Aberrations in the micro-RNA biogenesis machinery and the emerging roles of micro-RNAs in the pathogenesis of cutaneous malignant melanoma

Pigment Cell and Melanoma Research

Volumn 25, Issue 6, 2012, Pages 740-757

  Leibowitz Amit, Raya ^a   Sidi, Yechezkel ^a,b   Avni, Dror ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Biogenesis; Epigenetics; Melanoma; Micro RNA

Indexed keywords

ARGONAUTE 1 PROTEIN; B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DICER; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MICRORNA; MICRORNA 145; MICRORNA 148A; MICRORNA 15B; MICRORNA 181; MICRORNA 182; MICRORNA 200B; MICRORNA 205; MICRORNA 221; MICRORNA 222; MICRORNA 25; MICRORNA 92B; OLIGONUCLEOTIDE; P CADHERIN; PARAFFIN; RNA; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR; STAT1 PROTEIN; TRANSCRIPTION FACTOR E2F5; TRANSCRIPTION FACTOR ETS 1; TUMOR MARKER; UNCLASSIFIED DRUG; UVOMORULIN;

APOPTOSIS; BIOGENESIS; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER INVASION; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER TISSUE; CELL CYCLE REGULATION; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; CLINICAL DECISION MAKING; COMPARATIVE GENOMIC HYBRIDIZATION; DOWN REGULATION; EPIGENETICS; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; MELANOCYTE; MELANOMA; MELANOMA SKIN CANCER; METASTASIS; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; ONCOGENE C KIT; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PATHOGENESIS; PHENOTYPE; PREDICTIVE VALUE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA PROCESSING; RNA SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN CARCINOGENESIS; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOCYTES; MELANOMA; MICRORNAS; SKIN NEOPLASMS;

EID: 84867910105     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/pcmr.12018     Document Type: Review

References (119)

1. Bell, R.E., and Levy, C. (2011). The three M's: melanoma, microphthalmia-associated transcription factor and microRNA. Pigment Cell Melanoma Res. 24, 1088-1106.
2. Bemis, L.T., Chen, R., Amato, C.M., Classen, E.H., Robinson, S.E., Coffey, D.G., Erickson, P.F., Shellman, Y.G., and Robinson, W.A. (2008). MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. Cancer Res. 68, 1362-1368.
3. Bittner, M., Meltzer, P., Chen, Y. et al. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536-540.
4. Bonazzi, V.F., Stark, M.S., and Hayward, N.K. (2012). MicroRNA regulation of melanoma progression. Melanoma Res. 22, 101-113.
5. Boyle, G.M., Woods, S.L., Bonazzi, V.F., Stark, M.S., Hacker, E., Aoude, L.G., Dutton-Regester, K., Cook, A.L., Sturm, R.A., and Hayward, N.K. (2011). Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res. 24, 525-537.
6. Braig, S., Mueller, D.W., Rothhammer, T., and Bosserhoff, A.K. (2010). MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma. Cell. Mol. Life Sci. 67, 3535-3548.
7. Braun, R.P., Gutkowicz-Krusin, D., Rabinovitz, H. et al. (2012). Agreement of dermatopathologists in the evaluation of clinically difficult melanocytic lesions: how golden is the 'gold standard'? Dermatology 224, 51-58.
8. Brodell, R.T., and Santa Cruz, D.J. (1985). Borderline and atypical melanocytic lesions. Semin. Diagn. Pathol. 2, 63-86.
9. Calin, G.A., and Croce, C.M. (2006). MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene 25, 6202-6210.
10. Calin, G.A., Dumitru, C.D., Shimizu, M. et al. (2002). Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 99, 15524-15529.
11. Capoluongo, E. (2011). Insulin-like growth factor system and sporadic malignant melanoma. Am. J. Pathol. 178, 26-31.
12. Caramuta, S., Egyhazi, S., Rodolfo, M., Witten, D., Hansson, J., Larsson, C., and Lui, W.O. (2010). MicroRNA expression profiles associated with mutational status and survival in malignant melanoma. J. Invest. Dermatol. 130, 2062-2070.
13. Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K.S., Testori, A., Larue, L., and Goding, C.R. (2006). Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev. 20, 3426-3439.
14. Chan, E., Patel, R., Nallur, S. et al. (2011). MicroRNA signatures differentiate melanoma subtypes. Cell Cycle 10, 1845-1852.
15. Chen, J., Feilotter, H.E., Pare, G.C., Zhang, X., Pemberton, J.G., Garady, C., Lai, D., Yang, X., and Tron, V.A. (2010). MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma. Am. J. Pathol. 176, 2520-2529.
16. Chen, J., Zhang, X., Lentz, C., Abi-Daoud, M., Pare, G.C., Yang, X., Feilotter, H.E., and Tron, V.A. (2011). miR-193b Regulates Mcl-1 in Melanoma. Am. J. Pathol. 179, 2162-2168.
17. Chen, J., Abi-Daoud, M., Wang, A., Yang, X., Zhang, X., Feilotter, H.E., and Tron, V.A. (2012). Stathmin 1 is a potential novel oncogene in melanoma. Oncogene [Epub ahead of print] doi: 10.1038/onc.2012.141
18. Couts, K.L., Anderson, E.M., Gross, M.M., Sullivan, K., and Ahn, N.G. (2012). Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene[Epub ahead of print] doi: 10.1038/onc.2012.209
19. Curtin, J.A., Busam, K., Pinkel, D., and Bastian, B.C. (2006). Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346.
20. Da Rocha, S.T., Edwards, C.A., Ito, M., Ogata, T., and Ferguson-Smith, A.C. (2008). Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet. 24, 306-316.
21. Dar, A.A., Majid, S., De Semir, D., Nosrati, M., Bezrookove, V., and Kashani-Sabet, M. (2011). miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein. J. Biol. Chem. 286, 16606-16614.
22. Elson-Schwab, I., Lorentzen, A., and Marshall, C.J. (2010). MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion. PLoS ONE 5, e13176.
23. Felicetti, F., Errico, M.C., Bottero, L. et al. (2008). The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res. 68, 2745-2754.
24. Fu, T.Y., Chang, C.C., Lin, C.T., Lai, C.H., Peng, S.Y., Ko, Y.J., and Tang, P.C. (2011). Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells. Exp. Cell Res. 317, 445-451.
25. Garbe, C., Eigentler, T.K., Keilholz, U., Hauschild, A., and Kirkwood, J.M. (2011). Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist 16, 5-24.
26. Garraway, L.A., Widlund, H.R., Rubin, M.A. et al. (2005). Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122.
27. Garzon, R., Marcucci, G., and Croce, C.M. (2010). Targeting microRNAs in cancer: rationale, strategies and challenges. Nat. Rev. Drug Discov. 9, 775-789.
28. Gaur, A., Jewell, D.A., Liang, Y., Ridzon, D., Moore, J.H., Chen, C., Ambros, V.R., and Israel, M.A. (2007). Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res. 67, 2456-2468.
29. Gaziel-Sovran, A., Segura, M.F., Di Micco, R. et al. (2011). miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell 20, 104-118.
30. Git, A., Dvinge, H., Salmon-Divon, M., Osborne, M., Kutter, C., Hadfield, J., Bertone, P., and Caldas, C. (2010). Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression. RNA 16, 991-1006.
31. Glud, M., and Gniadecki, R. (2012). MicroRNAs in the pathogenesis of malignant melanoma. J. Eur. Acad. Dermatol. Venereol. [Epub ahead of print] doi: 10.1111/j.1468-3083.2012.04579.x.
32. Glud, M., Rossing, M., Hother, C., Holst, L., Hastrup, N., Nielsen, F.C., Gniadecki, R., and Drzewiecki, K.T. (2010). Downregulation of miR-125b in metastatic cutaneous malignant melanoma. Melanoma Res. 20, 479-484.
33. Glud, M., Manfe, V., Biskup, E., Holst, L., Dirksen, A.M., Hastrup, N., Nielsen, F.C., Drzewiecki, K.T., and Gniadecki, R. (2011). MicroRNA miR-125b induces senescence in human melanoma cells. Melanoma Res. 21, 253-256.
