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Volumn 16, Issue 4, 2012, Pages 839-850

Liver Cancer and Alcohol

Author keywords

Alcohol; Diabetes mellitus; Hepatitis C; Liver cancer; Obesity; Pathogenesis; Smoking

Indexed keywords

AFLATOXIN B1; ALCOHOL; ALPHA FETOPROTEIN; CARCINOGEN;

EID: 84867961769     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2012.08.011     Document Type: Review
Times cited : (88)

References (84)
  • 3
    • 84876720727 scopus 로고    scopus 로고
    • World Health Organization, International Agency for Research on Cancer. GLOBOCAN. Available at:
    • World Health Organization, International Agency for Research on Cancer. GLOBOCAN 2008. Available at: http://globocan.iarc.fr.
    • (2008)
  • 4
    • 0000106532 scopus 로고
    • Prevalence of DSM-IV alcohol abuse and dependence United States, 1992
    • Grant B., Harford T., Dawson D., et al. Prevalence of DSM-IV alcohol abuse and dependence United States, 1992. Alcohol Health Res World 1994, 18:243-248.
    • (1994) Alcohol Health Res World , vol.18 , pp. 243-248
    • Grant, B.1    Harford, T.2    Dawson, D.3
  • 5
    • 84876726076 scopus 로고    scopus 로고
    • Alcoholic beverage consumption and ethyl caramate (urethane). IARC monographs on the evaluation of carcinogenic risks to humans 96. Lyon: International Agency for Research on Cancer.
    • Alcoholic beverage consumption and ethyl caramate (urethane). IARC monographs on the evaluation of carcinogenic risks to humans 96. Lyon: International Agency for Research on Cancer.
  • 6
    • 84876723548 scopus 로고    scopus 로고
    • IARC. Preamble to the IARC monographs on the evaluation of carcinogenic risks to humans. Available at:
    • IARC. Preamble to the IARC monographs on the evaluation of carcinogenic risks to humans. Available at: http://monographs.iarc.fr/ENG/Preamble/CurrentPreamble.pdf.
  • 7
    • 16544383147 scopus 로고    scopus 로고
    • Alcohol, oxidative stress, and free radical damage
    • Wu D., Cederbaum A.I. Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 2003, 27(4):277-284.
    • (2003) Alcohol Res Health , vol.27 , Issue.4 , pp. 277-284
    • Wu, D.1    Cederbaum, A.I.2
  • 8
    • 0037083159 scopus 로고    scopus 로고
    • Alcohol and hepatocellular carcinoma the effect of lifetime intake and hepatitis virus infections in men and women
    • Donato F., Tagger A., Gelatti U., et al. Alcohol and hepatocellular carcinoma the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 2002, 155:323-331.
    • (2002) Am J Epidemiol , vol.155 , pp. 323-331
    • Donato, F.1    Tagger, A.2    Gelatti, U.3
  • 9
    • 0035977195 scopus 로고    scopus 로고
    • A meta-analysis of alcohol drinking and cancer risk
    • Bagnardi V., Blangiardo M., La Vecchia C., et al. A meta-analysis of alcohol drinking and cancer risk. Br J Cancer 2001, 85(11):1700-1705.
    • (2001) Br J Cancer , vol.85 , Issue.11 , pp. 1700-1705
    • Bagnardi, V.1    Blangiardo, M.2    La Vecchia, C.3
  • 10
    • 80755130275 scopus 로고    scopus 로고
    • Heavy alcohol use and premature death from hepatocellular carcinoma in the United States, 1999-2006
    • Dong C., Yoon Y.H., Chen C.M., et al. Heavy alcohol use and premature death from hepatocellular carcinoma in the United States, 1999-2006. J Stud Alcohol Drugs 2011, 72(6):892-902.
