Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex

Diabetes

Volumn 61, Issue 11, 2012, Pages 2823-2832

  Nakatsuka, Atsuko ^a   Wada, Jun ^a   Iseda, Izumi ^a   Teshigawara, Sanae ^a   Higashio, Kanji ^b   Murakami, Kazutoshi ^a   Kanzaki, Motoko ^a   Inoue, Kentaro ^a   Terami, Takahiro ^a   Katayama, Akihiro ^a   Hida, Kazuyuki ^a   Eguchi, Jun ^a   Horiguchi, Chikage Sato ^a   Ogawa, Daisuke ^a   Matsuki, Yasushi ^c   Hiramatsu, Ryuji ^c   Yagita, Hideo ^d   Kakuta, Shigeru ^e   Iwakura, Yoichiro ^e,f   Makino, Hirofumi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Metabolome Pharmaceuticals Inc   (Japan)

^c Genomic Science Laboratories   (Japan)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN DNAJ; PROTEIN KINASE B; VASPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM; FATTY LIVER; GLUCOSE INTOLERANCE; HUMAN; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ADIPOKINES; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; HEPATOCYTES; HSP40 HEAT-SHOCK PROTEINS; HUMANS; INTRA-ABDOMINAL FAT; LIGANDS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM PROTEINS; OBESITY; PROTEIN TRANSPORT; RATS; RECOMBINANT PROTEINS; SERPINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84868016006     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0232     Document Type: Article

References (30)

1. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917
2. Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004;306:457-461
3. Ozawa K, Miyazaki M, Matsuhisa M, et al. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 2005; 54:657-663
4. Nakatani Y, Kaneto H, Kawamori D, et al. Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 2005;280: 847-851
5. Ye R, Jung DY, Jun JY, et al. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes 2010;59:6-16
6. Kammoun HL, Chabanon H, Hainault I, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009;119:1201-1215
7. Wada J. Vaspin: a novel serpin with insulin-sensitizing effects. Expert Opin Investig Drugs 2008;17:327-333
8. Hida K, Wada J, Eguchi J, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 2005;102:10610-10615
9. Blüher M. Vaspin in obesity and diabetes: pathophysiological and clinical significance. Endocrine 2012;41:176-182
10. Chang HM, Lee HJ, Park HS, et al. Effects of weight reduction on serum vaspin concentrations in obese subjects: modification by insulin resistance. Obesity (Silver Spring) 2010;18:2105-2110
11. Youn BS, Klöting N, Kratzsch J, et al. Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes 2008;57:372-377
12. Tan BK, Heutling D, Chen J, et al. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance. Diabetes 2008;57:1501-1507
13. Seeger J, Ziegelmeier M, Bachmann A, et al. Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. J Clin Endocrinol Metab 2008;93:247-251
14. Hensley LL, Ranganathan G, Wagner EM, et al. Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation. J Biol Chem 2003;278:32702-32709
15. Horai R, Asano M, Sudo K, et al. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 1998;187:1463-1475
16. Zhang Y, Wada J, Yasuhara A, et al. The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells. PLoS ONE 2007;2:e414
17. Yilmaz Y. Circulating vaspin and its relationship with insulin sensitivity, adiponectin and liver histology in subjects with non-alcoholic steatohepatitis. Scand J Gastroenterol 2012;47:489-490
18. Zhang LH, Zhang X. Roles of GRP78 in physiology and cancer. J Cell Biochem 2010;110:1299-1305
19. Sato M, Yao VJ, Arap W, Pasqualini R. GRP78 signaling hub a receptor for targeted tumor therapy. Adv Genet 2010;69:97-114
20. Gonzalez-Gronow M, Selim MA, Papalas J, Pizzo SV. GRP78: a multifunctional receptor on the cell surface. Antioxid Redox Signal 2009;11:2299-2306
21. Quinones QJ, de Ridder GG, Pizzo SV. GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. Histol Histopathol 2008;23:1409-1416
22. Misra UK, Pizzo SV. Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. Apoptosis 2010;15:173-182
23. Misra UK, Sharma T, Pizzo SV. Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. J Immunol 2005;175:2525-2533
24. Misra UK, Gonzalez-Gronow M, Gawdi G, Pizzo SV. The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. J Immunol 2005;174:2092-2097
25. Misra UK, Deedwania R, Pizzo SV. Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. J Biol Chem 2005;280:26278-26286
26. Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol 2008;28:666-677
27. Philippova M, Ivanov D, Joshi MB, et al. Identification of proteins associating with glycosylphosphatidylinositol-anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. Mol Cell Biol 2008;28:4004-4017
28. Lu MC, Lai NS, Yu HC, Huang HB, Hsieh SC, Yu CL. Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production. Arthritis Rheum 2010;62:1213-1223
29. Phalitakul S, Okada M, Hara Y, Yamawaki H. Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-kB and PKCu activation in cultured rat vascular smooth muscle cells. Pharmacol Res 2011;64:493-500
30. Gonzalez-Gronow M, Cuchacovich M, Llanos C, Urzua C, Gawdi G, Pizzo SV. Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. Cancer Res 2006;66:11424-11431