Meningococcal carriage by age: A systematic review and meta-analysis

The Lancet Infectious Diseases

Volumn 10, Issue 12, 2010, Pages 853-861

  Christensen, Hannah ^a   May, Margaret ^a   Bowen, Leah ^a   Hickman, Matthew ^a   Trotter, Caroline L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULTHOOD; AGE DISTRIBUTION; ARTICLE; CHILDHOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DISEASE CARRIER; HERD IMMUNITY; HUMAN; INFANCY; MENINGOCOCCOSIS; META ANALYSIS; MULTICENTER STUDY; NEISSERIA MENINGITIDIS; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPTICEMIA; SYSTEMATIC REVIEW; THROAT CULTURE;

ADOLESCENT; ADULT; AGE FACTORS; CARRIER STATE; CHILD; CHILD, PRESCHOOL; HUMANS; INFANT; LOGISTIC MODELS; MENINGOCOCCAL INFECTIONS; MIDDLE AGED; NEISSERIA MENINGITIDIS; PREVALENCE; YOUNG ADULT;

EID: 78649449323     PISSN: 14733099     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1473-3099(10)70251-6     Document Type: Article

References (129)

1. Mortality statistics: deaths registered in 2007 Office for National Statistics, (accessed May 15, 2009). http://www.statistics.gov.uk/downloads/theme_health/DR2007/DR_07_2007.pdf.
2. Cartwright KAV, Stuart JM, Jones DM, Noah ND The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol Infect 1987, 99:591-601.
3. Kristiansen B-E, Tveten Y, Jenkins A Which contacts of patients with meningococcal disease carry the pathogenic strain of Neisseria meningitidis? A population based study. BMJ 1998, 317:621-625.
4. Kremastinou J, Tzanakaki G, Levidiotou S, et al. Carriage of Neisseria meningitidis and Neisseria lactamica in northern Greece. FEMS Immunol Med Microbiol 2003, 39:23-29.
5. Pether JVS, Lightfoot NF, Scott RJD, Morgan J, Steele-Perkins AP, Sheard SC Carriage of Neisseria meningitidis: investigations in a military establishment. Epidemiol Infect 1988, 101:21-42.
6. Olsen SF, Djurhuus B, Rasmussen K, et al. Pharyngeal carriage of Neisseria meningitidis and Neisseria lactamica in households with infants within areas with high and low incidences of meningococcal disease. Epidemiol Infect 1991, 106:445-457.
7. Fernández S, Arreaza L, Santiago I, et al. Carriage of a new epidemic strain of Neisseria meningitidis and its relationship with the incidence of meningococcal disease in Galicia, Spain. Epidemiol Infect 1999, 123:349-357.
8. Orr HJ, Gray SJ, MacDonald M, Stuart JM Saliva and meningococcal transmission. Emerg Infect Dis 2003, 9:1314-1315.
9. Cunningham R, Matthews R, Lewendon G, Harrison S, Stuart JM Improved rate of isolation of Neisseria meningitidis by direct plating of pharyngeal swabs. J Clin Microbiol 2001, 39:4575-4576.
10. Caugant DA, Tzanakaki G, Kriz P Lessons from meningococcal carriage studies. FEMS Microbiol Rev 2007, 31:52-63.
11. Trotter CL, Gay NJ, Edmunds WJ Dynamic models of meningococcal carriage, disease, and the impact of serogroup C conjugate vaccination. Am J Epidemiol 2005, 162:89-100.
12. Trotter CL, Maiden MC Meningococcal vaccines and herd immunity: lessons learned from serogroup C conjugate vaccination programs. Expert Rev Vaccines 2009, 8:851-861.
13. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 2000, 283:2008-2012.
14. Hollis DG, Wiggins GL, Weaver RE Neisseria lactamicus sp. n., a lactose-fermenting species resembling Neisseria meningitidis. Appl Microbiol 1969, 17:71-77.
15. Gold R, Goldschneider I, Lepow ML, Draper TF, Randolph M Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. J Infect Dis 1978, 137:112-121.