    • (2011) J Stud Alcohol Drugs , vol.72 , Issue.6 , pp. 892-902
    • Dong, C.1    Yoon, Y.H.2    Chen, C.M.3
  • 11
    • 81855206498 scopus 로고    scopus 로고
    • Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study
    • Trichopoulos D., Bamia C., Lagiou P., et al. Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study. J Natl Cancer Inst 2011, 103(22):1686-1695.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.22 , pp. 1686-1695
    • Trichopoulos, D.1    Bamia, C.2    Lagiou, P.3
  • 12
    • 79959361853 scopus 로고    scopus 로고
    • Factors that affect risk for hepatocellular carcinoma and effects of surveillance
    • Yang J.D., Harmsen W.S., Slettedahl S.W., et al. Factors that affect risk for hepatocellular carcinoma and effects of surveillance. Clin Gastroenterol Hepatol 2011, 9:617-623.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 617-623
    • Yang, J.D.1    Harmsen, W.S.2    Slettedahl, S.W.3
  • 13
    • 12444285909 scopus 로고    scopus 로고
    • Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma
    • Marrero J.A., Fontana R.J., Fu S., et al. Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J Hepatol 2005, 42:218-224.
    • (2005) J Hepatol , vol.42 , pp. 218-224
    • Marrero, J.A.1    Fontana, R.J.2    Fu, S.3
  • 14
    • 1842580431 scopus 로고    scopus 로고
    • A meta-analysis of alcohol consumption and the risk of 15 diseases
    • Corrao G., Bagnardi V., Zambon A., et al. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med 2004, 38:613-619.
    • (2004) Prev Med , vol.38 , pp. 613-619
    • Corrao, G.1    Bagnardi, V.2    Zambon, A.3
  • 15
    • 84859165072 scopus 로고    scopus 로고
    • Alcohol drinking and primary liver cancer: a pooled analysis of four Japanese cohort studies
    • Shimazu T., Sasazuki S., Wakai K., et al. Alcohol drinking and primary liver cancer: a pooled analysis of four Japanese cohort studies. Int J Cancer 2012, 130(11):2645-2653.
    • (2012) Int J Cancer , vol.130 , Issue.11 , pp. 2645-2653
    • Shimazu, T.1    Sasazuki, S.2    Wakai, K.3
  • 16
    • 80053925529 scopus 로고    scopus 로고
    • How the risk of liver cancer changes after alcohol cessation: a review and meta-analysis of the current literature
    • Heckley G.A., Jarl J., Asamoah B.O., et al. How the risk of liver cancer changes after alcohol cessation: a review and meta-analysis of the current literature. BMC Cancer 2011, 11:446.
    • (2011) BMC Cancer , vol.11 , pp. 446
    • Heckley, G.A.1    Jarl, J.2    Asamoah, B.O.3
  • 17
    • 0028012594 scopus 로고
    • Clinical significance of concomitant hepatitis C infection in patients with alcoholic liver disease
    • Fong T.L., Kanel G.C., Conrad A., et al. Clinical significance of concomitant hepatitis C infection in patients with alcoholic liver disease. Hepatology 1994, 19:554-557.
    • (1994) Hepatology , vol.19 , pp. 554-557
    • Fong, T.L.1    Kanel, G.C.2    Conrad, A.3
  • 18
    • 0029315004 scopus 로고
    • Hepatitis C virus antibodies in alcoholic patients
    • Gonzalez-Quintela A., Alende R., Aguilera A., et al. Hepatitis C virus antibodies in alcoholic patients. Rev Clin Esp 1995, 195:367-372.
    • (1995) Rev Clin Esp , vol.195 , pp. 367-372
    • Gonzalez-Quintela, A.1    Alende, R.2    Aguilera, A.3
  • 19
    • 0028181401 scopus 로고
    • "Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease
    • Zignego A.L., Foschi M., Laffi G., et al. "Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. Hepatology 1994, 19:577-582.
    • (1994) Hepatology , vol.19 , pp. 577-582
    • Zignego, A.L.1    Foschi, M.2    Laffi, G.3
  • 20
    • 0028030008 scopus 로고
    • Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis
    • Oshita M., Hayashi N., Kasahara A., et al. Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis. Hepatology 1994, 20:1115-1120.
    • (1994) Hepatology , vol.20 , pp. 1115-1120
    • Oshita, M.1    Hayashi, N.2    Kasahara, A.3
  • 21
    • 0028867324 scopus 로고
    • Chronic hepatitis C in alcoholic patients: prevalence, genotypes, and correlation to liver disease
    • Befrits R., Hedman M., Blomquist L. Chronic hepatitis C in alcoholic patients: prevalence, genotypes, and correlation to liver disease. Scand J Gastroenterol 1995, 30:1113-1118.
