Inflammation in the middle ear of children with recurrent or chronic otitis media is associated with bacterial load

Pediatric Infectious Disease Journal

Volumn 31, Issue 11, 2012, Pages 1128-1134

  Stol, Kim ^a   Diavatopoulos, Dimitri A ^a   Graamans, Kees ^a   Engel, Joost A M ^b   Melchers, Willem J G ^a   Savelkoul, Huub F J ^c   Hays, John P ^d   Warris, Adilia ^a   Hermans, Peter W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CANISIUS WILHELMINA HOSPITAL   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

cytokines; Haemophilus influenzae; Moraxella catarrhalis; otitis media; Streptococcus pneumoniae

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL LOAD; BACTERIUM DETECTION; CHILD; CHILDHOOD DISEASE; CHRONIC OTITIS MEDIA; CORONAVIRUS; CYTOKINE RESPONSE; ENDOLYMPH; ENTEROVIRUS; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INFLUENZA VIRUS A; INFLUENZA VIRUS B; MAJOR CLINICAL STUDY; MALE; MORAXELLA CATARRHALIS; PARAINFLUENZA VIRUS; PARECHOVIRUS; PRESCHOOL CHILD; PRIORITY JOURNAL; RECURRENT INFECTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOVIRUS; STREPTOCOCCUS PNEUMONIAE;

BACTERIAL INFECTIONS; BODY FLUIDS; CHILD, PRESCHOOL; CHRONIC DISEASE; CYTOKINES; HUMANS; INFANT; INFLAMMATION; OTITIS MEDIA; RECURRENCE; VIRUS DISEASES; VIRUSES;

EID: 84867878766     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3182611d6b     Document Type: Article

References (38)