16. Tikhomirov E, Santamaria M, Esteves K Meningococcal disease: public health burden and control. World Health Stat Q 1997, 50:170-177.
17. Gilmore A, Jones G, Barker M, Soltanpoor N, Stuart JM Meningococcal disease at the University of Southampton: outbreak investigation. Epidemiol Infect 1999, 123:185-192.
18. Imrey PB, Jackson LA, Ludwinski PH, et al. Meningococcal carriage, alcohol consumption, and campus bar patronage in a serogroup C meningococcal disease outbreak. J Clin Microbiol 1995, 33:3133-3137.
19. Güçlü E, Yavuz T, Tokmak A, et al. Nasal carriage of pathogenic bacteria in medical students: effects of clinic exposure on prevalence and antibiotic susceptibility. Eur Arch Otorhinolaryngol 2007, 264:85-88.
20. Stata Statistical Software: Release 10 2007, StataCorp LP, College Station, TX.
21. Dupont WD, Plummer WD RC_SPLINE: Stata module to generate restricted cubic splines. Department of Economics, College of Liberal Arts and Sciences, University of Connecticut (accessed Dec 17, 2008). http://ideas.repec.org/c/boc/bocode/s447301.html.
22. Young GA, Daniels HE Bootstrap bias. Biometrika 1990, 77:179-185.
23. Carpenter J, Bithell J Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Stat Med 2000, 19:1141-1164.
24. Agudelo CI, Sanabria OM, Ovalle MV Serogroup Y meningococcal disease, Colombia. Emerg Infect Dis (accessed June 4, 2009). http://www.cdc.gov/eid/content/14/6/990.htm.
25. Holmes DJ, Martin D, Ramsey C, Ypma E, Oster P Combined administration of serogroup B meningococcal vaccine and conjugated serogroup C meningococcal vaccine is safe and immunogenic in college students. Epidemiol Infect 2008, 136:790-799.
26. Perkins BA, Jonsdottir K, Briem H, et al. Immunogenicity of two efficacious outer membrane protein-based serogroup B meningococcal vaccines among young adults in Iceland. J Infect Dis 1998, 177:683-691.
27. Bol P, Spanjaard L Dutch research concerning bacterial meningitis; implications for chemoprophylaxis. Ned Tijdschr Geneeskd 1990, 134:577-581. (in Dutch).
28. Jackson LA, Alexander ER, DeBolt CA, et al. Evaluation of the use of mass chemoprophylaxis during a school outbreak of enzyme type 5 serogroup B meningococcal disease. Pediatr Infect Dis J 1996, 15:992-998.
29. Jacobson JA, Chester TJ, Fraser DW An epidemic of disease due to serogroup B Neisseria meningitidis in Alabama: report of an investigation and community-wide prophylaxis with a sulfonamide. J Infect Dis 1977, 136:104-108.
30. Kriz P, Kriz B, Svandova E, Musilek M Antimeningococcal herd immunity in the Czech Republic-influence of an emerging clone, Neisseria meningitidis ET-15/37. Epidemiol Infect 1999, 123:193-200.
31. Robinson K, Neal KR, Howard C, et al. Characterization of humoral and cellular immune responses elicited by meningococcal carriage. Infect Immun 2002, 70:1301-1309.
32. Cuccia I, Palumbo C, Scalia L Sensitivity to antibiotics of the " Neisseria meningitidis" strains isolated among healthy subjects. Ann Sclavo 1978, 20:671-674. (in Italian).
33. Neal KR, Newlands MC, Ashford K, et al. Carriage of Neisseria meningitidis and N. lactamica in a village community after antibiotic and vaccine interventions programmes in rural England (UK). In: Nassif X, Quentin-Millet M-J, Taha M-K, eds. Abstracts of the Eleventh International Pathogenic Neisseria Conference. 1998.
34. Porucznik CA, Simonsen SE, Drake H, Joy EA Carriage of Neisseria meningitidis among college athletes. Am J Epidemiol 2006, 163(suppl):S1-S258.
