Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: A prospective cohort study

Medicine

Volumn 87, Issue 4, 2008, Pages 185-192

  Heckenberg, Sebastiaan G B ^a   De Gans, Jan ^a   Brouwer, Matthijs C ^a   Weisfelt, Martijn ^b   Piet, Jurgen R ^a   Spanjaard, Lodewijk ^a   Van Der Ende, Arie ^a   Van De Beek, Diederik ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Kennemer Gasthuis ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CEPHALOSPORIN; DEXAMETHASONE; HYDROCORTISONE; PENICILLIN G; PREDNISOLONE; PREDNISONE; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ADULT; ARTICLE; BACTERIAL MENINGITIS; BLOOD GROUP TYPING; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ASSESSMENT; CLINICAL FEATURE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EPIDEMIC MENINGITIS; FEMALE; FEVER; GENOTYPE; GLASGOW OUTCOME SCALE; HEARING LOSS; HOSPITAL DISCHARGE; HUMAN; HYPOTENSION; INFECTION; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MORTALITY; NEISSERIA MENINGITIDIS; NEUROIMAGING; NEUROLOGIC EXAMINATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RASH; SEPSIS; SEPTICEMIA; TREATMENT OUTCOME; CLASSIFICATION; DNA SEQUENCE; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; PATHOPHYSIOLOGY; PREVALENCE; RISK FACTOR;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIOLOGICAL TECHNIQUES; DNA, BACTERIAL; FEMALE; GENOTYPE; GLASGOW OUTCOME SCALE; HUMANS; MALE; MENINGITIS, MENINGOCOCCAL; NEISSERIA MENINGITIDIS; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SEQUENCE ANALYSIS, DNA; TREATMENT OUTCOME;

EID: 49149085624     PISSN: 00257974     EISSN: None     Source Type: Journal    
DOI: 10.1097/MD.0b013e318180a6b4     Document Type: Article

References (24)

1. Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med. 1998;129:862-869.
2. Cartwright K, Reilly S, White D, Stuart J. Early treatment with parenteral penicillin in meningococcal disease. BMJ. 1992;305:143-147.
3. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med. 2003;348:727-734.
4. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N EnglJ Med. 2002;347:1549-1556.
5. de Greeff SC, de Melker HE, Spanjaard L, Schouls LM, van der Ende A. Protection from routine vaccination at the age of 14 months with meningococcal serogroup C conjugate vaccine in the Netherlands. Pediatr Infect Dis J. 2006;25:79-80.
6. Dodge PR, Davis H, Feigin RD, Holmes SJ, Kaplan SL, Jubelirer DP, techenberg BW, Hirsh SK. Prospective evaluation of hearing impairment as a sequela of acute bacterial meningitis. N Engl J Med. 1984;311:869-874.
7. Hahne SJ, Charlett A, Purcell B, Samuelsson S, Camaroni I, Ehrhard I, Heuberger S, Santamaria M, Stuart JM. Effectiveness of antibiotics given before admission in reducing mortality from meningococcal disease: systematic review. BMJ. 2006;332:1283-1284.
8. Harnden A, Ninis N, Thompson M, Perera R, Levin M, Mant D, Mayon-White R. Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. BMJ. 2006;332:1295-1298.
9. Heyderman RS. British Infection Society. Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults-second edition. J Infect. 2005;50:373-374.
10. Jolley KA, Chan MS, Maiden MC. mlstdbNet-distributed multi-locus sequence typing (MLST) databases. BMC Bioinformatics. 2004;5:86.
11. Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou J, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci. 1998;95:3140-3145.
12. McMillan DA, Lin CY, Aronin SI, Quagliarello VJ. Community-acquired bacterial meningitis in adults: categorization of causes and timing of death. Clin Infect Dis. 2001;33:969-975.
13. Neisseria Multi Locus Sequence Typing website. Available at http://pubmlst.org/neisseria/. Accessed 3 October 2007.
14. Proulx N, Frechette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM. 2005;98:291-298.
15. Riordan FA, Thomson AP, Sills JA, Hart CA. Who spots the spots? Diagnosis and treatment of early meningococcal disease in children. BMJ. 1996;313:1255-1256.
16. Snape MD, Pollard AJ. Meningococcal polysaccharide-protein conjugate vaccines. Lancet Infect Dis. 2004;5:21-30.
17. Spanos A, Harrell FE Jr, Durack DT. Differential diagnosis of acute meningitis: an analysis of the predictive value of initial observations. 1989;262:2700-2707.
18. Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia and Neisseria meningitidis. Lancet. 2007;369:2196-2210.
19. Thompson MJ, Ninis N, Perera R, Mayon-White R, Phillips C, Bailey L, Harnden A, Mant D, Levin M. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006;367:397-403.
20. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39:1267-1284.
21. van de Beek D, de Gans J. Dexamethasone and pneumococcal meningitis. Ann Intern Med. 2004;141:327.
22. van de Beek D, de Gans J, McIntyre P, Prasad K. Steroids in adults with acute bacterial meningitis: a systematic review. Lancet Infect Dis. 2004;4:139-143.
23. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351:1849-1859.
24. van de Beek D, de Gans J, Tunkel AR, Wijdicks EFM. Community- acquired bacterial meningitis in adults. N Engl J Med. 2006;354:44-53.