34. Godshalk, S.E., Paranjape, T., Nallur, S. et al. (2011). A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 30, 1542-1550.
35. Goswami, S., Tarapore, R.S., Teslaa, J.J., Grinblat, Y., Setaluri, V., and Spiegelman, V.S. (2010). MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. J. Biol. Chem. 285, 20532-20540.
36. Greenberg, E., Hershkovitz, L., Itzhaki, O. et al. (2011). Regulation of cancer aggressive features in melanoma cells by microRNAs. PLoS ONE 6, e18936.
37. Grignol, V., Fairchild, E.T., Zimmerer, J.M. et al. (2011). miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions. Br. J. Cancer 105, 1023-1029.
38. Haflidadottir, B.S., Bergsteinsdottir, K., Praetorius, C., and Steingrimsson, E. (2010). miR-148 regulates Mitf in melanoma cells. PLoS ONE 5, e11574.
39. Heinemann, A., Zhao, F., Pechlivanis, S., Eberle, J., Steinle, A., Diederichs, S., Schadendorf, D., and Paschen, A. (2012). Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res. 72, 460-471.
40. Hodgkinson, C.A., Moore, K.J., Nakayama, A., Steingrimsson, E., Copeland, N.G., Jenkins, N.A., and Arnheiter, H. (1993). Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74, 395-404.
41. Hoek, K.S., and Goding, C.R. (2010). Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res. 23, 746-759.
42. Hoek, K.S., Eichhoff, O.M., Schlegel, N.C., Dobbeling, U., Kobert, N., Schaerer, L., Hemmi, S., and Dummer, R. (2008). In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res. 68, 650-656.
43. Hussein, M.R., Haemel, A.K., and Wood, G.S. (2003). Apoptosis and melanoma: molecular mechanisms. J. Pathol. 199, 275-288.
44. Huynh, C., Segura, M.F., Gaziel-Sovran, A. et al. (2011). Efficient in vivo microRNA targeting of liver metastasis. Oncogene 30, 1481-1488.
45. Igoucheva, O., and Alexeev, V. (2009). MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem. Biophys. Res. Commun. 379, 790-794.
46. Jafarnejad, S.M., Ardekani, G.S., Ghaffari, M., Martinka, M., and Li, G. (2012). Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion. Oncogene [Epub ahead of print] doi: 10.1038/onc.2012.239.
47. Jin, L., Hu, W.L., Jiang, C.C. et al. (2011). MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proc. Natl Acad. Sci. USA 108, 15840-15845.
48. Jukic, D.M., Rao, U.N., Kelly, L., Skaf, J.S., Drogowski, L.M., Kirkwood, J.M., and Panelli, M.C. (2010). Microrna profiling analysis of differences between the melanoma of young adults and older adults. J. Transl. Med. 8, 27.
49. Kanemaru, H., Fukushima, S., Yamashita, J. et al. (2011). The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. J. Dermatol. Sci. 61, 187-193.
50. Kappelmann, M., Kuphal, S., Meister, G., Vardimon, L., and Bosserhoff, A.K. (2012). MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. Oncogene [Epub ahead of print] doi: 10.1038/onc.2012.307.
51. Karreth, F.A., Tay, Y., Perna, D. et al. (2011). In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382-395.
52. Krol, J., Loedige, I., and Filipowicz, W. (2010). The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610.
53. Kumar, M.S., Lu, J., Mercer, K.L., Golub, T.R., and Jacks, T. (2007). Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39, 673-677.
54. Kunej, T., Godnic, I., Ferdin, J., Horvat, S., Dovc, P., and Calin, G.A. (2011). Epigenetic regulation of microRNAs in cancer: an integrated review of literature. Mutat. Res. 717, 77-84.
55. Lavon, I., Zrihan, D., Granit, A. et al. (2010). Gliomas display a microRNA expression profile reminiscent of neural precursor cells. Neuro-oncology 12, 422-433.
56. Lee, R.C., Feinbaum, R.L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75, 843-854.
57. Lee, E.J., Baek, M., Gusev, Y., Brackett, D.J., Nuovo, G.J., and Schmittgen, T.D. (2008). Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA 14, 35-42.
