Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 22, 2012, Pages 6709-6723

  Lecis, Daniele ^a   Mastrangelo, Eloise ^b   Belvisi, Laura ^b   Bolognesi, Martino ^b   Civera, Monica ^b   Cossu, Federica ^b   De Cesare, Michelandrea ^a   Delia, Domenico ^a   Drago, Carmelo ^c   Manenti, Giacomo ^a   Manzoni, Leonardo ^d   Milani, Mario ^b   Moroni, Elisabetta ^b   Perego, Paola ^a   Potenza, Donatella ^b   Rizzo, Vincenzo ^c   Scavullo, Cinzia ^b   Scolastico, Carlo ^c   Servida, Federica ^b   Vasile, Francesca ^b   Seneci, Pierfausto ^b,c   more..

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CISI Scrl   (Italy)

^d CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

Apoptosis; IAP inhibitors; In vitro profiling; In vivo testing; Smac mimetics; Structural studies

Indexed keywords

1 AZA 2 OXOBICYCLO[5.3.0]DECANE DERIVATIVE; HETERODIMER; HOMODIMER; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CRYSTALLOGRAPHY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; FEMALE; GEL FILTRATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MATHEMATICAL MODEL; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OVARY CARCINOMA; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; FEMALE; HALF-LIFE; HL-60 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, NUDE; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; OVARIAN NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 84867863403     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.041     Document Type: Article

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