Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78

Apoptosis

Volumn 15, Issue 2, 2010, Pages 173-182

  Misra, U K ^a   Pizzo, S V ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antibody directed against the COOH terminal domain of GRP78; Apoptosis of cancer cells; The unfolded protein response; The unfolded protein response in prostate cancer; Upregulation of GADD153, PARP 1, and Erdj5

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTIBODY; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN; PROTEIN ERDJ5; PROTEIN IRE1; PROTEIN PERK; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FOLDING; SIGNAL TRANSDUCTION;

ANTIBODIES; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL LINE, TUMOR; DOWN-REGULATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOBLOTTING; MALE; MEMBRANE PROTEINS; NEOPLASM PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 77949273353     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0430-y     Document Type: Article

References (54)

1. Wang M, Wey S, Zhang Y, Risheng Ye, Lee AS (2009) Role of the unfolded protein response regulator GRP78/BiP in development, cancer and neurologic disorders. Antioxid Redox Signal. doi: 10.1089/ars.2009.2485
2. I Kim W Xu JC Reed 2008 Cell death and endoplasmic reticulum stress: disease relevance and the therapeutic opportunities Nat Rev Drug Discov 7 1013 1030 10.1038/nrd2755 1:CAS:528:DC%2BD1cXhsVenu7%2FM 19043451
3. JD Malhotra RJ Kaufman 2007 The endoplasmic reticulum and the unfolded protein responses Sem Cell Dev Biol 18 716 731 10.1016/j.semcdb.2007.09.003 1:CAS:528:DC%2BD2sXhtlGjtrrN (Pubitemid 350138453)
4. Y Ma LM Hendershot 2004 The role of the unfolded protein responsei n tumour development: friend or foe Nat Rev Cancer 4 966 977 10.1038/nrc1505 1:CAS:528:DC%2BD2cXhtVarsLjI 15573118 (Pubitemid 39626220)
5. R Kim M Emi K Tanabe S MuraKami 2006 Role of the unfolded protein response in cell death Apoptosis 11 5 13 10.1007/s10495-005-3088-0 1:CAS:528:DC%2BD28XovFygtQ%3D%3D 16374548 (Pubitemid 43151639)
6. J Wu RJ Kaufman 2006 From acute stress to physiological roles of the unfolded protein response Cell Death Differ 13 374 384 10.1038/sj.cdd.4401840 1:CAS:528:DC%2BD28Xhtl2mtL0%3D 16397578
7. T Yoneda K Imaizumi K Oono D Yui F Gomi T Katayama M Tokyama 2001 Activation of caspase-12 an endoplasmic reticulum (ER) resident caspase through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to ER stress J Biol Chem 276 13935 13940 1:CAS:528:DC%2BD3MXjt12rsr0%3D 11278723
8. RV Rao A Peel A Logvinova G delRio E Hermel T Yokota PC Goldsmith LM Ellerby HM Ellerby DE Bredesen 2002 Coupling endoplasmic reticulum stress to the cell death prognosis role of ER chaperone GRP78 FEBS Lett 514 122 128 1:CAS:528:DC%2BD38Xis1ejsbY%3D 11943137
9. J Hitomi T Katayama Y Eguchi T Kudo M Taniguchi Y Koyama T Manabe S Yamagishi Y Bando K Imaizumi Y Tsujimoto M Tokyama 2004 Involvement of caspase-4 in endoplasmic Aβ-induced cell death J Cell Biol 165 347 356 10.1083/jcb.200310015 1:CAS:528:DC%2BD2cXjvFKjs74%3D 15123740 (Pubitemid 38649910)