    • (1995) Scand J Gastroenterol , vol.30 , pp. 1113-1118
    • Befrits, R.1    Hedman, M.2    Blomquist, L.3
  • 22
    • 0027225164 scopus 로고
    • Epidemiology of hepatitis C among veterans with alcoholic liver disease
    • Mendenhall C.L., Moritz T., Rouster S., et al. Epidemiology of hepatitis C among veterans with alcoholic liver disease. Am J Gastroenterol 1993, 88:1022-1026.
    • (1993) Am J Gastroenterol , vol.88 , pp. 1022-1026
    • Mendenhall, C.L.1    Moritz, T.2    Rouster, S.3
  • 23
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C; for the OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC group
    • Poynard, Bedossa, Opolon Natural history of liver fibrosis progression in patients with chronic hepatitis C; for the OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC group. Lancet 1997, 349:825-832.
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard1    Bedossa2    Opolon3
  • 24
    • 79955612823 scopus 로고    scopus 로고
    • Hepatic and extrahepatic cancer in cirrhosis: a longitudinal cohort study
    • Berman K., Tandra S., Vuppalanch R., et al. Hepatic and extrahepatic cancer in cirrhosis: a longitudinal cohort study. Am J Gastroenterol 2011, 106:899-906.
    • (2011) Am J Gastroenterol , vol.106 , pp. 899-906
    • Berman, K.1    Tandra, S.2    Vuppalanch, R.3
  • 25
    • 0028672633 scopus 로고
    • A prospective study on hepatocellular carcinoma in liver cirrhosis respective roles of alcohol and hepatitis C virus infection
    • Miyakawa H., Sato C., Tazawa J., et al. A prospective study on hepatocellular carcinoma in liver cirrhosis respective roles of alcohol and hepatitis C virus infection. Alcohol Alcohol Suppl 1994, 29(1):75-79.
    • (1994) Alcohol Alcohol Suppl , vol.29 , Issue.1 , pp. 75-79
    • Miyakawa, H.1    Sato, C.2    Tazawa, J.3
  • 26
    • 0034098113 scopus 로고    scopus 로고
    • Clinical characteristics of patients in their 40s with HCV antibody-positive hepatocellular carcinoma
    • Shimauchi Y., Tanaka M., Koga K., et al. Clinical characteristics of patients in their 40s with HCV antibody-positive hepatocellular carcinoma. Alcohol Clin Exp Res 2000, 24:64S-67S.
    • (2000) Alcohol Clin Exp Res , vol.24
    • Shimauchi, Y.1    Tanaka, M.2    Koga, K.3
  • 27
    • 10144250306 scopus 로고    scopus 로고
    • Effect of heavy alcohol intake on long-term results after curative resection of hepatitis C virus-related hepatocellular carcinoma
    • Okada S., Ishii H., Nose H., et al. Effect of heavy alcohol intake on long-term results after curative resection of hepatitis C virus-related hepatocellular carcinoma. Jpn J Cancer Res 1996, 87:867-873.
    • (1996) Jpn J Cancer Res , vol.87 , pp. 867-873
    • Okada, S.1    Ishii, H.2    Nose, H.3
  • 28
    • 0030998115 scopus 로고    scopus 로고
    • High malignancy of hepatocellular carcinoma in alcoholic patients with hepatitis C virus
    • Kubo S., Kinoshita H., Hirohashi K., et al. High malignancy of hepatocellular carcinoma in alcoholic patients with hepatitis C virus. Surgery 1997, 121:425-429.
    • (1997) Surgery , vol.121 , pp. 425-429
    • Kubo, S.1    Kinoshita, H.2    Hirohashi, K.3
  • 29
    • 84858855623 scopus 로고    scopus 로고
    • To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection
    • [in Chinese]
    • Zhu G.T., Lou G.Q., Shi J.P. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011, 25(5):328-330. [in Chinese].