35. Caron F, Lemee L, Delbos V, et al. Carriage of Neisseria meningitidis (Nm) in a Normandy area affected by an epidemic and Hypervirulent serogroup-B strain. Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy 2008, 48:593.
36. Fraser PK, Bailey GK, Abbott JD, Gill JB, Walker DJC The meningococcal carrier-rate. Lancet 1973, 1:1235-1237.
37. Uwaydah M Carrier rate of Neisseria meningitidis and the occurrence of sulfonamide resistant strains in Lebanon. J Med Liban 1973, 26:495-500.
38. Renga G, Mellino M, Gregorio P Frequency of healthy carriers of Neisseria meningitidis. L'Ig Mod 1971, 64:139-153. (in Italian).
39. Zucchetti P, Palmieri GC, Floccia M Research of the health carriers of Neisseria meningitidis among the school population in two boroughs of the province of Rome. Ann Sclavo 1973, 15:170-180. (in Italian).
40. Lombos J Casal, Bourgon C Martin Bacteriological and immunological study of meningitis in a school population. Revista de Sanidad e Higiene 1975, 49:179-192. (in Spanish).
41. Altmann G, Egoz N, Bogokovsky B Observations on asymptomatic infections with Neisseria meningitidis. Am J Epidemiol 1973, 98:446-452.
42. Jatta E, Bellia G Survey on the frequency of N meningitidis carriers in some communities in Bari. L'Ig Mod 1976, 69:185-189. (in Italian).
43. Omer EE, Williams RF Epidemiology of contact and non-contact meningococcal carrier rate in hospital patients. East Afr Med J 1979, 56:339-343.
44. De Wals P, Gilquin C, De Maeyer S, et al. Longitudinal study of asymptomatic meningococcal carriage in two Belgian populations of schoolchildren. J Infect 1983, 6:147-156.
45. Rizzo G, Jatta E The epidemiologic problem of Neisseria meningitidis carriers. Ann Sclavo 1977, 19:225-233. (in Italian).
46. Campello C, Lach S, Majori L A survey on meningococcal carrier-rate in some populations of Friuli-Venezia Giulia. L'Ig Mod 1979, 5:474-488. (in Italian).
47. Delia S, Mauro A Research of healthy carriers of N meningitidis in a sample of Messina habitants. Ann Sclavo 1977, 19:1214-1223. (in Italian).
48. Mastrantonio P, Zampieri A, Occhionero M, Luzzi I An epidemiological investigation of the healthy carriers of meningococcus. G Mal Infett Parassit 1979, 31:8-13. (in Italian).
49. Rodríguez-Contreras R, Fernández-Crehuet J, Rosales M, Pérez JA, Maroto MC, Piédrola G Study of Neisseria meningitidis carriers in children in Grenada. Laboratorio 1981, 71:483-502.
50. Borgoño JM, Rodriguez H, García J, Cánepa I Efficacy of rifampicin in the treatment of Meningococcus carriers. Rev Chil Pediatr 1981, 52:146-148. (in Spanish).
51. Barbuti S, Quarto M, Montagna MT Meningococcal infection in Puglia: serogroups prevalence and sulfonamides resistance during 1978-87. L'Ig Mod 1988, 89:65-78. (in Italian).
52. Benčić Z, Madaric D, Manhalter T, John V, Amšel V, Weisglass H N meningitidis carriers in young age groups. Lijec Vjesn 1979, 100:703-705. (in Croatian).
53. de Gandarias FJ Goiriena, Sanemeterio JP Different serogroups of Neisseria meningitidis in sick people and in the normal population. Rev Sanid Hig Publica (Madr) 1979, 53:1395-1402. (in Spanish).
54. Pokorni D, Mel D, Radovanovic M, Cobeljic M, Birtasevic B Dynamics of the meningococcal carrier state in a military group. Vojnosanit Pregl 1983, 40:399-403. (in Serbian).
55. Ceddia T, Mancini A, Marinucci MC, Zepponi E Meningococcus carriers in the population of L'Aquila: distribution according to blood group, drug resistance and prophylaxis. (in Italian). Boll Soc Ital Biol Sper 1981, 57:195-201.