58. Leidinger, P., Keller, A., Borries, A., Reichrath, J., Rass, K., Jager, S.U., Lenhof, H.P., and Meese, E. (2010). High-throughput miRNA profiling of human melanoma blood samples. BMC Cancer 10, 262.
59. Levati, L., Alvino, E., Pagani, E. et al. (2009). Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155. Int. J. Oncol. 35, 393-400.
60. Levati, L., Pagani, E., Romani, S. et al. (2011). MicroRNA-155 targets the SKI gene in human melanoma cell lines. Pigment Cell Melanoma Res. 24, 538-550.
61. Levy, C., Khaled, M., and Fisher, D.E. (2006). MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol. Med. 12, 406-414.
62. Levy, C., Khaled, M., Iliopoulos, D. et al. (2010a). Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol. Cell 40, 841-849.
63. Levy, C., Khaled, M., Robinson, K.C. et al. (2010b). Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell 141, 994-1005.
64. Liu, S., Kumar, S.M., Lu, H., Liu, A., Yang, R., Pushparajan, A., Guo, W., and Xu, X. (2012). MicroRNA-9 up-regulates E-cadherin through inhibition of NF-kappaB1-Snail1 pathway in melanoma. J. Pathol. 226, 61-72.
65. Lodygin, D., Tarasov, V., Epanchintsev, A., Berking, C., Knyazeva, T., Korner, H., Knyazev, P., Diebold, J., and Hermeking, H. (2008). Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7, 2591-2600.
66. Lujambio, A., Calin, G.A., Villanueva, A. et al. (2008). A microRNA DNA methylation signature for human cancer metastasis. Proc. Natl Acad. Sci. USA 105, 13556-13561.
67. Ma, Z., Swede, H., Cassarino, D., Fleming, E., Fire, A., and Dadras, S.S. (2011). Up-regulated Dicer expression in patients with cutaneous melanoma. PLoS ONE 6, e20494.
68. Mattia, G., Errico, M.C., Felicetti, F. et al. (2011). Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma. Pigment Cell Melanoma Res. 24, 953-965.
69. Mazar, J., Deyoung, K., Khaitan, D., Meister, E., Almodovar, A., Goydos, J., Ray, A., and Perera, R.J. (2010). The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS ONE 5, e13779.
70. Mazar, J., Deblasio, D., Govindarajan, S.S., Zhang, S., and Perera, R.J. (2011a). Epigenetic regulation of microRNA-375 and its role in melanoma development in humans. FEBS Lett. 585, 2467-2476.
71. Mazar, J., Khaitan, D., Deblasio, D., Zhong, C., Govindarajan, S.S., Kopanathi, S., Zhang, S., Ray, A., and Perera, R.J. (2011b). Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma. PLoS ONE 6, e24922.
72. Migliore, C., Petrelli, A., Ghiso, E., Corso, S., Capparuccia, L., Eramo, A., Comoglio, P.M., and Giordano, S. (2008). MicroRNAs impair MET-mediated invasive growth. Cancer Res. 68, 10128-10136.
73. Mitchell, P.S., Parkin, R.K., Kroh, E.M. et al. (2008). Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA 105, 10513-10518.
74. Mobley, A.K., Braeuer, R.R., Kamiya, T., Shoshan, E., and Bar-Eli, M. (2012). Driving transcriptional regulators in melanoma metastasis. Cancer Metastasis Rev. [Epub ahead of print] doi: 10.1007/s10555-012-9358-8.
75. Molnar, V., Tamasi, V., Bakos, B., Wiener, Z., and Falus, A. (2008). Changes in miRNA expression in solid tumors: an miRNA profiling in melanomas. Semin. Cancer Biol. 18, 111-122.
76. Mueller, D.W., and Bosserhoff, A.K. (2010). The evolving concept of 'melano-miRs'-microRNAs in melanomagenesis. Pigment Cell Melanoma Res. 23, 620-626.
77. Mueller, D.W., and Bosserhoff, A.K. (2011). MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. Int. J. Cancer 129, 1064-1074.