    • (2011) Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi , vol.25 , Issue.5 , pp. 328-330
    • Zhu, G.T.1    Lou, G.Q.2    Shi, J.P.3
  • 30
    • 79959532964 scopus 로고    scopus 로고
    • Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study
    • Kwon O.S., Jung Y.K., Kim Y.S., et al. Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study. Korean J Hepatol 2010, 16:308-314.
    • (2010) Korean J Hepatol , vol.16 , pp. 308-314
    • Kwon, O.S.1    Jung, Y.K.2    Kim, Y.S.3
  • 31
    • 0033973253 scopus 로고    scopus 로고
    • Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma
    • Kuper H., Tzonou A., Kaklamani E., et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 2000, 85:498-502.
    • (2000) Int J Cancer , vol.85 , pp. 498-502
    • Kuper, H.1    Tzonou, A.2    Kaklamani, E.3
  • 32
    • 84983725611 scopus 로고    scopus 로고
    • Influences of tobacco and alcohol use on hepatocellular carcinoma survival
    • Shih W.L., Chang H.C., Liaw Y.F., et al. Influences of tobacco and alcohol use on hepatocellular carcinoma survival. Int J Cancer 2012, 10.1002/ijc.27508.
    • (2012) Int J Cancer
    • Shih, W.L.1    Chang, H.C.2    Liaw, Y.F.3
  • 33
    • 0031037572 scopus 로고    scopus 로고
    • Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes
    • Staretz M.E., Murphy S.E., Patten C.J., et al. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes. Drug Metab Dispos 1997, 25:154-162.
    • (1997) Drug Metab Dispos , vol.25 , pp. 154-162
    • Staretz, M.E.1    Murphy, S.E.2    Patten, C.J.3
  • 34
    • 4143065907 scopus 로고    scopus 로고
    • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S
    • Yuan J.M., Govindarajan S., Arakawa K., et al. Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 2004, 101(5):1009-1017.
    • (2004) Cancer , vol.101 , Issue.5 , pp. 1009-1017
    • Yuan, J.M.1    Govindarajan, S.2    Arakawa, K.3
  • 35
    • 77954547047 scopus 로고    scopus 로고
    • Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy
    • Balbi M., Donadon V., Ghersetti M., et al. Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy. Int J Environ Res Public Health 2010, 7:1366-1378.
    • (2010) Int J Environ Res Public Health , vol.7 , pp. 1366-1378
    • Balbi, M.1    Donadon, V.2    Ghersetti, M.3
  • 36
    • 77957124872 scopus 로고    scopus 로고
    • Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men
    • Loomba R., Yang H.I., Su J., et al. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Clin Gastroenterol Hepatol 2010, 8(10):891-898.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , Issue.10 , pp. 891-898
    • Loomba, R.1    Yang, H.I.2    Su, J.3
  • 37
    • 33746514438 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis
    • N'Kontchou G., Paries J., Htar M.T., et al. Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. Clin Gastroenterol Hepatol 2006, 4:1062-1068.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1062-1068
    • N'Kontchou, G.1    Paries, J.2    Htar, M.T.3
  • 38
    • 0034065378 scopus 로고    scopus 로고
    • Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study
    • Ganne-Carrie N., Christidis C., Chastang C., et al. Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study. Gut 2000, 46:277-282.
    • (2000) Gut , vol.46 , pp. 277-282
    • Ganne-Carrie, N.1    Christidis, C.2    Chastang, C.3
  • 39
    • 37349033182 scopus 로고    scopus 로고
    • Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis
    • Nahon P., Sutton A., Rufat P., et al. Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis. Gastroenterology 2008, 134:102-110.
    • (2008) Gastroenterology , vol.134 , pp. 102-110
    • Nahon, P.1    Sutton, A.2    Rufat, P.3
  • 40
    • 0036123930 scopus 로고    scopus 로고
    • HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma
    • Lauret E., Rodríguez M., González S., et al. HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. Am J Gastroenterol 2002, 97:1016-1021.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1016-1021
    • Lauret, E.1    Rodríguez, M.2    González, S.3
  • 41
    • 0037818787 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation
    • Scotet V., Mérour M.C., Mercier A.Y., et al. Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation. Am J Epidemiol 2003, 158:129-134.