56. Kamme C, Kahlmeter G Evaluation of spiramycin in meningococcal carriage. Scand J Infect Dis 1979, 11:229-232.
57. Marks MI, Frasch CE, Shapera RM Meningococcal colonization and infection in children and their household contacts. Am J Epidemiol 1979, 109:563-571.
58. Saez-Nieto JA, Dominguez JR, Monton JL, et al. Carriage of Neisseria meningitidis and Neisseria lactamica in a school population during an epidemic period in Spain. J Hyg (Lond) 1985, 94:279-288.
59. Kuzemenská P, Walter G Results of an all-state study " determination of circulation of N meningitidis in the healthy population of CSR" performed from 26 May till 7 June 1980 in all regions of CSR. Ceskoslovensk epidemiologie 1982, 31:30-37. (in Czech).
60. Savina D, Ricci M, Aliquò MR Research on the frequency of healthy carriers of Neisseria meningitidis in three towns of the Brindisi district. Ann Sclavo 1982, 24:192-197. (in Italian).
61. Stano G, Stevanato G, Piracci F, D'Angelo V A study on the prevalence of Neisseria meningitidis healthy carriers in infant-school children of Bari. L'Ig Mod 1985, 83:570-576.
62. Rønne T, Berthelsen L, Buhl LH, Lind I Comparative studies on pharyngeal carriage of Neisseria meningitidis during a localized outbreak of serogroup C meningococcal disease. Scand J Infect Dis 1993, 25:331-339.
63. Bernini A, Marmo F, Gastaldi R Use of antibiotics and the Neisseria meningitidis carrier state. G Med Mil 1985, 135:350-352. (in Italian).
64. Caugant DA, Kristiansen B-E, Frøholm LO, Bøvre K, Selander RK Clonal diversity of Neisseria meningitidis from a population of asymptomatic carriers. Infect Immun 1988, 56:2060-2068.
65. Cann KJ, Rogers TR, Jones DM, Noah ND, Burns C Neisseria meningitidis in a primary school. Arch Dis Child 1987, 62:1113-1117.
66. Schwan A, Eriksson M, Eriksson B-M, et al. Colonization with potentially pathogenic respiratory tract bacteria: a household study. Scand J Prim Health Care 1989, 7:203-209.
67. Le Saux N, Ashton F, Rahman M, et al. Carriage of Neisseria species in communities with different rates of meningococcal disease. Can J Infect Dis 1992, 3:60-64.
68. Ingram SB, Wilson BJ, Kemp RJ, Faoagali J Neisseria meningitidis in a school population in Queensland. Med J Aust 1990, 152:332.
69. Germinario C, Quarto M, Fontana A, Larocca AMV, Barbuti S Carriage of Neisseria lactamica and Neisseria meningitidis in a school population of Bari. L'Ig Mod 1992, 98:567-576. (in Italian).
70. Kremastinou J, Blackwell C, Tzanakaki G, Kallergi C, Elton R, Weir D Parental smoking and carriage of Neisseria meningitidis among Greek schoolchildren. Scand J Infect Dis 1994, 26:719-723.
71. Pokorni D Meningococcal carrier state and meningococcal diseases in a military unit. Vojnosanit Pregl 1990, 47:237-241. (in Serbian).
72. Wall R, Wilson J, MacArdle B, Vellani Z Meningococcal infection: evidence for school transmission. J Infect 1991, 23:155-159.
73. Puron ME Calle, Fernandez L Moreno, Leralta M, del Rey Calero J Estimation of the carriers of Neisseria meningitidis in the Madrid area as a result of contact between healthy patients and patients with septic meningococcus. An Esp Pediatr 1993, 39:102-104. (in Spanish).
74. Caugant DA, Høiby EA, Magnus P, et al. Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. J Clin Microbiol 1994, 32:323-330.
75. Puron EM Moreno, Fernandez L Moreno, Leralta M, del Rey Calero J The prevalence of Neisseria meningitidis carriers in a school population in the metropolitan area of Madrid. An Esp Pediatr 1993, 39:99-101. (in Spanish).
