메뉴 건너뛰기




Volumn 13, Issue 7, 2012, Pages 558-565

Systems biology in aging: Linking the old and the young

Author keywords

Aging; Genomics; Longevity; Network analysis; Proteomics; Systems biology

Indexed keywords

REGULATOR PROTEIN;

EID: 84867822272     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/138920212803251418     Document Type: Review
Times cited : (24)

References (65)
  • 1
    • 0141790263 scopus 로고    scopus 로고
    • Invited review: Theories of aging
    • Weinert, B.T.; Timiras, P.S. Invited review: Theories of aging. J Appl Physiol, 2003, 95(4), 1706-16.
    • (2003) J Appl Physiol , vol.95 , Issue.4 , pp. 1706-1716
    • Weinert, B.T.1    Timiras, P.S.2
  • 2
    • 34848911606 scopus 로고    scopus 로고
    • Genetics of aging in Caenorhabditis elegans
    • Antebi, A. Genetics of aging in Caenorhabditis elegans. PLoS Genet, 2007, 3(9), 1565-71.
    • (2007) PLoS Genet , vol.3 , Issue.9 , pp. 1565-1571
    • Antebi, A.1
  • 3
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon, C.J. The genetics of ageing. Nature, 2010, 464(7288), 504-12.
    • (2010) Nature , vol.464 , Issue.7288 , pp. 504-512
    • Kenyon, C.J.1
  • 4
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer, E.L.; Brunet, A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell, 2009, 8(2), 113-27.
    • (2009) Aging Cell , vol.8 , Issue.2 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 5
    • 59649120539 scopus 로고    scopus 로고
    • Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    • Honjoh, S.; Yamamoto, T.; Uno, M.; Nishida, E. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature, 2009, 457(7230), 726-30.
    • (2009) Nature , vol.457 , Issue.7230 , pp. 726-730
    • Honjoh, S.1    Yamamoto, T.2    Uno, M.3    Nishida, E.4
  • 6
    • 38849146505 scopus 로고    scopus 로고
    • Understanding biological functions through molecular networks
    • Han, J.D. Understanding biological functions through molecular networks. Cell Res, 2008, 18(2), 224-37.
    • (2008) Cell Res , vol.18 , Issue.2 , pp. 224-237
    • Han, J.D.1
  • 7
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee, C.K.; Klopp, R.G.; Weindruch, R.; Prolla, T.A. Gene expression profile of aging and its retardation by caloric restriction. Science, 1999, 285(5432), 1390-3.
    • (1999) Science , vol.285 , Issue.5432 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 8
    • 21644487750 scopus 로고    scopus 로고
    • Microarrays as a tool to investigate the biology of aging: A retrospective and a look to the future
    • Melov, S.; Hubbard, A. Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future. Sci Aging Knowledge Environ, 2004, 2004(42), re7.
    • (2004) Sci Aging Knowledge Environ , vol.2004 , Issue.42
    • Melov, S.1    Hubbard, A.2
  • 11
    • 0035942222 scopus 로고    scopus 로고
    • Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
    • Kayo, T.; Allison, D.B.; Weindruch, R.; Prolla, T.A. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A, 2001, 98(9), 5093-8.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5093-5098
    • Kayo, T.1    Allison, D.B.2    Weindruch, R.3    Prolla, T.A.4
  • 15
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • Lu, T.; Pan, Y.; Kao, S.Y.; Li, C.; Kohane, I.; Chan, J.; Yankner, B.A. Gene regulation and DNA damage in the ageing human brain. Nature, 2004, 429(6994), 883-91.
    • (2004) Nature , vol.429 , Issue.6994 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.Y.3    Li, C.4    Kohane, I.5    Chan, J.6    Yankner, B.A.7
  • 20
    • 33744485559 scopus 로고    scopus 로고
    • Modulated microRNA expression during adult lifespan in Caenorhabditis elegans
    • Ibanez-Ventoso, C.; Yang, M.; Guo, S.; Robins, H.; Padgett, R.W.; Driscoll, M. Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell, 2006, 5(3), 235-46.
    • (2006) Aging Cell , vol.5 , Issue.3 , pp. 235-246
    • Ibanez-Ventoso, C.1    Yang, M.2    Guo, S.3    Robins, H.4    Padgett, R.W.5    Driscoll, M.6
  • 21
    • 78650490230 scopus 로고    scopus 로고
    • MicroRNAs both promote and antagonize longevity in C. elegans
    • de Lencastre, A.; Pincus, Z.; Zhou, K.; Kato, M.; Lee, S.S.; Slack, F.J. MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol, 2010, 20(24), 2159-68.
    • (2010) Curr Biol , vol.20 , Issue.24 , pp. 2159-2168
    • de Lencastre, A.1    Pincus, Z.2    Zhou, K.3    Kato, M.4    Lee, S.S.5    Slack, F.J.6
