomerase activation and expression of its catalytic subunits in benign and malignant tumors of the parathyroid
    • DOI 10.1007/s00595-003-2729-6
    • Onoda N, Ogisawa K, Ishikawa T, Takenaka C, Tahara H, Inaba M, Takashima T and Hirakawa K: Telomerase activation and expression of its catalytic subunits in benign and malignant tumors of the parathyroid. Surg Today 34:389-393, 2004. (Pubitemid 38626483)
    • (2004) Surgery Today , vol.34 , Issue.5 , pp. 389-393
    • Onoda, N.1    Ogisawa, K.2    Ishikawa, T.3    Takenaka, C.4    Tahara, H.5    Inaba, M.6    Takashima, T.7    Hirakawa, K.8
  • 8
    • 75449089521 scopus 로고    scopus 로고
    • Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: Predictive factors for local tumor control and early recurrences
    • Sorbe B, Bohr L, Karlsson L and Bermark B: Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: predictive factors for local tumor control and early recurrences. Int J Oncol 36:371-378, 2010.
    • (2010) Int J Oncol , vol.36 , pp. 371-378
    • Sorbe, B.1    Bohr, L.2    Karlsson, L.3    Bermark, B.4
  • 9
    • 0034038595 scopus 로고    scopus 로고
    • Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p
    • Shay JW and Wright WE: Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p. Neoplasia 2:195-196, 2000. (Pubitemid 30346074)
    • (2000) Neoplasia , vol.2 , Issue.3 , pp. 195-196
    • Shay, J.W.1    Wright, W.E.2
  • 10
    • 69449099710 scopus 로고    scopus 로고
    • HTERT promotes the invasion of telomerase-negative tumor cells in vitro
    • Yu ST, Chen L, Wang HJ, Tang XD, Fang DC and Yang SM: hTERT promotes the invasion of telomerase-negative tumor cells in vitro. Int J Oncol 35:329-336, 2009.
    • (2009) Int J Oncol , vol.35 , pp. 329-336
    • Yu, S.T.1    Chen, L.2    Wang, H.J.3    Tang, X.D.4    Fang, D.C.5    Yang, S.M.6
  • 14
    • 80051520893 scopus 로고    scopus 로고
    • A novel prodrug of epigallocatechin-3-gallate: Differential epigenetic hTERT repression in human breast cancer cells
    • Meeran SM, Patel SN, Chan TH and Tollefsbol TO: A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev Res 4:1243-1254, 2011.
    • (2011) Cancer Prev Res , vol.4 , pp. 1243-1254
    • Meeran, S.M.1    Patel, S.N.2    Chan, T.H.3    Tollefsbol, T.O.4
  • 16
    • 18644366859 scopus 로고    scopus 로고
    • In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer
    • Amarnath SM, Dyer CE, Ramesh A, Iwuagwu O, Drew PJ and Greenman J: In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. Int J Oncol 25:211-217, 2004.
    • (2004) Int J Oncol , vol.25 , pp. 211-217
    • Amarnath, S.M.1    Dyer, C.E.2    Ramesh, A.3    Iwuagwu, O.4    Drew, P.J.5    Greenman, J.6
  • 17
    • 16644376274 scopus 로고    scopus 로고
    • Cytotoxic T-cell immunity against telomerase reverse transcriptase in colorectal cancer patients
    • Titu LV, Loveday RL, Madden LA, Cawkwell L, Monson JR and Greenman J: Cytotoxic T-cell immunity against telomerase reverse transcriptase in colorectal cancer patients. Oncol Rep 12:871-876, 2004.
    • (2004) Oncol Rep , vol.12 , pp. 871-876
    • Titu, L.V.1    Loveday, R.L.2    Madden, L.A.3    Cawkwell, L.4    Monson, J.R.5    Greenman, J.6
  • 18
    • 33747149328 scopus 로고    scopus 로고
    • Mature dendritic cells generated from patient-derived peripheral blood monocytes in one-step culture using streptococcal preparation OK-432 exert an enhanced antigen-presenting capacity
    • Naito K, Ueda Y, Itoh T, Fuji N, Shimizu K, Yano Y, Yamamoto Y, Imura K, Kohara J, Iwamoto A, et al: Mature dendritic cells generated from patient-derived peripheral blood monocytes in one-step culture using streptococcal preparation OK-432 exert an enhanced antigen-presenting capacity. Int J Oncol 28:1481-1489, 2006.