10. HP Harding Y Zhang A Bertolotti H Zeng D Ron 2000 Perk is essential for translational regulation and cell survival during unfolded protein response Mol Cell 5 897 904 10.1016/S1097-2765(00)80330-5 1:CAS:528:DC%2BD3cXjsl2ku7c%3D 10882126
11. K Zhang RJ Kaufman 2008 From the endoplasmic-reticulum stress to the inflammatory response Nature 454 455 462 10.1038/nature07203 1:CAS:528:DC%2BD1cXovV2mtbo%3D 18650916
12. PD Lu HP Harding D Ron 2004 Translation retinitiation at alternative open reading frames regulates gene expression in an integrated stress response J Cell Biol 167 27 33 10.1083/jcb.200408003 1:CAS:528:DC%2BD2cXosVOiurc%3D 15479734 (Pubitemid 39363411)
13. HP Harding Y Zhang H Zeng I Novoa PD Lu M Calton N Sadri C Yun B Popko R Paules DF Stojdl JC Bell T Hettmann JM Leiden D Ron 2003 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress Mol Cell 11 619 633 10.1016/S1097-2765(03)00105-9 1:CAS:528:DC%2BD3sXjtVWkt74%3D 12667446 (Pubitemid 36385118)
14. DT Rutkowski RJ Kaufman 2003 All roads lead to ATF4 Dev Cell 4 442 444 10.1016/S1534-5807(03)00100-X 1:CAS:528:DC%2BD3sXjtFSmt7c%3D 12689582 (Pubitemid 36437550)
15. Y Ma LM Hendershot 2003 Delination of the negative feedback regulatory loop that controls protein translation during ER stress J Biol Chem 278 34864 34873 10.1074/jbc.M301107200 1:CAS:528:DC%2BD3sXntVWqsb8%3D 12840028 (Pubitemid 37102245)
16. DT Rutkowski SM Arnold CN Miller J Wu J Lu KM Gunnison K Mori AA Sadighi Akha D Raden J Kaufman 2006 Adaptation to ER stress is mediated by differential stabilities and prosurvival and pro-apoptotic mRNAs and proteins PLoS Biol 4 2024 2041 10.1371/journal.pbio.0040374 1:CAS:528:DC%2BD28XhtlenurrF (Pubitemid 44760017)
17. HO Puthalakath LA Reilly P Gunn L Lee PN Kelly ND Huntington PD Hughes EM Michalak J McKimm-Breschkin N Motoyama T Gotoh S Akira P Bouillet A Strasser 2007 ER stress triggers apoptosis by activating BH3-only protein BIM Cell 129 1337 1349 10.1016/j.cell.2007.04.027 1:CAS:528:DC%2BD2sXotV2hsLw%3D 17604722 (Pubitemid 46962086)
18. KE Ewings CM Wiggins SJ Cook 2007 BIM and the pro-survival BCl-2 proteins. Opposite attract, ERK repels Cell Cycle 6 2236 2240 1:CAS:528:DC%2BD2sXhtlKkt7rE 17881896
19. R Ley KE Ewings K Hadfield SJ Cook 2005 Regulatory phosphorylation of BIM: sorting out at the ERK from JNK Cell Death Differen 12 1008 1014 10.1038/sj.cdd.4401688 1:CAS:528:DC%2BD2MXmtVylsr4%3D (Pubitemid 41065418)
20. DW Koh TM Dawson VL Dawson 2005 Mediation of cell death by poly(ADP-ribose) polymerase Pharmacol Res 52 5 14 10.1016/j.phrs.2005.02.011 1:CAS:528:DC%2BD2MXks1Wltrg%3D 15911329 (Pubitemid 40725595)
21. JT Heeres PJ Hergenrother 2007 Poly(ADP-ribose) makes a date with death Curr Opin Chem Biol 11 644 653 10.1016/j.cbpa.2007.08.038 1:CAS:528: DC%2BD2sXhtlyrtbrJ 17936669 (Pubitemid 350180567)
22. A Fassio R Sitia 2002 Formation: isomerization and reductional disulphide bonds during protein quality control in the endoplasmic reticulum Histochem Cell Biol 117 151 157 10.1007/s00418-001-0364-0 1:CAS:528:DC%2BD38Xht1yktr8%3D 11935291 (Pubitemid 34185621)
23. CG Thomas G Spyron 2009 Erdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis J Biol Chem 284 6282 6290 10.1074/jbc.M806189200 1:CAS:528:DC%2BD1MXisVSktbY%3D 19122239