76. King WJ, MacDonald NE, Wells G, Manion D, Chan F, Allen UD Relationship between parental occupation and children's oropharyngeal colonisation with Neisseria meningitidis. J Pediatr 1995, 126:937-939.
77. Fontanals D, Van Esso D, Pons I, et al. Prevalence of Neisseria meningitidis carriers in Cerdanyola population (Barcelona). Enferm Infecc Microbiol Clin 1995, 13:398-405. (in Spanish).
78. Andersen J, Berthelsen L, Jensen BB, Lind I Dynamics of the meningococcal carrier state and characteristics of the carrier strains: a longitudinal study within three cohorts of military recruits. Epidemiol Infect 1998, 121:85-94.
79. Gilja OH, Halstensen A, Digranes A, Mylvaganam H, Aksnes A, Høiby EA Use of single-dose ofloxacin to eradicate tonsillopharyngeal carriage of Neisseria meningitidis. Antimicrob Agents Chemother 1993, 37:2024-2026.
80. Jolley KA, Kalmusova J, Feil EJ, et al. Carried meningococci in the Czech Republic: a diverse recombining population. J Clin Microbiol 2000, 38:4492-4498.
81. Blackwell CC, MacKenzia DAC, James VS, et al. Toxigenic bacteria and sudden infant death syndrome (SIDS): nasopharyngeal flora during the first year of life. FEMS Immunol Med Microbiol 1999, 25:51-58.
82. Homøe P, Prag J, Farholt S, et al. High rate of nasopharyngeal carriage of potential pathogens among children in Greenland: results of a clinical survey of middle-ear disease. Clin Infect Dis 1996, 23:1081-1090.
83. Rosenqvist E, Bjune G, Feiring B, et al. Changes in carrier status of Neisseria meningitis in teenagers during a group B outer membrane vaccination trial in Norway. Abstracts of the 8th International Pathogenic Neisseria Conference 1994, 895-901. Insituto National de Salud Publica-Morelos-Mexico, Mexico. C.J. Conde-Glez, S. Morse, P. Rice, F. Sparling, E. Calderon (Eds.).
84. Parodi V, Allende F, Torres E, Macedo M, Maglione R, Algorta G Neisseria meningitidis carriers in a population of Montevideo. Rev Med Uruguay 1998, 14:221-225.
85. Tayal SC, Rashid S, Muttu KMS, Hildreth AJ Meningococcal carriage: prevalence and sex-related risk factors. J Infect 1997, 34:101-105.
86. Davies AL, O'Flanagan D, Salmon RL, Coleman TJ Risk factors for Neisseria meningitidis carriage in a school during a community outbreak of meningococcal infection. Epidemiol Infect 1996, 117:259-266.
87. Kremastinou J, Tzanakaki G, Velonakis E, et al. Carriage of Neisseria meningitidis and Neisseria lactamica among ethnic Greek school children from Russian immigrant families in Athens. FEMS Immunol Med Microbiol 1999, 23:13-20.
88. Smith I, Lehmann AK, Lie L, et al. Outbreak of meningococcal disease in western Norway due to a new serogroup C variant of the ET-5 clone: effect of vaccination and selective carriage eradication. Epidemiol Infect 1999, 123:373-382.
89. Fitzpatrick PE, Salmon RL, Hunter PR, Roberts RJ, Palmer SR Risk factors for carriage of Neisseria meningitidis during an outbreak in Wales. Emerg Infect Dis 2000, 6:65-69.
90. Křižová P, Vlckova J Factors influencing carriership of Neisseria meningitidis and Neisseria lactamica. Epidemiol Mikrobiol Imunol 1998, 47:131-136. (in Czech).
91. Neal KR, Irwin DJ, Davies S, Kaczmarski EB, Wale MCJ Sustained reduction in the carriage of Neisseria meningitidis as a result of a community meningococcal disease control programme. Epidemiol Infect 1998, 121:487-493.