    • (2006) Int J Oncol , vol.28 , pp. 1481-1489
    • Naito, K.1    Ueda, Y.2    Itoh, T.3    Fuji, N.4    Shimizu, K.5    Yano, Y.6    Yamamoto, Y.7    Imura, K.8    Kohara, J.9    Iwamoto, A.10
  • 21
    • 84856805188 scopus 로고    scopus 로고
    • + regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis
    • + regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. J Neuroimmunol 242:39-46, 2012.
    • (2012) J Neuroimmunol , vol.242 , pp. 39-46
    • Chen, M.1    Chen, G.2    Deng, S.3    Liu, X.4    Hutton, G.J.5    Hong, J.6
  • 24
    • 0037126037 scopus 로고    scopus 로고
    • Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells
    • Hernandez J, Garcia-Pons F, Lone YC, Firat H, Schmidt JD, Langlade-Demoyen P and Zanetti M: Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells. Proc Natl Acad Sci USA 99:12275-12280, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12275-12280
    • Hernandez, J.1    Garcia-Pons, F.2    Lone, Y.C.3    Firat, H.4    Schmidt, J.D.5    Langlade-Demoyen, P.6    Zanetti, M.7
  • 28
    • 33745527109 scopus 로고    scopus 로고
    • Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma
    • DOI 10.1002/hep.21203
    • Mizukoshi E, Nakamoto Y, Marukawa Y, Arai K, Yamashita T, Tsuji H, Kuzushima K, Takiguchi M and Kaneko S: Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma. Hepatology 43:1284-1294, 2006. (Pubitemid 43980107)
    • (2006) Hepatology , vol.43 , Issue.6 , pp. 1284-1294
    • Mizukoshi, E.1    Nakamoto, Y.2    Marukawa, Y.3    Arai, K.4    Yamashita, T.5    Tsuji, H.6    Kuzushima, K.7    Takiguchi, M.8    Kaneko, S.9
  • 32
    • 79959769072 scopus 로고    scopus 로고
    • HTERT mRNA dendritic cell vaccination: Complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
    • Suso EM, Dueland S, Rasmussen AM, Vetrhus T, Aamdal S, Kvalheim G and Gaudernack G: hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes. Cancer Immunol Immunother 60:809-818, 2011.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 809-818
    • Suso, E.M.1    Dueland, S.2    Rasmussen, A.M.3    Vetrhus, T.4    Aamdal, S.5    Kvalheim, G.6    Gaudernack, G.7
  • 33
    • 35348887887 scopus 로고    scopus 로고
    • Characterization of a human telomerase reverse transcriptase sequence containing two antigenic epitopes with high affinity for human leucocyte antigen
    • DOI 10.1042/BA20060245
    • Wang J, Yu L, Li J, Deng R and Wang X: Characterization of a human telomerase reverse transcriptase sequence containing two antigenic epitopes with high affinity for human leucocyte antigen. Biotechnol Appl Biochem 48:93-99, 2007. (Pubitemid 47572186)
    • (2007) Biotechnology and Applied Biochemistry , vol.48 , Issue.2 , pp. 93-99
    • Wang, J.1    Yu, L.2    Li, J.3    Deng, R.4    Wang, X.5
  • 34
    • 0035176221 scopus 로고    scopus 로고
    • Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase
    • Vonderheide RH, Anderson KS, Hahn WC, Butler MO, Schultze JL and Nadler LM: Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase. Clin Cancer Res 7:3343-3348, 2001. (Pubitemid 33069964)
    • (2001) Clinical Cancer Research , vol.7 , Issue.11 , pp. 3343-3348
    • Vonderheide, R.H.1    Anderson, K.S.2    Hahn, W.C.3    Butler, M.O.4    Schultze, J.L.5    Nadler, L.M.6
  • 35
    • 0036569585 scopus 로고    scopus 로고
    • Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells
    • Schroers R, Huang XF, Hammer J, Zhang J and Chen SY: Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells. Cancer Res 62:2600-2605, 2002. (Pubitemid 34462740)
    • (2002) Cancer Research , vol.62 , Issue.9 , pp. 2600-2605
    • Schroers, R.1    Huang, X.F.2    Hammer, J.3    Zhang, J.4    Chen, S.-Y.5
  • 36
    • 0142157136 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes
    • Schroers R, Shen L, Rollins L, Rooney CM, Slawin K, Sonderstrup G, Huang XF and Chen SY: Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes. Clin Cancer Res 9:4743-4755, 2003. (Pubitemid 37323277)
    • (2003) Clinical Cancer Research , vol.9 , Issue.13 , pp. 4743-4755
    • Schroers, R.1    Shen, L.2    Rollins, L.3    Rooney, C.M.4    Slawin, K.5    Sonderstrup, G.6    Huang, X.F.7    Chen, S.-Y.8
  • 37
  • 38
    • 0028052724 scopus 로고
    • Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
    • Parker KC, Bednarek MA and Coligan JE: Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J Immunol 152:163-175, 1994.