78. Mueller, D.W., Rehli, M., and Bosserhoff, A.K. (2009). miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J. Invest. Dermatol. 129, 1740-1751.
79. Muller, D.W., and Bosserhoff, A.K. (2008). Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma. Oncogene 27, 6698-6706.
80. Nair, V.S., Maeda, L.S., and Ioannidis, J.P. (2012). Clinical outcome prediction by microRNAs in human cancer: a systematic review. J. Natl Cancer Inst. 104, 528-540.
81. Nguyen, T., Kuo, C., Nicholl, M.B., Sim, M.S., Turner, R.R., Morton, D.L., and Hoon, D.S. (2011). Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Epigenetics 6, 388-394.
82. Noguchi, S., Mori, T., Otsuka, Y., Yamada, N., Yasui, Y., Iwasaki, J., Kumazaki, M., Maruo, K., and Akao, Y. (2012). Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells. J. Biol. Chem. 287, 11769-11777.
83. Olive, V., Jiang, I., and He, L. (2010). mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int. J. Biochem. Cell Biol. 42, 1348-1354.
84. Ozsolak, F., Poling, L.L., Wang, Z., Liu, H., Liu, X.S., Roeder, R.G., Zhang, X., Song, J.S., and Fisher, D.E. (2008). Chromatin structure analyses identify miRNA promoters. Genes Dev. 22, 3172-3183.
85. Pasquinelli, A.E., Reinhart, B.J., Slack, F. et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408, 86-89.
86. Penna, E., Orso, F., Cimino, D. et al. (2011). microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 30, 1990-2007.
87. Philippidou, D., Schmitt, M., Moser, D., Margue, C., Nazarov, P.V., Muller, A., Vallar, L., Nashan, D., Behrmann, I., and Kreis, S. (2010). Signatures of microRNAs and selected microRNA target genes in human melanoma. Cancer Res. 70, 4163-4173.
88. Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W.J., and Pandolfi, P.P. (2010). A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033-1038.
89. Poliseno, L., Haimovic, A., Segura, M.F. et al. (2012). Histology-specific microRNA alterations in melanoma. J. Invest. Dermatol. 132, 1860-1868.
90. Pradervand, S., Weber, J., Thomas, J., Bueno, M., Wirapati, P., Lefort, K., Dotto, G.P., and Harshman, K. (2009). Impact of normalization on miRNA microarray expression profiling. RNA 15, 493-501.
91. Reed, J.A., Lin, Q., Chen, D., Mian, I.S., and Medrano, E.E. (2005). SKI pathways inducing progression of human melanoma. Cancer Metastasis Rev. 24, 265-272.
92. Reinsbach, S., Nazarov, P.V., Philippidou, D., Schmitt, M., Wienecke-Baldacchino, A., Muller, A., Vallar, L., Behrmann, I., and Kreis, S. (2012). Dynamic regulation of microRNA expression following Interferon-gamma-induced gene transcription. RNA Biol. 9, [Epub ahead of print].
93. Rosenfeld, N., Aharonov, R., Meiri, E. et al. (2008). MicroRNAs accurately identify cancer tissue origin. Nat. Biotechnol. 26, 462-469.
94. Rothhammer, T., Braig, S., and Bosserhoff, A.K. (2008). Bone morphogenetic proteins induce expression of metalloproteinases in melanoma cells and fibroblasts. Eur. J. Cancer 44, 2526-2534.
95. Ryan, B.M., Robles, A.I., and Harris, C.C. (2010). Genetic variation in microRNA networks: the implications for cancer research. Nat. Rev. Cancer 10, 389-402.
96. Sakurai, E., Maesawa, C., Shibazaki, M. et al. (2011). Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells. Int. J. Oncol. 39, 665-672.
97. Sand, M., Gambichler, T., Sand, D., Altmeyer, P., Stuecker, M., and Bechara, F.G. (2011). Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi. Eur. J. Dermatol. 21, 18-21.
98. Sand, M., Skrygan, M., Georgas, D., Sand, D., Gambichler, T., Altmeyer, P., and Bechara, F.G. (2012). The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi. Cell Tissue Res. [Epub ahead of print] doi: 10.1007/s00441-012-1446-00.