    • (2003) Am J Epidemiol , vol.158 , pp. 129-134
    • Scotet, V.1    Mérour, M.C.2    Mercier, A.Y.3
  • 42
    • 0037285572 scopus 로고    scopus 로고
    • Mutations of the HFE gene in patients with hepatocellular carcinoma
    • Cauza E., Peck-Radosavljevic M., Ulrich-Pur H., et al. Mutations of the HFE gene in patients with hepatocellular carcinoma. Am J Gastroenterol 2003, 98:442-447.
    • (2003) Am J Gastroenterol , vol.98 , pp. 442-447
    • Cauza, E.1    Peck-Radosavljevic, M.2    Ulrich-Pur, H.3
  • 43
    • 0037961144 scopus 로고    scopus 로고
    • Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis
    • Boige V., Castéra L., de Roux N., et al. Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis. Gut 2003, 52:1178-1181.
    • (2003) Gut , vol.52 , pp. 1178-1181
    • Boige, V.1    Castéra, L.2    de Roux, N.3
  • 44
    • 0019945614 scopus 로고
    • A case-control dietary study of primary liver cancer risk from aflatoxin exposure
    • Bulatao-Jayme J., Almero E.M., Castro C.A., et al. A case-control dietary study of primary liver cancer risk from aflatoxin exposure. Int J Epidemiol 1982, 11:112-119.
    • (1982) Int J Epidemiol , vol.11 , pp. 112-119
    • Bulatao-Jayme, J.1    Almero, E.M.2    Castro, C.A.3
  • 45
    • 0019726543 scopus 로고
    • Primary hepatic cancer in alcoholics
    • Tamburro C.H., Lee H.M. Primary hepatic cancer in alcoholics. Clin Gastroenterol 1981, 10:457-477.
    • (1981) Clin Gastroenterol , vol.10 , pp. 457-477
    • Tamburro, C.H.1    Lee, H.M.2
  • 46
    • 33746807252 scopus 로고    scopus 로고
    • Individual susceptibility and alcohol effects: biochemical and genetic aspects
    • Gemma S., Vichi S., Testai E. Individual susceptibility and alcohol effects: biochemical and genetic aspects. Ann Ist Super Sanita 2006, 42(1):8-16.
    • (2006) Ann Ist Super Sanita , vol.42 , Issue.1 , pp. 8-16
    • Gemma, S.1    Vichi, S.2    Testai, E.3
  • 47
    • 0037227494 scopus 로고    scopus 로고
    • Role of variability in explaining ethanol pharmacokinetics: research and forensic applications
    • Norberg A., Jones A.W., Hahn R.G., et al. Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin Pharmacokinet 2003, 42(1):1-31.
    • (2003) Clin Pharmacokinet , vol.42 , Issue.1 , pp. 1-31
    • Norberg, A.1    Jones, A.W.2    Hahn, R.G.3
  • 48
    • 38149016706 scopus 로고    scopus 로고
    • Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes
    • [discussion: 16-22]
    • Crabb D.W., Liangpunsakul S. Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Novartis Found Symp 2007, 285:4-16. [discussion: 16-22].
    • (2007) Novartis Found Symp , vol.285 , pp. 4-16
    • Crabb, D.W.1    Liangpunsakul, S.2
  • 49
    • 0034975104 scopus 로고    scopus 로고
    • The role of acetaldehyde in the actions of alcohol (update 2000)
    • Eriksson C.J. The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 2001, 25(Suppl):15S-32S.
    • (2001) Alcohol Clin Exp Res , vol.25 , Issue.SUPPL.
    • Eriksson, C.J.1
  • 50
    • 34547472124 scopus 로고    scopus 로고
    • Alcohol metabolism and cancer risk
    • Seitz H.K., Becker P. Alcohol metabolism and cancer risk. Alcohol Res Health 2007, 30(1):38-41.
    • (2007) Alcohol Res Health , vol.30 , Issue.1 , pp. 38-41
    • Seitz, H.K.1    Becker, P.2
  • 51
    • 16544373246 scopus 로고    scopus 로고
    • Dangerous byproducts of alcohol breakdown-focus on adducts
    • Tuma D.J., Casey C.A. Dangerous byproducts of alcohol breakdown-focus on adducts. Alcohol Res Health 2003, 27(4):285-290.
