Interleukin 8 in middle ear fluid during acute otitis media: Correlation with aetiology and bacterial eradication

Archives of Disease in Childhood

Volumn 82, Issue 2, 2000, Pages 165-168

  Leibovitz, Eugene ^a   Dagan, Ron ^a   Laver, Joseph H ^c   Piglansky, Lolita ^a   Raiz, Simon ^a   Abboud, Miguel R ^c   Fliss, Dan M ^a   Leiberman, Alberto ^a   Barzilai, Asher ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Haemophilus influenzae; Interleukin 8; Otitis media; Streptococcus pneumoniae

Indexed keywords

CYTOKINE; INTERLEUKIN 8;

ARTICLE; BACTERIAL INFECTION; CHILD; HAEMOPHILUS INFLUENZAE; HUMAN; IMMUNE SYSTEM; INFANT; MAJOR CLINICAL STUDY; MIDDLE EAR EFFUSION; OTITIS MEDIA; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CHILD, PRESCHOOL; EXUDATES AND TRANSUDATES; HUMANS; INFANT; INTERLEUKIN-8; OTITIS MEDIA WITH EFFUSION;

EID: 0034084936     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.82.2.165     Document Type: Article

References (20)

1. 1 Klein JO. Otitis media. Clin Infect Dis 1994;19:823-33.
2. 2 Berman S. Otitis media in children. N Engl J Med 1995:332: 1560-5.
3. 3 Bernstein JM. Immunologic reactivity in the middle ear in otitis media with effusion. Otolaryngol Clin North Am 1991; 24:845-59.
4. 4 Saez-Llorens X. Pathogenesis of acute otitis media. Pediatr Infect Dis J 1994;13:1035-8.
5. 5 Fergie JE, Purcell K. The role of inflammatory mediators and anti-inflammatory drugs in otitis media. Pediatr Ann 1998;27;76-81.
6. 6 Yellon RF, Leonard G, Marucha PT, et al. Characterization of cytokines present in middle ear effusions. Laryngoscope 1991;101:165-9.
7. 7 Ovesen T, Ledet T. Bacteria and endotoxin in middle ear fluid and the course of secretory otitis media. Clin Otolaryngol 1992;17:531-4.
8. 8 Takeuchi K, Maesako K, Yuta A, Sakakura Y. Interleukin-8 gene expression in middle ear effusions. Ann Otol Rhinol Laryngol 1994;103:404-7.
9. 9 Maxwell KS, Fitzgerald JE, Burleson JA, Leonard G, Carpenter R, Kreutzer DL. Interleukin-8 expression in otitis media. Laryngoscope 1994;104:989-95.
10. 10 Storgaard M, Larsen K, Blegvad S, et al. Interleukin-8 and chemotactic activity of middle ear effusions. J Infect Dis 1997;175:474-7.
11. 11 Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997;176:1253-9.
12. 12 Lewis DM, Meadema SJ, Schron JL, Lim DL. Experimental otitis media in chinchillas. Ann Otol Rhinol Laryngol 1980;89(suppl 68):344-50.
13. 13 Bernstein JM, Humbert JR, Hliwa MM. Oxygen consumption of middle ear and peripheral blood neutrophils in acute suppurative otitis media. Am J Otolaryngol 1985;6: 169-72.
14. 14 Patel J, Chomaitree T, Schmalsteig F. Effect of modulation of polymorpholeukocyte migration with anti-CD18 antibody on pathogenesis of experimental otitis media in guinea pigs. Infect Immun 1993;61:1132-5.
15. 15 Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide 1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-9.
16. 16 Mukaida N, Harada A, Yasumoto K, Matsushima K. Properties of proinflammatory cell type-specific leukocyte chemotactic cytokines, interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF). Microbiol Immunol 1992;36:773-89.
17. 17 Miller MD, Krangel MS. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 1992;12:17-46.
18. 18 Chonmaitree T, Patel JA, Garofalo R, et al. Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. Ann Otol Rhinol Laryngol 1996;105:968-74.
19. 19 Carlin SA, Marchant CA, Shurin PA, Johnson CE, Super DM, Rehmus JM. Host factors and early therapeutic response in acute otitis media. J Pediatr 1991;118:178-83.
20. 20 Dagan R, Leibovitz E, Greenberg D, Yagupsky P, Fliss DM, Leiberman A. Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome. Pediatr Infect Dis J 1998;17:776-82.