Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes

Future Medicinal Chemistry

Volumn 4, Issue 15, 2012, Pages 1933-1944

  Zakharov, Alexey V ^a   Peach, Megan L ^b   Sitzmann, Markus ^a   Filippov, Igor V ^b   McCartney, Heather J ^a,c   Smith, Layton H ^d   Pugliese, Angelo ^a,e   Nicklaus, Marc C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Chemical Biology Laboratory   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d BURNHAM INSTITUTE   (United States)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; ESMOLOL; REMIFENTANIL;

ACCURACY; AORTA DISSECTION; CHEMICAL STRUCTURE; COMMERCIAL PHENOMENA; COMPUTATIONAL FLUID DYNAMICS; COMPUTATIONAL TOOL; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; HUMAN; KERNEL METHOD; LIVER MICROSOME; LIVER MICROSOME METABOLISM; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; HALF-LIFE; HUMANS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOFTWARE;

EID: 84867955838     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.152     Document Type: Review

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