    • (2003) Alcohol Res Health , vol.27 , Issue.4 , pp. 285-290
    • Tuma, D.J.1    Casey, C.A.2
  • 52
    • 34347252306 scopus 로고    scopus 로고
    • Overview: how is alcohol metabolized by the body?
    • Zakhari S. Overview: how is alcohol metabolized by the body?. Alcohol Res Health 2006, 29(4):245-254.
    • (2006) Alcohol Res Health , vol.29 , Issue.4 , pp. 245-254
    • Zakhari, S.1
  • 53
    • 38449102937 scopus 로고    scopus 로고
    • Removal of acetaldehyde from the body
    • [discussion: 40-51]
    • Deitrich R.A., Petersen D., Vasiliou V. Removal of acetaldehyde from the body. Novartis Found Symp 2007, 285:23-40. [discussion: 40-51].
    • (2007) Novartis Found Symp , vol.285 , pp. 23-40
    • Deitrich, R.A.1    Petersen, D.2    Vasiliou, V.3
  • 54
    • 33645232958 scopus 로고    scopus 로고
    • Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    • Homann N., Stickel F., Konig I.R., et al. Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 2006, 118(8):1998-2002.
    • (2006) Int J Cancer , vol.118 , Issue.8 , pp. 1998-2002
    • Homann, N.1    Stickel, F.2    Konig, I.R.3
  • 55
    • 33746329952 scopus 로고    scopus 로고
    • CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury
    • Cederbaum A.I. CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med 2006, 73(4):657-672.
    • (2006) Mt Sinai J Med , vol.73 , Issue.4 , pp. 657-672
    • Cederbaum, A.I.1
  • 56
    • 34250824010 scopus 로고    scopus 로고
    • Alcohol-induced oxidative stress
    • Das S.K., Vasudevan D.M. Alcohol-induced oxidative stress. Life Sci 2007, 81(3):177-187.
    • (2007) Life Sci , vol.81 , Issue.3 , pp. 177-187
    • Das, S.K.1    Vasudevan, D.M.2
  • 57
    • 34249788178 scopus 로고    scopus 로고
    • Role of microsomal enzymes in development of alcoholic liver diseases
    • Konishi M., Ishii H. Role of microsomal enzymes in development of alcoholic liver diseases. J Gastroenterol Hepatol 2007, 22(Suppl 1):S7-S10.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.SUPPL. 1
    • Konishi, M.1    Ishii, H.2
  • 58
    • 39149123560 scopus 로고    scopus 로고
    • CYP2E1 and oxidative liver injury by alcohol
    • Lu Y., Cederbaum A.I. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 2008, 44(5):723-738.
    • (2008) Free Radic Biol Med , vol.44 , Issue.5 , pp. 723-738
    • Lu, Y.1    Cederbaum, A.I.2
  • 59
    • 0015333453 scopus 로고
    • The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo
    • Lieber C.S., DeCarli L.M. The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 1972, 181(2):279-287.
    • (1972) J Pharmacol Exp Ther , vol.181 , Issue.2 , pp. 279-287
    • Lieber, C.S.1    DeCarli, L.M.2
  • 60
    • 0037327127 scopus 로고    scopus 로고
    • Alcohol metabolism: role in toxicity and carcinogenesis
    • Badger T.M., Ronis M.J., Seitz H.K., et al. Alcohol metabolism: role in toxicity and carcinogenesis. Alcohol Clin Exp Res 2003, 27(2):336-347.
    • (2003) Alcohol Clin Exp Res , vol.27 , Issue.2 , pp. 336-347
    • Badger, T.M.1    Ronis, M.J.2    Seitz, H.K.3
  • 61
    • 0026567713 scopus 로고
    • Oxidative and reductive metabolism by cytochrome P450 2E1
    • Koop D.R. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 1992, 6(2):724-730.