  • 22
    • 70349438679 scopus 로고    scopus 로고
    • 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
    • Zid, B.M.; Rogers, A.N.; Katewa, S.D.; Vargas, M.A.; Kolipinski, M.C.; Lu, T.A.; Benzer, S.; Kapahi, P. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell, 2009, 139(1), 149-60.
    • (2009) Cell , vol.139 , Issue.1 , pp. 149-160
    • Zid, B.M.1    Rogers, A.N.2    Katewa, S.D.3    Vargas, M.A.4    Kolipinski, M.C.5    Lu, T.A.6    Benzer, S.7    Kapahi, P.8
  • 23
    • 79959981053 scopus 로고    scopus 로고
    • Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans
    • Rogers, A.N.; Chen, D.; McColl, G.; Czerwieniec, G.; Felkey, K.; Gibson, B.W.; Hubbard, A.; Melov, S.; Lithgow, G.J.; Kapahi, P. Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans. Cell Metab, 2011, 14(1), 55-66.
    • (2011) Cell Metab , vol.14 , Issue.1 , pp. 55-66
    • Rogers, A.N.1    Chen, D.2    McColl, G.3    Czerwieniec, G.4    Felkey, K.5    Gibson, B.W.6    Hubbard, A.7    Melov, S.8    Lithgow, G.J.9    Kapahi, P.10
  • 24
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of agerelated gene expression profiles identifies common signatures of aging
    • de Magalhaes, J.P.; Curado, J.; Church, G.M. Meta-analysis of agerelated gene expression profiles identifies common signatures of aging. Bioinformatics, 2009, 25(7), 875-81.
    • (2009) Bioinformatics , vol.25 , Issue.7 , pp. 875-881
    • de Magalhaes, J.P.1    Curado, J.2    Church, G.M.3
  • 25
    • 0025004091 scopus 로고
    • Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
    • Johnson, T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science, 1990, 249(4971), 908-12.
    • (1990) Science , vol.249 , Issue.4971 , pp. 908-912
    • Johnson, T.E.1
  • 26
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin, K.; Dorman, J.B.; Rodan, A.; Kenyon, C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science, 1997, 278(5341), 1319-22.
    • (1997) Science , vol.278 , Issue.5341 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 27
    • 84867772824 scopus 로고    scopus 로고
    • Genome-wide RNAi longevity screens in Caenorhabditis elegans
    • This issue
    • Bennett, C.F.; Yanos, M.; Kaeberlein, M. Genome-wide RNAi longevity screens in Caenorhabditis elegans. Curr Genomics, 2012, This issue.
    • (2012) Curr Genomics
    • Bennett, C.F.1    Yanos, M.2    Kaeberlein, M.3
  • 28
  • 29
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen, M.; Hsu, A.L.; Dillin, A.; Kenyon, C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet, 2005, 1(1), 119-28.
    • (2005) PLoS Genet , vol.1 , Issue.1 , pp. 119-128
    • Hansen, M.1    Hsu, A.L.2    Dillin, A.3    Kenyon, C.4
  • 31
    • 9644270707 scopus 로고    scopus 로고
    • Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
    • Kojima, T.; Kamei, H.; Aizu, T.; Arai, Y.; Takayama, M.; Nakazawa, S.; Ebihara, Y.; Inagaki, H.; Masui, Y.; Gondo, Y.; Sakaki, Y.; Hirose, N. Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp Gerontol, 2004, 39(11-12), 1595-8.
    • (2004) Exp Gerontol , vol.39 , Issue.11-12 , pp. 1595-1598
    • Kojima, T.1    Kamei, H.2    Aizu, T.3    Arai, Y.4    Takayama, M.5    Nakazawa, S.6    Ebihara, Y.7    Inagaki, H.8    Masui, Y.9    Gondo, Y.10    Sakaki, Y.11    Hirose, N.12
  • 35
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • Adler, A.S.; Sinha, S.; Kawahara, T.L.; Zhang, J.Y.; Segal, E.; Chang, H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev, 2007, 21(24), 3244-57.
    • (2007) Genes Dev , vol.21 , Issue.24 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 36
  • 37
    • 57049158206 scopus 로고    scopus 로고
    • Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity
    • Managbanag, J.R.; Witten, T.M.; Bonchev, D.; Fox, L.A.; Tsuchiya, M.; Kennedy, B.K.; Kaeberlein, M. Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One, 2008, 3(11), e3802.
    • (2008) PLoS One , vol.3 , Issue.11
    • Managbanag, J.R.1    Witten, T.M.2    Bonchev, D.3    Fox, L.A.4    Tsuchiya, M.5    Kennedy, B.K.6    Kaeberlein, M.7
  • 42
    • 38949175007 scopus 로고    scopus 로고
    • A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    • Miller, J.A.; Oldham, M.C.; Geschwind, D.H. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci, 2008, 28(6), 1410-20.
    • (2008) J Neurosci , vol.28 , Issue.6 , pp. 1410-1420
    • Miller, J.A.1    Oldham, M.C.2    Geschwind, D.H.3