92. Neal KR, Nguyen-Van-Tam JS, Jeffrey N, et al. Changing carriage rate of Neisseria meningitidis among university students during the first week of term: cross sectional study. BMJ 2000, 320:846-849.
93. Punar M, Eraksoy H, Cagatay AA, et al. Neisseria meningitidis with decreased susceptibility to penicillin in Istanbul, Turkey. Scand J Infect Dis 2002, 34:11-13.
94. Vogel U, Morelli G, Zurth K, et al. Necessity of molecular techniques to distinguish between Neisseria meningitidis strains isolated from patients with meningococcal disease and from their healthy contacts. J Clin Microbiol 1998, 36:2465-2470.
95. Conyn-van Spaendonck MAE, Reintjes R, Spanjaard L, van Kregten E, Kraaijeveld AG, Jacobs PHA Meningococcal carriage in relation to an outbreak of invasive disease due to Neisseria meningitidis serogroup C in the Netherlands. J Infect 1999, 39:42-48.
96. Kellerman SE, McCombs K, Ray M, et al. Genotype-specific carriage of Neisseria meningitidis in Georgia counties with hyper- and hyposporadic rates of meningococcal disease. J Infect Dis 2002, 186:40-48.
97. Domínguez A, Cardeñosa N, Izquierdo C, et al. Prevalence of Neisseria meningitidis carriers in the school population of Catalonia, Spain. Epidemiol Infect 2001, 127:425-433.
98. Fernández S, Arreaza L, Santiago I, et al. Impact of meningococcal vaccination with combined serogroups A and C polysaccharide vaccine on carriage of Neisseria meningitidis C. J Med Microbiol 2003, 52:75-77.
99. Ala'Aldeen DAA, Neal KR, Ait-Tahar K, et al. Dynamics of meningococcal long-term carriage among university students and their implications for mass vaccination. J Clin Microbiol 2000, 38:2311-2316.
100. Martinez I, Matute I, Gutiérrez M, et al. Methodologically designee trial for carriers N meningitidis. VacciMonitor 1999, 8:2-9. (in Spanish).
101. Tyski S, Grzybowska W, Dulny G Neisseria meningitidis carrier study among young people and adults (recruits). Med Dosw Mikrobiol 2000, 52:247-255. (in Polish).
102. Rojas A García, Benítez A Bordes, Capuz B Lafarga, et al. Survey of N meningitidis carriers in the Gran Canary health jurisdiction. Rev Esp Salud Publica 2000, 74:419-424. (in Spanish).
103. Jordens JZ, Williams JN, Jones GR, Christodoulides M, Heckels JE Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students. Infect Immun 2004, 72:6503-6510.
104. Claus H, Maiden MCJ, Wilson DJ, et al. Genetic analysis of meningococci carried by children and young adults. J Infect Dis 2005, 191:1263-1271.
105. MacLennan J, Kafatos G, Neal K, et al. Social behavior and meningococcal carriage in British teenagers. Emerg Infect Dis 2006, 12:950-957.
106. Montagna MT, Caggiano G, Germinario C, et al. Carriers of N meningitidis among teenagers in Apulia (Italy). Ann Ig 2003, 15:845-850. (in Italian).
107. Linde H, Gluck T, Metz M, Reng C, Erlmeier S, Lehn N Six different strains of Neisseria meningitidis in a case with meningococcal sepsis and five contact persons in a boys' home. Infection 2000, 28:157-160.
108. Bakir M, Yagci A, Ulger N, Akbenlioglu C, Ilki A, Soyletir G Asymtomatic carriage of Neisseria meningitidis and Neisseria lactamica in relation to Streptococcus pneumoniae and Haemophilus influenzae colonization in healthy children: apropos of 1400 children sampled. Eur J Epidemiol 2001, 17:1015-1018.
109. Glitza IC, Ehrhard I, Müller-Pebody B, et al. Longitudinal study of meningococcal carrier rates in teenagers. Int J Hyg Environ Health 2008, 211:263-272.
