Dangerous byproducts of alcohol breakdown - Focus on adducts

Alcohol Research and Health

Volumn 27, Issue 4, 2003, Pages 285-290

  Tuma, Dean J ^a,b   Casey, Carol A ^b,c  

^a VA Alcohol Research Center   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

Acetaldehyde; Adduct; Alcoholic liver disorder; Aldehydes; Biochemical mechanism; Ethanol metabolism; Immune system; Lipids; Oxygen radicals; Peroxidation; Proteins; Toxic drug effect

Indexed keywords

4 HYDROXYNONENAL; ACETALDEHYDE; ALCOHOL; CYTOCHROME P450 2E1; MALONALDEHYDE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; FREE RADICAL;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANTIBODY DETECTION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; LIVER INJURY; NONHUMAN; PEROXIDATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; ANIMAL; LIVER; METABOLISM;

ANIMALS; ETHANOL; FREE RADICALS; HUMANS; LIVER; REACTIVE OXYGEN SPECIES;

EID: 16544373246     PISSN: 0090838X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. CEDERBAUM, A.I. Introduction - Serial review: Alcohol, oxidative stress and cell injury. Free Radical Biology & Medicine 31:1524-1526, 2001.
2. CLOT, P.; PAROLA, M.; BELLOMO, G.; ET AL. Plasma membrane hydroxyethyl radical adduces cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology 113:265-276, 1997.
3. ESTERBAUER, H.; SCHAUR, R.J.; AND ZOLLNER, H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radical Biology & Medicine 11:81-128, 1991.
4. HALSTED, C.H.; VILLANUEVA, J.; CHANDLER, C.J.; ET AL. Centri-lobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 18:954-960, 1993.
5. KLASSEN, L.W.; TUMA, D.J.; AND SORRELL, M.F. Immune mechanisms of alcohol-induced liver disease. Hepatology 22:355-357, 1995.
6. LIEBER, C.S. Metabolic effects of acetaldehyde. Biochemical Society Transactions 16:241-247, 1988.
7. MONCADA, C., AND ISRAEL, Y. Protein binding of α-hydroxyethyl free radicals. Alcoholism: Clinical and Experimental Research 25:1723-1728, 2001.
8. NIEMELA, O. Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress. Frontiers in Bioscience 4:d506-d513, 1999.
9. NIEMELA, O. Distribution of ethanol-induced protein adducts in vivo: Relationship to tissue injury. Free Radical Biology & Medicine 31:1533-1538, 2001.
10. NIEMELA, O.; PARKKILA, S.; YLA-HERTTUALA, S.; ET AL. Sequential acetaldehyde production, lipid peroxidation and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 22:1208-1214, 1995.
11. THIELE, G.M.; WORRALL, S.; TUMA, D.J.; ET AL. The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcoholism: Clinical and Experimental Research 25:218S-224S, 2001.
12. TUMA, D.J. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radical Biology & Medicine 32:303-308, 2002.
13. TUMA, D.J., AND SORRELL, M.F. The role of acetaldehyde adducts in liver injury. In: Hall, P., ed. Alcoholic Liver Disease: Pathology and Pathogenesis. London: Edward Arnold, 1995. pp. 89-99.
14. TUMA, D.J.; SMITH, S.L.; AND SORRELL, M.F. Acetaldehyde and microtubules. Annals of the New York Academy of Sciences 625:786-792, 1991.
15. TUMA, D.J.; THIELE, G.M.; XU, D.S.; ET AL. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology 23:872-880, 1996.
16. WORRALL, S., AND THIELE, G.M. Protein modification in ethanol toxicity. Adverse Drug Reactions and Toxicological Reviews 20:133-159, 2001.
17. YOKOYAMA, H.; ISHII, H.; NAGATA, S.; ET AL. Experimental hepatitis induced by ethanol after immunization with acetaldehyde adducts. Hepatology 17:14-19, 1993.