    • (1994) J Immunol , vol.152 , pp. 163-175
    • Parker, K.C.1    Bednarek, M.A.2    Coligan, J.E.3
  • 39
    • 84859819967 scopus 로고    scopus 로고
    • Myeloid dendritic cells loaded with dendritic tandem multiple antigenic telomerase reverse transcriptase (hTERT) epitope peptides: A potentially promising tumor vaccine
    • Niu BL, Du HM, Shen H P, Lian ZR, Li JZ, Lai X, Wei SD, Zou LQ and Gong JP: Myeloid dendritic cells loaded with dendritic tandem multiple antigenic telomerase reverse transcriptase (hTERT) epitope peptides: a potentially promising tumor vaccine. Vaccine 30:3395-3404, 2012.
    • (2012) Vaccine , vol.30 , pp. 3395-3404
    • Niu, B.L.1    Du, H.M.2    Shen, H.P.3    Lian, Z.R.4    Li, J.Z.5    Lai, X.6    Wei, S.D.7    Zou, L.Q.8    Gong, J.P.9
  • 40
    • 33749345778 scopus 로고    scopus 로고
    • Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: A promising implication of telomerasedependent targeted cancer gene therapy
    • Murofushi Y, Nagano S, Kamizono J, Takahashi T, Fujiwara H, Komiya S, Matsuishi T and Kosai K: Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: a promising implication of telomerasedependent targeted cancer gene therapy. Int J Oncol 29:681-688, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 681-688
    • Murofushi, Y.1    Nagano, S.2    Kamizono, J.3    Takahashi, T.4    Fujiwara, H.5    Komiya, S.6    Matsuishi, T.7    Kosai, K.8
  • 41
    • 2542454709 scopus 로고    scopus 로고
    • Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter
    • DOI 10.1158/1078-0432.CCR-03-0512
    • Jacob D, Davis J, Zhu H, Zhang L, Teraishi F, Wu S, Marini FC III and Fang B: Suppressing orthotopic pancreatic tumor growth with a fiber-modified adenovector expressing the TRAIL gene from the human telomerase reverse transcriptase promoter. Clin Cancer Res 10:3535-3541, 2004. (Pubitemid 38685464)
    • (2004) Clinical Cancer Research , vol.10 , Issue.10 , pp. 3535-3541
    • Jacob, D.1    Davis, J.2    Zhu, H.3    Zhang, L.4    Teraishi, F.5    Wu, S.6    Marini III, F.C.7    Fang, B.8
  • 42
    • 0037148327 scopus 로고    scopus 로고
    • Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?
