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Volumn 11, Issue 20, 2012, Pages 3745-3749

Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae

Author keywords

Budding yeast; Kinases; Lipids; Rapamycin; Signal transduction

Indexed keywords


EID: 84868036605     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.21752     Document Type: Review
Times cited : (30)

References (30)
  • 1
    • 84857131380 scopus 로고    scopus 로고
    • Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    • PMID:22307609; http://dx.doi.org/10.1073/pn a s.11175 6 310 9
    • Niles BJ, Mogri H, Hill A, Vlahakis A, Powers T. Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proc Natl Acad Sci USA 2012;109:1536-41; PMID:22307609; http://dx.doi.org/10.1073/pn a s.11175 6 310 9.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1536-1541
    • Niles, B.J.1    Mogri, H.2    Hill, A.3    Vlahakis, A.4    Powers, T.5
  • 2
    • 83455177213 scopus 로고    scopus 로고
    • Target of rapamycin (TOR) in nutrient signaling and growth control
    • PMID:22174183; http://dx.doi.org/10.1534/genetics.111.133363
    • Loewith R, Hall MN. Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 2011;189:1177-201; PMID:22174183; http://dx.doi.org/10. 1534/genetics.111.133363.
    • (2011) Genetics , vol.189 , pp. 1177-1201
    • Loewith, R.1    Hall, M.N.2
  • 3
    • 0029020282 scopus 로고
    • Protein kinases 6. The eukary-otic protein kinase superfamily: Kinase (catalytic) domain structure and classification
    • PMID:7768349
    • Hanks SK, Hunter T. Protein kinases 6. The eukary-otic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 1995;9:576-96; PMID:7768349.
    • (1995) FASEB J , vol.9 , pp. 576-596
    • Hanks, S.K.1    Hunter, T.2
  • 4
    • 58649092475 scopus 로고    scopus 로고
    • MTOR complex 2 (mTORC2) controls hydrophobic motif phos-phorylation and activation of serum-and glucocor-ticoid-induced protein kinase 1 (SGK1)
    • PMID:18925875; http://dx.doi.org/10.1042/BJ20081668
    • García-Martínez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phos-phorylation and activation of serum-and glucocor-ticoid-induced protein kinase 1 (SGK1). Biochem J 2008;416:375-85; PMID:18925875; http://dx.doi.org/10.1042/BJ20081668.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • García-Martínez, J.M.1    Alessi, D.R.2
  • 5
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101; PMID:15718470; http://dx.doi.org/10.1126/science.1106148. (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 6
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • DOI 10.1016/S0092-8674(02)00833-4
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-89; PMID:12150926; http://dx.doi.org/10.1016/S0092-8674 (02) 00833-4. (Pubitemid 34876546)
    • (2002) Cell , vol.110 , Issue.2 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.-I.4    Oshiro, N.5    Hidayat, S.6    Tokunaga, C.7    Avruch, J.8    Yonezawa, K.9
  • 7
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • DOI 10.1128/MCB.22.17.6247-6260.2002
    • Scheid MP, Marignani PA, Woodgett JR. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 2002;22:6247-60; PMID:12167717; http://dx.doi.org/10.1128/MCB.22.17.6247-6260. 2002. (Pubitemid 34857843)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.17 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 8
    • 34447648371 scopus 로고    scopus 로고
    • 2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions
    • DOI 10.1152/ajprenal.00027.2007
    • Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, et al. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phos-phoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol 2007;292:F1741-50; PMID:17356130; http://dx.doi.org/10.1152/ajprenal.00027.2007. (Pubitemid 47105364)
    • (2007) American Journal of Physiology - Renal Physiology , vol.292 , Issue.6
    • Pao, A.C.1    McCormick, J.A.2    Li, H.3    Siu, J.4    Govaerts, C.5    Bhalla, V.6    Soundararajan, R.7    Pearce, D.8
  • 9
    • 0035882103 scopus 로고    scopus 로고
    • The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
    • DOI 10.1093/emboj/20.16.4380
    • Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J 2001;20:4380-90; PMID:11500365; http://dx.doi.org/10.1093/emboj/20.16.4380. (Pubitemid 32772032)
    • (2001) EMBO Journal , vol.20 , Issue.16 , pp. 4380-4390
    • Biondi, R.M.1    Kieloch, A.2    Currie, R.A.3    Deak, M.4    Alessi, D.R.5
  • 12
    • 84860501617 scopus 로고    scopus 로고
    • Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
    • PMID:22504275; http://dx.doi.org/10.1038/ncb2480
    • Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, et al. Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 2012;14:542-7; PMID:22504275; http://dx.doi.org/10.1038/ncb2480.
    • (2012) Nat Cell Biol , vol.14 , pp. 542-547
    • Berchtold, D.1    Piccolis, M.2    Chiaruttini, N.3    Riezman, I.4    Riezman, H.5    Roux, A.6
  • 13
    • 82755163564 scopus 로고    scopus 로고
    • Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cere-visiae
    • PMID:22080611; http://dx.doi.org/10.1073/pna s.1116948108
    • Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J. Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cere-visiae. Proc Natl Acad Sci USA 2011;108:19222-7; PMID:22080611; http://dx.doi.org/10.1073/pna s.1116948108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19222-19227
    • Roelants, F.M.1    Breslow, D.K.2    Muir, A.3    Weissman, J.S.4    Thorner, J.5
  • 14
    • 63749117393 scopus 로고    scopus 로고
    • TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain
    • PMID:19144819; http://dx.doi.org/10.1091/mbc. E08-10-1001
    • Berchtold D, Walther TC. TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell 2009;20:1565-75; PMID:19144819; http://dx.doi.org/10.1091/mbc. E08-10-1001.
    • (2009) Mol Biol Cell , vol.20 , pp. 1565-1575
    • Berchtold, D.1    Walther, T.C.2
  • 15
    • 12344298783 scopus 로고    scopus 로고
    • Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells
    • DOI 10.1242/jcs.01493
    • Malinska K, Malinsky J, Opekarova M, Tanner W. Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells. J Cell Sci 2004;117:6031-41; PMID:15536122; http://dx.doi.org/10.1242/jcs.01493. (Pubitemid 40123969)
    • (2004) Journal of Cell Science , vol.117 , Issue.25 , pp. 6031-6041
    • Malinska, K.1    Malinsky, J.2    Opekarova, M.3    Tanner, W.4
  • 16
    • 33644503549 scopus 로고    scopus 로고
    • Eisosomes mark static sites of endocytosis
    • DOI 10.1038/nature04472, PII N04472
    • Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature 2006;439:998-1003; PMID:16496001; http://dx.doi.org/10.1038/nature04472. (Pubitemid 43292420)
    • (2006) Nature , vol.439 , Issue.7079 , pp. 998-1003
    • Walther, T.C.1    Brickner, J.H.2    Aguilar, P.S.3    Bernales, S.4    Pantoja, C.5    Walter, P.6
  • 17
    • 33746506061 scopus 로고    scopus 로고
    • The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
    • DOI 10.1128/MCB.02403-05
    • Tabuchi M, Audhya A, Parsons AB, Boone C, Emr SD. The phosphatidylinositol 4, 5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol 2006;26:5861-75; PMID:16847337; http://dx.doi.org/10.1128/MCB.02403-05. (Pubitemid 44134340)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.15 , pp. 5861-5875
    • Tabuchi, M.1    Audhya, A.2    Parsons, A.B.3    Boone, C.4    Emr, S.D.5
  • 18
    • 6344265083 scopus 로고    scopus 로고
    • 2 effectors that regulate the actin cytoskeleton
    • DOI 10.1038/sj.emboj.7600384
    • Audhya A, Loewith R, Parsons AB, Gao L, Tabuchi M, Zhou H, et al. Genome-wide lethality screen identifies new PI4, 5P2 effectors that regulate the actin cytoskeleton. EMBO J 2004;23:3747-57; PMID:15372071; http://dx.doi.org/ 10.1038/sj.emboj.7600384. (Pubitemid 39389706)
    • (2004) EMBO Journal , vol.23 , Issue.19 , pp. 3747-3757
    • Audhya, A.1    Loewith, R.2    Parsons, A.B.3    Gao, L.4    Tabuchi, M.5    Zhou, H.6    Boone, C.7    Hall, M.N.8    Emr, S.D.9
  • 19
    • 0031438164 scopus 로고    scopus 로고
    • Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
    • Stathopoulos AM, Cyert MS. Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev 1997;11:3432-44; PMID:9407035; http://dx.doi. or g/10.1101/g a d.11. 2 4. 3 4 32. (Pubitemid 28023965)
    • (1997) Genes and Development , vol.11 , Issue.24 , pp. 3432-3444
    • Stathopoulos, A.M.1    Cyert, M.S.2
  • 21
    • 0036734541 scopus 로고    scopus 로고
    • Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity
    • DOI 10.1091/mbc.E02-04-0201
    • Roelants FM, Torrance PD, Bezman N, Thorner J. Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 2002;13:3005-28; PMID:12221112; http://dx.doi.org/10.1091/mbc. E02-04-0201. (Pubitemid 35034242)
    • (2002) Molecular Biology of the Cell , vol.13 , Issue.9 , pp. 3005-3028
    • Roelants, F.M.1    Torrance, P.D.2    Bezman, N.3    Thorner, J.4
  • 22
    • 0343130542 scopus 로고    scopus 로고
    • Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast
    • DOI 10.1128/MCB.20.12.4411-4419.2000