24. R Ushioda J Hoseki K Araki G Jonson DY Thomas K Nagata 2008 Erdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER Science 321 569 572 10.1126/science.1159293 1:CAS:528:DC%2BD1cXoslGht78%3D 18653895
25. Y Fu AS Lee 2006 Glucose regulated protein in cancer progression, drug resistance and immunotherapy Cancer Biol Ther 5 741 744 1:CAS:528: DC%2BD28XhtVOju77I 16861902
26. J Li AS Lee 2006 Stress induction of GRP78/BiP and its role in cancer Curr Mol Med 6 45 54 10.2174/156652406775574523 1:CAS:528:DC%2BD28Xislygtr4%3D 16472112
27. D Dong M Ni J Li S Xiong W Ye JJ Virrey C Mao R Ye M Wang L Peri L Dubean S Groshen FM Hofman AS Lee 2008 Critical role of the stress chaperone GRP78 BiP in tumor proliferation survival and tumor angiogenesis in transgene-induced mammary tumro devleopment Cancer Res 68 498 505 10.1158/0008-5472.CAN-07-2950 1:CAS:528:DC%2BD1cXmt1OmsQ%3D%3D 18199545
28. MA Arap J Lahderiranta PJ Mintz A Hajiton AS Sarkis W Arap R Pasqualini 2004 Cell surface expression of the stress response chapterone GRP78 enable tumor targeting by circulating ligands Cancer Cell 6 275 284 10.1016/j.ccr.2004.08.018 1:CAS:528:DC%2BD2cXot1Kis7c%3D 15380518 (Pubitemid 39222040)
29. 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with but not necessary for GRP78-mediated signal transduction J Biol Chem 277 42082 42087 10.1074/jbc.M206174200 1:CAS:528:DC%2BD38XotF2gt7k%3D 12194978 (Pubitemid 35257523)
30. 2M- stimulated macrophages J Cell Biochem 104 96 104 10.1002/jcb.21607 1:CAS:528:DC%2BD1cXhtFantrbE 18213612
31. 2- macroglobulin-dependent signaling J Immunol 174 2092 2097 1:CAS:528: DC%2BD2MXhtV2rsLY%3D 15699139
32. 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages Biochem J 290 885 891 1:CAS:528:DyaK3sXhs1Grs7c%3D 7681282
33. 2-macroglobulin receptor J Biol Chem 269 12541 12547 1:CAS:528:DyaK2cXivFCqu74%3D 7513689
34. 2-macroglobulin signaling receptor activates phosphatidyl inositol 3-kinase J Biol Chem 273 13399 13402 10.1074/jbc.273.22.13399 1:CAS:528:DyaK1cXjvVejsb0%3D 9593670 (Pubitemid 28268376)
35. 2M-induced signaling Cell Signal 16 929 938 10.1016/j.cellsig.2003.09.010 15157672 (Pubitemid 38058631)
36. 2-macroglobulin to the cell surface GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK J Biol Chem 280 26278 27286 10.1074/jbc.M414467200 1:CAS:528:DC%2BD2MXlvFymtLg%3D 15908432 (Pubitemid 41022225)
37. UK Misra R Deedwania SV Pizzo 2006 Activation and crosstalk between Akt, NF-kappa B and unfolded protein response signaling in 1-LN prostate cancer cells consequent to the ligation of cell surface GRP78 J Biol Chem 281 13694 13707 10.1074/jbc.M511694200 1:CAS:528:DC%2BD28Xkt1ymtbs%3D 16543232 (Pubitemid 43855285)
38. M Goznalez-Gronow M Cuchacovich C Llanos C Urzua G Gawdi SV Pizzo 2006 Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum Cancer Res 66 11424 11431 10.1158/0008-5472.CAN-06-1721 (Pubitemid 46009974)
39. DJ Mintz J Kim K-A Do X Wang RG Zinner M Cristofanilli MA Arap WK Hong P Troncoso CJ Logothetis R Pasqualini W Arap 2003 Finger printing the circulating repertoire of antibodies from cancer patients Nat Biotechnol 21 57 63 10.1038/nbt774 1:CAS:528:DC%2BD3sXhvV2l 12496764 (Pubitemid 36055828)
