High cytokine levels in perforated acute otitis media exudates containing live bacteria

Clinical Microbiology and Infection

Volumn 16, Issue 9, 2010, Pages 1382-1388

  Skovbjerg, S ^a   Roos, K ^b   Nowrouzian, F ^a   Lindh, M ^a   Holm, S E ^a   Adlerberth, I ^a   Olofsson, S ^a   Wold, A E ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Capio AB   (Sweden)

Author keywords

Acute otitis media; Bacteria; Cytokines; Middle ear fluid; PCR

Indexed keywords

8 ISOPROSTAGLANDIN E2; BACTERIAL DNA; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA;

ACUTE OTITIS MEDIA; ADENOVIRUS; ARTICLE; BACTERIUM CULTURE; BACTERIUM DETECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORONAVIRUS; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; EARDRUM; ENTEROVIRUS; HAEMOPHILUS INFLUENZAE; HUMAN; INFLUENZA VIRUS A; INFLUENZA VIRUS B; LEUKOCYTE; METAPNEUMOVIRUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHINOVIRUS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; VIRUS CULTURE; VIRUS DETECTION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 77956121682     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2010.03083.x     Document Type: Article

References (30)

1. Kilpi T, Herva E, Kaijalainen T, Syrjanen R, Takala AK. Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infect Dis J 2001, 20:654-662.
2. Heikkinen T, Chonmaitree T. Importance of respiratory viruses in acute otitis media. Clin Microbiol Rev 2003, 16:230-241.
3. Davies P, Bailey PJ, Goldenberg MM, Ford-Hutchinson AW. The role of arachidonic acid oxygenation products in pain and inflammation. Annu Rev Immunol 1984, 2:335-357.
4. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 1990, 70:427-451.
5. Mukaida N, Harada A, Matsushima K. Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions. Cytokine Growth Factor Rev 1998, 9:9-23.
6. Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol 2003, 24:25-29.
7. Conti P, Kempuraj D, Kandere K. IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett 2003, 86:123-129.
8. Aloisi F, De Simone R, Columba-Cabezas S, Levi G. Opposite effects of interferon-gamma and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activities. J Neurosci Res 1999, 56:571-580.
9. Hessle CC, Andersson B, Wold AE. Gram-negative, but not Gram-positive, bacteria elicit strong PGE2 production in human monocytes. Inflammation 2003, 27:329-332.
10. Hessle C, Andersson B, Wold AE. Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production. Infect Immun 2000, 68:3581-3586.
11. Hessle CC, Andersson B, Wold AE. Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes. Cytokine 2005, 30:311-318.
12. Barkman C, Martner A, Hessle C, Wold AE. Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria. Microbes Infect 2008, 10:1484-1493.
13. Martner A, Skovbjerg S, Paton JC, Wold AE. Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte-activating cytokines. Infect Immun 2009, 77:3826-3837.
14. Fritzell P, Bergstrom T, Welinder-Olsson C. Detection of bacterial DNA in painful degenerated spinal discs in patients without signs of clinical infection. Eur Spine J 2004, 13:702-706.
15. Hendolin PH, Markkanen A, Ylikoski J, Wahlfors JJ. Use of multiplex PCR for simultaneous detection of four bacterial species in middle ear effusions. J Clin Microbiol 1997, 35:2854-2858.
16. Skovbjerg S, Roos K, Holm SE. Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media. Arch Dis Child 2009, 94:92-98.
17. Brittain-Long R, Nord S, Olofsson S, Westin J, Anderson LM, Lindh M. Multiplex real-time PCR for detection of respiratory tract infections. J Clin Virol 2008, 41:53-56.
18. Karlsson H, Hessle C, Rudin A. Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora. Infect Immun 2002, 70:6688-6696.
19. Barzilai A, Leibovitz E, Laver JH. Dynamics of interleukin-1 production in middle ear fluid during acute otitis media treated with antibiotics. Infection 1999, 27:173-176.
20. Barzilai A, Dekel B, Dagan R, Passwell JH, Leibovitz E. Cytokine analysis of middle ear effusions during acute otitis media: significant reduction in tumor necrosis factor alpha concentrations correlates with bacterial eradication. Pediatr Infect Dis J 1999, 18:301-303.
21. Leibovitz E, Dagan R, Laver JH. Interleukin 8 in middle ear fluid during acute otitis media: correlation with aetiology and bacterial eradication. Arch Dis Child 2000, 82:165-168.
22. Jones SA. Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 2005, 175:3463-3468.
23. Forseni M, Melhus A, Ryan AF, Bagger-Sjoback D, Hultcrantz M. Detection and localization of interleukin-6 in the rat middle ear during experimental acute otitis media, using mRNA in situ hybridization and immunohistochemistry. Int J Pediatr Otorhinolaryngol 2001, 57:115-121.
24. Mariathasan S, Monack DM. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 2007, 7:31-40.
25. Havemose-Poulsen A, Holmstrup P. Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature. Crit Rev Oral Biol Med 1997, 8:217-236.
26. Arva E, Andersson B. Induction of phagocyte-stimulating cytokines by in vitro stimulation of human peripheral blood mononuclear cells with Haemophilus influenzae. Scand J Immunol 1999, 49:411-416.
27. Heikkinen T, Ghaffar F, Okorodudu AO, Chonmaitree T. Serum interleukin-6 in bacterial and nonbacterial acute otitis media. Pediatrics 1998, 102:296-299.
28. Chonmaitree T, Patel JA, Sim T. Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. Ann Otol Rhinol Laryngol 1996, 105:968-974.
29. Leskinen K, Hendolin P, Virolainen-Julkunen A, Ylikoski J, Jero J. Alloiococcus otitidis in acute otitis media. Int J Pediatr Otorhinolaryngol 2004, 68:51-56.
30. Palmu AA, Herva E, Savolainen H, Karma P, Makela PH, Kilpi TM. Association of clinical signs and symptoms with bacterial findings in acute otitis media. Clin Infect Dis 2004, 38:234-242.