1. Alper CM, Winther B, Mandel EM, et al. Temporal relationships for cold-like illnesses and otitis media in sibling pairs. Pediatr Infect Dis J. 2007;26:778-781. (Pubitemid 47329846)
2. Nokso-Koivisto J, Räty R, Blomqvist S, et al. Presence of specific viruses in the middle ear fluids and respiratory secretions of young children with acute otitis media. J Med Virol. 2004;72:241-248. (Pubitemid 38020551)
3. Ogra PL. Respiratory syncytial virus: the virus, the disease and the immune response. Paediatr Respir Rev. 2004;5(suppl A):S119-S126.
4. Ruohola A, Meurman O, Nikkari S, et al. Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses. Clin Infect Dis. 2006;43:1417-1422. (Pubitemid 44845642)
5. Willett DN, Rezaee RP, Billy JM, et al. Relationship of endotoxin to tumor necrosis factor-alpha and interleukin-1 beta in children with otitis media with effusion. Ann Otol Rhinol Laryngol. 1998;107:28-33. (Pubitemid 28041884)
6. Scharer G, Zaldivar F, Gonzalez G, et al. Systemic inflammatory responses in children with acute otitis media due to Streptococcus pneumoniae and the impact of treatment with clarithromycin. Clin Diagn Lab Immunol. 2003;10:721-724. (Pubitemid 36890464)
7. Maeda K, Hirano T, Ichimiya I, et al. Cytokine expression in experimental chronic otitis media with effusion in mice. Laryngoscope. 2004;114:1967-1972. (Pubitemid 39539857)
8. Skotnicka B, Hassmann E. Proinflammatory and immunoregulatory cytokines in the middle ear effusions. Int J Pediatr Otorhinolaryngol. 2008;72:13-17. (Pubitemid 350198649)
9. Leibovitz E, Dagan R, Laver JH, et al. Interleukin 8 in middle ear fluid during acute otitis media: correlation with aetiology and bacterial eradication. Arch Dis Child. 2000;82:165-168. (Pubitemid 30305715)
10. Bikhazi P, Ryan AF. Expression of immunoregulatory cytokines during acute and chronic middle ear immune response. Laryngoscope. 1995;105:629-634.
11. Smirnova MG, Birchall JP, Pearson JP. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators Inflamm. 2004;13:75-88. (Pubitemid 38698136)
12. van der Sluijs KF, van Elden LJ, Nijhuis M, et al. IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. J Immunol. 2004;172:7603-7609. (Pubitemid 38747624)
13. Besnard AG, Togbe D, Couillin I, et al. Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol. 2012;4:3-10.
14. Oliver BG, Lim S, Wark P, et al. Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax. 2008;63:519-525. (Pubitemid 351831162)
15. Veenhoven R, Bogaert D, Uiterwaal C, et al. Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet. 2003;361:2189-2195. (Pubitemid 36782552)
16. van Heerbeek N, Straetemans M, Wiertsema SP, et al. Effect of combined pneumococcal conjugate and polysaccharide vaccination on recurrent otitis media with effusion. Pediatrics. 2006;117:603-608. (Pubitemid 46063199)
17. Kais M, Spindler C, Kalin M, et al. Quantitative detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in lower respiratory tract samples by real-time PCR. Diagn Microbiol Infect Dis. 2006;55:169-178. (Pubitemid 43949456)
18. Hall-Stoodley L, Hu FZ, Gieseke A, et al. Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA. 2006;296:202-211. (Pubitemid 44050374)
19. Hays JP, van Selm S, Hoogenboezem T, et al. Identification and characterization of a novel outer membrane protein (OMP J) of Moraxella catarrhalis that exists in two major forms. J Bacteriol. 2005;187:7977-7984. (Pubitemid 41691691)
20. Templeton KE, Scheltinga SA, Beersma MF, et al. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. J Clin Microbiol. 2004;42:1564-1569. (Pubitemid 38500797)
21. Patel JA, Nair S, Grady J, et al. Systemic cytokine response profiles associated with respiratory virus-induced acute otitis media. Pediatr Infect Dis J. 2009;28:407-411.
22. Patel JA, Nair S, Revai K, et al. Nasopharyngeal acute phase cytokines in viral upper respiratory infection: impact on acute otitis media in children. Pediatr Infect Dis J. 2009;28:1002-1007.
23. Berman S. Otitis media in children. N Engl J Med. 1995;332:1560-1565.
24. Rovers MM, Schilder AG, Zielhuis GA, et al. Otitis media. Lancet. 2004;363:465-473. (Pubitemid 38210066)
25. Post JC, Preston RA, Aul JJ, et al. Molecular analysis of bacterial pathogens in otitis media with effusion. JAMA. 1995;273:1598-1604.
26. Coates H, Thornton R, Langlands J, et al. The role of chronic infection in children with otitis media with effusion: evidence for intracellular persistence of bacteria. Otolaryngol Head Neck Surg. 2008;138: 778-781. (Pubitemid 351707534)
27. Skovbjerg S, Roos K, Nowrouzian F, et al. High cytokine levels in perforated acute otitis media exudates containing live bacteria. Clin Microbiol Infect. 2010;16:1382-1388.
28. Rodriguez WJ, Schwartz RH. Streptococcus pneumoniae causes otitis media with higher fever and more redness of tympanic membranes than Haemophilus influenzae or Moraxella catarrhalis. Pediatr Infect Dis J. 1999;18:942-944. (Pubitemid 29487522)
29. Message SD, Laza-Stanca V, Mallia P, et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci USA. 2008;105:13562-13567.
30. Chattoraj SS, Ganesan S, Jones AM, et al. Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells. Thorax. 2011;66:333-339.
31. Chantzi FM, Papadopoulos NG, Bairamis T, et al. Human rhinoviruses in otitis media with effusion. Pediatr Allergy Immunol. 2006;17: 514-518. (Pubitemid 44511085)
32. Peltola V, Waris M, Osterback R, et al. Clinical effects of rhinovirus infections. J Clin Virol. 2008;43:411-414.
33. Rezes S, Söderlund-Venermo M, Roivainen M, et al. Human bocavirus and rhino-enteroviruses in childhood otitis media with effusion. J Clin Virol. 2009;46:234-237.
34. Pitkäranta A, Rihkanen H, Carpén O, et al. Rhinovirus RNA in children with longstanding otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2002;66:247-250. (Pubitemid 35351323)
35. Elkhatieb A, Hipskind G, Woerner D, et al. Middle ear abnormalities during natural rhinovirus colds in adults. J Infect Dis. 1993;168:618-621. (Pubitemid 23254280)
36. Pitkäranta A, Jero J, Arruda E, et al. Polymerase chain reaction-based detection of rhinovirus, respiratory syncytial virus, and coronavirus in otitis media with effusion. J Pediatr. 1998;133:390-394. (Pubitemid 28413624)
37. Smith-Vaughan HC, McBroom J, Mathews JD. Modelling of endemic carriage of Haemophilus influenzae in Aboriginal infants in Northern Australia. FEMS Immunol Med Microbiol. 2001;31:137-143. (Pubitemid 32822878)
38. Jartti T, Lee WM, Pappas T, et al. Serial viral infections in infants with recurrent respiratory illnesses. Eur Respir J. 2008;32:314-320.