40. UK Misra Y Mowery S Kaczowka SV Pizzo 2009 Ligation of cell surface GRP78 with antibodies directed against its COOH-terminal domain upregulates p53 activity and promotes apoptosis Mol Cancer Therap 8 1350 1362 10.1158/1535-7163.MCT-08-0990 1:CAS:528:DC%2BD1MXmtlGqt70%3D
41. UK Misra F Wang SV Pizzo 2009 Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells J Cell Biochem 106 381 389 10.1002/jcb.22016 1:CAS:528:DC%2BD1MXhvVyhur0%3D 19097122
42. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding Anal Biochem 72 248 254 10.1016/0003-2697(76)90527-3 1:CAS:528: DyaE28XksVehtrY%3D 942051
43. DM Schewe JA Aguirre-Ghiso 2008 ATF6-alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo Proc Natl Acad Sci USA 105 10519 10524 10.1073/pnas.0800939105 1:CAS:528:DC%2BD1cXpsVGmur0%3D 18650380
44. D Ron P Walter 2007 Signal integration in the endoplasmic reticuloum unfolded protein response Nat Rev Mol Cell Biol 8 519 529 10.1038/nrm2199 1:CAS:528:DC%2BD2sXmvVaktLY%3D 17565364 (Pubitemid 46985379)
45. S Oyadomari M Mori 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress Cell Death Differ 11 381 389 10.1038/sj.cdd.4401373 1:CAS:528: DC%2BD2cXit12ntbc%3D 14685163 (Pubitemid 38489416)
46. C Hetz P Bernasconi J Fisher A-H Lee MC Bassik B Antonsson GS Brandt NN Iwakoshi A Schnizel LH Glicher SJ Koresemeyer 2006 Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRIα Science 312 572 576 10.1126/science.1123480 1:CAS:528:DC%2BD28XjvVGktbw%3D 16645094
47. P Pinton C Giorgi R Siviero E Zecchini R Rizzuto 2008 Calcium and apoptosis: ER-mitochondria transfer in the control of apoptosis Oncogene 27 6407 6418 10.1038/onc.2008.308 1:CAS:528:DC%2BD1cXht12ltLvL 18955969
48. T Suzuki J Lu M Zahed K Kita N Suzuki 2007 Reduction of GPR78 expression with SiRNA activates unfolded protein response leading to apoptosis in HeLa cells Arch Biochem Biophy 468 1 14 10.1016/j.abb.2007.09.004 1:CAS:528:DC%2BD2sXhtlajsL%2FN (Pubitemid 350087841)
49. N Rauschert S Brandlein E Holzinger F Hensel H-K Muller-Hermelink HP Vollmers 2008 A new tumor specific variant of GRP78 as target for antibody-based therapy Lab Invest 88 375 388 10.1038/labinvest.2008.2 1:CAS:528: DC%2BD1cXjs1aksr4%3D 18268478
50. A Bellacosa CC Kumar A Di Cristofano JR Testa 2005 Activation of Akt kinases in cancer, implications, and therapeutic targeting Adv Cancer Res 94 29 86 10.1016/S0065-230X(05)94002-5 1:CAS:528:DC%2BD28Xot1elur4%3D 16095999 (Pubitemid 41202364)
51. SR Dutta A Brunet ME Greenberg 1999 Cellular survival: a play in three Akts Genes Dev 13 2905 2927 10.1101/gad.13.22.2905
52. RJ Shaw LC Cantley 2006 Ras PI(3)K and mTOR signaling controls tumor cell growth Nature 441 424 430 10.1038/nature04869 1:CAS:528:DC%2BD28XkvVyrsr8%3D 16724053 (Pubitemid 44050136)
53. RB Robey N Hay 2006 Mitochondrial hexokinase, novel mediatros of antiapoptotic effects of growth factors and Akt Oncogene 25 4683 4696 10.1038/sj.onc.1209595 1:CAS:528:DC%2BD28Xnsl2hs7g%3D 16892082 (Pubitemid 44187618)
54. RB Robey N Hay 2009 The "Warburg kinase" 2. Akt energy-metabolism interaction and oncogenesis Semin Cancer Biol 19 25 31 10.1016/j.semcancer.2008.11.010 1:CAS:528:DC%2BD1MXitF2hsro%3D 19130886