110. Maiden MCJ, Stuart JM Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination. Lancet 2002, 359:1829-1831. for The UK Meningococcal Carriage Group.
111. Pavlopoulou ID, Daikos GL, Alexandrou H, et al. Carriage of Neisseria meningitidis by Greek children: risk factors and strain characteristics. Clin Microbiol Infect 2004, 10:137-142.
112. Motas I Martínez, García N Alvarez, Padrón F Sotolongo, Pérez L Izquierdo, Gutiérrez N Nuñez Carriers of Neisseria meningitidis in a day care centre in Havana. Reseñas en Quimioterapia Latinoamericana 2003, 11:93-99.
113. Maiden MCJ, Ibarz-Pavon AB, Urwin R, et al. Impact of Meningococcal serogroup C conjugate vaccines on carriage and herd immunity. J Infect Dis 2008, 197:737-743.
114. Patrick DM, Champagne S, Goh S-H, et al. Neisseria meningitidis carriage during an outbreak of serogroup C disease. Clin Infect Dis 2003, 37:1183-1188.
115. Gazi H, Surucuoglu S, Ozbakkaloglu B, et al. Oropharyngeal carriage and penicillin resistance of Neisseria meningitidis in primary school children in Manisa, Turkey. Ann Acad Med Singapore 2004, 33:758-762.
116. Bogaert D, Hermans PWM, Boelens H, et al. Epidemiology of nasopharyngeal carriage of Neisseria meningitidis in healthy Dutch children. Clin Infect Dis 2005, 40:899-902.
117. Jordens JZ, Williams JN, Jones GR, et al. Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles. J Clin Microbiol 2002, 40:75-79.
118. Krížová P, Kalmusová J, Musílek M, Felsberg J, Haugvicová R, Vlcková J A study of long-term duration and multiple carriage of Neisseria meningitidis in healthy population by molecular biology methods. Epidemiol Mikrobiol Imunol 2004, 53:25-36. (in Czech).
119. Martínez I, López O, Sotolongo F, Mirabal M, Bencomo A Carriers of Neisseria meningitidis in children from a primary school. Rev Cubana Med Trop 2003, 55:162-168. (in Spanish).
120. de los Monteros LE Espinosa, Aguilar-Ituarte F, Jimenez-Rojas LV, Kuri P, Rodriguez-Suarez RS, Gomez-Barreto D Prevalence of Neisseria meningitidis carriers in children under five years of age and teenagers in certain populations of Mexico City. Salud Publica Mex 2009, 51:114-118.
121. Robinson K, Wooldridge KG, Wells DB, et al. T-cell-stimulating protein A elicits immune responses during meningococcal carriage and human disease. Infect Immun 2005, 73:4684-4693.
122. Oppermann H, Thriene B, Irmscher HM, et al. Meningococcal carriage in high school students and possible risk factors. Gesundheitswesen 2006, 68:633-637. (in German).
123. Waldbeser LS, Abudiab M, Ommani S Risk factors assessment and mathematical modeling of Neisseria meningitidis carriage in a university student population. WSEAS Transactions on Biology and Biomedicine 2006, 3:421-428.
124. Uberos J, Molina-Carballo A, Galdo-Munoz G, et al. Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis. Epidemiol Infect 2007, 135:857-860.
125. Exindari M, Gioula G, Godosis D, et al. Influence of smoking on pharyngeal flora. Acta Microbiologica Hellenica 2008, 53:223-229. (in Greek).
126. Harrell FE General aspects of fitting regression models. Regression modelling strategies: with application to linear models, logistic regression, and survival analysis 2001, 23-24. Springer-Verlag New York, New York.
127. Mossong J, Hens N, Jit M, et al. Social contacts and mixing patterns relevant to the spread of infectious diseases. PLoS Med 2008, 5:e74.
128. Stuart JM, Cartwright KA, Robinson PM, Noah ND Effect of smoking on meningococcal carriage. Lancet 1989, 2:723-725.
129. Roberts J, Greenwood B, Stuart J Sampling methods to detect carriage of Neisseria meningitidis; literature review. J Infect 2009, 58:103-107.