Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma

Modern Pathology

Volumn 19, Issue 8, 2006, Pages 1034-1041

  Cheung, Hannah C ^a,b   Corley, Lynda J ^a   Fuller, Gregory N ^a   McCutcheon, Ian E ^a   Cote, Gilbert J ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Glioma; Notch; Polypyrimidine tract binding protein; Tissue microarray

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; NOTCH1 RECEPTOR; POLYPYRIMIDINE TRACT BINDING PROTEIN; TRANSCRIPTION FACTOR HES 1; TUMOR MARKER;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE SEVERITY; GLIOMA; GLIOSARCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TISSUE MICROARRAY; TUMOR CELL; TUMOR GROWTH;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; NEOPLASM STAGING; POLYPYRIMIDINE TRACT-BINDING PROTEIN; RECEPTOR, NOTCH1; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 33746322370     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800635     Document Type: Article

References (42)

1. Zhang W, Fuller GN (eds). Genomic and Molecular Neuro-Oncology. Jones and Bartlett Publishers: Sudbury, 2004.
2. Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 2005;64:479-489.
3. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111.
4. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828.
5. Sanai N, Alvarez-Buylla A, Berger MS. Neural stem cells and the origin of gliomas. N Engl J Med 2005;353:811-822.
6. Dahlstrand J, Collins VP, Lendahl U. Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 1992;52:5334-5341.
7. Tohyama T, Lee VM, Rorke LB, et al. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab Invest 1992;66:303-313.
8. Golestaneh N, Mishra B. TGF-beta, neuronal stem cells and glioblastoma. Oncogene 2005;24:5722-5730.
9. Purow BW, Haque RM, Noel MW, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005;65:2353-2363.
10. Fomchenko EI, Holland EC. Stem cells and brain cancer. Exp Cell Res 2005;306:323-329.
11. Wagner EJ, Garcia-Blanco MA. Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 2001;21:3281-3288.
12. Rustighi A, Tessari MA, Vascotto F, et al. A polypyrimidine/polypurine tract within the Hmga2 minimal promoter: a common feature of many growth-related genes. Biochemistry 2002;41:1229-1240.
13. Lillevali K, Kulla A, Ord T. Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain. Mech Dev 2001;101:217-220.
14. McCutcheon IE, Hentschel SJ, Fuller GN, et al. Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain. Neuro-oncol 2004;6:9-14.
15. Castrillon DH, Gonczy P, Alexander S, et al. Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 1993;135:489-505.
16. Dansereau DA, Lunke MD, Finkielsztein A, et al. Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster. Development 2002;129:5553-5566.
17. Lundkvist J, Lendahl U. Notch and the birth of glial cells. Trends Neurosci 2001;24:492-494.
18. Gaiano N, Fishell G. The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci 2002;25:471-490.
19. Grandbarbe L, Bouissac J, Rand M, et al. Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development 2003;130:1391-1402.
20. Joutel A, Tournier-Lasserve E. Notch signalling pathway and human diseases. Semin Cell Dev Biol 1998;9:619-625.
21. Bresnick EH, Chu J, Christensen HM, et al. Linking Notch signaling, chromatin remodeling, and T-cell leukemogenesis. J Cell Biochem Suppl 2000;79(Suppl 35):46-53.
22. Allenspach EJ, Maillard I, Aster JC, et al. Notch signaling in cancer. Cancer Biol Ther 2002;1:466-476.
23. Brennan K, Brown AM. Is there a role for Notch signalling in human breast cancer? Breast Cancer Res 2003;5:69-75.
24. Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell 2003;3:203-205.
25. Nickoloff BJ, Osborne BA, Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 2003;22:6598-6608.
26. Pan Y, Lin MH, Tian X, et al. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell 2004;7:731-743.
27. Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev 2004;14:48-54.
28. Zweidler-McKay PA, Pear WS. Notch and T cell malignancy. Semin Cancer Biol 2004;14:329-340.
29. Hallahan AR, Pritchard JI, Hansen S, et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 2004;64:7794-7800.
30. Grossman JS, Meyer MI, Wang YC, et al. The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. Rna 1998;4:613-625.
31. Yoon K, Gaiano N. Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci 2005;8:709-715.
32. Shimizu K, Chiba S, Saito T, et al. Functional diversity among Notch1, Notch2, and Notch3 receptors. Biochem Biophys Res Commun 2002;291:775-779.
33. Wu Y, Liu Y, Levine EM, et al. Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Dev Dyn 2003;226:675-689.
34. Chan RC, Black DL. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol 1997;17:4667-4676.
35. Zhang L, Liu W, Grabowski PJ. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. Rna 1999;5:117-130.
36. Jin W, McCutcheon IE, Fuller GN, et al. Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. Cancer Res 2000;60:1221-1224.
37. Carstens RP, Wagner EJ, Garcia-Blanco MA. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol 2000;20:7388-7400.
38. Cote J, Dupuis S, Wu JY. Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion. J Biol Chem 2001;276:8535-8543.
39. Giraud S, Greco A, Brink M, et al. Translation initiation of the insulin-like growth factor I receptor mRNA is mediated by an internal ribosome entry site. J Biol Chem 2001;276:5668-5675.
40. Mitchell SA, Brown EC, Coldwell MJ, et al. Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras. Mol Cell Biol 2001;21:3364-3374.
41. Coles LS, Bartley MA, Bert A, et al. A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization. Eur J Biochem 2004;271:648-660.
42. Izquierdo JM, Majos N, Bonnal S, et al. Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol Cell 2005;19:475-484.