    • Sun Y, Taniguchi R, Tanoue D, Yamaji T, Takematsu H, Mori K, et al. Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol Cell Biol 2000;20:4411-9; PMID:10825204; http://dx.doi.org/10.1128/MCB.20.12.4411-4419. 2000. (Pubitemid 30346635)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.12 , pp. 4411-4419
    • Yidi, S.1    Taniguchi, R.2    Tanoue, D.3    Yamaji, T.4    Takematsu, H.5    Mori, K.6    Fujita, T.7    Kawasaki, T.8    Kozutsumi, Y.9
  • 23
    • 0033602281 scopus 로고    scopus 로고
    • Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
    • DOI 10.1016/S0960-9822(99)80088-8
    • Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 1999;9:186-97; PMID:10074427; http://dx.doi.org/10.1016/S0960-9822 (99) 80088-8. (Pubitemid 29120382)
    • (1999) Current Biology , vol.9 , Issue.4 , pp. 186-197
    • Casamayor, A.1    Torrance, P.D.2    Kobayashi, T.3    Thorner, J.4    Alessi, D.R.5
  • 24
    • 38649105202 scopus 로고    scopus 로고
    • Regulation of ceramide biosynthesis by TOR complex 2
    • DOI 10.1016/j.cmet.2007.11.015, PII S1550413107003725
    • Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, et al. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 2008;7:148-58; PMID:18249174; http://dx.doi.org/10.1016/j.cmet.2007.11.015. (Pubitemid 351168557)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 148-158
    • Aronova, S.1    Wedaman, K.2    Aronov, P.A.3    Fontes, K.4    Ramos, K.5    Hammock, B.D.6    Powers, T.7
  • 25
    • 77649121162 scopus 로고    scopus 로고
    • Orm family proteins mediate sphingolipid homeostasis
    • PMID:20182505; http://dx.doi.org/10.1038/nature08787
    • Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, et al. Orm family proteins mediate sphingolipid homeostasis. Nature 2010;463:1048-53; PMID:20182505; http://dx.doi.org/10.1038/nature08787.
    • (2010) Nature , vol.463 , pp. 1048-1053
    • Breslow, D.K.1    Collins, S.R.2    Bodenmiller, B.3    Aebersold, R.4    Simons, K.5    Shevchenko, A.6
  • 26
    • 84862571264 scopus 로고    scopus 로고
    • Orm protein phosphoregula-tion mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways
    • PMID:22535525; http://dx.doi.org/10.1091/mbc. E12-03-0209
    • Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, et al. Orm protein phosphoregula-tion mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell 2012;23:2388-98; PMID:22535525; http://dx.doi.org/10.1091/mbc. E12-03-0209.
    • (2012) Mol Biol Cell , vol.23 , pp. 2388-2398
    • Sun, Y.1    Miao, Y.2    Yamane, Y.3    Zhang, C.4    Shokat, K.M.5    Takematsu, H.6
  • 27
    • 33846147991 scopus 로고    scopus 로고
    • The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress
    • DOI 10.1128/MCB.00461-06
    • Daquinag A, Fadri M, Jung SY, Qin J, Kunz J. The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Mol Cell Biol 2007;27:633-50; PMID:17101780; http://dx.doi.org/10.1128/ MCB.00461-06. (Pubitemid 46080130)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.2 , pp. 633-650
    • Daquinag, A.1    Fadri, M.2    Jung, S.Y.3    Qin, J.4    Kunz, J.5
  • 28
    • 23044500717 scopus 로고    scopus 로고
    • Mutant kinesin-2 motor subunits increase chromosome loss
    • DOI 10.1091/mbc.
    • Fadri M, Daquinag A, Wang S, Xue T, Kunz J. The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4, 5-bisphosphate and TORC2. Mol Biol Cell 2005;16:1883-900; PMID:15689497; http://dx.doi.org/10.1091/mbc. E04-07-0564. (Pubitemid 41077089)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.8 , pp. 3810-3820
    • Miller, M.S.1    Esparza, J.M.2    Lippa, A.M.3    Lux III, F.G.4    Cole, D.G.5    Dutcher, S.K.6
  • 29
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • PMID:21376236; http://dx.doi.org/10.1016/j.cell.2011.02.014
    • Zinzalla V, Stracka D, Oppliger W, Hall MN. Activation of mTORC2 by association with the ribosome. Cell 2011;144:757-68; PMID:21376236; http://dx.doi.org/10.1016/j.cell.2011.02.014.
    • (2011) Cell , vol.144 , pp. 757-768
    • Zinzalla, V.1    Stracka, D.2    Oppliger, W.3    Hall, M.N.4
  • 30
    • 8744281675 scopus 로고    scopus 로고
    • Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1p Rtg3p-dependent target genes
    • DOI 10.1074/jbc.M409012200
    • Dilova I, Aronova S, Chen JC, Powers T. Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1. Rtg3p-dependent target genes. J Biol Chem 2004;279:46527-35; PMID:15326168; http://dx.doi.org/10.1074/jbc. M409012200. (Pubitemid 39518296)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.45 , pp. 46527-46535
    • Dilova, I.1    Aronova, S.2    Chen, J.C.-Y.3    Powers, T.4


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