    • (1992) FASEB J , vol.6 , Issue.2 , pp. 724-730
    • Koop, D.R.1
  • 62
    • 32044457123 scopus 로고    scopus 로고
    • Oxidative stress and signal transduction pathways in alcoholic liver disease
    • Zima T., Kalousova M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcohol Clin Exp Res 2005, 29(Suppl 11):110S-115S.
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.SUPPL. 11
    • Zima, T.1    Kalousova, M.2
  • 63
    • 34247624006 scopus 로고    scopus 로고
    • Carcinogenicity of alcoholic beverages
    • Baan R., Straif K., Grosse Y., et al. Carcinogenicity of alcoholic beverages. Lancet Oncol 2007, 8(4):292-293.
    • (2007) Lancet Oncol , vol.8 , Issue.4 , pp. 292-293
    • Baan, R.1    Straif, K.2    Grosse, Y.3
  • 64
    • 23144448354 scopus 로고    scopus 로고
    • DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
    • Brooks P.J., Theruvathu J.A. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol 2005, 35(3):187-193.
    • (2005) Alcohol , vol.35 , Issue.3 , pp. 187-193
    • Brooks, P.J.1    Theruvathu, J.A.2
  • 65
    • 0036139856 scopus 로고    scopus 로고
    • The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology
    • Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 2001, 52(3-5):159-164.
    • (2001) IUBMB Life , vol.52 , Issue.3-5 , pp. 159-164
    • Lenaz, G.1
  • 66
    • 0033916349 scopus 로고    scopus 로고
    • Cytochrome P450 2E1: its clinical and toxicological role
    • Tanaka E., Terada M., Misawa S. Cytochrome P450 2E1: its clinical and toxicological role. J Clin Pharm Ther 2000, 25(3):165-175.
    • (2000) J Clin Pharm Ther , vol.25 , Issue.3 , pp. 165-175
    • Tanaka, E.1    Terada, M.2    Misawa, S.3
  • 67
    • 0028803002 scopus 로고
    • Studies of the reaction of acetaldehyde with deoxynucleosides
    • Vaca C.E., Fang J.L., Schweda E.K. Studies of the reaction of acetaldehyde with deoxynucleosides. Chem Biol Interact 1995, 98(1):51-67.
    • (1995) Chem Biol Interact , vol.98 , Issue.1 , pp. 51-67
    • Vaca, C.E.1    Fang, J.L.2    Schweda, E.K.3
  • 68
    • 0030935567 scopus 로고    scopus 로고
    • Cytochrome P-4502E1: its physiological and pathological role
    • Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 1997, 77(2):517-544.
    • (1997) Physiol Rev , vol.77 , Issue.2 , pp. 517-544
    • Lieber, C.S.1
  • 69
    • 0033835308 scopus 로고    scopus 로고
    • ALCOHOL: its metabolism and interaction with nutrients
    • Lieber C.S. ALCOHOL: its metabolism and interaction with nutrients. Annu Rev Nutr 2000, 20:395-430.
    • (2000) Annu Rev Nutr , vol.20 , pp. 395-430
    • Lieber, C.S.1
  • 70
    • 0028586852 scopus 로고
    • Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes
    • Guengerich F.P., Shimada T., Yun C.H., et al. Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Environ Health Perspect 1994, 102(Suppl 9):49-53.
    • (1994) Environ Health Perspect , vol.102 , Issue.SUPPL. 9 , pp. 49-53
    • Guengerich, F.P.1    Shimada, T.2    Yun, C.H.3
  • 71
    • 0025167020 scopus 로고
    • Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation
    • Yang C.S., Yoo J.S., Ishizaki H., et al. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 1990, 22(2-3):147-159.
    • (1990) Drug Metab Rev , vol.22 , Issue.2-3 , pp. 147-159
    • Yang, C.S.1    Yoo, J.S.2    Ishizaki, H.3
  • 72
    • 38349078988 scopus 로고    scopus 로고
    • Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
    • Nagata K., Suzuki H., Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci 2007, 32(5):453-468.
    • (2007) J Toxicol Sci , vol.32 , Issue.5 , pp. 453-468
    • Nagata, K.1    Suzuki, H.2    Sakaguchi, S.3
  • 73
    • 0032185432 scopus 로고    scopus 로고
    • Alcoholic liver injury involves activation of Kupffer cells by endotoxin
    • Thurman R.G. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998, 275(4 Pt 1):G605-G611.