  • 43
    • 70349653568 scopus 로고    scopus 로고
    • Diseaseaging network reveals significant roles of aging genes in connecting genetic diseases
    • Wang, J.; Zhang, S.; Wang, Y.; Chen, L.; Zhang, X.S. Diseaseaging network reveals significant roles of aging genes in connecting genetic diseases. PLoS Comput Biol, 2009, 5(9), e1000521.
    • (2009) PLoS Comput Biol , vol.5 , Issue.9
    • Wang, J.1    Zhang, S.2    Wang, Y.3    Chen, L.4    Zhang, X.S.5
  • 44
    • 24944442468 scopus 로고    scopus 로고
    • Effect of sampling on topology predictions of protein-protein interaction networks
    • Han, J.D.; Dupuy, D.; Bertin, N.; Cusick, M.E.; Vidal, M. Effect of sampling on topology predictions of protein-protein interaction networks. Nat Biotechnol, 2005, 23(7), 839-44.
    • (2005) Nat Biotechnol , vol.23 , Issue.7 , pp. 839-844
    • Han, J.D.1    Dupuy, D.2    Bertin, N.3    Cusick, M.E.4    Vidal, M.5
  • 45
    • 84867794356 scopus 로고    scopus 로고
    • Chromatin remodeling, DNA damage repair and aging
    • This issue
    • Liu, B.; Zhou, Z. Chromatin remodeling, DNA damage repair and aging. Curr Genomics, 2012, This issue.
    • (2012) Curr Genomics
    • Liu, B.1    Zhou, Z.2
  • 46
    • 40949093544 scopus 로고    scopus 로고
    • Epigenetics at the epicenter of modern medicine
    • Feinberg, A.P. Epigenetics at the epicenter of modern medicine. Jama, 2008, 299(11), 1345-50.
    • (2008) Jama , vol.299 , Issue.11 , pp. 1345-1350
    • Feinberg, A.P.1
  • 50
    • 54749095200 scopus 로고    scopus 로고
    • Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator
    • Li, J.; Ebata, A.; Dong, Y.; Rizki, G.; Iwata, T.; Lee, S.S. Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol, 2008, 6(9), e233.
    • (2008) PLoS Biol , vol.6 , Issue.9
    • Li, J.1    Ebata, A.2    Dong, Y.3    Rizki, G.4    Iwata, T.5    Lee, S.S.6
  • 51
    • 76249126432 scopus 로고    scopus 로고
    • Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
    • Siebold, A.P.; Banerjee, R.; Tie, F.; Kiss, D.L.; Moskowitz, J.; Harte, P.J. Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci U S A, 2010, 107(1), 169-74.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.1 , pp. 169-174
    • Siebold, A.P.1    Banerjee, R.2    Tie, F.3    Kiss, D.L.4    Moskowitz, J.5    Harte, P.J.6
  • 58
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl, B.D.; Allis, C.D. The language of covalent histone modifications. Nature, 2000, 403(6765), 41-5.
    • (2000) Nature , vol.403 , Issue.6765 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 59
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T.; Allis, C.D. Translating the histone code. Science, 2001, 293(5532), 1074-80.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 61
    • 48949099045 scopus 로고    scopus 로고
    • Inferring causal relationships among different histone modifications and gene expression
    • Yu, H.; Zhu, S.; Zhou, B.; Xue, H.; Han, J.D. Inferring causal relationships among different histone modifications and gene expression. Genome Res, 2008, 18(8), 1314-24.
    • (2008) Genome Res , vol.18 , Issue.8 , pp. 1314-1324
    • Yu, H.1    Zhu, S.2    Zhou, B.3    Xue, H.4    Han, J.D.5
  • 62
    • 13444249959 scopus 로고    scopus 로고
    • HAGR: The Human Ageing Genomic Resources
    • de Magalhaes, J.P.; Costa, J.; Toussaint, O. HAGR: the Human Ageing Genomic Resources. Nucleic Acids Res, 2005, 33(Database issue), D537-43.
    • (2005) Nucleic Acids Res , vol.33 , Issue.DATABASE ISSUE
    • de Magalhaes, J.P.1    Costa, J.2    Toussaint, O.3
  • 64
    • 0036529479 scopus 로고    scopus 로고
    • An efficient algorithm for large-scale detection of protein families
    • Enright, A.J.; Van Dongen, S.; Ouzounis, C.A. An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res, 2002, 30(7), 1575-84.
    • (2002) Nucleic Acids Res , vol.30 , Issue.7 , pp. 1575-1584
    • Enright, A.J.1    van Dongen, S.2    Ouzounis, C.A.3
  • 65
    • 77952310528 scopus 로고    scopus 로고
    • A human functional protein interaction network and its application to cancer data analysis
    • Wu, G.; Feng, X.; Stein, L. A human functional protein interaction network and its application to cancer data analysis. Genome Biol, 2010, 11(5), R53.
    • (2010) Genome Biol , vol.11 , Issue.5
    • Wu, G.1    Feng, X.2    Stein, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.