Meningococcal Factor H Binding Protein fHbpd184 Polymorphism Influences Clinical Course of Meningococcal Meningitis

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Piet, Jurgen R ^a   Brouwer, Matthijs C ^a   Exley, Rachel ^b   van der Veen, Stijn ^b   van de Beek, Diederik ^a   van der Ende, Arie ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Netherlands Reference Laboratory for Bacterial Meningitis   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; FACTOR H BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM ISOLATE; DISEASE SEVERITY; FACTOR H BINDING PROTEIN GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HYDROGEN BOND; MAJOR CLINICAL STUDY; MENINGOCOCCEMIA; MULTILOCUS SEQUENCE TYPING; MUTATOR GENE; NONHUMAN; OUTCOME ASSESSMENT; SEPTIC SHOCK; SEQUENCE ANALYSIS; SURFACE PLASMON RESONANCE;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CHILD; COHORT STUDIES; COMPLEMENT FACTOR H; DNA BARCODING, TAXONOMIC; HOST-PATHOGEN INTERACTIONS; HUMANS; KINETICS; MENINGITIS, MENINGOCOCCAL; MIDDLE AGED; NEISSERIA MENINGITIDIS; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECOMBINANT PROTEINS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SURFACE PLASMON RESONANCE;

EID: 84867868065     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047973     Document Type: Article

References (33)

1. Stephens DS, Greenwood B, Brandtzaeg P, (2007) Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 369: 2196-2210.
2. Heckenberg SG, de Gans J, Brouwer MC, Weisfelt M, Piet JR, et al. (2008) Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. Medicine (Baltimore) 87: 185-192.
3. Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM, (2001) Meningococcal disease. N Engl J Med 344: 1378-1388.
4. Claus H, Maiden MC, Wilson DJ, McCarthy ND, Jolley KA, et al. (2005) Genetic analysis of meningococci carried by children and young adults. J Infect Dis 191: 1263-1271.
5. Kellerman SE, McCombs K, Ray M, Baughman W, Reeves MW, et al. (2002) Genotype-specific carriage of Neisseria meningitidis in Georgia counties with hyper- and hyposporadic rates of meningococcal disease. J Infect Dis 186: 40-48.
6. Maclennan J, Kafatos G, Neal K, Andrews N, Cameron JC, et al. (2006) Social behavior and meningococcal carriage in British teenagers. Emerg Infect Dis 12: 950-957.
7. Christensen H, May M, Bowen L, Hickman M, Trotter CL, (2010) Meningococcal carriage by age: a systematic review and meta-analysis. Lancet Infect Dis 10: 853-861.
8. Gardner P, (2006) Clinical practice. Prevention of meningococcal disease. N Engl J Med 355: 1466-1473.
9. Davila S, Wright VJ, Khor CC, Sim KS, Binder A, et al. (2010) Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet 42: 772-776.
10. Brouwer MC, van de Beek D, (2009) Genetics in meningococcal disease: one step beyond. Clin Infect Dis 48: 595-597.
11. Caugant DA, Tzanakaki G, Kriz P, (2007) Lessons from meningococcal carriage studies. FEMS Microbiol Rev 31: 52-63.
12. Fransen F, Heckenberg SG, Hamstra HJ, Feller M, Boog CJ, et al. (2009) Naturally occurring lipid A mutants in Neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. PLoS Pathog 5: e1000396.
13. Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, et al. (2009) Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis 9: 31-44.
14. Brouwer MC, Read RC, van de Beek D, (2010) Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis 10: 262-274.
15. Lo H, Tang CM, Exley RM, (2009) Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development. Lancet Infect Dis 9: 418-427.
16. Lambris JD, Ricklin D, Geisbrecht BV, (2008) Complement evasion by human pathogens. Nat Rev Microbiol 6: 132-142.
17. Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, et al. (2006) The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol 177: 501-510.
18. Schneider MC, Prosser BE, Caesar JJ, Kugelberg E, Li S, Zhang Q, et al. (2009) Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature 458: 890-893.
19. Masignani V, Comanducci M, Giuliani MM, Bambini S, Adu-Bobie J, et al. (2003) Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870. J Exp Med 197: 789-799.
20. Fletcher LD, Bernfield L, Barniak V, Farley JE, Howell A, et al. (2004) Vaccine potential of the Neisseria meningitidis 2086 lipoprotein. Infect Immun 72: 2088-2100.
21. Schneider MC, Exley RM, Chan H, Feavers I, Kang YH, et al. (2006) Functional significance of factor H binding to Neisseria meningitidis. J Immunol 176: 7566-7575.
22. Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, et al. (2011) Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies. Infect Immun 79: 970-981.
23. Dunphy KY, Beernink PT, Brogioni B, Granoff DM, (2011) Effect of Factor H-Binding Protein Sequence Variation on Factor H Binding and Survival of Neisseria meningitidis in Human Blood. Infect Immun 79: 353-359.
24. Murphy E, Andrew L, Lee KL, Dilts DA, Nunez L, et al. (2009) Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis. J Infect Dis 200: 379-389.
25. Beernink PT, Granoff DM, (2009) The modular architecture of meningococcal factor H-binding protein. Microbiology 155: 2873-2883.
26. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, et al. (2004) Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 351: 1849-1859.
27. Jennett B, Bond M, (1975) Assessment of outcome after severe brain damage. Lancet 1: 480-484.
28. Ingram G, Hakobyan S, Hirst CL, Harris CL, Pickersgill TP, et al. (2010) Complement regulator factor H as a serum biomarker of multiple sclerosis disease state. Brain 133: 1602-1611.
29. de Greeff SC, de Melker HE, Spanjaard L, Schouls LM, van der Ende A, (2006) Protection from routine vaccination at the age of 14 months with meningococcal serogroup C conjugate vaccine in the Netherlands. Pediatr Infect Dis J 25: 79-80.
30. Jennett B and Teasdale G (1981) Management of head injuries. Philadelphia: F.A.Davis.
31. Saitou N, Nei M, (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406-425.
32. Tamura K, Dudley J, Nei M, Kumar S, (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.
33. Jolley KA, Maiden MC, (2010) BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics 11: 595.