    • (1998) Am J Physiol , vol.275 , Issue.4 PART 1
    • Thurman, R.G.1
  • 74
    • 32044469602 scopus 로고    scopus 로고
    • Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol
    • Bode C., Bode J.C. Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol. Alcohol Clin Exp Res 2005, 29(Suppl):166S-171S.
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.SUPPL.
    • Bode, C.1    Bode, J.C.2
  • 75
    • 0036017180 scopus 로고    scopus 로고
    • Ethanol, oxidative stress, and cytokine-induced liver cell injury
    • Hoek J.B., Pastorino J.G. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002, 27(1):63-68.
    • (2002) Alcohol , vol.27 , Issue.1 , pp. 63-68
    • Hoek, J.B.1    Pastorino, J.G.2
  • 76
    • 4444359123 scopus 로고    scopus 로고
    • Cellular signaling mechanisms in alcohol-induced liver damage
    • Hoek J.B., Pastorino J.G. Cellular signaling mechanisms in alcohol-induced liver damage. Semin Liver Dis 2004, 24(3):257-272.
    • (2004) Semin Liver Dis , vol.24 , Issue.3 , pp. 257-272
    • Hoek, J.B.1    Pastorino, J.G.2
  • 77
    • 33847262105 scopus 로고    scopus 로고
    • Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    • Roberts R.A., Ganey P.E., Ju C., et al. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 2007, 96(1):2-15.
    • (2007) Toxicol Sci , vol.96 , Issue.1 , pp. 2-15
    • Roberts, R.A.1    Ganey, P.E.2    Ju, C.3
  • 78
    • 34249809161 scopus 로고    scopus 로고
    • Regulation of macrophage activation in alcoholic liver disease
    • Thakur V., McMullen M.R., Pritchard M.T., et al. Regulation of macrophage activation in alcoholic liver disease. J Gastroenterol Hepatol 2007, 22(Suppl 1):S53-S56.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.SUPPL. 1
    • Thakur, V.1    McMullen, M.R.2    Pritchard, M.T.3
  • 79
    • 0030445219 scopus 로고    scopus 로고
    • In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade
    • Ruttinger D., Vollmar B., Wanner G.A., et al. In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade. J Hepatol 1996, 25(6):960-967.
    • (1996) J Hepatol , vol.25 , Issue.6 , pp. 960-967
    • Ruttinger, D.1    Vollmar, B.2    Wanner, G.A.3
  • 80
    • 0030330332 scopus 로고    scopus 로고
    • Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats
    • Vollmar B., Ruttinger D., Wanner G.A., et al. Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 1996, 6(6):434-441.
    • (1996) Shock , vol.6 , Issue.6 , pp. 434-441
    • Vollmar, B.1    Ruttinger, D.2    Wanner, G.A.3
  • 81
    • 39749090649 scopus 로고    scopus 로고
    • Oxidative mechanisms in the pathogenesis of alcoholic liver disease
    • Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 2008, 29(1-2):9-16.
    • (2008) Mol Aspects Med , vol.29 , Issue.1-2 , pp. 9-16
    • Albano, E.1
  • 82
    • 34249053143 scopus 로고    scopus 로고
    • Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis
    • CD004996
    • Lirussi F., Azzalini L., Orando S., et al. Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis. Cochrane Database Syst Rev 2007, (1). CD004996.
    • (2007) Cochrane Database Syst Rev , Issue.1
    • Lirussi, F.1    Azzalini, L.2    Orando, S.3
  • 83
    • 28844443794 scopus 로고    scopus 로고
    • Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization
    • Yang X., Lu P., Ishida Y., et al. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer 2006, 118(2):335-345.
    • (2006) Int J Cancer , vol.118 , Issue.2 , pp. 335-345
    • Yang, X.1    Lu, P.2    Ishida, Y.3
  • 84
    • 79952231921 scopus 로고    scopus 로고
    • AASLD practice guideline for management of HCC
    • Bruix J., Sherman M. AASLD practice guideline for management of HCC. Hepatology 2011, 53(3):1020-1022.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2


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