    • DOI 10.1038/sj/onc/1205163
    • Kyo S and Inoue M: Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? Oncogene 21:688-697, 2002. (Pubitemid 34146272)
    • (2002) Oncogene , vol.21 , Issue.4 , pp. 688-697
    • Kyo, S.1    Inoue, M.2
  • 44
    • 0037130460 scopus 로고    scopus 로고
    • A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo
    • DOI 10.1038/sj.onc.1205582
    • Gu J, Zhang L, Huang X, Lin T, Yin M, Xu K, Ji L, Roth JA and Fang B: A novel single tetracycline-regulative adenoviral vector for tumor-specific Bax gene expression and cell killing in vitro and in vivo. Oncogene 21:4757-4764, 2002. (Pubitemid 34879451)
    • (2002) Oncogene , vol.21 , Issue.31 , pp. 4757-4764
    • Gu, J.1    Zhang, L.2    Huang, X.3    Lin, T.4    Yin, M.5    Xu, K.6    Ji, L.7    Roth, J.A.8    Fang, B.9
  • 45
    • 35148876642 scopus 로고    scopus 로고
    • Lentiviral vector mediated siRNA knock-down of hTERT results in diminished capacity in invasiveness and in vivo growth of human glioma cells in a telomere length-independent manner
    • Zhao P, Wang C, Fu Z, You Y, Cheng Y, Lu X, Lu A, Liu N, Pu P, Kang C, Salford LG and Fan X: Lentiviral vector mediated siRNA knock-down of hTERT results in diminished capacity in invasiveness and in vivo growth of human glioma cells in a telomere length-independent manner. Int J Oncol 31:361-368, 2007.
    • (2007) Int J Oncol , vol.31 , pp. 361-368
    • Zhao, P.1    Wang, C.2    Fu, Z.3    You, Y.4    Cheng, Y.5    Lu, X.6    Lu, A.7    Liu, N.8    Pu, P.9    Kang, C.10    Salford, L.G.11    Fan, X.12
  • 46
    • 79957582182 scopus 로고    scopus 로고
    • Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo
    • Liu X, Huang H, Wang J, Wang C, Wang M, Zhang B and Pan C: Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. Biochem Pharmacol 82:17-23, 2011.
    • (2011) Biochem Pharmacol , vol.82 , pp. 17-23
    • Liu, X.1    Huang, H.2    Wang, J.3    Wang, C.4    Wang, M.5    Zhang, B.6    Pan, C.7
  • 47
    • 34247167211 scopus 로고    scopus 로고
    • Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment
    • DOI 10.1016/j.bcp.2007.01.035, PII S0006295207000640
    • Gandellini P, Folini M, Bandiera R, De Cesare M, Binda M, Veronese S, Daidone MG, Zunino F and Zaffaroni N: Downregulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairment. Biochem Pharmacol 73:1703-1714, 2007. (Pubitemid 46601404)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.11 , pp. 1703-1714
    • Gandellini, P.1    Folini, M.2    Bandiera, R.3    De Cesare, M.4    Binda, M.5    Veronese, S.6    Daidone, M.G.7    Zunino, F.8    Zaffaroni, N.9
  • 48
    • 77956453939 scopus 로고    scopus 로고
    • Cancer therapy via modulation of micro RNA levels: A promising future
    • Kota SK and Balasubramanian S: Cancer therapy via modulation of micro RNA levels: a promising future. Drug Discov Today 15:733-740, 2010.
    • (2010) Drug Discov Today , vol.15 , pp. 733-740
    • Kota, S.K.1    Balasubramanian, S.2
  • 49
    • 27744446137 scopus 로고    scopus 로고
    • Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway
    • Hao ZM, Luo JY, Cheng J, Li L, He D, Wang QY and Yang GX: Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway. Cancer Biol Ther 4:1098-1103, 2005. (Pubitemid 41598564)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.10 , pp. 1098-1103
    • Hao, Z.-M.1    Luo, J.-Y.2    Cheng, J.3    Li, L.4    He, D.5    Wang, Q.-Y.6    Yang, G.-X.7
  • 50
    • 0035878750 scopus 로고    scopus 로고
    • Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells
    • Sachsinger J, Gonzalez-Suarez E, Samper E, Heicappell R, Muller M and Blasco MA: Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells. Cancer Res 61:5580-5586, 2001. (Pubitemid 32694946)
    • (2001) Cancer Research , vol.61 , Issue.14 , pp. 5580-5586
    • Sachsinger, J.1    Gonzalez-Suarez, E.2    Samper, E.3    Heicappell, R.4    Muller, M.5    Blasco, M.A.6
  • 51
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Models, mechanisms and implications
    • Cesare AJ and Reddel RR: Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 11:319-330, 2010.
    • (2010) Nat Rev Genet , vol.11 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.