99. Satzger, I., Mattern, A., Kuettler, U., Weinspach, D., Voelker, B., Kapp, A., and Gutzmer, R. (2010). MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. Int. J. Cancer 126, 2553-2562.
100. Schultz, J., Lorenz, P., Gross, G., Ibrahim, S., and Kunz, M. (2008). MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 18, 549-557.
101. Segura, M.F., Hanniford, D., Menendez, S. et al. (2009). Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc. Natl Acad. Sci. USA 106, 1814-1819.
102. Segura, M.F., Belitskaya-Levy, I., Rose, A.E. et al. (2010). Melanoma MicroRNA signature predicts post-recurrence survival. Clin. Cancer Res. 16, 1577-1586.
103. Segura, M., Greenwald, H., Hanniford, D., Osman, I., and Hernando, E. (2012). MicroRNA & cutaneous melanoma: from discovery to prognosis and therapy. Carcinogenesis [Epub ahead of print] doi:10.1093/carcin/bgs205.
104. Selzer, E., Wacheck, V., Lucas, T. et al. (2002). The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma. Cancer Res. 62, 2098-2103.
105. Sotiropoulou, G., Pampalakis, G., Lianidou, E., and Mourelatos, Z. (2009). Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15, 1443-1461.
106. Sparrow, L.E., Soong, R., Dawkins, H.J., Iacopetta, B.J., and Heenan, P.J. (1995). p53 gene mutation and expression in naevi and melanomas. Melanoma Res. 5, 93-100.
107. Stark, M.S., Tyagi, S., Nancarrow, D.J., Boyle, G.M., Cook, A.L., Whiteman, D.C., Parsons, P.G., Schmidt, C., Sturm, R.A., and Hayward, N.K. (2010). Characterization of the Melanoma miRNAome by Deep Sequencing. PLoS ONE 5, e9685.
108. Steingrimsson, E., Copeland, N.G., and Jenkins, N.A. (2004). Melanocytes and the microphthalmia transcription factor network. Annu. Rev. Genet. 38, 365-411.
109. Streicher, K.L., Zhu, W., Lehmann, K.P. et al. (2012). A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth. Oncogene 31, 1558-1570.
110. Thompson, J.F., Scolyer, R.A., and Kefford, R.F. (2005). Cutaneous melanoma. Lancet 365, 687-701.
111. Vandewalle, C., Comijn, J., De Craene, B., Vermassen, P., Bruyneel, E., Andersen, H., Tulchinsky, E., Van Roy, F., and Berx, G. (2005). SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res. 33, 6566-6578.
112. Wang, Y., and Lee, C.G. (2009). MicroRNA and cancer-focus on apoptosis. J. Cell Mol. Med. 13, 12-23.
113. Winter, J., and Diederichs, S. (2011). MicroRNA biogenesis and cancer. Methods Mol. Biol. 676, 3-22.
114. Xu, Y., Brenn, T., Brown, E.R., Doherty, V., and Melton, D.W. (2012). Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br. J. Cancer 106, 553-561.
115. Yang, C.H., Yue, J., Pfeffer, S.R., Handorf, C.R., and Pfeffer, L.M. (2011). MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells. J. Biol. Chem. 286, 39172-39178.
116. Zehavi, L., Avraham, R., Barzilai, A., Bar-Ilan, D., Navon, R., Sidi, Y., Avni, D., and Leibowitz-Amit, R. (2012). Silencing of a large micro-RNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor. Mol. Cancer 11, 44-58.
117. Zeisel, A., Amir, A., Kostler, W.J., and Domany, E. (2010). Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes. BMC Bioinformatics 11, 400.
118. Zhang, L., Huang, J., Yang, N. et al. (2006). microRNAs exhibit high frequency genomic alterations in human cancer. Proc. Natl Acad. Sci. USA 103, 9136-9141.
119. Zhang, H., Hao, Y., Yang, J., Zhou, Y., Li, J., Yin, S., Sun, C., Ma, M., Huang, Y., and Xi, J.J. (2011). Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. Nat. Commun. [Epub ahead of print]. doi: 10.1038/ncomms1555.