Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats

Toxicology and Applied Pharmacology

Volumn 264, Issue 3, 2012, Pages 423-430

  Liu, Tao ^a   Meng, Qiang ^a   Wang, Changyuan ^a   Liu, Qi ^a   Guo, Xinjin ^a   Sun, Huijun ^a   Peng, Jinyong ^a   Ma, Xiaochi ^a   Kaku, Taiichi ^b   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Japan Bioproducts Industry Co Ltd   (Japan)

Author keywords

Cisplatin; JBP485; Mrp2; Nephrotoxicity; Oat1; Oat3

Indexed keywords

CISPLATIN; COMPLEMENTARY DNA; CREATININE; CYCLO 4 HYDROXYPROLYLSERINE; DIPEPTIDE; INDICAN; JBP 485; MALONALDEHYDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; GLOMERULUS FILTRATION RATE; KIDNEY FUNCTION; LIPID PEROXIDATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TOXICOKINETICS; UREA NITROGEN BLOOD LEVEL; UREMIA; URINARY EXCRETION; WESTERN BLOTTING;

ACUTE KIDNEY INJURY; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CISPLATIN; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; MOLECULAR STRUCTURE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; PEPTIDES, CYCLIC; RATS; RATS, WISTAR; RNA, MESSENGER;

RATTUS;

EID: 84867870133     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.019     Document Type: Article

References (34)

1. Aleksunes L.M., Augustine L.M., Scheffer G.L., Cherrington N.J., Manautou J.E. Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment. Toxicology 2008, 250:82-88.
2. Arany I., Safirstein R.L. Cisplatin nephrotoxicity. Semin. Nephrol. 2003, 23:460-464.
3. Bar-Or D., Rael L.T., Bar-Or R., Craun M.L., Statz J., Garrett R.E. Mass spectrometry analysis of urine and catheter of a patient with purple urinary bag syndrome. Clin. Chim. Acta 2007, 378:216-218.
4. Borst P., Zelcer N., Van De Wetering K. MRP2 and 3 in health and disease. Cancer Lett. 2006, 234:51-61.
5. Brandoni A., Anzai N., Kanai Y., Endou H., Torres A.M. Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3. Biochim. Biophys. Acta 2006, 1762(7):673-682.
6. Cha S.H., Sekine T., Fukushima J.I., Kanai Y., Kobayashi Y., Goya T., Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 2001, 59:1277-1286.
7. Cui Y., König J., Buchholz J.K., Spring H., Leier I., Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharmacol. 1999, 55:929-937.
8. Deguchi T., Ohtsuki S., Otagiri M., Takanaga H., Asaba H., Mori S., Terasaki T. Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int. 2002, 61:1760-1768.
9. Demeule M., Brossard M., Béliveau R. Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter. Am. J. Physiol. 1999, 277:832-840.
10. Dobyan D.C., Levi J., Jacobs C., Kosek J., Weiner M.W. Mechanism of cisplatinum nephrotoxicity: II. Morphologic observations. J. Pharmacol. Exp. Ther. 1980, 213(3):551-556.
11. Enomoto A., Takeda M., Tojo A., Sekine T., Cha S.H., Khamdang S., Takayama F., Aoyama I., Nakamura S., Endou H., Niwa T. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J. Am. Soc. Nephrol. 2002, 13(7):1711-1720.
12. Hanigan M.H., Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther. 2003, 1:47-61.
13. Ji B., Ito K., Suzuki H., Sugiyama Y., Horie T. Multidrug resistance-associated protein 2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal. Free Radic. Biol. Med. 2002, 33:370-378.
14. Ji L., Masuda S., Saito H., Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int. 2002, 62:514-524.
15. Liu K.X., Kato Y., Kaku T., Sugiyama Y. Human placental extract stimulates liver regeneration in rats. Biol. Pharm. Bull. 1998, 21:44-49.
16. Liu K.X., Kato Y., Kaku T.I., Santa T., Imai K., Yagi A., Ishizu T., Sugiyama Y. Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. J. Pharmacol. Exp. Ther. 2000, 294:510-515.
17. Liu Z., Wang C., Liu Q., Meng Q., Cang J., Mei L., Kaku T., Liu K. Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo. Peptides 2011, 32:747-754.
18. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
19. Naud J., Michaud J., Beauchemin S., Hébert M.J., Roger M., Lefrancois S., Leblond F.A., Pichette V. Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats. Drug Metab. Dispos. 2011, 39:1363-1369.
20. Niwa T. Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. Semin. Nephrol. 1996, 16:167-182.
21. Niwa T. Indoxyl sulfate is a nephro-vascular toxin. J. Ren. Nutr. 2010, 20:S2-S6.
22. Reichard J.F., Doorn J.A., Simon F., Taylor M.S., Petersen D.R. Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Arch. Biochem. Biophys. 2003, 411:243-250.
23. Safaei R., Katano K., Larson B.J., Samimi G., Holzer A.K., Naerdemann W., Tomioka M., Goodman M., Howell S.B. Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells. Clin. Cancer Res. 2005, 11:756-767.
24. Santos N.A., Catão C.S., Martins N.M., Curti C., Bianchi M.L., Santos A.C. Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Arch. Toxicol. 2007, 81:495-504.
25. Smeets P.H., van Aubel R.A., Wouterse A.C., van den Heuvel J.J., Russel F.G. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J. Am. Soc. Nephrol. 2004, 15:2828-2835.
26. Somani S.M., Husain K., Whitworth C., Trammell G.L., Malafa M., Rybak L.P. Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: antioxidant defense system. Pharmacol. Toxicol. 2000, 86:234-241.
27. Sun H., Frassetto L., Benet L.Z. Effects of renal failure on drug transport and metabolism. Pharmacol. Ther. 2006, 109:1-11.
28. Suzuki H., Sugiyama Y. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin. Liver Dis. 1998, 18:359-376.
29. Tanaka Y., Kobayashi Y., Gabazza E.C., Higuchi K., Kamisako T., Kuroda M., et al. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 282:G656-G662.
30. Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M. A human anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 1996, 56:4123-4129.
31. Wang W., Liu Q., Wang C.Y., Meng Q., Kaku T., Liu K.X. Effects of JBP485 on the expression and function of PEPT1 in indomethacin-induced intestinal injury in rats and damage in Caco-2 cells. Peptides 2011, 32:946-955.
32. Wu J., Yang T., Wang C., Liu Q., Yao J., Sun H., Kaku T., Liu K.X. Laennec protects murine from concanavalin A-induced liver injury through inhibition of inflammatory reactions and hepatocyte apoptosis. Biol. Pharm. Bull. 2008, 31:2040-2044.
33. Yagi A., Nagao Okamura N., Ishizu T., Itoh H., Shida T. Effect of cyclo (trans-4-Lhydroxyprolyl-l-serine) from hydrolysate of human placenta on baby hamster kidney-21/C-13 cells. Nat. Med. 1998, 52:156-159.
34. Zhang J., Wang C., Liu Q., Meng Q., Cang J., Sun H., Gao Y., Kaku T., Liu K.X. Pharmacokinetic interaction between JBP485 and Cephalexin in rats. Drug Metab. Dispos. 2010, 38:930-938.